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The map label for this gene is thyX [H]

Identifier: 189183983

GI number: 189183983

Start: 1103791

End: 1104693

Strand: Direct

Name: thyX [H]

Synonym: OTT_1076

Alternate gene names: 189183983

Gene position: 1103791-1104693 (Clockwise)

Preceding gene: 189183982

Following gene: 189183984

Centisome position: 54.94

GC content: 32.56

Gene sequence:

>903_bases
ATGGAATTGAAAAAAAGTACTACTAAGAGAAGTAGTGTTAATGCTTTAGAAGAAATATTATACAATGAAATAAAAGTATT
AGACCATGGATTTATAAGAGTTGTAGATTATATGGGAGATGATTTTTCAGTAGTACAAGCTGCTAGAGTCTCTTATGGTC
GTGGAACGAAGCAACTTTCTCAAGATAGAGGATTGATAAGATATTTAATGCGACACAGACATACAACACCATTTGAGATG
TGTGATATAAAGTTTCATATTAAACTGCCAATTTTTGTAGCACGTCAATGGATCAGACATCGTACAGCAAGTATTAATGA
ATATTCAGCTCGTTACTCAATTTTAGCAAAAGAGTTTTATTTGCCAAGAAATGATGATATAACTCCTCAGTCAAAAACCA
ATAAGCAGGGTAGGTCAGAAGAGGTAATATCTGAGCAGTGGACAATGAGAGTTCTAGAAATATTAAAGAGCGATGCTGAA
AGATGTTATCAACACTATGAAGAAATGCTTAATGAAGATAGTGAAGGGCATATAGTAAATTCTGAAAACGTAGGGATTGC
AAGAGAGTTAGCTAGAATTAATCTGCCTCTAAATTATTATACTGAGTGGTATTGGAAAGTGAACTTACATAATTTATTAC
ATTTTCTATCCTTAAGAGGAAGTAAACATGCTCAATATGAAATTAGAGCTTATGCAAAAAAGATGATTGATATAGTAAAG
CTTTGGGTTCCTTATAGTTTTGAGGCATTTGAAGATTATGTATTGCATTCAGCATTAATATCAAAGGGAGGCTTGGCAGT
AGTTAGAAAAATGATAAAAGGTGAAAAGGTTAGTATGGAGGATAGTAACCTTTCAAAAAGAGAATGGGAAGAGTTAATGG
AGATAGTTAATGGAGATAGTTAA

Upstream 100 bases:

>100_bases
CGTGCCAGTATGCTATAGAGTTACTGCGAGATTATGTATGTAATATACTATAATAATCTTTAATAATTAAGTAATTTTAA
CTAATAGGATATACAATTTA

Downstream 100 bases:

>100_bases
TGTATTATTGAATATGGAATTAATAAATGCTGTTTTTATAGATTAAATTGAATTTTAAATGTGAATAGTGAGAAAAAACA
TTATAAAAATAAGAATACTT

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MELKKSTTKRSSVNALEEILYNEIKVLDHGFIRVVDYMGDDFSVVQAARVSYGRGTKQLSQDRGLIRYLMRHRHTTPFEM
CDIKFHIKLPIFVARQWIRHRTASINEYSARYSILAKEFYLPRNDDITPQSKTNKQGRSEEVISEQWTMRVLEILKSDAE
RCYQHYEEMLNEDSEGHIVNSENVGIARELARINLPLNYYTEWYWKVNLHNLLHFLSLRGSKHAQYEIRAYAKKMIDIVK
LWVPYSFEAFEDYVLHSALISKGGLAVVRKMIKGEKVSMEDSNLSKREWEELMEIVNGDS

Sequences:

>Translated_300_residues
MELKKSTTKRSSVNALEEILYNEIKVLDHGFIRVVDYMGDDFSVVQAARVSYGRGTKQLSQDRGLIRYLMRHRHTTPFEM
CDIKFHIKLPIFVARQWIRHRTASINEYSARYSILAKEFYLPRNDDITPQSKTNKQGRSEEVISEQWTMRVLEILKSDAE
RCYQHYEEMLNEDSEGHIVNSENVGIARELARINLPLNYYTEWYWKVNLHNLLHFLSLRGSKHAQYEIRAYAKKMIDIVK
LWVPYSFEAFEDYVLHSALISKGGLAVVRKMIKGEKVSMEDSNLSKREWEELMEIVNGDS
>Mature_300_residues
MELKKSTTKRSSVNALEEILYNEIKVLDHGFIRVVDYMGDDFSVVQAARVSYGRGTKQLSQDRGLIRYLMRHRHTTPFEM
CDIKFHIKLPIFVARQWIRHRTASINEYSARYSILAKEFYLPRNDDITPQSKTNKQGRSEEVISEQWTMRVLEILKSDAE
RCYQHYEEMLNEDSEGHIVNSENVGIARELARINLPLNYYTEWYWKVNLHNLLHFLSLRGSKHAQYEIRAYAKKMIDIVK
LWVPYSFEAFEDYVLHSALISKGGLAVVRKMIKGEKVSMEDSNLSKREWEELMEIVNGDS

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 35293; Mature: 35293

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELKKSTTKRSSVNALEEILYNEIKVLDHGFIRVVDYMGDDFSVVQAARVSYGRGTKQLS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHH
QDRGLIRYLMRHRHTTPFEMCDIKFHIKLPIFVARQWIRHRTASINEYSARYSILAKEFY
HHHHHHHHHHHHCCCCCHHEEEEEEEEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
LPRNDDITPQSKTNKQGRSEEVISEQWTMRVLEILKSDAERCYQHYEEMLNEDSEGHIVN
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEC
SENVGIARELARINLPLNYYTEWYWKVNLHNLLHFLSLRGSKHAQYEIRAYAKKMIDIVK
CCCCHHHHHHHHHCCCHHHCEEEEEEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
LWVPYSFEAFEDYVLHSALISKGGLAVVRKMIKGEKVSMEDSNLSKREWEELMEIVNGDS
HHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MELKKSTTKRSSVNALEEILYNEIKVLDHGFIRVVDYMGDDFSVVQAARVSYGRGTKQLS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHH
QDRGLIRYLMRHRHTTPFEMCDIKFHIKLPIFVARQWIRHRTASINEYSARYSILAKEFY
HHHHHHHHHHHHCCCCCHHEEEEEEEEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
LPRNDDITPQSKTNKQGRSEEVISEQWTMRVLEILKSDAERCYQHYEEMLNEDSEGHIVN
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEC
SENVGIARELARINLPLNYYTEWYWKVNLHNLLHFLSLRGSKHAQYEIRAYAKKMIDIVK
CCCCHHHHHHHHHCCCHHHCEEEEEEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
LWVPYSFEAFEDYVLHSALISKGGLAVVRKMIKGEKVSMEDSNLSKREWEELMEIVNGDS
HHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA