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The map label for this gene is thrS [H]

Identifier: 189183871

GI number: 189183871

Start: 1010862

End: 1012808

Strand: Direct

Name: thrS [H]

Synonym: OTT_0964

Alternate gene names: 189183871

Gene position: 1010862-1012808 (Clockwise)

Preceding gene: 189183869

Following gene: 189183872

Centisome position: 50.32

GC content: 33.69

Gene sequence:

>1947_bases
ATGATTGATATTATTCTTCCTGATGGATCAGTTAAACAATATAAGATAGGAGTTACTGGCCAAGAAATTATACAGTCATT
GTCGATTTCTTTATTCAAAAAAACTATTGCTGTTGCAGTAAATAATGAGTTAATGGATCTTTACATACCTATTATTAATA
CTGCAACAGTAAAAGCTATTACTATAGATAGTGTGCAAGGAATTGAAATTCTTCGTCATGATACTGCTCACATTCTAGCT
CAGGCAGTTAAAAAATTATTTCCAGATACTCAAGTAGTTATTGGGCCTGTTATTAAAGATGGATTTTACTATGATTTTGC
TCGCGATAAGCCTTTTACTAGCAAGGATTTAGAAATTATCGAACAAGAAATGCAAGATATTATCACCAAAAATGATTTAA
TTCAACGAGAAGTATGGTTACGTGCTAAAGCAATAGAGTTTTTTAAGCAGCAAAAGGAGTTTTATAAGGTCAAGCTTATC
GAAGAAATTCCTGAGTCTGAAGAGATAAGTATATACAGACAAGGAAACTTTGTAGATTTGTGTCGTGGGCCTCATTCACC
AAGCACGGGTTACTGCGCGAAGTATTTTAAGCTAACTAAAGTATCAGGTGCATATTGGCGTGGTAATAGTAAAAACGAGT
CTTTACAACGAATTTATGGGACAGCTTGGGGAAAAAAATCAGACCTTGACTCTTACTTGCATAGACTATCTGAAGCTCAA
AAGCGAGATCATAGAAAGCTTGGCCGTGAACTTGAATTATTTCATTTTCAGGATGAAGCGCAAGGTATGCCATTTTGGCA
TAGTAAAGGGTGGACTATTTTTAAAATTATTAAAGACTATATTAGTTGTCAAATTCAACGAGCTGGCTATATTGAAGTTA
ATACTCCTATGGTGCTGAATCAAAAACTATGGGAAAAGTCTGGGCACTGGGAAAAATTTAGAGAAAATATGTTTACTTTA
GATACCAATGCTGCTGAGCAAGATCATAATTTAATTAAAGATAGTATAGAAACAAAATGCGCTCTTGCATTAAAGCCAAT
GAATTGTCCTGGGCACATACAGATTTTTAATTATACAATAAAAAGCTATCGAGATTTACCACTGCGTATGGCTGAATTTG
GATCTTGTCATCGTTATGAACCTTCAGGAGCATTATATGGGTTGATGAGAGTGAGAAGCTTTGTGCAAGATGATGCGCAT
ATTTTTTGTACAGAAGATCAAATTACAGATGAAACAATAAAATTTTGCCATCTATTAAAACAAGTATACCAAGATTTTGG
ATTTCCAGAAGTAAAGATTAAGTTTTCAGACAGACCTGAAAAACGGGCTGGTACAGATAAAATATGGGATAAAGCTGAGC
AAGCTTTAATTCATGCTATTCAAACGTTAGGTGAGGAATATACTATTAATCGAGGTGAAGGAGCTTTCTATGGCCCTAAG
CTTGAGTTTATATTAACAGATGCAATTGGACGTGAATGGCAATGTGGTACTTTACAGGTAGATTTCGTTTTACCAGAGCG
ACTTAATGCTAGCTATATTAGTTCTGAAGGAAGTAAAAAGCGTCCAGTAATATTGCATCGAGCAATATTAGGGTCATTTG
AAAGATTTATTGGCATATTAATAGAGCACTACTCAGGTAAGTTGCCAATATGGTTAGCTCCAATACAAGTTGCAGTAGTA
TCAATTACAGACGAAGCAGTCAACTATGCAAAACAGCTACATCAAGAATTAATTGATAACAATATTAGATCTACACTTGA
CATTTCTAATCAGAAAATTAATTATAAAATACGTAATTTTTTTACAGCTAAGGTTCCTTTAATTGCTATTCTTGGTAAAA
AAGAATCAGAGTCCGGGAAAATTGCTATAAGAACACTAGGAAGTCAAGAACAACATGTTATAAGTAGTAGTGAATTAATT
GCTCATATAAGAAAAAACAAAAAATAA

Upstream 100 bases:

>100_bases
AGTTATATAACATTTTGAACAAGTAATTATTAACAACTTCCAATATAAAGCATTCTGCCTTCAAAAACAATTAAAAAATT
CTAGAGATATTTAGGTATAT

Downstream 100 bases:

>100_bases
GATTAACTAATTGAGGAGAAGTTTTATTTCCACAAATAAAAGTAGCGGCTATTTGAAGGTAAATGGCGAAATTAAGGCTA
AGCAAGTTAGGCTAATTGAT

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 648; Mature: 648

Protein sequence:

>648_residues
MIDIILPDGSVKQYKIGVTGQEIIQSLSISLFKKTIAVAVNNELMDLYIPIINTATVKAITIDSVQGIEILRHDTAHILA
QAVKKLFPDTQVVIGPVIKDGFYYDFARDKPFTSKDLEIIEQEMQDIITKNDLIQREVWLRAKAIEFFKQQKEFYKVKLI
EEIPESEEISIYRQGNFVDLCRGPHSPSTGYCAKYFKLTKVSGAYWRGNSKNESLQRIYGTAWGKKSDLDSYLHRLSEAQ
KRDHRKLGRELELFHFQDEAQGMPFWHSKGWTIFKIIKDYISCQIQRAGYIEVNTPMVLNQKLWEKSGHWEKFRENMFTL
DTNAAEQDHNLIKDSIETKCALALKPMNCPGHIQIFNYTIKSYRDLPLRMAEFGSCHRYEPSGALYGLMRVRSFVQDDAH
IFCTEDQITDETIKFCHLLKQVYQDFGFPEVKIKFSDRPEKRAGTDKIWDKAEQALIHAIQTLGEEYTINRGEGAFYGPK
LEFILTDAIGREWQCGTLQVDFVLPERLNASYISSEGSKKRPVILHRAILGSFERFIGILIEHYSGKLPIWLAPIQVAVV
SITDEAVNYAKQLHQELIDNNIRSTLDISNQKINYKIRNFFTAKVPLIAILGKKESESGKIAIRTLGSQEQHVISSSELI
AHIRKNKK

Sequences:

>Translated_648_residues
MIDIILPDGSVKQYKIGVTGQEIIQSLSISLFKKTIAVAVNNELMDLYIPIINTATVKAITIDSVQGIEILRHDTAHILA
QAVKKLFPDTQVVIGPVIKDGFYYDFARDKPFTSKDLEIIEQEMQDIITKNDLIQREVWLRAKAIEFFKQQKEFYKVKLI
EEIPESEEISIYRQGNFVDLCRGPHSPSTGYCAKYFKLTKVSGAYWRGNSKNESLQRIYGTAWGKKSDLDSYLHRLSEAQ
KRDHRKLGRELELFHFQDEAQGMPFWHSKGWTIFKIIKDYISCQIQRAGYIEVNTPMVLNQKLWEKSGHWEKFRENMFTL
DTNAAEQDHNLIKDSIETKCALALKPMNCPGHIQIFNYTIKSYRDLPLRMAEFGSCHRYEPSGALYGLMRVRSFVQDDAH
IFCTEDQITDETIKFCHLLKQVYQDFGFPEVKIKFSDRPEKRAGTDKIWDKAEQALIHAIQTLGEEYTINRGEGAFYGPK
LEFILTDAIGREWQCGTLQVDFVLPERLNASYISSEGSKKRPVILHRAILGSFERFIGILIEHYSGKLPIWLAPIQVAVV
SITDEAVNYAKQLHQELIDNNIRSTLDISNQKINYKIRNFFTAKVPLIAILGKKESESGKIAIRTLGSQEQHVISSSELI
AHIRKNKK
>Mature_648_residues
MIDIILPDGSVKQYKIGVTGQEIIQSLSISLFKKTIAVAVNNELMDLYIPIINTATVKAITIDSVQGIEILRHDTAHILA
QAVKKLFPDTQVVIGPVIKDGFYYDFARDKPFTSKDLEIIEQEMQDIITKNDLIQREVWLRAKAIEFFKQQKEFYKVKLI
EEIPESEEISIYRQGNFVDLCRGPHSPSTGYCAKYFKLTKVSGAYWRGNSKNESLQRIYGTAWGKKSDLDSYLHRLSEAQ
KRDHRKLGRELELFHFQDEAQGMPFWHSKGWTIFKIIKDYISCQIQRAGYIEVNTPMVLNQKLWEKSGHWEKFRENMFTL
DTNAAEQDHNLIKDSIETKCALALKPMNCPGHIQIFNYTIKSYRDLPLRMAEFGSCHRYEPSGALYGLMRVRSFVQDDAH
IFCTEDQITDETIKFCHLLKQVYQDFGFPEVKIKFSDRPEKRAGTDKIWDKAEQALIHAIQTLGEEYTINRGEGAFYGPK
LEFILTDAIGREWQCGTLQVDFVLPERLNASYISSEGSKKRPVILHRAILGSFERFIGILIEHYSGKLPIWLAPIQVAVV
SITDEAVNYAKQLHQELIDNNIRSTLDISNQKINYKIRNFFTAKVPLIAILGKKESESGKIAIRTLGSQEQHVISSSELI
AHIRKNKK

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=651, Percent_Identity=38.4024577572965, Blast_Score=451, Evalue=1e-126,
Organism=Homo sapiens, GI38570111, Length=654, Percent_Identity=37.9204892966361, Blast_Score=447, Evalue=1e-125,
Organism=Homo sapiens, GI20070344, Length=633, Percent_Identity=35.8609794628752, Blast_Score=404, Evalue=1e-112,
Organism=Escherichia coli, GI1788013, Length=645, Percent_Identity=47.1317829457364, Blast_Score=635, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984192, Length=648, Percent_Identity=36.2654320987654, Blast_Score=444, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI71984184, Length=648, Percent_Identity=36.2654320987654, Blast_Score=444, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6322112, Length=670, Percent_Identity=37.4626865671642, Blast_Score=441, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6322654, Length=401, Percent_Identity=35.9102244389027, Blast_Score=262, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24583842, Length=647, Percent_Identity=38.0216383307573, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI28574141, Length=647, Percent_Identity=38.0216383307573, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24583839, Length=647, Percent_Identity=38.0216383307573, Blast_Score=451, Evalue=1e-127,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 74501; Mature: 74501

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDIILPDGSVKQYKIGVTGQEIIQSLSISLFKKTIAVAVNNELMDLYIPIINTATVKAI
CEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHEEECCCEEEEEEEHCCCCEEEEE
TIDSVQGIEILRHDTAHILAQAVKKLFPDTQVVIGPVIKDGFYYDFARDKPFTSKDLEII
EECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCEEEECCCCCCCCCHHHHHH
EQEMQDIITKNDLIQREVWLRAKAIEFFKQQKEFYKVKLIEEIPESEEISIYRQGNFVDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEE
CRGPHSPSTGYCAKYFKLTKVSGAYWRGNSKNESLQRIYGTAWGKKSDLDSYLHRLSEAQ
CCCCCCCCCCHHHHHEEEEECCCCEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHH
KRDHRKLGRELELFHFQDEAQGMPFWHSKGWTIFKIIKDYISCQIQRAGYIEVNTPMVLN
HHHHHHHCCEEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHEEEECCCEEEECCCEEEC
QKLWEKSGHWEKFRENMFTLDTNAAEQDHNLIKDSIETKCALALKPMNCPGHIQIFNYTI
HHHHHCCCCHHHHHCCEEEEECCCCHHHHHHHHHHHCCEEEEEEECCCCCCCEEEEEEEH
KSYRDLPLRMAEFGSCHRYEPSGALYGLMRVRSFVQDDAHIFCTEDQITDETIKFCHLLK
HHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHH
QVYQDFGFPEVKIKFSDRPEKRAGTDKIWDKAEQALIHAIQTLGEEYTINRGEGAFYGPK
HHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEECCE
LEFILTDAIGREWQCGTLQVDFVLPERLNASYISSEGSKKRPVILHRAILGSFERFIGIL
EEEEEEHHCCCCCCCCEEEEEEECCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
IEHYSGKLPIWLAPIQVAVVSITDEAVNYAKQLHQELIDNNIRSTLDISNQKINYKIRNF
HHHCCCCCCEEEECEEEEEEEECHHHHHHHHHHHHHHHHCCCHHHEECCCCEEEEEEHHE
FTAKVPLIAILGKKESESGKIAIRTLGSQEQHVISSSELIAHIRKNKK
EECCCCEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIDIILPDGSVKQYKIGVTGQEIIQSLSISLFKKTIAVAVNNELMDLYIPIINTATVKAI
CEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHEEECCCEEEEEEEHCCCCEEEEE
TIDSVQGIEILRHDTAHILAQAVKKLFPDTQVVIGPVIKDGFYYDFARDKPFTSKDLEII
EECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCEEEECCCCCCCCCHHHHHH
EQEMQDIITKNDLIQREVWLRAKAIEFFKQQKEFYKVKLIEEIPESEEISIYRQGNFVDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEE
CRGPHSPSTGYCAKYFKLTKVSGAYWRGNSKNESLQRIYGTAWGKKSDLDSYLHRLSEAQ
CCCCCCCCCCHHHHHEEEEECCCCEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHH
KRDHRKLGRELELFHFQDEAQGMPFWHSKGWTIFKIIKDYISCQIQRAGYIEVNTPMVLN
HHHHHHHCCEEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHEEEECCCEEEECCCEEEC
QKLWEKSGHWEKFRENMFTLDTNAAEQDHNLIKDSIETKCALALKPMNCPGHIQIFNYTI
HHHHHCCCCHHHHHCCEEEEECCCCHHHHHHHHHHHCCEEEEEEECCCCCCCEEEEEEEH
KSYRDLPLRMAEFGSCHRYEPSGALYGLMRVRSFVQDDAHIFCTEDQITDETIKFCHLLK
HHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHH
QVYQDFGFPEVKIKFSDRPEKRAGTDKIWDKAEQALIHAIQTLGEEYTINRGEGAFYGPK
HHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEECCE
LEFILTDAIGREWQCGTLQVDFVLPERLNASYISSEGSKKRPVILHRAILGSFERFIGIL
EEEEEEHHCCCCCCCCEEEEEEECCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
IEHYSGKLPIWLAPIQVAVVSITDEAVNYAKQLHQELIDNNIRSTLDISNQKINYKIRNF
HHHCCCCCCEEEECEEEEEEEECHHHHHHHHHHHHHHHHCCCHHHEECCCCEEEEEEHHE
FTAKVPLIAILGKKESESGKIAIRTLGSQEQHVISSSELIAHIRKNKK
EECCCCEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA