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The map label for this gene is icd [H]

Identifier: 189184546

GI number: 189184546

Start: 1668819

End: 1670378

Strand: Direct

Name: icd [H]

Synonym: OTT_1639

Alternate gene names: 189184546

Gene position: 1668819-1670378 (Clockwise)

Preceding gene: 189184543

Following gene: 189184547

Centisome position: 83.07

GC content: 30.9

Gene sequence:

>1560_bases
ATGAAAAATGTTATTCCAGTAACAATTGCATATGGCGATGGTATTGGCCCAGAAATTATGGAAGCAGTAGTTTATGTTTT
AAAAGAAGCAGCTGTACCTTTAAGGCTTGAAACAATAGAAATTGGCGAAAAATTATACAACAAATACTATACTTACGGTA
TTACTGAAGATACATGGTCTCAAATATTTCGTACAAAAGCATTACTTAAAGGCCCTGTTACTACTCCTCAGGGTGAAGGA
TATAAAAGCTTGAATGTTACTCTAAAAAAAACTTTAGGATTATACGCAAACGTTAGACCTAGCATTTCTTATTTTCCATT
TGTTAATACTTCAGCTCCAGAAATAGATGTAGTAATAATTCGTGAAAACGAAGAAGATTTATATACAGGTATTGAATATC
ATCATACAGCAGATACATATGAATCTATTAAGTTAATTAGTCGTAGTGGTAGTGAAAAAATCATTCGATTTGCTTTTGAG
TACGCACTAAAAAATAATAGAAAAAAAATCAGCTGTTTTAGTAAAGATAATATTATGAAATTTACAGATGGAATATTTCA
TAATACATTTAATGAAATAGCAAGTCAATATAGCAATATTCAAGTAGATCATTACCTTATTGATATCGGTAGTGCGCGTT
TGATTAGCTCTCCTCAAAAATTCGATGTAATAGTAACATCAAATTTATATGGTGATATCTTATCTGATATTGCAGCTGAA
ATTTCTGATTCAATAGGCCTGGCTGGTTCAGCAAATATTGGTAAAGATTATGCTATGTTTGAAGCTGTACATGGATCAGC
GCCTGATATAGCTGGTCAAAATATTGCTAACCCTTCCGGATTACTTAATGCAGCTATAATGATGTTAGTCCATCTTGGGT
TAACTGAGCATGCAGCTAAAATAGAAAACGCCTTAAAAAAAACTATTGAAGATGGTATTCACACTGCAGATATTTATAAT
CCAAGCATTTCTAGTAAAAAAGTTGGAACTAAAGAATTTGCTCAGGCTATAATTAATAATTTAGAATATAAGCCTAAAAA
ATTAAAGATAGCAGAATATCACAATCTTGATGTTGAAAGCAATATTATCAATAATTCTCAAATTCAAACTATTACTGAAA
CTAGACAACAAAAAAAATTAGTTGGCGTAGACGTATTTTTTGATAGTCATAATATAATTGATTACCATCGCATTACCAAG
CAATTAACAAAAAGAATAGCTAGCCTCAGTAGCTTGCATGGTATGCACCTAGTTACTATTTCAGCAAAAGGGCTAAAATT
ATGGCCTAATAGTACTGTTAGAGAAATGTTCAGTGATCATTGGTGTTGTCGTTTCATGGTACAAAGTAGCGGTAAAGATA
AGACTGTTACAGCAAAAAACCTTACAATGAAAGATATTCTAAGCTTACTTAATGATTTAGTAGCTACAATTAATAATCCA
ATACACTCTGAATCTAAAGATGATAATTATGATAACAGTATCAAATTTGAACTAATTAAAGTGGAAAATCTATATCTATT
TAATGATACAGTAGGATTTAGCTTAGCGCAAGGAGAGTAA

Upstream 100 bases:

>100_bases
CATAAATTAGTATAAAAAATAGCTTTTCTTTATATATTTAGTGCATATACTACATATACTACACTAAAGATAAAAATATA
ACACAACCTTAATAGCAAGC

Downstream 100 bases:

>100_bases
AAATCAAATCACAAGTTACAAATGAAGGTGTTGTTAAGACTTGACTGTATATATTATTAAGTATATATTTACTCGCAAAC
ATGTAGCAAGCATTACTAAG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MKNVIPVTIAYGDGIGPEIMEAVVYVLKEAAVPLRLETIEIGEKLYNKYYTYGITEDTWSQIFRTKALLKGPVTTPQGEG
YKSLNVTLKKTLGLYANVRPSISYFPFVNTSAPEIDVVIIRENEEDLYTGIEYHHTADTYESIKLISRSGSEKIIRFAFE
YALKNNRKKISCFSKDNIMKFTDGIFHNTFNEIASQYSNIQVDHYLIDIGSARLISSPQKFDVIVTSNLYGDILSDIAAE
ISDSIGLAGSANIGKDYAMFEAVHGSAPDIAGQNIANPSGLLNAAIMMLVHLGLTEHAAKIENALKKTIEDGIHTADIYN
PSISSKKVGTKEFAQAIINNLEYKPKKLKIAEYHNLDVESNIINNSQIQTITETRQQKKLVGVDVFFDSHNIIDYHRITK
QLTKRIASLSSLHGMHLVTISAKGLKLWPNSTVREMFSDHWCCRFMVQSSGKDKTVTAKNLTMKDILSLLNDLVATINNP
IHSESKDDNYDNSIKFELIKVENLYLFNDTVGFSLAQGE

Sequences:

>Translated_519_residues
MKNVIPVTIAYGDGIGPEIMEAVVYVLKEAAVPLRLETIEIGEKLYNKYYTYGITEDTWSQIFRTKALLKGPVTTPQGEG
YKSLNVTLKKTLGLYANVRPSISYFPFVNTSAPEIDVVIIRENEEDLYTGIEYHHTADTYESIKLISRSGSEKIIRFAFE
YALKNNRKKISCFSKDNIMKFTDGIFHNTFNEIASQYSNIQVDHYLIDIGSARLISSPQKFDVIVTSNLYGDILSDIAAE
ISDSIGLAGSANIGKDYAMFEAVHGSAPDIAGQNIANPSGLLNAAIMMLVHLGLTEHAAKIENALKKTIEDGIHTADIYN
PSISSKKVGTKEFAQAIINNLEYKPKKLKIAEYHNLDVESNIINNSQIQTITETRQQKKLVGVDVFFDSHNIIDYHRITK
QLTKRIASLSSLHGMHLVTISAKGLKLWPNSTVREMFSDHWCCRFMVQSSGKDKTVTAKNLTMKDILSLLNDLVATINNP
IHSESKDDNYDNSIKFELIKVENLYLFNDTVGFSLAQGE
>Mature_519_residues
MKNVIPVTIAYGDGIGPEIMEAVVYVLKEAAVPLRLETIEIGEKLYNKYYTYGITEDTWSQIFRTKALLKGPVTTPQGEG
YKSLNVTLKKTLGLYANVRPSISYFPFVNTSAPEIDVVIIRENEEDLYTGIEYHHTADTYESIKLISRSGSEKIIRFAFE
YALKNNRKKISCFSKDNIMKFTDGIFHNTFNEIASQYSNIQVDHYLIDIGSARLISSPQKFDVIVTSNLYGDILSDIAAE
ISDSIGLAGSANIGKDYAMFEAVHGSAPDIAGQNIANPSGLLNAAIMMLVHLGLTEHAAKIENALKKTIEDGIHTADIYN
PSISSKKVGTKEFAQAIINNLEYKPKKLKIAEYHNLDVESNIINNSQIQTITETRQQKKLVGVDVFFDSHNIIDYHRITK
QLTKRIASLSSLHGMHLVTISAKGLKLWPNSTVREMFSDHWCCRFMVQSSGKDKTVTAKNLTMKDILSLLNDLVATINNP
IHSESKDDNYDNSIKFELIKVENLYLFNDTVGFSLAQGE

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=307, Percent_Identity=41.6938110749186, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI4758582, Length=326, Percent_Identity=36.5030674846626, Blast_Score=198, Evalue=9e-51,
Organism=Homo sapiens, GI28178838, Length=308, Percent_Identity=37.012987012987, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI28178821, Length=304, Percent_Identity=35.8552631578947, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI28178816, Length=304, Percent_Identity=35.8552631578947, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI28178819, Length=166, Percent_Identity=38.5542168674699, Blast_Score=122, Evalue=6e-28,
Organism=Escherichia coli, GI1787381, Length=385, Percent_Identity=32.987012987013, Blast_Score=176, Evalue=4e-45,
Organism=Escherichia coli, GI1788101, Length=332, Percent_Identity=31.9277108433735, Blast_Score=155, Evalue=6e-39,
Organism=Escherichia coli, GI87081683, Length=359, Percent_Identity=30.08356545961, Blast_Score=145, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI71986051, Length=306, Percent_Identity=41.5032679738562, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI25144293, Length=344, Percent_Identity=37.5, Blast_Score=204, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17505779, Length=313, Percent_Identity=37.3801916932907, Blast_Score=202, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI17550882, Length=346, Percent_Identity=32.0809248554913, Blast_Score=180, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6324709, Length=340, Percent_Identity=42.0588235294118, Blast_Score=255, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6324291, Length=340, Percent_Identity=39.4117647058824, Blast_Score=224, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6322097, Length=353, Percent_Identity=33.4277620396601, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6319830, Length=352, Percent_Identity=28.6931818181818, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24661184, Length=343, Percent_Identity=39.9416909620991, Blast_Score=258, Evalue=5e-69,
Organism=Drosophila melanogaster, GI24643270, Length=313, Percent_Identity=42.1725239616613, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24643268, Length=313, Percent_Identity=42.1725239616613, Blast_Score=253, Evalue=3e-67,
Organism=Drosophila melanogaster, GI161078637, Length=316, Percent_Identity=37.0253164556962, Blast_Score=188, Evalue=9e-48,
Organism=Drosophila melanogaster, GI161078633, Length=316, Percent_Identity=37.0253164556962, Blast_Score=188, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24650122, Length=316, Percent_Identity=37.0253164556962, Blast_Score=188, Evalue=1e-47,
Organism=Drosophila melanogaster, GI281362242, Length=345, Percent_Identity=34.2028985507246, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24648872, Length=345, Percent_Identity=34.2028985507246, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI161078635, Length=316, Percent_Identity=37.0253164556962, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI161078639, Length=311, Percent_Identity=36.9774919614148, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI20130355, Length=341, Percent_Identity=26.9794721407625, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI45550436, Length=240, Percent_Identity=23.75, Blast_Score=87, Evalue=4e-17,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR014273 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 58018; Mature: 58018

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNVIPVTIAYGDGIGPEIMEAVVYVLKEAAVPLRLETIEIGEKLYNKYYTYGITEDTWS
CCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHEEECCCHHHHH
QIFRTKALLKGPVTTPQGEGYKSLNVTLKKTLGLYANVRPSISYFPFVNTSAPEIDVVII
HHHHHHHHHCCCCCCCCCCCCEEEEEEHHHHHCHHCCCCCCCEECCEECCCCCCEEEEEE
RENEEDLYTGIEYHHTADTYESIKLISRSGSEKIIRFAFEYALKNNRKKISCFSKDNIMK
ECCCCHHHCCCEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHH
FTDGIFHNTFNEIASQYSNIQVDHYLIDIGSARLISSPQKFDVIVTSNLYGDILSDIAAE
HHHHHHHHHHHHHHHHHCCEEEEEEEEEECCHHHHCCCCCEEEEEECCHHHHHHHHHHHH
ISDSIGLAGSANIGKDYAMFEAVHGSAPDIAGQNIANPSGLLNAAIMMLVHLGLTEHAAK
HHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHH
IENALKKTIEDGIHTADIYNPSISSKKVGTKEFAQAIINNLEYKPKKLKIAEYHNLDVES
HHHHHHHHHHCCCCEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCC
NIINNSQIQTITETRQQKKLVGVDVFFDSHNIIDYHRITKQLTKRIASLSSLHGMHLVTI
CCCCCCHHHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEE
SAKGLKLWPNSTVREMFSDHWCCRFMVQSSGKDKTVTAKNLTMKDILSLLNDLVATINNP
EECCEEECCCHHHHHHHCCCHHEEHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCC
IHSESKDDNYDNSIKFELIKVENLYLFNDTVGFSLAQGE
CCCCCCCCCCCCCEEEEEEEEEEEEEEECCCCCEECCCC
>Mature Secondary Structure
MKNVIPVTIAYGDGIGPEIMEAVVYVLKEAAVPLRLETIEIGEKLYNKYYTYGITEDTWS
CCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHEEECCCHHHHH
QIFRTKALLKGPVTTPQGEGYKSLNVTLKKTLGLYANVRPSISYFPFVNTSAPEIDVVII
HHHHHHHHHCCCCCCCCCCCCEEEEEEHHHHHCHHCCCCCCCEECCEECCCCCCEEEEEE
RENEEDLYTGIEYHHTADTYESIKLISRSGSEKIIRFAFEYALKNNRKKISCFSKDNIMK
ECCCCHHHCCCEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHH
FTDGIFHNTFNEIASQYSNIQVDHYLIDIGSARLISSPQKFDVIVTSNLYGDILSDIAAE
HHHHHHHHHHHHHHHHHCCEEEEEEEEEECCHHHHCCCCCEEEEEECCHHHHHHHHHHHH
ISDSIGLAGSANIGKDYAMFEAVHGSAPDIAGQNIANPSGLLNAAIMMLVHLGLTEHAAK
HHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHH
IENALKKTIEDGIHTADIYNPSISSKKVGTKEFAQAIINNLEYKPKKLKIAEYHNLDVES
HHHHHHHHHHCCCCEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCC
NIINNSQIQTITETRQQKKLVGVDVFFDSHNIIDYHRITKQLTKRIASLSSLHGMHLVTI
CCCCCCHHHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEE
SAKGLKLWPNSTVREMFSDHWCCRFMVQSSGKDKTVTAKNLTMKDILSLLNDLVATINNP
EECCEEECCCHHHHHHHCCCHHEEHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCC
IHSESKDDNYDNSIKFELIKVENLYLFNDTVGFSLAQGE
CCCCCCCCCCCCCEEEEEEEEEEEEEEECCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA