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The map label for this gene is invA

Identifier: 189183864

GI number: 189183864

Start: 1000516

End: 1001001

Strand: Direct

Name: invA

Synonym: OTT_0957

Alternate gene names: 189183864

Gene position: 1000516-1001001 (Clockwise)

Preceding gene: 189183862

Following gene: 189183865

Centisome position: 49.8

GC content: 30.45

Gene sequence:

>486_bases
ATGGATGATAAAATAAAAAATTACAATAACTTACCATATCGAATAGGCGTAGGTATGGTGATTATTAATCAGAAGAAAGA
AATTTTTACAGGTCAAAGAATAGATTCAGCACGTCAATACTGGCAAATGCCACAAGGAGGGATCATTTTGGGAGAAACAT
ATAGTAAAGCTGTATTAAGAGAAATGAAGGAGGAAATTGGTTGCAATAAAGCTATTATAATGGCAGAAAGTAGAAATTGG
TACAGTTATCACATTCCAAAATTTCTTGTGCATAAATTGTGGAATAGCAACTTTAAGGGGCAAAAACAAAAGTGGTTTCT
GATAAAATTCCTTGGAAAGGATGAAGACATTAATATAAATACAATATACCCAGAATTTAGTCAATGGAAGTGGATGAATA
GTAACCAACTGATAAATAATGCGTTGCCATTTAAAAGAAAGCTTTATAAAGCAGTAATCAATGAATTTCACATATTTTTA
TTATAA

Upstream 100 bases:

>100_bases
AACGCGAAGACTTGATTAGTGCAAAATTCAGATCTATGTTTTTCTATTTTCTATATTGAACTGTAGTTAATAATAGTACA
AATTAAAGCCTTTATACATC

Downstream 100 bases:

>100_bases
TTGCTCTTTTTAATATTTTATCAATTGCAACTATAACATAATTGTAGAAGCTGTTAACAAATAGCTAACTTAATATAGCT
AAACCTTTATAAAATAGTTA

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase

Number of amino acids: Translated: 161; Mature: 161

Protein sequence:

>161_residues
MDDKIKNYNNLPYRIGVGMVIINQKKEIFTGQRIDSARQYWQMPQGGIILGETYSKAVLREMKEEIGCNKAIIMAESRNW
YSYHIPKFLVHKLWNSNFKGQKQKWFLIKFLGKDEDININTIYPEFSQWKWMNSNQLINNALPFKRKLYKAVINEFHIFL
L

Sequences:

>Translated_161_residues
MDDKIKNYNNLPYRIGVGMVIINQKKEIFTGQRIDSARQYWQMPQGGIILGETYSKAVLREMKEEIGCNKAIIMAESRNW
YSYHIPKFLVHKLWNSNFKGQKQKWFLIKFLGKDEDININTIYPEFSQWKWMNSNQLINNALPFKRKLYKAVINEFHIFL
L
>Mature_161_residues
MDDKIKNYNNLPYRIGVGMVIINQKKEIFTGQRIDSARQYWQMPQGGIILGETYSKAVLREMKEEIGCNKAIIMAESRNW
YSYHIPKFLVHKLWNSNFKGQKQKWFLIKFLGKDEDININTIYPEFSQWKWMNSNQLINNALPFKRKLYKAVINEFHIFL
L

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Escherichia coli, GI1789194, Length=152, Percent_Identity=37.5, Blast_Score=106, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPPH_ORITB (A5CD16)

Other databases:

- EMBL:   AM494475
- RefSeq:   YP_001248437.1
- ProteinModelPortal:   A5CD16
- SMR:   A5CD16
- STRING:   A5CD16
- GeneID:   5218927
- GenomeReviews:   AM494475_GR
- KEGG:   ots:OTBS_0590
- eggNOG:   COG0494
- HOGENOM:   HBG302451
- OMA:   GQKQIWY
- ProtClustDB:   PRK00714
- BioCyc:   OTSU357244:OTBS_0590-MONOMER
- HAMAP:   MF_00298
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927
- Gene3D:   G3DSA:3.90.79.10

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: 3.6.1.- [C]

Molecular weight: Translated: 19256; Mature: 19256

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDKIKNYNNLPYRIGVGMVIINQKKEIFTGQRIDSARQYWQMPQGGIILGETYSKAVLR
CCCCCCCCCCCCEEECCCEEEECCCHHHHCCCCHHHHHHHHCCCCCCEEECCHHHHHHHH
EMKEEIGCNKAIIMAESRNWYSYHIPKFLVHKLWNSNFKGQKQKWFLIKFLGKDEDININ
HHHHHHCCCEEEEEEECCCCEEECCHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEE
TIYPEFSQWKWMNSNQLINNALPFKRKLYKAVINEFHIFLL
EECCCCHHEEECCCCCHHHCCCCHHHHHHHHHHHHHEEEEC
>Mature Secondary Structure
MDDKIKNYNNLPYRIGVGMVIINQKKEIFTGQRIDSARQYWQMPQGGIILGETYSKAVLR
CCCCCCCCCCCCEEECCCEEEECCCHHHHCCCCHHHHHHHHCCCCCCEEECCHHHHHHHH
EMKEEIGCNKAIIMAESRNWYSYHIPKFLVHKLWNSNFKGQKQKWFLIKFLGKDEDININ
HHHHHHCCCEEEEEEECCCCEEECCHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEE
TIYPEFSQWKWMNSNQLINNALPFKRKLYKAVINEFHIFLL
EECCCCHHEEECCCCCHHHCCCCHHHHHHHHHHHHHEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA