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The map label for this gene is nrdA [H]

Identifier: 189184363

GI number: 189184363

Start: 1488476

End: 1490290

Strand: Direct

Name: nrdA [H]

Synonym: OTT_1456

Alternate gene names: 189184363

Gene position: 1488476-1490290 (Clockwise)

Preceding gene: 189184362

Following gene: 189184364

Centisome position: 74.09

GC content: 33.33

Gene sequence:

>1815_bases
ATGACAAGCTCACCAAAATTTAATATAAAAATCAATAATGAACGGAATAAGTTACTATCTACTTCTAGTCAGGCTACTCT
AGCAGACAGATATCTACTTAAAGGTGAAACATTCCAAGATTTATGCGTAAGGATAGCAAGTTATTACGCTGATAATAAAT
CCCACGCTCAAAGATTGTACGACTATATGAGCCAACATTGGTTTTTACCAGCCACTCCTATATTAAGCAATGGAGGTACT
AATAGAGGATTGGCAATATCTTGTTTTGTAAATGAAGTAGAAGATAGCCTTTATGGAATAGTTAATACATGGATTGAAAA
TGTTTGGTTAGCATCACGTGGTGGTGGTATTGGAAGCTACTGGGGTAATGTTCGATCTATTAATGAAAAAATTGGCGAAA
ACGGATATAGTTCTGGAATTATTCCATTTATCAAAGTTCAAGATACTATGACTCTTGCTATTTCACAAGGATCTTTAAGA
CGCGGCAGTGCTGCAGTTTATCTGCCAATTTCTCATCCAGAAATAGAAGAGTTTATTGATATCAGAAGACATACAGGTGG
AGATTCTAATCGTAAGTCATTAAATATTCACCACGGTATAGTAATCTCTGATCAATTTATGCATGCTGTTGAAAAAAATG
AGTCATGGAATTTAATTAGCCCTTATGATGATAGGATCATTAATACAGTTAAAGCTAGAGATTTATGGGTTAAACTTTTA
ACAACTAGAATTGAAACTGGAGAGCCTTATATTCTATTCATTGATACAGTTAATAAATCTTTACCTGAGCATCATCAAAA
ATTAGGATTAAAGGTAAAAACATCTAATTTATGTAGTGAAATAACTCTACCGACTGGCCGTGATTATACAAATAACATTA
GGACAGCAGTATGCTGCCTATCGTCATTAAACCTAGAATATTTCGGACTATGGCAAAGTAATGAACATTTTATACCAGAC
ATTATAAGGTTTTTAGACAATGTACTTGAGGATTTTATTAATAAGGCTCCAGATACAATGTCTAATGCTAAATATTCTGC
TATGCATGAACGTAGTATAGGGCTTGGAGTAATGGGATTTCATTCGCTGTTGCAAGCTAACAATATACCAATCGCTTCTG
TAATGGCTAAAGTCTGGAATAAAAAAATATTTGAGCATATAAAATTGCAGACAGATAACATGTCTGTAGTTCTAGCTAAG
GAGCGTGGAGCATGTATTGATGCCCAAAAATGCAATATACAGGAAAGATTTAGCTATAAAACGGCAGTTGCTCCTACAGC
TTCAATCTCAATAATAGCTAATAATGCTTCACCTGGTATCGAACCGTATGCTGCTAACAGTTTTACACAAAAAACTTTAA
CTGGATCATTTTCCATCAAAAATAAGAATTTGGAAAAATTACTTGAGTCTAAAGGACTAAATAATGATCAAGTTTGGTCT
TCAATCGCAACTCATGAAGGCTCAGTGCAACATTTAACTTTTTTATCTGATCATGAAAAAGAAGTATATAAAACTGCTTA
TGAAATTGATCAGCGTTGGTTGATTGAATTAGCAGCTGATCGCACACAATATATTTCACAATCTCAATCACTTAATATAT
TTCTACCAGGTAATTGTAGTAAACAATTATTACATGATATACATTTTGATGCCTGGAAAAAAAACATAAAAAGTTTATAT
TATTGTAGATCTACTTCTATTCAGCGCGCAGAAAAGGTTTCACATGTGGTTACAATTGATGAATTAGCAAAATTAACAGA
TAAAGAACAGCTAGCAACAAGTAATAACGACGATGAATGCTTGGCATGCCAGTAA

Upstream 100 bases:

>100_bases
CTATTGTTGCTAAACAATTAAAAGTTACATTTGATAGAAGCAATAATATATATAATATGTATATTTTTATAAATTTACAA
AATTTTAAAGTTATTTTGAT

Downstream 100 bases:

>100_bases
TTATAATTTAGGAAAGAGAACAATGTCACTACTTAATGCACGACCAATTTACAAGCCATTTTCATACCCTTGGGCATATA
AAGCATGGCACACTCAGCAA

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 604; Mature: 603

Protein sequence:

>604_residues
MTSSPKFNIKINNERNKLLSTSSQATLADRYLLKGETFQDLCVRIASYYADNKSHAQRLYDYMSQHWFLPATPILSNGGT
NRGLAISCFVNEVEDSLYGIVNTWIENVWLASRGGGIGSYWGNVRSINEKIGENGYSSGIIPFIKVQDTMTLAISQGSLR
RGSAAVYLPISHPEIEEFIDIRRHTGGDSNRKSLNIHHGIVISDQFMHAVEKNESWNLISPYDDRIINTVKARDLWVKLL
TTRIETGEPYILFIDTVNKSLPEHHQKLGLKVKTSNLCSEITLPTGRDYTNNIRTAVCCLSSLNLEYFGLWQSNEHFIPD
IIRFLDNVLEDFINKAPDTMSNAKYSAMHERSIGLGVMGFHSLLQANNIPIASVMAKVWNKKIFEHIKLQTDNMSVVLAK
ERGACIDAQKCNIQERFSYKTAVAPTASISIIANNASPGIEPYAANSFTQKTLTGSFSIKNKNLEKLLESKGLNNDQVWS
SIATHEGSVQHLTFLSDHEKEVYKTAYEIDQRWLIELAADRTQYISQSQSLNIFLPGNCSKQLLHDIHFDAWKKNIKSLY
YCRSTSIQRAEKVSHVVTIDELAKLTDKEQLATSNNDDECLACQ

Sequences:

>Translated_604_residues
MTSSPKFNIKINNERNKLLSTSSQATLADRYLLKGETFQDLCVRIASYYADNKSHAQRLYDYMSQHWFLPATPILSNGGT
NRGLAISCFVNEVEDSLYGIVNTWIENVWLASRGGGIGSYWGNVRSINEKIGENGYSSGIIPFIKVQDTMTLAISQGSLR
RGSAAVYLPISHPEIEEFIDIRRHTGGDSNRKSLNIHHGIVISDQFMHAVEKNESWNLISPYDDRIINTVKARDLWVKLL
TTRIETGEPYILFIDTVNKSLPEHHQKLGLKVKTSNLCSEITLPTGRDYTNNIRTAVCCLSSLNLEYFGLWQSNEHFIPD
IIRFLDNVLEDFINKAPDTMSNAKYSAMHERSIGLGVMGFHSLLQANNIPIASVMAKVWNKKIFEHIKLQTDNMSVVLAK
ERGACIDAQKCNIQERFSYKTAVAPTASISIIANNASPGIEPYAANSFTQKTLTGSFSIKNKNLEKLLESKGLNNDQVWS
SIATHEGSVQHLTFLSDHEKEVYKTAYEIDQRWLIELAADRTQYISQSQSLNIFLPGNCSKQLLHDIHFDAWKKNIKSLY
YCRSTSIQRAEKVSHVVTIDELAKLTDKEQLATSNNDDECLACQ
>Mature_603_residues
TSSPKFNIKINNERNKLLSTSSQATLADRYLLKGETFQDLCVRIASYYADNKSHAQRLYDYMSQHWFLPATPILSNGGTN
RGLAISCFVNEVEDSLYGIVNTWIENVWLASRGGGIGSYWGNVRSINEKIGENGYSSGIIPFIKVQDTMTLAISQGSLRR
GSAAVYLPISHPEIEEFIDIRRHTGGDSNRKSLNIHHGIVISDQFMHAVEKNESWNLISPYDDRIINTVKARDLWVKLLT
TRIETGEPYILFIDTVNKSLPEHHQKLGLKVKTSNLCSEITLPTGRDYTNNIRTAVCCLSSLNLEYFGLWQSNEHFIPDI
IRFLDNVLEDFINKAPDTMSNAKYSAMHERSIGLGVMGFHSLLQANNIPIASVMAKVWNKKIFEHIKLQTDNMSVVLAKE
RGACIDAQKCNIQERFSYKTAVAPTASISIIANNASPGIEPYAANSFTQKTLTGSFSIKNKNLEKLLESKGLNNDQVWSS
IATHEGSVQHLTFLSDHEKEVYKTAYEIDQRWLIELAADRTQYISQSQSLNIFLPGNCSKQLLHDIHFDAWKKNIKSLYY
CRSTSIQRAEKVSHVVTIDELAKLTDKEQLATSNNDDECLACQ

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 ATP-cone domains [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=661, Percent_Identity=30.7110438729198, Blast_Score=254, Evalue=2e-67,
Organism=Escherichia coli, GI1789030, Length=601, Percent_Identity=27.6206322795341, Blast_Score=172, Evalue=8e-44,
Organism=Escherichia coli, GI2367133, Length=619, Percent_Identity=26.1712439418417, Blast_Score=134, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17555242, Length=665, Percent_Identity=31.2781954887218, Blast_Score=261, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6320914, Length=667, Percent_Identity=30.8845577211394, Blast_Score=239, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6322123, Length=639, Percent_Identity=30.3599374021909, Blast_Score=234, Evalue=3e-62,
Organism=Drosophila melanogaster, GI17352481, Length=611, Percent_Identity=29.6235679214403, Blast_Score=231, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 68092; Mature: 67961

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSPKFNIKINNERNKLLSTSSQATLADRYLLKGETFQDLCVRIASYYADNKSHAQRLY
CCCCCEEEEEECCCCHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHH
DYMSQHWFLPATPILSNGGTNRGLAISCFVNEVEDSLYGIVNTWIENVWLASRGGGIGSY
HHHHCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHEEEECCCCCCHHH
WGNVRSINEKIGENGYSSGIIPFIKVQDTMTLAISQGSLRRGSAAVYLPISHPEIEEFID
HCCHHHHHHHHCCCCCCCCCEEEEEECCEEEEEEECCCCCCCCEEEEEECCCCCHHHHHH
IRRHTGGDSNRKSLNIHHGIVISDQFMHAVEKNESWNLISPYDDRIINTVKARDLWVKLL
HHHCCCCCCCCCEEEEECCEEECHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
TTRIETGEPYILFIDTVNKSLPEHHQKLGLKVKTSNLCSEITLPTGRDYTNNIRTAVCCL
HHHHCCCCCEEEEEECCCCCCHHHHHHCCCEEECCCCHHHCCCCCCCCCHHHHHHHHHHH
SSLNLEYFGLWQSNEHFIPDIIRFLDNVLEDFINKAPDTMSNAKYSAMHERSIGLGVMGF
HHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHH
HSLLQANNIPIASVMAKVWNKKIFEHIKLQTDNMSVVLAKERGACIDAQKCNIQERFSYK
HHHHHCCCCCHHHHHHHHHHHHHHHHHEEECCCEEEEEEECCCCEECHHHCCHHHHHCCC
TAVAPTASISIIANNASPGIEPYAANSFTQKTLTGSFSIKNKNLEKLLESKGLNNDQVWS
EECCCCCEEEEEEECCCCCCCCCCCCCHHHHHEECEEEECCCHHHHHHHHCCCCCHHHHH
SIATHEGSVQHLTFLSDHEKEVYKTAYEIDQRWLIELAADRTQYISQSQSLNIFLPGNCS
HHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCH
KQLLHDIHFDAWKKNIKSLYYCRSTSIQRAEKVSHVVTIDELAKLTDKEQLATSNNDDEC
HHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHEEEHHHHHHHCCHHHHHCCCCCCCE
LACQ
EECC
>Mature Secondary Structure 
TSSPKFNIKINNERNKLLSTSSQATLADRYLLKGETFQDLCVRIASYYADNKSHAQRLY
CCCCEEEEEECCCCHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHH
DYMSQHWFLPATPILSNGGTNRGLAISCFVNEVEDSLYGIVNTWIENVWLASRGGGIGSY
HHHHCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHEEEECCCCCCHHH
WGNVRSINEKIGENGYSSGIIPFIKVQDTMTLAISQGSLRRGSAAVYLPISHPEIEEFID
HCCHHHHHHHHCCCCCCCCCEEEEEECCEEEEEEECCCCCCCCEEEEEECCCCCHHHHHH
IRRHTGGDSNRKSLNIHHGIVISDQFMHAVEKNESWNLISPYDDRIINTVKARDLWVKLL
HHHCCCCCCCCCEEEEECCEEECHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
TTRIETGEPYILFIDTVNKSLPEHHQKLGLKVKTSNLCSEITLPTGRDYTNNIRTAVCCL
HHHHCCCCCEEEEEECCCCCCHHHHHHCCCEEECCCCHHHCCCCCCCCCHHHHHHHHHHH
SSLNLEYFGLWQSNEHFIPDIIRFLDNVLEDFINKAPDTMSNAKYSAMHERSIGLGVMGF
HHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHH
HSLLQANNIPIASVMAKVWNKKIFEHIKLQTDNMSVVLAKERGACIDAQKCNIQERFSYK
HHHHHCCCCCHHHHHHHHHHHHHHHHHEEECCCEEEEEEECCCCEECHHHCCHHHHHCCC
TAVAPTASISIIANNASPGIEPYAANSFTQKTLTGSFSIKNKNLEKLLESKGLNNDQVWS
EECCCCCEEEEEEECCCCCCCCCCCCCHHHHHEECEEEECCCHHHHHHHHCCCCCHHHHH
SIATHEGSVQHLTFLSDHEKEVYKTAYEIDQRWLIELAADRTQYISQSQSLNIFLPGNCS
HHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCH
KQLLHDIHFDAWKKNIKSLYYCRSTSIQRAEKVSHVVTIDELAKLTDKEQLATSNNDDEC
HHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHEEEHHHHHHHCCHHHHHCCCCCCCE
LACQ
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]