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The map label for this gene is ethA [H]

Identifier: 189352255

GI number: 189352255

Start: 299008

End: 300570

Strand: Reverse

Name: ethA [H]

Synonym: BMULJ_03473

Alternate gene names: 189352255

Gene position: 300570-299008 (Counterclockwise)

Preceding gene: 189352256

Following gene: 189352254

Centisome position: 12.15

GC content: 67.88

Gene sequence:

>1563_bases
ATGACCTCGACGACGACCGACCGGCGCGCCGCGCCGCCCGCCTGCGGCGACAGCCGCGACCTCGACGTGCTGATCGTCGG
TGCCGGCCTGTCCGGCATCGGCGCGGCCTATCACCTGAACAAGCGCTGCCCGCATGCGAGCGTTGCGATCGTCGAGGCGC
GCGACGCGATCGGCGGCACGTGGGACCTGTTCCGCTATCCGGGCGTGCGCTCGGATTCGGACATGTTCACGCTCGGCTAC
AGCTTCCGCCCGTGGCACAGCGACAAGGCGATTTCCGACGGCCAGACGATCCTCGACTACATCTGCGACACCGCGCGCAC
GTACGGGATCGACAAGCTGATCCGCTACGGGCAGAAGGTCGTCGCGGCCGACTGGGATTCGAACCGTGCACGCTGGACGG
TGCGCGTCGAGCGCACGCGCGACGGCGCGACCGACACGCTCGTCTACACGTGCCGCTTCCTCTATATGTGCAGCGGCTAC
TACGACTACGATGCGGGCTACCTGCCCGACTGGCCCGCGATGGACACGTTCGAGGGCCGCATCGTGCATCCGCAGCACTG
GCCGAAGGATCTGTCGTACGCGAACCGGCGCGTCGTCGTGATCGGCAGCGGCGCGACGGCCGTCACGCTCGTGCCGTCGA
TGGCGGCCGACGCGCAGCATGTGACGATGCTGCAGCGCTCGCCGACCTACATCGTGTCGCTGCCGGCGCGCGACAAGATC
GCAAATGCGCTGCGCCGCGTGCTGCCGTCGCGGCTCGCGCACCGGCTCGTGCGCGTGAAGAACGTGCTGCTGACGATGTA
TCTGTACAACGTGTCGCGCCGCAAGCCCGAGCGCACGAAGCAGTTCATCATCCGCGCGGCGAGCCGGCAACTCGGCCCCG
ACTTTGACGTCGCGAAGCATCTGACGCCGCGCTACAACCCGTGGGACCAGCGCCTCTGCCTCGTGCCGAACGGCGATCTG
TTCAAGGCGATCCGCGCAGGCCGCGCGTCGATCGTCACCGACGAGATCGAGCGCTTCACGCCGACCGGGCTGAAACTGAA
AAGCGGCGCGCAGCTCGACGCCGACGTGATCGTCACCGCGACCGGCCTGAAGGTGAAGATGCTCGGCGGCGCGCGCGTGA
CGGTCGACGGCCGCGCGGTCGACCTGCCGCAGACCGTGTCCTATAAAGGGATGATGTACAGCGACGTGCCGAACCTCGCG
TCGTCGTTCGGCTATACGAACGCGTCGTGGACGCTGAAGGCCGAACTGATCGCGCGCTACGTGTGCCGGCTGCTGAACCA
CATGCGCGCGCACGGGTACGATACCTGCGTGCCGCGCCTCGCGCCCGGCGATCTCGGCGACGTGCCGGCCGTGAACCTGA
GCTCCGGCTATATCCAGCGTGCGGCCGGCATCCTGCCGAAGCAGGGCCACCGCAAGCCGTGGAAGTTTCATCAGAACTAC
GTGCTCGATCTCGCATCGCTGAAGTTCAGCGGACTCGCCGACTCGGCGATGCATTTCGAACGCCGCGCGACAGCCGGCCC
GGCGGCGACGCCGGCGACCGAACCCGTACTCGAAACCCGCTGA

Upstream 100 bases:

>100_bases
AGCGGCTCGTGCTGCGCCACGTGCGCCGCGCCCGCGCGCGCAATCTCGCACGCACGGCCACGCCGGCCGCGCCCGCCTCG
ACCGCGATCAAGGACACCGC

Downstream 100 bases:

>100_bases
GGCCGCCATGAGCCCGACGCTCCATCTGATCCTGAACATCCTGCTCGGCATCGTCGCGGTGCTCGCCGCGCTCGCGCTGT
TTTCCGGCTACGTCGCGCGC

Product: cyclohexanone monooxygenase

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MTSTTTDRRAAPPACGDSRDLDVLIVGAGLSGIGAAYHLNKRCPHASVAIVEARDAIGGTWDLFRYPGVRSDSDMFTLGY
SFRPWHSDKAISDGQTILDYICDTARTYGIDKLIRYGQKVVAADWDSNRARWTVRVERTRDGATDTLVYTCRFLYMCSGY
YDYDAGYLPDWPAMDTFEGRIVHPQHWPKDLSYANRRVVVIGSGATAVTLVPSMAADAQHVTMLQRSPTYIVSLPARDKI
ANALRRVLPSRLAHRLVRVKNVLLTMYLYNVSRRKPERTKQFIIRAASRQLGPDFDVAKHLTPRYNPWDQRLCLVPNGDL
FKAIRAGRASIVTDEIERFTPTGLKLKSGAQLDADVIVTATGLKVKMLGGARVTVDGRAVDLPQTVSYKGMMYSDVPNLA
SSFGYTNASWTLKAELIARYVCRLLNHMRAHGYDTCVPRLAPGDLGDVPAVNLSSGYIQRAAGILPKQGHRKPWKFHQNY
VLDLASLKFSGLADSAMHFERRATAGPAATPATEPVLETR

Sequences:

>Translated_520_residues
MTSTTTDRRAAPPACGDSRDLDVLIVGAGLSGIGAAYHLNKRCPHASVAIVEARDAIGGTWDLFRYPGVRSDSDMFTLGY
SFRPWHSDKAISDGQTILDYICDTARTYGIDKLIRYGQKVVAADWDSNRARWTVRVERTRDGATDTLVYTCRFLYMCSGY
YDYDAGYLPDWPAMDTFEGRIVHPQHWPKDLSYANRRVVVIGSGATAVTLVPSMAADAQHVTMLQRSPTYIVSLPARDKI
ANALRRVLPSRLAHRLVRVKNVLLTMYLYNVSRRKPERTKQFIIRAASRQLGPDFDVAKHLTPRYNPWDQRLCLVPNGDL
FKAIRAGRASIVTDEIERFTPTGLKLKSGAQLDADVIVTATGLKVKMLGGARVTVDGRAVDLPQTVSYKGMMYSDVPNLA
SSFGYTNASWTLKAELIARYVCRLLNHMRAHGYDTCVPRLAPGDLGDVPAVNLSSGYIQRAAGILPKQGHRKPWKFHQNY
VLDLASLKFSGLADSAMHFERRATAGPAATPATEPVLETR
>Mature_519_residues
TSTTTDRRAAPPACGDSRDLDVLIVGAGLSGIGAAYHLNKRCPHASVAIVEARDAIGGTWDLFRYPGVRSDSDMFTLGYS
FRPWHSDKAISDGQTILDYICDTARTYGIDKLIRYGQKVVAADWDSNRARWTVRVERTRDGATDTLVYTCRFLYMCSGYY
DYDAGYLPDWPAMDTFEGRIVHPQHWPKDLSYANRRVVVIGSGATAVTLVPSMAADAQHVTMLQRSPTYIVSLPARDKIA
NALRRVLPSRLAHRLVRVKNVLLTMYLYNVSRRKPERTKQFIIRAASRQLGPDFDVAKHLTPRYNPWDQRLCLVPNGDLF
KAIRAGRASIVTDEIERFTPTGLKLKSGAQLDADVIVTATGLKVKMLGGARVTVDGRAVDLPQTVSYKGMMYSDVPNLAS
SFGYTNASWTLKAELIARYVCRLLNHMRAHGYDTCVPRLAPGDLGDVPAVNLSSGYIQRAAGILPKQGHRKPWKFHQNYV
LDLASLKFSGLADSAMHFERRATAGPAATPATEPVLETR

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17561948, Length=382, Percent_Identity=23.2984293193717, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 57688; Mature: 57556

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTTTDRRAAPPACGDSRDLDVLIVGAGLSGIGAAYHLNKRCPHASVAIVEARDAIGGT
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHEECCCCCCCCEEEEEEECCCCCCC
WDLFRYPGVRSDSDMFTLGYSFRPWHSDKAISDGQTILDYICDTARTYGIDKLIRYGQKV
CHHHCCCCCCCCCCEEEECCEECCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHCCCEE
VAADWDSNRARWTVRVERTRDGATDTLVYTCRFLYMCSGYYDYDAGYLPDWPAMDTFEGR
EEECCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCE
IVHPQHWPKDLSYANRRVVVIGSGATAVTLVPSMAADAQHVTMLQRSPTYIVSLPARDKI
EECCCCCCCCHHHCCCEEEEEECCCEEEEECCHHHCCHHHHHHHCCCCCEEEECCCHHHH
ANALRRVLPSRLAHRLVRVKNVLLTMYLYNVSRRKPERTKQFIIRAASRQLGPDFDVAKH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHH
LTPRYNPWDQRLCLVPNGDLFKAIRAGRASIVTDEIERFTPTGLKLKSGAQLDADVIVTA
CCCCCCCCCCEEEECCCCHHHHHHHCCCCHHHHHHHHHCCCCCEEECCCCCCCCEEEEEE
TGLKVKMLGGARVTVDGRAVDLPQTVSYKGMMYSDVPNLASSFGYTNASWTLKAELIARY
CCEEEEEECCEEEEECCCEECCCCCCCCCCEEECCCHHHHHHCCCCCCCEEEHHHHHHHH
VCRLLNHMRAHGYDTCVPRLAPGDLGDVPAVNLSSGYIQRAAGILPKQGHRKPWKFHQNY
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCCCHHHHHHHCCCCCCCCCCCCHHCCHH
VLDLASLKFSGLADSAMHFERRATAGPAATPATEPVLETR
HEEHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TSTTTDRRAAPPACGDSRDLDVLIVGAGLSGIGAAYHLNKRCPHASVAIVEARDAIGGT
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHEECCCCCCCCEEEEEEECCCCCCC
WDLFRYPGVRSDSDMFTLGYSFRPWHSDKAISDGQTILDYICDTARTYGIDKLIRYGQKV
CHHHCCCCCCCCCCEEEECCEECCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHCCCEE
VAADWDSNRARWTVRVERTRDGATDTLVYTCRFLYMCSGYYDYDAGYLPDWPAMDTFEGR
EEECCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCE
IVHPQHWPKDLSYANRRVVVIGSGATAVTLVPSMAADAQHVTMLQRSPTYIVSLPARDKI
EECCCCCCCCHHHCCCEEEEEECCCEEEEECCHHHCCHHHHHHHCCCCCEEEECCCHHHH
ANALRRVLPSRLAHRLVRVKNVLLTMYLYNVSRRKPERTKQFIIRAASRQLGPDFDVAKH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHH
LTPRYNPWDQRLCLVPNGDLFKAIRAGRASIVTDEIERFTPTGLKLKSGAQLDADVIVTA
CCCCCCCCCCEEEECCCCHHHHHHHCCCCHHHHHHHHHCCCCCEEECCCCCCCCEEEEEE
TGLKVKMLGGARVTVDGRAVDLPQTVSYKGMMYSDVPNLASSFGYTNASWTLKAELIARY
CCEEEEEECCEEEEECCCEECCCCCCCCCCEEECCCHHHHHHCCCCCCCEEEHHHHHHHH
VCRLLNHMRAHGYDTCVPRLAPGDLGDVPAVNLSSGYIQRAAGILPKQGHRKPWKFHQNY
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCCCHHHHHHHCCCCCCCCCCCCHHCCHH
VLDLASLKFSGLADSAMHFERRATAGPAATPATEPVLETR
HEEHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]