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The map label for this gene is merA [H]

Identifier: 189352242

GI number: 189352242

Start: 283300

End: 284679

Strand: Reverse

Name: merA [H]

Synonym: BMULJ_03460

Alternate gene names: 189352242

Gene position: 284679-283300 (Counterclockwise)

Preceding gene: 189352243

Following gene: 189352240

Centisome position: 11.51

GC content: 67.68

Gene sequence:

>1380_bases
ATGACGCAACACTTCGACGCGATCGTGATCGGCACCGGCCAGGCCGGGCCGCCGCTCGCCGCACGGCTCTCGGCAGCCGG
CATGACCGTCGCGATCGTCGAACGCGGCCGCTTCGGCGGCACGTGCGTGAACACCGGCTGCATTCCGACCAAGACGCTGA
TCGCGAGCGCGTACGCCGCGCAGCTCGCGCGGCGCGCAAGCGAATACGGCGTATCGGTCGGCGGCGACGTCACCGTCGAC
ATGAAGGCCGTGAAGGCGCGCAAGGACCGGATCGCCGGCCGCTCGAACCACGGCGTCGAGCAATGGGTGCGCGGGCTCGA
GCGCACGACCGTGTTCCAGGGACACGCGCGCTTCGAGGGCGCGAAGACGGTGCGCGTCGGCGACGCGCTGCTCGAAGCGG
ACCGCATCTTCATCAATGTCGGCGGACGGGCGCAGGTGCCGCCGATGCCGGGCCTCGACACCGTGCGTTATCTGACCAAC
TCGTCGATGATGGACGTCGACTTCCTGCCCGATCATCTCGTGATCGTCGGCGGCAGCTACGTCGGGCTCGAGTTCGGTCA
GATGTATCGCCGCTTCGGCTCGAAGGTGACGATCGTCGAGAAAGGCCCGCGGCTGATCCGGCGCGAGGACGAAGACGTGT
CGGACGCGGTGCGCGAGATTCTCGAAAACGAAGGGATCGACGTGCAGCTCGACGCAAATTGCCTGAGCGCACGGCCCGAC
GGCGCCGGCATCGCGATCGGGCTCGACTGCGGCGGCAGCGGCCGCGAAGTGACGGGCTCGCATCTGCTGCTCGCGGTCGG
CCGCGTGCCGAACACCGACGATCTCGGGCTCGACCGCGCGGGCGTCGATACCGACGAGCGCGGCTACATCAAGGTCGACG
AGCAGCTGCGCACGAACGTCGACGGCATCTGGGCGCTCGGCGACTGCAACGGCCGCGGCGCGTTCACGCATACCGCCTAC
AACGACTACGAGATCGTCGCGGCGAACCTGCTCGACAACGATCCGCGCAAGGTCTCCGATCGCGTCCCCGCCTATGCGAT
GTACATCGATCCGCCGCTCGGCCGCGTCGGCATGACGCTCGCGGAAGCGAAACGAAGCGGCCGCAAGCTGCTGGTCGGCA
CGCGGCCGATGACGCGCGTCGGCCGCGCGGTCGAAAAGGGCGAAAGCCAGGGCTTCATGAAGGTGATCGTCGATGCGGAC
AACCACGCGATTCTCGGTGCATCGATCCTCGGCGTGACGGGCGACGAGGTCGTGCATACGCTGCTCGACGTGATGACGGC
CGGGGCGCCCTATACGACGATCAGCCGCGCGATGCACATTCACCCGACCGTGTCGGAACTGCTGCCGACATTGCTGCAGG
ATCTGCATCCGGTCGAATGA

Upstream 100 bases:

>100_bases
GCGTGCGCGCCGCCCGGACGTCGTCGGGCGGGCGGACGCCGCCGTCGCGTGCGGGCTCGCCCGTCCGCACTTTCCCGATC
CACCAGCGCAGGAGAACGCC

Downstream 100 bases:

>100_bases
CGCAAGTCGCGCGTGCGTGCGGGTCGTGTACCGACGCAGCGATTGCCGATGCGCGAGGCTGAACGCGTTACTCGACGCGT
TGAACGCACGGGACGGCCCG

Product: mercuric reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MTQHFDAIVIGTGQAGPPLAARLSAAGMTVAIVERGRFGGTCVNTGCIPTKTLIASAYAAQLARRASEYGVSVGGDVTVD
MKAVKARKDRIAGRSNHGVEQWVRGLERTTVFQGHARFEGAKTVRVGDALLEADRIFINVGGRAQVPPMPGLDTVRYLTN
SSMMDVDFLPDHLVIVGGSYVGLEFGQMYRRFGSKVTIVEKGPRLIRREDEDVSDAVREILENEGIDVQLDANCLSARPD
GAGIAIGLDCGGSGREVTGSHLLLAVGRVPNTDDLGLDRAGVDTDERGYIKVDEQLRTNVDGIWALGDCNGRGAFTHTAY
NDYEIVAANLLDNDPRKVSDRVPAYAMYIDPPLGRVGMTLAEAKRSGRKLLVGTRPMTRVGRAVEKGESQGFMKVIVDAD
NHAILGASILGVTGDEVVHTLLDVMTAGAPYTTISRAMHIHPTVSELLPTLLQDLHPVE

Sequences:

>Translated_459_residues
MTQHFDAIVIGTGQAGPPLAARLSAAGMTVAIVERGRFGGTCVNTGCIPTKTLIASAYAAQLARRASEYGVSVGGDVTVD
MKAVKARKDRIAGRSNHGVEQWVRGLERTTVFQGHARFEGAKTVRVGDALLEADRIFINVGGRAQVPPMPGLDTVRYLTN
SSMMDVDFLPDHLVIVGGSYVGLEFGQMYRRFGSKVTIVEKGPRLIRREDEDVSDAVREILENEGIDVQLDANCLSARPD
GAGIAIGLDCGGSGREVTGSHLLLAVGRVPNTDDLGLDRAGVDTDERGYIKVDEQLRTNVDGIWALGDCNGRGAFTHTAY
NDYEIVAANLLDNDPRKVSDRVPAYAMYIDPPLGRVGMTLAEAKRSGRKLLVGTRPMTRVGRAVEKGESQGFMKVIVDAD
NHAILGASILGVTGDEVVHTLLDVMTAGAPYTTISRAMHIHPTVSELLPTLLQDLHPVE
>Mature_458_residues
TQHFDAIVIGTGQAGPPLAARLSAAGMTVAIVERGRFGGTCVNTGCIPTKTLIASAYAAQLARRASEYGVSVGGDVTVDM
KAVKARKDRIAGRSNHGVEQWVRGLERTTVFQGHARFEGAKTVRVGDALLEADRIFINVGGRAQVPPMPGLDTVRYLTNS
SMMDVDFLPDHLVIVGGSYVGLEFGQMYRRFGSKVTIVEKGPRLIRREDEDVSDAVREILENEGIDVQLDANCLSARPDG
AGIAIGLDCGGSGREVTGSHLLLAVGRVPNTDDLGLDRAGVDTDERGYIKVDEQLRTNVDGIWALGDCNGRGAFTHTAYN
DYEIVAANLLDNDPRKVSDRVPAYAMYIDPPLGRVGMTLAEAKRSGRKLLVGTRPMTRVGRAVEKGESQGFMKVIVDADN
HAILGASILGVTGDEVVHTLLDVMTAGAPYTTISRAMHIHPTVSELLPTLLQDLHPVE

Specific function: Unknown

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=462, Percent_Identity=28.7878787878788, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI91199540, Length=462, Percent_Identity=26.1904761904762, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI22035672, Length=436, Percent_Identity=30.045871559633, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI33519430, Length=437, Percent_Identity=24.7139588100687, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI33519428, Length=437, Percent_Identity=24.7139588100687, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI33519426, Length=437, Percent_Identity=24.7139588100687, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI148277071, Length=438, Percent_Identity=24.8858447488584, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI148277065, Length=438, Percent_Identity=24.8858447488584, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI291045266, Length=440, Percent_Identity=24.0909090909091, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI291045268, Length=433, Percent_Identity=23.7875288683603, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI87081717, Length=457, Percent_Identity=34.7921225382932, Blast_Score=251, Evalue=6e-68,
Organism=Escherichia coli, GI1786307, Length=451, Percent_Identity=29.7117516629712, Blast_Score=205, Evalue=5e-54,
Organism=Escherichia coli, GI1789915, Length=465, Percent_Identity=29.8924731182796, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI87082354, Length=458, Percent_Identity=25.5458515283843, Blast_Score=128, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI32565766, Length=459, Percent_Identity=28.322440087146, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI71983429, Length=464, Percent_Identity=28.8793103448276, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71983419, Length=464, Percent_Identity=28.8793103448276, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17557007, Length=479, Percent_Identity=26.7223382045929, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI71982272, Length=444, Percent_Identity=23.6486486486486, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17559934, Length=179, Percent_Identity=27.9329608938547, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321091, Length=466, Percent_Identity=29.1845493562232, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6325166, Length=476, Percent_Identity=26.6806722689076, Blast_Score=133, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6325240, Length=482, Percent_Identity=24.896265560166, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21358499, Length=464, Percent_Identity=28.0172413793103, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24640549, Length=471, Percent_Identity=25.2653927813163, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24640553, Length=471, Percent_Identity=25.2653927813163, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24640551, Length=471, Percent_Identity=25.2653927813163, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI17737741, Length=469, Percent_Identity=23.454157782516, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: NA

Molecular weight: Translated: 49196; Mature: 49065

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQHFDAIVIGTGQAGPPLAARLSAAGMTVAIVERGRFGGTCVNTGCIPTKTLIASAYAA
CCCCCCEEEEECCCCCCCHHHHHHHCCCEEEEEECCCCCCEEEECCCCCHHHHHHHHHHH
QLARRASEYGVSVGGDVTVDMKAVKARKDRIAGRSNHGVEQWVRGLERTTVFQGHARFEG
HHHHHHHHCCCCCCCCEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHEEEECCCCCCC
AKTVRVGDALLEADRIFINVGGRAQVPPMPGLDTVRYLTNSSMMDVDFLPDHLVIVGGSY
CCEEEHHHHHHCCCEEEEEECCEECCCCCCCCHHHHHHCCCCCEEEECCCCEEEEECCCE
VGLEFGQMYRRFGSKVTIVEKGPRLIRREDEDVSDAVREILENEGIDVQLDANCLSARPD
ECHHHHHHHHHHCCEEEEEECCCHHHCCCCCCHHHHHHHHHHCCCCEEEECCHHCCCCCC
GAGIAIGLDCGGSGREVTGSHLLLAVGRVPNTDDLGLDRAGVDTDERGYIKVDEQLRTNV
CCEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEECHHHHCCC
DGIWALGDCNGRGAFTHTAYNDYEIVAANLLDNDPRKVSDRVPAYAMYIDPPLGRVGMTL
CEEEEEECCCCCCCEEECCCCCEEEEEEECCCCCCHHHHHCCCEEEEEECCCCCHHHHHH
AEAKRSGRKLLVGTRPMTRVGRAVEKGESQGFMKVIVDADNHAILGASILGVTGDEVVHT
HHHHHCCCEEEEECCCHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEEECCCHHHHHHH
LLDVMTAGAPYTTISRAMHIHPTVSELLPTLLQDLHPVE
HHHHHHCCCCHHHHHHEEEECCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TQHFDAIVIGTGQAGPPLAARLSAAGMTVAIVERGRFGGTCVNTGCIPTKTLIASAYAA
CCCCCEEEEECCCCCCCHHHHHHHCCCEEEEEECCCCCCEEEECCCCCHHHHHHHHHHH
QLARRASEYGVSVGGDVTVDMKAVKARKDRIAGRSNHGVEQWVRGLERTTVFQGHARFEG
HHHHHHHHCCCCCCCCEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHEEEECCCCCCC
AKTVRVGDALLEADRIFINVGGRAQVPPMPGLDTVRYLTNSSMMDVDFLPDHLVIVGGSY
CCEEEHHHHHHCCCEEEEEECCEECCCCCCCCHHHHHHCCCCCEEEECCCCEEEEECCCE
VGLEFGQMYRRFGSKVTIVEKGPRLIRREDEDVSDAVREILENEGIDVQLDANCLSARPD
ECHHHHHHHHHHCCEEEEEECCCHHHCCCCCCHHHHHHHHHHCCCCEEEECCHHCCCCCC
GAGIAIGLDCGGSGREVTGSHLLLAVGRVPNTDDLGLDRAGVDTDERGYIKVDEQLRTNV
CCEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEECHHHHCCC
DGIWALGDCNGRGAFTHTAYNDYEIVAANLLDNDPRKVSDRVPAYAMYIDPPLGRVGMTL
CEEEEEECCCCCCCEEECCCCCEEEEEEECCCCCCHHHHHCCCEEEEEECCCCCHHHHHH
AEAKRSGRKLLVGTRPMTRVGRAVEKGESQGFMKVIVDADNHAILGASILGVTGDEVVHT
HHHHHCCCEEEEECCCHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEEECCCHHHHHHH
LLDVMTAGAPYTTISRAMHIHPTVSELLPTLLQDLHPVE
HHHHHHCCCCHHHHHHEEEECCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]