The gene/protein map for NC_010805 is currently unavailable.
Definition Burkholderia multivorans ATCC 17616 chromosome 2, complete genome.
Accession NC_010805
Length 2,473,162

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The map label for this gene is fabG [H]

Identifier: 189352069

GI number: 189352069

Start: 88380

End: 89219

Strand: Direct

Name: fabG [H]

Synonym: BMULJ_03286

Alternate gene names: 189352069

Gene position: 88380-89219 (Clockwise)

Preceding gene: 189352068

Following gene: 189352073

Centisome position: 3.57

GC content: 71.07

Gene sequence:

>840_bases
ATGGACACGCCCCACCCGCCGACGCACACCGCGATCCCGGAAACCGAATTCGAAGCCGAGGTCGACGCCGAAGTCGAAAC
CGCCGTCGAGCCGCGCGCGTCGCGCGTGCATCGGCCCGTCGCGCTCGTCACGGGATCGACGTCGGGGATCGGCGCGGCGA
TTGCACGGCGCCTCGCCGCGGACGGTTACGCGGTGATCCTGCATTCGCTGCGGTCCGTCGAGACGGGCCGCGCGATGGCG
ACCGAACTCGGCGGGGCATACGTGCAGGCCGATCTCGCCGACGATGCCGAACGCGTGCGGCTGATCCGCGATGCGCTCGC
GGTGCACGGCCGCCTCGACGTGCTCGTCAACAACGCGGGCATCAGCCGCACGATCGCGCACGACGATCTGGCGGCCGCGA
CGCCCGACGTATGGCGCGAGCTGTACGAGATCAACGCGATCGCGCCGTTTCGGCTCGTCGCCGAAGCGCAGCCCGCGCTG
CTCGAAGCGGCGTCGCACGGGCGTGCCGGCTGCGTCGTGAACGTCAGTTCGCACGCCGGTGTGCGGCCGAAGGGCGCATC
GATTCCGTATGCGGCCGCGAAAGCGGCGCTCAATCACACGACGCGCCTGCTCGCGCGCACGCTGGCGCCGGCCATCCGCA
TCAATGCGGTCGCGCCGGGCCTCGTCGATACGCCGCTGACGGCCGACTGGACCGACGCGCAGCAGCTCTGGCGCGAGCGT
GCGCCGATGCGCCGCGCGGCGACGCCGGACGACGTCGCGCAGACGGTCGCGATGCTCGTCGCGTCCGACTACGTGACGGG
CGAGATCATCATGCTCGACGGCGGATTGAATCTGACGTAG

Upstream 100 bases:

>100_bases
CACGATGTGCGACGCGCGCGCTGCCGCGATCGCGCGCGAGATTCGCGCGGCGGCGCGCGTCGCGCTTATGATGCGGAATC
GCCATCCGCAGGGTTCCGCC

Downstream 100 bases:

>100_bases
CGGGGCGTCGCGGGCTGCCGGTCCGCTGATCGGGGTCGTCGCGCTGTGTGCTGCGGCCAGGATCGGGGGCTGCGTCTCGC
TACGGTCGATGAGCCCCCAC

Product: 3-oxoacyl-[acyl-carrier protein] reductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: ORF6 [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MDTPHPPTHTAIPETEFEAEVDAEVETAVEPRASRVHRPVALVTGSTSGIGAAIARRLAADGYAVILHSLRSVETGRAMA
TELGGAYVQADLADDAERVRLIRDALAVHGRLDVLVNNAGISRTIAHDDLAAATPDVWRELYEINAIAPFRLVAEAQPAL
LEAASHGRAGCVVNVSSHAGVRPKGASIPYAAAKAALNHTTRLLARTLAPAIRINAVAPGLVDTPLTADWTDAQQLWRER
APMRRAATPDDVAQTVAMLVASDYVTGEIIMLDGGLNLT

Sequences:

>Translated_279_residues
MDTPHPPTHTAIPETEFEAEVDAEVETAVEPRASRVHRPVALVTGSTSGIGAAIARRLAADGYAVILHSLRSVETGRAMA
TELGGAYVQADLADDAERVRLIRDALAVHGRLDVLVNNAGISRTIAHDDLAAATPDVWRELYEINAIAPFRLVAEAQPAL
LEAASHGRAGCVVNVSSHAGVRPKGASIPYAAAKAALNHTTRLLARTLAPAIRINAVAPGLVDTPLTADWTDAQQLWRER
APMRRAATPDDVAQTVAMLVASDYVTGEIIMLDGGLNLT
>Mature_279_residues
MDTPHPPTHTAIPETEFEAEVDAEVETAVEPRASRVHRPVALVTGSTSGIGAAIARRLAADGYAVILHSLRSVETGRAMA
TELGGAYVQADLADDAERVRLIRDALAVHGRLDVLVNNAGISRTIAHDDLAAATPDVWRELYEINAIAPFRLVAEAQPAL
LEAASHGRAGCVVNVSSHAGVRPKGASIPYAAAKAALNHTTRLLARTLAPAIRINAVAPGLVDTPLTADWTDAQQLWRER
APMRRAATPDDVAQTVAMLVASDYVTGEIIMLDGGLNLT

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=248, Percent_Identity=37.5, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI5031737, Length=247, Percent_Identity=35.2226720647773, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI40254992, Length=248, Percent_Identity=33.0645161290323, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI126723750, Length=252, Percent_Identity=32.1428571428571, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI33667109, Length=195, Percent_Identity=36.9230769230769, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI4758504, Length=250, Percent_Identity=30, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI15277342, Length=266, Percent_Identity=32.3308270676692, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI19923817, Length=261, Percent_Identity=27.5862068965517, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI126723191, Length=185, Percent_Identity=37.8378378378378, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI59889578, Length=213, Percent_Identity=29.5774647887324, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI109715829, Length=252, Percent_Identity=27.7777777777778, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI31542939, Length=202, Percent_Identity=29.2079207920792, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI83715985, Length=249, Percent_Identity=28.5140562248996, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI7706318, Length=203, Percent_Identity=30.0492610837438, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI7705925, Length=241, Percent_Identity=28.6307053941909, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI20149619, Length=205, Percent_Identity=28.780487804878, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI1787335, Length=248, Percent_Identity=34.6774193548387, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1788459, Length=248, Percent_Identity=30.6451612903226, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI2367175, Length=248, Percent_Identity=33.8709677419355, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1789378, Length=258, Percent_Identity=31.3953488372093, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI2367365, Length=240, Percent_Identity=32.5, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082100, Length=256, Percent_Identity=33.59375, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1789208, Length=254, Percent_Identity=31.496062992126, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1786812, Length=251, Percent_Identity=29.4820717131474, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790717, Length=246, Percent_Identity=28.8617886178862, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1787905, Length=250, Percent_Identity=29.2, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082160, Length=244, Percent_Identity=27.0491803278689, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787891, Length=240, Percent_Identity=30, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787820, Length=226, Percent_Identity=27.4336283185841, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787526, Length=211, Percent_Identity=28.436018957346, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=248, Percent_Identity=35.8870967741936, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17560332, Length=273, Percent_Identity=34.0659340659341, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17561402, Length=258, Percent_Identity=31.3953488372093, Blast_Score=110, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17562910, Length=268, Percent_Identity=31.3432835820896, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17563726, Length=264, Percent_Identity=31.0606060606061, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17538182, Length=253, Percent_Identity=30.8300395256917, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI72000259, Length=270, Percent_Identity=30.3703703703704, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71994604, Length=263, Percent_Identity=32.319391634981, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17551412, Length=273, Percent_Identity=30.4029304029304, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17544670, Length=272, Percent_Identity=28.6764705882353, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17531453, Length=269, Percent_Identity=31.9702602230483, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17562908, Length=271, Percent_Identity=32.1033210332103, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17555706, Length=258, Percent_Identity=30.6201550387597, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17562904, Length=267, Percent_Identity=30.3370786516854, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562906, Length=271, Percent_Identity=31.3653136531365, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562990, Length=262, Percent_Identity=30.1526717557252, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71994600, Length=255, Percent_Identity=29.0196078431373, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI193204405, Length=270, Percent_Identity=31.4814814814815, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI115534694, Length=246, Percent_Identity=30.4878048780488, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17560220, Length=269, Percent_Identity=29.7397769516729, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17538486, Length=272, Percent_Identity=31.6176470588235, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17559104, Length=268, Percent_Identity=29.4776119402985, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17538480, Length=271, Percent_Identity=29.8892988929889, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17565030, Length=271, Percent_Identity=31.3653136531365, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25147288, Length=249, Percent_Identity=28.9156626506024, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17560150, Length=271, Percent_Identity=27.6752767527675, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17568967, Length=284, Percent_Identity=22.887323943662, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322227, Length=198, Percent_Identity=30.3030303030303, Blast_Score=79, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6322226, Length=193, Percent_Identity=32.6424870466321, Blast_Score=76, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21355319, Length=252, Percent_Identity=31.3492063492063, Blast_Score=110, Evalue=7e-25,
Organism=Drosophila melanogaster, GI23397609, Length=258, Percent_Identity=34.8837209302326, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28571526, Length=258, Percent_Identity=32.9457364341085, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=30.7086614173228, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24644339, Length=253, Percent_Identity=31.6205533596838, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24639444, Length=248, Percent_Identity=31.4516129032258, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24643142, Length=246, Percent_Identity=32.520325203252, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21357041, Length=252, Percent_Identity=30.1587301587302, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24640442, Length=198, Percent_Identity=32.8282828282828, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24644337, Length=179, Percent_Identity=34.0782122905028, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI116007236, Length=208, Percent_Identity=28.3653846153846, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 29483; Mature: 29483

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MDTPHPPTHTAIPETEFEAEVDAEVETAVEPRASRVHRPVALVTGSTSGIGAAIARRLAA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHCCCEEEEECCCCCHHHHHHHHHHC
DGYAVILHSLRSVETGRAMATELGGAYVQADLADDAERVRLIRDALAVHGRLDVLVNNAG
CCHHHHHHHHHHHHCCHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCEEEEEEECCC
ISRTIAHDDLAAATPDVWRELYEINAIAPFRLVAEAQPALLEAASHGRAGCVVNVSSHAG
CCCHHCCCHHHHCCHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHCCCCCCEEEEECCCCC
VRPKGASIPYAAAKAALNHTTRLLARTLAPAIRINAVAPGLVDTPLTADWTDAQQLWRER
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCHHHHHHHHHH
APMRRAATPDDVAQTVAMLVASDYVTGEIIMLDGGLNLT
CCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MDTPHPPTHTAIPETEFEAEVDAEVETAVEPRASRVHRPVALVTGSTSGIGAAIARRLAA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHCCCEEEEECCCCCHHHHHHHHHHC
DGYAVILHSLRSVETGRAMATELGGAYVQADLADDAERVRLIRDALAVHGRLDVLVNNAG
CCHHHHHHHHHHHHCCHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCEEEEEEECCC
ISRTIAHDDLAAATPDVWRELYEINAIAPFRLVAEAQPALLEAASHGRAGCVVNVSSHAG
CCCHHCCCHHHHCCHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHCCCCCCEEEEECCCCC
VRPKGASIPYAAAKAALNHTTRLLARTLAPAIRINAVAPGLVDTPLTADWTDAQQLWRER
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCHHHHHHHHHH
APMRRAATPDDVAQTVAMLVASDYVTGEIIMLDGGLNLT
CCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2583128; 9831526 [H]