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The map label for this gene is pth [H]

Identifier: 189184106

GI number: 189184106

Start: 1228628

End: 1229188

Strand: Direct

Name: pth [H]

Synonym: OTT_1199

Alternate gene names: 189184106

Gene position: 1228628-1229188 (Clockwise)

Preceding gene: 189184105

Following gene: 189184107

Centisome position: 61.16

GC content: 30.66

Gene sequence:

>561_bases
GTGTTGGTAGTAGGGCTTGGTAATCCTGGTAAAGAATATGCAAACTCAAGGCATAATGCTGGCTATATTGTTCTAGAACA
AATTGCACTTTATAATGATTTAAGCTTTAGTAAAAGCACTAAATATAAATCTGACATTGCTAAAATATTGCTTTTAGGCA
AAAAAATTATTTTTATAAAACCATTAACCTATATGAATCTTTCTGGTACAGCAGTTTGCTTAATAAAGGATTTTTATAAG
TTGCAGAATTACGATATAATCGTTATTCATGACGATATTGACCTGCCTTTAGGTATTGTAAAGTTAAAGGTAGGTGGTGG
TAGTGGAGGGCATAACGGGCTAAAATCTATTAGTAGTGCAATTGGTGACAGTTATTTAAGAATTAAGATAGGTATTGGTA
GACCTCTCTCTGAGCATTTATCAGTTGCAAGTTATGTTTTATCTGATTTTTTAGTTACGGAATTAACAGTGTTATATTCT
ATAGCAAGAAAAATTGCTGAAAATTTTGAGCTAGCAGTTCAAAAACAATTCAGTGAATTTATGTTTAAGATAAAAAATTG
A

Upstream 100 bases:

>100_bases
AGAGGACTACAGACTATGTCATTGCATCTGTTATTGGTAAATCTAGTAAGCAGGATAAAGAGGAAGAAGGAACAGCAGAA
GATGGTGCTGATAGTAAGTA

Downstream 100 bases:

>100_bases
TTGATAAAAATGGAACTTAGATATGGAATAGTTGGATTGCCTAACGTAGGAAAATCAACATTATTTAATGCTTTAACTGC
TACTCAATCTGCTAATGTTG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MLVVGLGNPGKEYANSRHNAGYIVLEQIALYNDLSFSKSTKYKSDIAKILLLGKKIIFIKPLTYMNLSGTAVCLIKDFYK
LQNYDIIVIHDDIDLPLGIVKLKVGGGSGGHNGLKSISSAIGDSYLRIKIGIGRPLSEHLSVASYVLSDFLVTELTVLYS
IARKIAENFELAVQKQFSEFMFKIKN

Sequences:

>Translated_186_residues
MLVVGLGNPGKEYANSRHNAGYIVLEQIALYNDLSFSKSTKYKSDIAKILLLGKKIIFIKPLTYMNLSGTAVCLIKDFYK
LQNYDIIVIHDDIDLPLGIVKLKVGGGSGGHNGLKSISSAIGDSYLRIKIGIGRPLSEHLSVASYVLSDFLVTELTVLYS
IARKIAENFELAVQKQFSEFMFKIKN
>Mature_186_residues
MLVVGLGNPGKEYANSRHNAGYIVLEQIALYNDLSFSKSTKYKSDIAKILLLGKKIIFIKPLTYMNLSGTAVCLIKDFYK
LQNYDIIVIHDDIDLPLGIVKLKVGGGSGGHNGLKSISSAIGDSYLRIKIGIGRPLSEHLSVASYVLSDFLVTELTVLYS
IARKIAENFELAVQKQFSEFMFKIKN

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=160, Percent_Identity=33.125, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI1787455, Length=155, Percent_Identity=40.6451612903226, Blast_Score=100, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6321983, Length=175, Percent_Identity=30.8571428571429, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 20563; Mature: 20563

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVVGLGNPGKEYANSRHNAGYIVLEQIALYNDLSFSKSTKYKSDIAKILLLGKKIIFIK
CEEEECCCCCHHHCCCCCCCCEEEEEHHHHHCCCCCCCCCHHHHHHHHHHHHCCEEEEEE
PLTYMNLSGTAVCLIKDFYKLQNYDIIVIHDDIDLPLGIVKLKVGGGSGGHNGLKSISSA
CEEEECCCCCEEHEEHHHHHHCCCCEEEEECCCCCCEEEEEEEECCCCCCCHHHHHHHHH
IGDSYLRIKIGIGRPLSEHLSVASYVLSDFLVTELTVLYSIARKIAENFELAVQKQFSEF
HCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MFKIKN
HHEECC
>Mature Secondary Structure
MLVVGLGNPGKEYANSRHNAGYIVLEQIALYNDLSFSKSTKYKSDIAKILLLGKKIIFIK
CEEEECCCCCHHHCCCCCCCCEEEEEHHHHHCCCCCCCCCHHHHHHHHHHHHCCEEEEEE
PLTYMNLSGTAVCLIKDFYKLQNYDIIVIHDDIDLPLGIVKLKVGGGSGGHNGLKSISSA
CEEEECCCCCEEHEEHHHHHHCCCCEEEEECCCCCCEEEEEEEECCCCCCCHHHHHHHHH
IGDSYLRIKIGIGRPLSEHLSVASYVLSDFLVTELTVLYSIARKIAENFELAVQKQFSEF
HCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MFKIKN
HHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA