Click here to switch to the map view.

The map label for this gene is adh [C]

Identifier: 189352121

GI number: 189352121

Start: 146966

End: 148012

Strand: Direct

Name: adh [C]

Synonym: BMULJ_03339

Alternate gene names: 189352121

Gene position: 146966-148012 (Clockwise)

Preceding gene: 189352120

Following gene: 189352122

Centisome position: 5.94

GC content: 70.68

Gene sequence:

>1047_bases
ATGGCGAACTCAGCGACCTACCGCGCGGCGGTAGTGAAGGCACCGGGGCAACTGGAACTGGTCGAGCGCCCGATGCCTGA
CCCGGCGCCCGGACAGGTGCGCATCCGCGTGGAAGCGTGCGGCGTGTGCCACTCCGACAGCGCAACCGTGGAGCGCGAGG
CGCCGGTCGGCGCGCCGCCGCGCGTACCGGGACATGAAGTGGTCGGGCGCATCGATGCGCTGGGCGACGGCGTCGCGGGC
TGGCGCGTCGGCGAGCGCGTCGGCGTCGGCTTCCTCGCGGGCGAGGACCGCACGTGTCCGTCGTGCCGGCACGGCGATGT
CGTCAACTGCGAGAACCCGATCATCACGGGCATGACGACCGACGGCGGCTACGCGGAAATCATGCTGGCGCAAGCGCGCG
GGCTCGTACGCGTGCCGGAAGACCTCGATGCGGCCGAAGCGGCACCGCTGCTCTGCGCAGGGCTCACGACGTTCAACGCA
TTGCGCAATGCCGGCGCGCGGGCGGGCGACGTGGTCGCAATTCATGGCCTGGGCGGTCTCGGCCATCTTGCCGTGCAGTT
CGCGAGGAAGATGGGTTTCTACACCGTCGCGATCGCGCGCGGCGCCGACAAGGCCGCGCTGGCCGCGCAGCTTGGCGCAC
ACCGTTATATCAATGCCGCCGCCGACGACGTCGCCGCGACGTTGCGCACGTTGGGCGGCGCGAAGGTCGTGCTCGGCACG
GCGCCGACCGGTACCGGCATGGCCGAGACCGTTGCGGGGCTTGCGGCGCGCGGCAAGCTGATCGTCGTGGCGGTGCCCGG
CGAGCCGATCGCGGTCAACGCGGTCGATCTCGTGTTCGGCGGCCGCTCGATCGTCGGTGCGCTGACCGGCACGGTGGCGG
ACAACGAAGAGACGCTGGCGTTCGCGCGGCTGCAGAACGTGCGGCCGATGATCGAGACCTTCCCGCTCGAGCACGCGCAG
GCGGCATACGACCGGATGATGCGCGCGGACGTCCGGTTCCGCGCGGTACTCACCATGCATTCCGCACCGACAGGAGTTTC
CGCATGA

Upstream 100 bases:

>100_bases
TTCGCATTTATCCGCGTACTGCCGAGAACCGCGCCCTGCCGGCGCCGCTGATCGTCGGTGTCGATCTGTCGAACTTCCGT
TTCGAGTGACGAGGGGAACC

Downstream 100 bases:

>100_bases
ATACGATCGCTCAATCCGTCATCGATGCGCACGGCGGTCTTGCGCAATGGCGCAAGTTTCGGCAGGTCAGCGCGCGGCTC
GTGCAAGGCGGCGCGCTGTG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: ADH-HT [H]

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MANSATYRAAVVKAPGQLELVERPMPDPAPGQVRIRVEACGVCHSDSATVEREAPVGAPPRVPGHEVVGRIDALGDGVAG
WRVGERVGVGFLAGEDRTCPSCRHGDVVNCENPIITGMTTDGGYAEIMLAQARGLVRVPEDLDAAEAAPLLCAGLTTFNA
LRNAGARAGDVVAIHGLGGLGHLAVQFARKMGFYTVAIARGADKAALAAQLGAHRYINAAADDVAATLRTLGGAKVVLGT
APTGTGMAETVAGLAARGKLIVVAVPGEPIAVNAVDLVFGGRSIVGALTGTVADNEETLAFARLQNVRPMIETFPLEHAQ
AAYDRMMRADVRFRAVLTMHSAPTGVSA

Sequences:

>Translated_348_residues
MANSATYRAAVVKAPGQLELVERPMPDPAPGQVRIRVEACGVCHSDSATVEREAPVGAPPRVPGHEVVGRIDALGDGVAG
WRVGERVGVGFLAGEDRTCPSCRHGDVVNCENPIITGMTTDGGYAEIMLAQARGLVRVPEDLDAAEAAPLLCAGLTTFNA
LRNAGARAGDVVAIHGLGGLGHLAVQFARKMGFYTVAIARGADKAALAAQLGAHRYINAAADDVAATLRTLGGAKVVLGT
APTGTGMAETVAGLAARGKLIVVAVPGEPIAVNAVDLVFGGRSIVGALTGTVADNEETLAFARLQNVRPMIETFPLEHAQ
AAYDRMMRADVRFRAVLTMHSAPTGVSA
>Mature_347_residues
ANSATYRAAVVKAPGQLELVERPMPDPAPGQVRIRVEACGVCHSDSATVEREAPVGAPPRVPGHEVVGRIDALGDGVAGW
RVGERVGVGFLAGEDRTCPSCRHGDVVNCENPIITGMTTDGGYAEIMLAQARGLVRVPEDLDAAEAAPLLCAGLTTFNAL
RNAGARAGDVVAIHGLGGLGHLAVQFARKMGFYTVAIARGADKAALAAQLGAHRYINAAADDVAATLRTLGGAKVVLGTA
PTGTGMAETVAGLAARGKLIVVAVPGEPIAVNAVDLVFGGRSIVGALTGTVADNEETLAFARLQNVRPMIETFPLEHAQA
AYDRMMRADVRFRAVLTMHSAPTGVSA

Specific function: Thermophilic NAD(+)-dependent alcohol dehydrogenase. Bears mainly an ethanol-dehydrogenase activity [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=319, Percent_Identity=26.9592476489028, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI13236495, Length=319, Percent_Identity=26.9592476489028, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI194239676, Length=214, Percent_Identity=29.4392523364486, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI156627571, Length=345, Percent_Identity=25.5072463768116, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI22538446, Length=261, Percent_Identity=28.735632183908, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI22538444, Length=261, Percent_Identity=28.735632183908, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1786518, Length=325, Percent_Identity=33.5384615384615, Blast_Score=151, Evalue=6e-38,
Organism=Escherichia coli, GI87082401, Length=330, Percent_Identity=31.5151515151515, Blast_Score=147, Evalue=7e-37,
Organism=Escherichia coli, GI87081918, Length=335, Percent_Identity=30.7462686567164, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI87082125, Length=339, Percent_Identity=27.7286135693215, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787863, Length=275, Percent_Identity=30.5454545454545, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1788075, Length=340, Percent_Identity=26.1764705882353, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1788407, Length=264, Percent_Identity=29.1666666666667, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790045, Length=336, Percent_Identity=25, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788073, Length=294, Percent_Identity=27.2108843537415, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI226510992, Length=178, Percent_Identity=28.0898876404494, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786552, Length=382, Percent_Identity=27.4869109947644, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71988145, Length=338, Percent_Identity=27.5147928994083, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17562582, Length=340, Percent_Identity=29.1176470588235, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17562584, Length=344, Percent_Identity=27.906976744186, Blast_Score=130, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17562876, Length=346, Percent_Identity=26.0115606936416, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323961, Length=346, Percent_Identity=32.3699421965318, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6324486, Length=331, Percent_Identity=32.3262839879154, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6323729, Length=328, Percent_Identity=31.7073170731707, Blast_Score=165, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6319621, Length=328, Percent_Identity=31.4024390243902, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6323980, Length=336, Percent_Identity=27.9761904761905, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6319949, Length=330, Percent_Identity=30, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320033, Length=229, Percent_Identity=28.82096069869, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI17737895, Length=242, Percent_Identity=28.5123966942149, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35821; Mature: 35689

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANSATYRAAVVKAPGQLELVERPMPDPAPGQVRIRVEACGVCHSDSATVEREAPVGAPP
CCCCCCEEEEEEECCCCEEEECCCCCCCCCCEEEEEEEEECEECCCCCCEECCCCCCCCC
RVPGHEVVGRIDALGDGVAGWRVGERVGVGFLAGEDRTCPSCRHGDVVNCENPIITGMTT
CCCCHHHHHHHHHCCCCCCCCCCCHHHCEEEEECCCCCCCCCCCCCEEECCCCEEEEEEC
DGGYAEIMLAQARGLVRVPEDLDAAEAAPLLCAGLTTFNALRNAGARAGDVVAIHGLGGL
CCCCEEEEEECCCCCEECCCCCCHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCH
GHLAVQFARKMGFYTVAIARGADKAALAAQLGAHRYINAAADDVAATLRTLGGAKVVLGT
HHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEC
APTGTGMAETVAGLAARGKLIVVAVPGEPIAVNAVDLVFGGRSIVGALTGTVADNEETLA
CCCCCCHHHHHHHHHCCCCEEEEEECCCCEEEEEEEEEECCCHHHHHHHCCCCCCCHHHH
FARLQNVRPMIETFPLEHAQAAYDRMMRADVRFRAVLTMHSAPTGVSA
HHHHHCCCHHHHHCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCC
>Mature Secondary Structure 
ANSATYRAAVVKAPGQLELVERPMPDPAPGQVRIRVEACGVCHSDSATVEREAPVGAPP
CCCCCEEEEEEECCCCEEEECCCCCCCCCCEEEEEEEEECEECCCCCCEECCCCCCCCC
RVPGHEVVGRIDALGDGVAGWRVGERVGVGFLAGEDRTCPSCRHGDVVNCENPIITGMTT
CCCCHHHHHHHHHCCCCCCCCCCCHHHCEEEEECCCCCCCCCCCCCEEECCCCEEEEEEC
DGGYAEIMLAQARGLVRVPEDLDAAEAAPLLCAGLTTFNALRNAGARAGDVVAIHGLGGL
CCCCEEEEEECCCCCEECCCCCCHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCH
GHLAVQFARKMGFYTVAIARGADKAALAAQLGAHRYINAAADDVAATLRTLGGAKVVLGT
HHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEC
APTGTGMAETVAGLAARGKLIVVAVPGEPIAVNAVDLVFGGRSIVGALTGTVADNEETLA
CCCCCCHHHHHHHHHCCCCEEEEEECCCCEEEEEEEEEECCCHHHHHHHCCCCCCCHHHH
FARLQNVRPMIETFPLEHAQAAYDRMMRADVRFRAVLTMHSAPTGVSA
HHHHHCCCHHHHHCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8020473 [H]