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The map label for this gene is coxB [H]

Identifier: 189184309

GI number: 189184309

Start: 1434580

End: 1435440

Strand: Reverse

Name: coxB [H]

Synonym: OTT_1402

Alternate gene names: 189184309

Gene position: 1435440-1434580 (Counterclockwise)

Preceding gene: 189184310

Following gene: 189184308

Centisome position: 71.45

GC content: 33.1

Gene sequence:

>861_bases
TTGTATCAGCACTTCATACAGCTGATAAAGGTTGCAATATTAATAAATAGAAGTTTTAGAATTGAGGTATATCTGCTACT
ACTATCACCAGCACGACTACTACTGCTACTGTTAATACTAAGTTACAACACACCAATATACCCTAACGCTCCTAAGGCAT
GGCAGATGTATTTTCAGCCTCAAGTAACAGAAGCAATGTCATCGATACGTGGTCTCCATGATTTTGTTTTGATTGTATTA
GCTATGGTAGTACTAATTGTCCTAGGGCTACTTATCTACATATGTATAAATTTTAATTCAAAGTCTCATCCAAAACCAAT
GCAGTTTTCTGCTAATTACAAACTAGAAGCAATATGGACATTAATTCCTGCATTATTGCTGGTTATTATTGCTGTACCAT
CATTTAAAATATTATACAATATAGAAACAATTCCACCAATAGAAATGAATATTAAAGTAGTAGGATATCAGTGGTACTGG
CATTATCAATATCCAGACCATGATAATATAGGCTTTAATAGTAATATCCTTGATGATAGTGAGCTAAAACCAGGAGATTT
AAGATTACTAGAAGTAGATAATAGATTAGTTATACCTGAAAATACCTGGGTTAGGTTTATTATCACAGCTGGTGATGCAA
TTCATAGTTTTGCAGTACCTGCTTTTGGTACTAAAGTTGATGCTGTACCAGGAAGAATCAATGAAACATGGATTAAAGTA
CAAAAAAAAGGAGTATATTATGGACAGTGCTCAGAGCTATGCGGAGTAAATCATGGATTTATGCCAATTGCTATTGAAGT
AGTTTCAAAAGAAGAATTTACTGATTGGCTCAAAACAGCTAAACAAAAATTTGCAGAATAA

Upstream 100 bases:

>100_bases
CATCACAGAGGATTGCATGATAAAATTGCTGGTACAACTATTATAAAAATATAAGGTAAATAATTTTACTTTAATTAATT
TAAAAAATACTTTATTATGG

Downstream 100 bases:

>100_bases
CTATGTTATGTAATATTATTTTATGGTGTCTTGAAGAACAATTATCCTTTTAATCCCAATATTTCAATTCATCAGAAATA
ATAATTTTATAAAAACTTAC

Product: cytochrome c oxidase polypeptide II

Products: NA

Alternate protein names: Cytochrome aa3 subunit 2; Cytochrome c oxidase polypeptide II [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MYQHFIQLIKVAILINRSFRIEVYLLLLSPARLLLLLLILSYNTPIYPNAPKAWQMYFQPQVTEAMSSIRGLHDFVLIVL
AMVVLIVLGLLIYICINFNSKSHPKPMQFSANYKLEAIWTLIPALLLVIIAVPSFKILYNIETIPPIEMNIKVVGYQWYW
HYQYPDHDNIGFNSNILDDSELKPGDLRLLEVDNRLVIPENTWVRFIITAGDAIHSFAVPAFGTKVDAVPGRINETWIKV
QKKGVYYGQCSELCGVNHGFMPIAIEVVSKEEFTDWLKTAKQKFAE

Sequences:

>Translated_286_residues
MYQHFIQLIKVAILINRSFRIEVYLLLLSPARLLLLLLILSYNTPIYPNAPKAWQMYFQPQVTEAMSSIRGLHDFVLIVL
AMVVLIVLGLLIYICINFNSKSHPKPMQFSANYKLEAIWTLIPALLLVIIAVPSFKILYNIETIPPIEMNIKVVGYQWYW
HYQYPDHDNIGFNSNILDDSELKPGDLRLLEVDNRLVIPENTWVRFIITAGDAIHSFAVPAFGTKVDAVPGRINETWIKV
QKKGVYYGQCSELCGVNHGFMPIAIEVVSKEEFTDWLKTAKQKFAE
>Mature_286_residues
MYQHFIQLIKVAILINRSFRIEVYLLLLSPARLLLLLLILSYNTPIYPNAPKAWQMYFQPQVTEAMSSIRGLHDFVLIVL
AMVVLIVLGLLIYICINFNSKSHPKPMQFSANYKLEAIWTLIPALLLVIIAVPSFKILYNIETIPPIEMNIKVVGYQWYW
HYQYPDHDNIGFNSNILDDSELKPGDLRLLEVDNRLVIPENTWVRFIITAGDAIHSFAVPAFGTKVDAVPGRINETWIKV
QKKGVYYGQCSELCGVNHGFMPIAIEVVSKEEFTDWLKTAKQKFAE

Specific function: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) [H]

COG id: COG1622

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 2

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome c oxidase subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831110, Length=221, Percent_Identity=40.2714932126697, Blast_Score=187, Evalue=9e-48,
Organism=Saccharomyces cerevisiae, GI6226540, Length=250, Percent_Identity=41.2, Blast_Score=199, Evalue=4e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001505
- InterPro:   IPR008972
- InterPro:   IPR014222
- InterPro:   IPR015964
- InterPro:   IPR002429
- InterPro:   IPR011759
- InterPro:   IPR005728 [H]

Pfam domain/function: PF00116 COX2; PF02790 COX2_TM [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 32828; Mature: 32828

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: PS50999 COX2_TM ; PS50857 COX2_CUA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQHFIQLIKVAILINRSFRIEVYLLLLSPARLLLLLLILSYNTPIYPNAPKAWQMYFQP
CHHHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHEEEEECC
QVTEAMSSIRGLHDFVLIVLAMVVLIVLGLLIYICINFNSKSHPKPMQFSANYKLEAIWT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCEEECCCCHHHHHH
LIPALLLVIIAVPSFKILYNIETIPPIEMNIKVVGYQWYWHYQYPDHDNIGFNSNILDDS
HHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEEEEEEEEEEEECCCCCCCCCCCCCCCCC
ELKPGDLRLLEVDNRLVIPENTWVRFIITAGDAIHSFAVPAFGTKVDAVPGRINETWIKV
CCCCCCEEEEEECCEEECCCCCEEEEEEECCCHHHHHCCCCCCCEECCCCCCCCHHEEEE
QKKGVYYGQCSELCGVNHGFMPIAIEVVSKEEFTDWLKTAKQKFAE
EECCCEEECHHHHHCCCCCCEEEEEEEECHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYQHFIQLIKVAILINRSFRIEVYLLLLSPARLLLLLLILSYNTPIYPNAPKAWQMYFQP
CHHHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHEEEEECC
QVTEAMSSIRGLHDFVLIVLAMVVLIVLGLLIYICINFNSKSHPKPMQFSANYKLEAIWT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCEEECCCCHHHHHH
LIPALLLVIIAVPSFKILYNIETIPPIEMNIKVVGYQWYWHYQYPDHDNIGFNSNILDDS
HHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEEEEEEEEEEEECCCCCCCCCCCCCCCCC
ELKPGDLRLLEVDNRLVIPENTWVRFIITAGDAIHSFAVPAFGTKVDAVPGRINETWIKV
CCCCCCEEEEEECCEEECCCCCEEEEEEECCCHHHHHCCCCCCCEECCCCCCCCHHEEEE
QKKGVYYGQCSELCGVNHGFMPIAIEVVSKEEFTDWLKTAKQKFAE
EECCCEEECHHHHHCCCCCCEEEEEEEECHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]