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The map label for this gene is pepA [H]

Identifier: 189183508

GI number: 189183508

Start: 618877

End: 620529

Strand: Reverse

Name: pepA [H]

Synonym: OTT_0601

Alternate gene names: 189183508

Gene position: 620529-618877 (Counterclockwise)

Preceding gene: 189183509

Following gene: 189183507

Centisome position: 30.89

GC content: 31.88

Gene sequence:

>1653_bases
ATGATTATAAATTTTATACAAACAGATAGTCAAAATTTTTTTAATTGCTTAGAAGGAATAAATAAAACAGATGTTACAGC
TATATCCAATAGTCAGTCTATATGTTTATTGATTGGTTCAGATTTAGTGTTAACAGATAGCATGTTACAGCTTGATCAGC
AATGTGGTGGAATTATATCAAAATTTTTGCAACAAAATACGAAGAATAAGCAAATATTTAGTGGTAAGTTTGGTGAAATT
AAATTTTTAACTATTGCTAACGGTGAAGAGATTAAAAATATAATTTTGTTAGGTATTGGCCAAAGTAATCAACTGAAGGA
GTTTCAAATTCAGGAACTAGGAGGAATTATACAAAAATCGATTGCTGCAAATACAATAATGGATGTAATAATTTTGGTGG
ATTATGATATTAGTAATTACAACAGATTTAAAATTGCATCATTGATTGCGTCAGGAGCTGAATTAGCATCTTATAAATTT
AAAAAGTATTTTACTAAAAAGAATGTTAATAATAATGATAATAAGTTGCAAGAAACTAGCGAAATGCATTTATTTATCAG
CTTAAAAGATGCTAACGATATTGAGCAGGCTAAAGCTTATTTTAACAATATTCTACAACCAATTAATGAAGGGGTTGTGT
TAGCAAGAAATCTAATTTCAGAGCCTCCAAATAAATTATATCCTGCTACTTACGCTCAAAAGATCGAAGAAGAATTTAAG
ATATTAAAAAATGAGTTTGGAGTTGAAGTAAATGTAAAGATTTTAGGTGCACAAGAGATGTGTGATTTAAATATGGGAGC
ATTACTTGGAGTTGGACAAGGATCCCAAAAAGAATCAAAATTAGTATCAATATCTTATCTAGGAGCAGTTGATAAAGATC
AAGCACCGTTAACTTTAGTAGGGAAAGGAGTAACTTTTGATACTGGAGGAATTAGTTTGAAACCATCTGCTGGCATGGAA
GATATGAAATATGATATGGCTGGATCAGCAGCAGTAGTTGGAGCTATAAAAGCTTTAGCGCGTAGAAAGGCAAAAGTAAA
TGTAGTTGGAGTAGTGGCTTTGGTTGAAAATATGCCAGGCAGTAACGCTCAAAGACCTAGTGATGTTGTAACAACAATGT
CAGGTCAAACAGTAGAAGTACTTAATACTGATGCAGAAGGACGGTTAATACTTGCTGATGCATTATGGTATGTTCAAGAA
GTATTTAAGCCTGAGTCTATTATAGATTTAGCAACTTTAACTGGAGCAATAACTATAGCACTTGGTTATAGTTATGCTGG
ATGTTTTTCTAATAATAATGAATTAGCTCAGAAATTAATCATATCAGGCGAAAAGGTTAATGAAAATTTGTGGCGTATGC
CATTACATAAAGATTATGACGACATGCTTAAATCTAATATTGCTGATATAGCAAATATTGGTAATGTTCGTGGTGCCGCC
GGTAGCTGTACTGCCGCTAGTTTTTTACAAAAATTTATTCAATTTAAGCAGAATCATGATAGTAACAAAGCTCCTATTCC
ATGGGCTCATTTAGATATAGCTTCTGTTGCTTGGAACAAAAAAGGAGGCAATATTTGTCCTGCAGGAGCAGTAGGATTTG
GAGTTAGATTAATTAACAAGTTTGTAGAAGATAATTATGAATGCATCAAATAA

Upstream 100 bases:

>100_bases
ATTTTATTGTTTTAGTAATAATGGTGAGACTTGCAAATCTGTACCATAAACTTTAATATCAAAGAATAATAAGTTATTAT
TCTAAATTTAGTGAGTCCAA

Downstream 100 bases:

>100_bases
AGAAATCACATTACCTTACATTTTTGTTATAGGAAATGAAAAAGGTGGTGCAGGTAAGACTACTGTTGCTATGCACTTAA
TTGCTGCTTTGCTTGACAAT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MIINFIQTDSQNFFNCLEGINKTDVTAISNSQSICLLIGSDLVLTDSMLQLDQQCGGIISKFLQQNTKNKQIFSGKFGEI
KFLTIANGEEIKNIILLGIGQSNQLKEFQIQELGGIIQKSIAANTIMDVIILVDYDISNYNRFKIASLIASGAELASYKF
KKYFTKKNVNNNDNKLQETSEMHLFISLKDANDIEQAKAYFNNILQPINEGVVLARNLISEPPNKLYPATYAQKIEEEFK
ILKNEFGVEVNVKILGAQEMCDLNMGALLGVGQGSQKESKLVSISYLGAVDKDQAPLTLVGKGVTFDTGGISLKPSAGME
DMKYDMAGSAAVVGAIKALARRKAKVNVVGVVALVENMPGSNAQRPSDVVTTMSGQTVEVLNTDAEGRLILADALWYVQE
VFKPESIIDLATLTGAITIALGYSYAGCFSNNNELAQKLIISGEKVNENLWRMPLHKDYDDMLKSNIADIANIGNVRGAA
GSCTAASFLQKFIQFKQNHDSNKAPIPWAHLDIASVAWNKKGGNICPAGAVGFGVRLINKFVEDNYECIK

Sequences:

>Translated_550_residues
MIINFIQTDSQNFFNCLEGINKTDVTAISNSQSICLLIGSDLVLTDSMLQLDQQCGGIISKFLQQNTKNKQIFSGKFGEI
KFLTIANGEEIKNIILLGIGQSNQLKEFQIQELGGIIQKSIAANTIMDVIILVDYDISNYNRFKIASLIASGAELASYKF
KKYFTKKNVNNNDNKLQETSEMHLFISLKDANDIEQAKAYFNNILQPINEGVVLARNLISEPPNKLYPATYAQKIEEEFK
ILKNEFGVEVNVKILGAQEMCDLNMGALLGVGQGSQKESKLVSISYLGAVDKDQAPLTLVGKGVTFDTGGISLKPSAGME
DMKYDMAGSAAVVGAIKALARRKAKVNVVGVVALVENMPGSNAQRPSDVVTTMSGQTVEVLNTDAEGRLILADALWYVQE
VFKPESIIDLATLTGAITIALGYSYAGCFSNNNELAQKLIISGEKVNENLWRMPLHKDYDDMLKSNIADIANIGNVRGAA
GSCTAASFLQKFIQFKQNHDSNKAPIPWAHLDIASVAWNKKGGNICPAGAVGFGVRLINKFVEDNYECIK
>Mature_550_residues
MIINFIQTDSQNFFNCLEGINKTDVTAISNSQSICLLIGSDLVLTDSMLQLDQQCGGIISKFLQQNTKNKQIFSGKFGEI
KFLTIANGEEIKNIILLGIGQSNQLKEFQIQELGGIIQKSIAANTIMDVIILVDYDISNYNRFKIASLIASGAELASYKF
KKYFTKKNVNNNDNKLQETSEMHLFISLKDANDIEQAKAYFNNILQPINEGVVLARNLISEPPNKLYPATYAQKIEEEFK
ILKNEFGVEVNVKILGAQEMCDLNMGALLGVGQGSQKESKLVSISYLGAVDKDQAPLTLVGKGVTFDTGGISLKPSAGME
DMKYDMAGSAAVVGAIKALARRKAKVNVVGVVALVENMPGSNAQRPSDVVTTMSGQTVEVLNTDAEGRLILADALWYVQE
VFKPESIIDLATLTGAITIALGYSYAGCFSNNNELAQKLIISGEKVNENLWRMPLHKDYDDMLKSNIADIANIGNVRGAA
GSCTAASFLQKFIQFKQNHDSNKAPIPWAHLDIASVAWNKKGGNICPAGAVGFGVRLINKFVEDNYECIK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=398, Percent_Identity=36.1809045226131, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI47155554, Length=336, Percent_Identity=33.3333333333333, Blast_Score=150, Evalue=3e-36,
Organism=Escherichia coli, GI1790710, Length=519, Percent_Identity=37.9576107899807, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI87082123, Length=325, Percent_Identity=38.1538461538462, Blast_Score=193, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17556903, Length=317, Percent_Identity=33.4384858044164, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17565172, Length=391, Percent_Identity=26.5984654731458, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21355725, Length=304, Percent_Identity=35.5263157894737, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24661038, Length=304, Percent_Identity=36.1842105263158, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI20129969, Length=482, Percent_Identity=28.0082987551867, Blast_Score=172, Evalue=7e-43,
Organism=Drosophila melanogaster, GI161077148, Length=301, Percent_Identity=33.8870431893688, Blast_Score=172, Evalue=7e-43,
Organism=Drosophila melanogaster, GI20130057, Length=301, Percent_Identity=33.8870431893688, Blast_Score=172, Evalue=7e-43,
Organism=Drosophila melanogaster, GI20129963, Length=483, Percent_Identity=28.3643892339545, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24662227, Length=300, Percent_Identity=30.6666666666667, Blast_Score=160, Evalue=3e-39,
Organism=Drosophila melanogaster, GI21355645, Length=472, Percent_Identity=25.8474576271186, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI24662223, Length=472, Percent_Identity=25.8474576271186, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI19922386, Length=475, Percent_Identity=26.9473684210526, Blast_Score=155, Evalue=8e-38,
Organism=Drosophila melanogaster, GI221379063, Length=337, Percent_Identity=31.1572700296736, Blast_Score=152, Evalue=8e-37,
Organism=Drosophila melanogaster, GI221379062, Length=337, Percent_Identity=31.1572700296736, Blast_Score=152, Evalue=8e-37,
Organism=Drosophila melanogaster, GI21357381, Length=337, Percent_Identity=31.1572700296736, Blast_Score=151, Evalue=9e-37,
Organism=Drosophila melanogaster, GI24646701, Length=353, Percent_Identity=25.7790368271955, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24646703, Length=353, Percent_Identity=25.7790368271955, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21358201, Length=353, Percent_Identity=25.7790368271955, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 60015; Mature: 60015

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIINFIQTDSQNFFNCLEGINKTDVTAISNSQSICLLIGSDLVLTDSMLQLDQQCGGIIS
CEEEEEECCCHHHHHHHCCCCCCCEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHH
KFLQQNTKNKQIFSGKFGEIKFLTIANGEEIKNIILLGIGQSNQLKEFQIQELGGIIQKS
HHHHCCCCCCEEECCCCCCEEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHH
IAANTIMDVIILVDYDISNYNRFKIASLIASGAELASYKFKKYFTKKNVNNNDNKLQETS
HHHHHHEEEEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHCCC
EMHLFISLKDANDIEQAKAYFNNILQPINEGVVLARNLISEPPNKLYPATYAQKIEEEFK
CEEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
ILKNEFGVEVNVKILGAQEMCDLNMGALLGVGQGSQKESKLVSISYLGAVDKDQAPLTLV
HHHHHCCCEEEEEEECCHHHHCCCCCCEEECCCCCCCCCCEEEEEEECCCCCCCCCEEEE
GKGVTFDTGGISLKPSAGMEDMKYDMAGSAAVVGAIKALARRKAKVNVVGVVALVENMPG
ECCEEECCCCEEECCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCEEHEEEEEHHHCCCC
SNAQRPSDVVTTMSGQTVEVLNTDAEGRLILADALWYVQEVFKPESIIDLATLTGAITIA
CCCCCCCHHHEECCCCEEEEEECCCCCCEEEHHHHHHHHHHHCCHHHHHHHHHHHEEEEE
LGYSYAGCFSNNNELAQKLIISGEKVNENLWRMPLHKDYDDMLKSNIADIANIGNVRGAA
ECCCEEEECCCCHHHHHHHHHCCCHHCCHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
GSCTAASFLQKFIQFKQNHDSNKAPIPWAHLDIASVAWNKKGGNICPAGAVGFGVRLINK
CCHHHHHHHHHHHHHHHCCCCCCCCCCEECCCHHHHEECCCCCCCCCCCHHHHHHHHHHH
FVEDNYECIK
HHHCCCHHCC
>Mature Secondary Structure
MIINFIQTDSQNFFNCLEGINKTDVTAISNSQSICLLIGSDLVLTDSMLQLDQQCGGIIS
CEEEEEECCCHHHHHHHCCCCCCCEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHH
KFLQQNTKNKQIFSGKFGEIKFLTIANGEEIKNIILLGIGQSNQLKEFQIQELGGIIQKS
HHHHCCCCCCEEECCCCCCEEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHH
IAANTIMDVIILVDYDISNYNRFKIASLIASGAELASYKFKKYFTKKNVNNNDNKLQETS
HHHHHHEEEEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHCCC
EMHLFISLKDANDIEQAKAYFNNILQPINEGVVLARNLISEPPNKLYPATYAQKIEEEFK
CEEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
ILKNEFGVEVNVKILGAQEMCDLNMGALLGVGQGSQKESKLVSISYLGAVDKDQAPLTLV
HHHHHCCCEEEEEEECCHHHHCCCCCCEEECCCCCCCCCCEEEEEEECCCCCCCCCEEEE
GKGVTFDTGGISLKPSAGMEDMKYDMAGSAAVVGAIKALARRKAKVNVVGVVALVENMPG
ECCEEECCCCEEECCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCEEHEEEEEHHHCCCC
SNAQRPSDVVTTMSGQTVEVLNTDAEGRLILADALWYVQEVFKPESIIDLATLTGAITIA
CCCCCCCHHHEECCCCEEEEEECCCCCCEEEHHHHHHHHHHHCCHHHHHHHHHHHEEEEE
LGYSYAGCFSNNNELAQKLIISGEKVNENLWRMPLHKDYDDMLKSNIADIANIGNVRGAA
ECCCEEEECCCCHHHHHHHHHCCCHHCCHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
GSCTAASFLQKFIQFKQNHDSNKAPIPWAHLDIASVAWNKKGGNICPAGAVGFGVRLINK
CCHHHHHHHHHHHHHHHCCCCCCCCCCEECCCHHHHEECCCCCCCCCCCHHHHHHHHHHH
FVEDNYECIK
HHHCCCHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA