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The map label for this gene is czcD [H]

Identifier: 189352025

GI number: 189352025

Start: 42188

End: 43225

Strand: Direct

Name: czcD [H]

Synonym: BMULJ_03242

Alternate gene names: 189352025

Gene position: 42188-43225 (Clockwise)

Preceding gene: 189352024

Following gene: 189352026

Centisome position: 1.71

GC content: 67.44

Gene sequence:

>1038_bases
GTGAGCGATTTCAGAAATGCCGCGTTCGGCGCGGGTCACGATCACATCTTTCTCGGCGCCGCGCACGAGCGGAACGAGCG
CAGGACATGGGCCGTCATCGCGCTGTGCGCGGCGATGATGGTGGCGGAGATCGTCGGCGGGTCGCTGTTCGGCTCGCTCG
CGCTCGTCGCCGACGGGCTGCACATGTCGACGCACGCGGGCGCGATGCTGATCGCCGCGCTCGCGTACACCTACGCGCGC
CGGCACGCGCGCGATCCGCGTTTCGTGTTCGGCACCGGCAAGCTCGGCGATCTGGCCGGCTTTACGAGTGCGATCGTGCT
CGCGATGATCGCGCTGCTCATCGGCTACGAGGCTGTCGTCCGCCTGCTGTCGCCGGTGCCGATCCATTTCGGCGAGGCGA
TTCCGATCGCGGTGGTCGGGCTGATCGTCAACATCGTGAGCGCGTGGTTGTTGAGCGGCGATCATCATCACGGGCACGAC
CATCACGGTCATCACCACTACCACAACCACGCCCACGCCCACGATCACGATCACGAGCACGAGCACGAGCACGAGCACGA
GCACGAGCACGCGCACGACGCCCACACGCCCTCCGCCGCCACAACACGCGACCACAATCTCCGCTCCGCCTACATCCACG
TGATCGCCGATGCCGCCGTCTCGCTGTTGACGATCGTCGGGCTGCTGCTCGCGCGCGCATTCGGCTGGATCTGGATGGAC
CCGCTCGCCGGCATCGTGGGCGCGCTCGTGATCGCGAACTGGTCGTACGGGCTGATGCGCGACACCGGCGGCGTCCTGCT
CGACATGAATGCCGACCGCCGCTTGACGGAACGCGTGCGGCACGCGCTGGAGCACGATGGCGATACGGTCGCCGATCTGC
ACGTATGGCGTGTGGGGCCCGGTCACATGAGCGCGATCGTCTCCGTGACGACCGACGATCCGACGCGCGATGCGCGCTTC
TATCACGGCCTGCTGAAGCACATCGGCGGCCTGTCGCACGTGACCGTCGAAGTGCTGCCGGCCGCGGCGGGGCAATGA

Upstream 100 bases:

>100_bases
GCCATCTGGTCGACGCGGACGATACGCACGCGGACGAAGGCGGTGCGACCGAGCAGCTCGTCGCGGTTGTCCGAAGCTAC
TTCAAGTGATCGGGGGCCGG

Downstream 100 bases:

>100_bases
CGATGGCAGTCCGATCGCCTTGCGTCGAAGTCTGCACGTTCGACGGCCGCACCGGCTACTGCATCGCATGTCTCCGCACG
CGCGACGAAGCGCGCGAGTG

Product: CDF family cation efflux system protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MSDFRNAAFGAGHDHIFLGAAHERNERRTWAVIALCAAMMVAEIVGGSLFGSLALVADGLHMSTHAGAMLIAALAYTYAR
RHARDPRFVFGTGKLGDLAGFTSAIVLAMIALLIGYEAVVRLLSPVPIHFGEAIPIAVVGLIVNIVSAWLLSGDHHHGHD
HHGHHHYHNHAHAHDHDHEHEHEHEHEHEHAHDAHTPSAATTRDHNLRSAYIHVIADAAVSLLTIVGLLLARAFGWIWMD
PLAGIVGALVIANWSYGLMRDTGGVLLDMNADRRLTERVRHALEHDGDTVADLHVWRVGPGHMSAIVSVTTDDPTRDARF
YHGLLKHIGGLSHVTVEVLPAAAGQ

Sequences:

>Translated_345_residues
MSDFRNAAFGAGHDHIFLGAAHERNERRTWAVIALCAAMMVAEIVGGSLFGSLALVADGLHMSTHAGAMLIAALAYTYAR
RHARDPRFVFGTGKLGDLAGFTSAIVLAMIALLIGYEAVVRLLSPVPIHFGEAIPIAVVGLIVNIVSAWLLSGDHHHGHD
HHGHHHYHNHAHAHDHDHEHEHEHEHEHEHAHDAHTPSAATTRDHNLRSAYIHVIADAAVSLLTIVGLLLARAFGWIWMD
PLAGIVGALVIANWSYGLMRDTGGVLLDMNADRRLTERVRHALEHDGDTVADLHVWRVGPGHMSAIVSVTTDDPTRDARF
YHGLLKHIGGLSHVTVEVLPAAAGQ
>Mature_344_residues
SDFRNAAFGAGHDHIFLGAAHERNERRTWAVIALCAAMMVAEIVGGSLFGSLALVADGLHMSTHAGAMLIAALAYTYARR
HARDPRFVFGTGKLGDLAGFTSAIVLAMIALLIGYEAVVRLLSPVPIHFGEAIPIAVVGLIVNIVSAWLLSGDHHHGHDH
HGHHHYHNHAHAHDHDHEHEHEHEHEHEHAHDAHTPSAATTRDHNLRSAYIHVIADAAVSLLTIVGLLLARAFGWIWMDP
LAGIVGALVIANWSYGLMRDTGGVLLDMNADRRLTERVRHALEHDGDTVADLHVWRVGPGHMSAIVSVTTDDPTRDARFY
HGLLKHIGGLSHVTVEVLPAAAGQ

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI222080086, Length=333, Percent_Identity=24.6246246246246, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI40255009, Length=333, Percent_Identity=24.6246246246246, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI20070323, Length=336, Percent_Identity=28.5714285714286, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI21359890, Length=291, Percent_Identity=23.0240549828179, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1786966, Length=142, Percent_Identity=42.2535211267606, Blast_Score=89, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI32564488, Length=281, Percent_Identity=25.2669039145907, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17555794, Length=323, Percent_Identity=26.625386996904, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17555796, Length=326, Percent_Identity=26.9938650306748, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193210990, Length=332, Percent_Identity=25, Blast_Score=74, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6323899, Length=348, Percent_Identity=22.7011494252874, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6320411, Length=231, Percent_Identity=24.2424242424242, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24645863, Length=271, Percent_Identity=26.1992619926199, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 37450; Mature: 37319

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDFRNAAFGAGHDHIFLGAAHERNERRTWAVIALCAAMMVAEIVGGSLFGSLALVADGL
CCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HMSTHAGAMLIAALAYTYARRHARDPRFVFGTGKLGDLAGFTSAIVLAMIALLIGYEAVV
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RLLSPVPIHFGEAIPIAVVGLIVNIVSAWLLSGDHHHGHDHHGHHHYHNHAHAHDHDHEH
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
EHEHEHEHEHAHDAHTPSAATTRDHNLRSAYIHVIADAAVSLLTIVGLLLARAFGWIWMD
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLAGIVGALVIANWSYGLMRDTGGVLLDMNADRRLTERVRHALEHDGDTVADLHVWRVGP
HHHHHHHHHHHHCCCCHHEECCCCEEEECCCCHHHHHHHHHHHHCCCCEEEEEEEEEECC
GHMSAIVSVTTDDPTRDARFYHGLLKHIGGLSHVTVEVLPAAAGQ
CCEEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHEEECCCCCC
>Mature Secondary Structure 
SDFRNAAFGAGHDHIFLGAAHERNERRTWAVIALCAAMMVAEIVGGSLFGSLALVADGL
CCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HMSTHAGAMLIAALAYTYARRHARDPRFVFGTGKLGDLAGFTSAIVLAMIALLIGYEAVV
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RLLSPVPIHFGEAIPIAVVGLIVNIVSAWLLSGDHHHGHDHHGHHHYHNHAHAHDHDHEH
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
EHEHEHEHEHAHDAHTPSAATTRDHNLRSAYIHVIADAAVSLLTIVGLLLARAFGWIWMD
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLAGIVGALVIANWSYGLMRDTGGVLLDMNADRRLTERVRHALEHDGDTVADLHVWRVGP
HHHHHHHHHHHHCCCCHHEECCCCEEEECCCCHHHHHHHHHHHHCCCCEEEEEEEEEECC
GHMSAIVSVTTDDPTRDARFYHGLLKHIGGLSHVTVEVLPAAAGQ
CCEEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]