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The map label for this gene is ptxR [H]

Identifier: 189352258

GI number: 189352258

Start: 302263

End: 303216

Strand: Reverse

Name: ptxR [H]

Synonym: BMULJ_03476

Alternate gene names: 189352258

Gene position: 303216-302263 (Counterclockwise)

Preceding gene: 189352264

Following gene: 189352256

Centisome position: 12.26

GC content: 72.12

Gene sequence:

>954_bases
ATGGCCGATCTGCGCGACGTGAACCTGAACCGGCTGGCGGTGTTCGTTGCGGTCGTCGAAGCGGGGTCGCTGACGGCCGC
GGCCGAACGGCTCGGCCTCGCGAAGACGGTGGTCAGCACGCACATGCAGCGTCTCGAATCGGAAGTCGGCGCGAACCTGC
TCGTGCGCACGACGCGGCGGCTCAGCGTGACCGACGCGGGCCGCGCGTTCTACGAGGCGTGCCGCGACATCGTGCAGGCC
GCCGAAACCGCACTCGACGCCGTGTCGTCGGACGCCGGGCCGCTGCGCGGCACGCTGCGCGTAAGCGTGCCGGTCGATTA
CGGCGCGCAGGTCGTCGCGCCGGCGGTCGTCGCGCTGCGCGATGCGCATCCGTCGCTCGACGTCGAGTTGATCGCGAACG
ACCGCGTCGTCGATCTCGTCGCGGAGAGCCTCGACGTCGCCGTCCGCATCGGCCGGCTCGCCGATTCGAACTATCGCGCG
GTGCAGCTCGGCACGTACGAGAAGTGGCTGGTGGCAAGCCCCGCGTTCGTCGCGCGCTACGGGCTGCCGCGCGATCCGGC
CGCGCTCGCGACGCTGCCGTTCGTGATGCTGTCGACGCTTGCGCGCCCGCATACGCTCGAACTCGAAAGCGCACGCGGCG
GCAAGGCGTCGGTGCGCTGTAACGCGTCGGTCGTGTCGAACACGGCCACCGCCTGCCGCTCGATCGCGCTCGCGGGTGGC
GGCTTCGGGCTGCTGACGGATTTCTCGATCGCCGACGACGTCGCGGCCGGCACGCTCGTGCGGCTGCTGCCCGCATGGCG
CGCCGCGCCGGCCGGGATTCACGCGGTGTATCCGTCCACGCGGCTGCCGTCGCCGAAGGTGCGTGCGTTCATCGACGCGA
TGAAGGCGACGATCGGCGCCACGCCGCGCACGCCGTCCGCACGCCCCGCGACGCGCAGGCGCACCGCACGCTGA

Upstream 100 bases:

>100_bases
CCGGACGCGGCGACGAACGGCCTCAGCGTACCGCTCGCCGCCGTTCGCCAGAAGGCGGATAATCGCGGAAACATTATCCG
CCTCCATAGGACAATCGACG

Downstream 100 bases:

>100_bases
AGCGCCGCGCGCGGCGCGCCGGTCTCGTTCACGTCGGCGACTTGTCCGCGCCGCCCACTTCCCGCAACGTCCCCAGCAGG
ACCTTCCTGCAACTCGCGAC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MADLRDVNLNRLAVFVAVVEAGSLTAAAERLGLAKTVVSTHMQRLESEVGANLLVRTTRRLSVTDAGRAFYEACRDIVQA
AETALDAVSSDAGPLRGTLRVSVPVDYGAQVVAPAVVALRDAHPSLDVELIANDRVVDLVAESLDVAVRIGRLADSNYRA
VQLGTYEKWLVASPAFVARYGLPRDPAALATLPFVMLSTLARPHTLELESARGGKASVRCNASVVSNTATACRSIALAGG
GFGLLTDFSIADDVAAGTLVRLLPAWRAAPAGIHAVYPSTRLPSPKVRAFIDAMKATIGATPRTPSARPATRRRTAR

Sequences:

>Translated_317_residues
MADLRDVNLNRLAVFVAVVEAGSLTAAAERLGLAKTVVSTHMQRLESEVGANLLVRTTRRLSVTDAGRAFYEACRDIVQA
AETALDAVSSDAGPLRGTLRVSVPVDYGAQVVAPAVVALRDAHPSLDVELIANDRVVDLVAESLDVAVRIGRLADSNYRA
VQLGTYEKWLVASPAFVARYGLPRDPAALATLPFVMLSTLARPHTLELESARGGKASVRCNASVVSNTATACRSIALAGG
GFGLLTDFSIADDVAAGTLVRLLPAWRAAPAGIHAVYPSTRLPSPKVRAFIDAMKATIGATPRTPSARPATRRRTAR
>Mature_316_residues
ADLRDVNLNRLAVFVAVVEAGSLTAAAERLGLAKTVVSTHMQRLESEVGANLLVRTTRRLSVTDAGRAFYEACRDIVQAA
ETALDAVSSDAGPLRGTLRVSVPVDYGAQVVAPAVVALRDAHPSLDVELIANDRVVDLVAESLDVAVRIGRLADSNYRAV
QLGTYEKWLVASPAFVARYGLPRDPAALATLPFVMLSTLARPHTLELESARGGKASVRCNASVVSNTATACRSIALAGGG
FGLLTDFSIADDVAAGTLVRLLPAWRAAPAGIHAVYPSTRLPSPKVRAFIDAMKATIGATPRTPSARPATRRRTAR

Specific function: Transcriptional activator of the toxA (exotoxin) and regA genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786401, Length=295, Percent_Identity=31.5254237288136, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI87081978, Length=287, Percent_Identity=33.1010452961672, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI145693193, Length=292, Percent_Identity=27.7397260273973, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1789639, Length=288, Percent_Identity=29.1666666666667, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1789440, Length=285, Percent_Identity=27.719298245614, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1787128, Length=304, Percent_Identity=26.9736842105263, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1787589, Length=286, Percent_Identity=26.5734265734266, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788297, Length=146, Percent_Identity=34.2465753424658, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1789173, Length=254, Percent_Identity=25.5905511811024, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1787601, Length=186, Percent_Identity=25.2688172043011, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788748, Length=139, Percent_Identity=28.7769784172662, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33428; Mature: 33297

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLRDVNLNRLAVFVAVVEAGSLTAAAERLGLAKTVVSTHMQRLESEVGANLLVRTTRR
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHE
LSVTDAGRAFYEACRDIVQAAETALDAVSSDAGPLRGTLRVSVPVDYGAQVVAPAVVALR
EEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHH
DAHPSLDVELIANDRVVDLVAESLDVAVRIGRLADSNYRAVQLGTYEKWLVASPAFVARY
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHCCCHHHHHC
GLPRDPAALATLPFVMLSTLARPHTLELESARGGKASVRCNASVVSNTATACRSIALAGG
CCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEECHHHHHHHHHHHHHHHHCCC
GFGLLTDFSIADDVAAGTLVRLLPAWRAAPAGIHAVYPSTRLPSPKVRAFIDAMKATIGA
CCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCC
TPRTPSARPATRRRTAR
CCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ADLRDVNLNRLAVFVAVVEAGSLTAAAERLGLAKTVVSTHMQRLESEVGANLLVRTTRR
CCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHE
LSVTDAGRAFYEACRDIVQAAETALDAVSSDAGPLRGTLRVSVPVDYGAQVVAPAVVALR
EEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHH
DAHPSLDVELIANDRVVDLVAESLDVAVRIGRLADSNYRAVQLGTYEKWLVASPAFVARY
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHCCCHHHHHC
GLPRDPAALATLPFVMLSTLARPHTLELESARGGKASVRCNASVVSNTATACRSIALAGG
CCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEECHHHHHHHHHHHHHHHHCCC
GFGLLTDFSIADDVAAGTLVRLLPAWRAAPAGIHAVYPSTRLPSPKVRAFIDAMKATIGA
CCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCC
TPRTPSARPATRRRTAR
CCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8843437; 10984043 [H]