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The map label for this gene is dut [H]

Identifier: 189183873

GI number: 189183873

Start: 1013531

End: 1013977

Strand: Direct

Name: dut [H]

Synonym: OTT_0966

Alternate gene names: 189183873

Gene position: 1013531-1013977 (Clockwise)

Preceding gene: 189183872

Following gene: 189183874

Centisome position: 50.45

GC content: 36.69

Gene sequence:

>447_bases
ATGAAAGTAAAAATTAAGCAAATTTATCAATTTGAGGGAACATCATCTCTGCCTGCGTATTCTACTAATGGCAGTGCTGG
TATGGACTTGTATGCTGCGATAGCTAGTCCTATGATAATTAAGCCTCATGAAACTGCTCTTGTACCTGCTGGTATTGCTA
TTTCCTTGCCTTATGGATATGAAGCGCAAATACGTTCTAGATCAGGGCTTGCTAGTAAGTTTGGTGTAATAGTTTTAAAC
TCTCCAGGTACTATTGACTCCGATTATCGAGGAGAATTGAAGATTATTATGATCAATTTAGGTCAAAAAGATTTTCAGCT
GACTCCAGCTATGCGTATTGCTCAAATGGTAATAGCTAAATATGAGGTTATTAGTTGGGAAATTGTAGATGATTTAGATG
AAACAGAAAGAGGTGAAAAAGGGTTTGGTTCTAGTGGCTTAAAGTAA

Upstream 100 bases:

>100_bases
TGCTCTCTATAGTTTGACATATTTTTTATATTGAACTCGTGCTAATTAAGCTTTGATAAAGTTTATTGACTAAAAGATAA
GGTAGTGGTATAAAGGAGTA

Downstream 100 bases:

>100_bases
TAAATACTGCTGTTGTATAGCTAATTTGGCCAAAGTTTTTTCAATCGCAATATTAATTTGTTAGAAGTTAGTAGTTTATC
TAGGTAATGATTAAATGCAT

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MKVKIKQIYQFEGTSSLPAYSTNGSAGMDLYAAIASPMIIKPHETALVPAGIAISLPYGYEAQIRSRSGLASKFGVIVLN
SPGTIDSDYRGELKIIMINLGQKDFQLTPAMRIAQMVIAKYEVISWEIVDDLDETERGEKGFGSSGLK

Sequences:

>Translated_148_residues
MKVKIKQIYQFEGTSSLPAYSTNGSAGMDLYAAIASPMIIKPHETALVPAGIAISLPYGYEAQIRSRSGLASKFGVIVLN
SPGTIDSDYRGELKIIMINLGQKDFQLTPAMRIAQMVIAKYEVISWEIVDDLDETERGEKGFGSSGLK
>Mature_148_residues
MKVKIKQIYQFEGTSSLPAYSTNGSAGMDLYAAIASPMIIKPHETALVPAGIAISLPYGYEAQIRSRSGLASKFGVIVLN
SPGTIDSDYRGELKIIMINLGQKDFQLTPAMRIAQMVIAKYEVISWEIVDDLDETERGEKGFGSSGLK

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=132, Percent_Identity=38.6363636363636, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI4503423, Length=132, Percent_Identity=38.6363636363636, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI70906441, Length=146, Percent_Identity=35.6164383561644, Blast_Score=88, Evalue=3e-18,
Organism=Escherichia coli, GI1790071, Length=131, Percent_Identity=44.2748091603053, Blast_Score=110, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71988561, Length=140, Percent_Identity=38.5714285714286, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6319729, Length=144, Percent_Identity=32.6388888888889, Blast_Score=82, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24583610, Length=131, Percent_Identity=34.3511450381679, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI19921126, Length=131, Percent_Identity=34.3511450381679, Blast_Score=79, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 16092; Mature: 16092

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVKIKQIYQFEGTSSLPAYSTNGSAGMDLYAAIASPMIIKPHETALVPAGIAISLPYGY
CCEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCEEECCCCCEEECCCEEEECCCCC
EAQIRSRSGLASKFGVIVLNSPGTIDSDYRGELKIIMINLGQKDFQLTPAMRIAQMVIAK
CEEECCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEEECCCCCEEECHHHHHHHHHHHH
YEVISWEIVDDLDETERGEKGFGSSGLK
HHHEEEEECCCCCHHCCCCCCCCCCCCC
>Mature Secondary Structure
MKVKIKQIYQFEGTSSLPAYSTNGSAGMDLYAAIASPMIIKPHETALVPAGIAISLPYGY
CCEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCEEECCCCCEEECCCEEEECCCCC
EAQIRSRSGLASKFGVIVLNSPGTIDSDYRGELKIIMINLGQKDFQLTPAMRIAQMVIAK
CEEECCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEEECCCCCEEECHHHHHHHHHHHH
YEVISWEIVDDLDETERGEKGFGSSGLK
HHHEEEEECCCCCHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA