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The map label for this gene is dapA [H]

Identifier: 189182990

GI number: 189182990

Start: 88358

End: 89254

Strand: Direct

Name: dapA [H]

Synonym: OTT_0083

Alternate gene names: 189182990

Gene position: 88358-89254 (Clockwise)

Preceding gene: 189182989

Following gene: 189182991

Centisome position: 4.4

GC content: 32.89

Gene sequence:

>897_bases
ATGACGAAGAAGATGTTTAATGGACTAATTACTGCTTTAGTTACTCCTTTTAAAAATGCTGCAAAGCAGATTGATTTTTG
TGCATTAGAGAAATTATTAGATTTACAAATTAAAGCTCAAGTTGATGGAATTTTAGTTGCTGGTTCTACTGGAGAAAGTT
TATCATTAAGTTATGAGGAATATATTAGTTTAATAAATTTTACAATCAAGTATGTTAATGGTAGAACATTAGTGATTGCT
GGGTGTTGTGCTTCTGATATTGATAAAGCTGTAATGATGGTTAAAGAGTGTGAAAGATTAGCAGTACAAGGAATAATGTG
TGTTACTCCATTTTATAGCAGACCTAGCCAAGAAGGGTTGCATCAATACTTTAAAACTATTCATGATGCATGTAATTTAC
CAATTATGCTTTACACAGTTCCAAGTAGAACCGGAGTTAATTTGAATGATGAAACAGTAATAAAGTTAGCTAAACTTGAT
AGAATCGTAGCAATCAAAGACGCTACTGGTAACCTAGAAGCTCCATTAAGAATAAGGTCTAAGTTAGATATCGATAAGGA
ATTTGCTTTTCTATGTGGAGTTGATTCACTAGCATTAGGGTTTAATGCACAAGGTGGAAGTGGCTTAGTATCAGTAACTG
CAAATGTTGCTCCTTTTGAGAGTAAAGAAATACAGTTACTATGGAATCATGGTAAAACCGAAGAAGCTTTTCAGTTACAC
ATGAAGCTAATGCCTATTTATAGTGCTATATCTATTGAAACTAATCCAGTTCCAGTAAAATATGCAGCATCATTACGCAA
ATTGTGTACTCCTGAAGTAAGATTACCATTATGCCAGTTAATGCCATCTAGCATCAAATTAGTAAACGAAGTTTTTAGTG
AAGTTGTAATAAGGTAG

Upstream 100 bases:

>100_bases
TTTACTGCACTTAAAAATCATAATCTGCAAGTTGAAAAGATTTATGATCTTGATAATTCAGTTACTAGTGTTATAAAAAA
CTATTATAATAAGTTAGTTA

Downstream 100 bases:

>100_bases
TTATGGAGAATTATTGTAAAATAGTTGCTCAAAATAGAAAAGCTAAGTTTAATTACTTTATTGAAGATAAAATGGAAGCA
GGAATAGTTTTACAGGGCAG

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MTKKMFNGLITALVTPFKNAAKQIDFCALEKLLDLQIKAQVDGILVAGSTGESLSLSYEEYISLINFTIKYVNGRTLVIA
GCCASDIDKAVMMVKECERLAVQGIMCVTPFYSRPSQEGLHQYFKTIHDACNLPIMLYTVPSRTGVNLNDETVIKLAKLD
RIVAIKDATGNLEAPLRIRSKLDIDKEFAFLCGVDSLALGFNAQGGSGLVSVTANVAPFESKEIQLLWNHGKTEEAFQLH
MKLMPIYSAISIETNPVPVKYAASLRKLCTPEVRLPLCQLMPSSIKLVNEVFSEVVIR

Sequences:

>Translated_298_residues
MTKKMFNGLITALVTPFKNAAKQIDFCALEKLLDLQIKAQVDGILVAGSTGESLSLSYEEYISLINFTIKYVNGRTLVIA
GCCASDIDKAVMMVKECERLAVQGIMCVTPFYSRPSQEGLHQYFKTIHDACNLPIMLYTVPSRTGVNLNDETVIKLAKLD
RIVAIKDATGNLEAPLRIRSKLDIDKEFAFLCGVDSLALGFNAQGGSGLVSVTANVAPFESKEIQLLWNHGKTEEAFQLH
MKLMPIYSAISIETNPVPVKYAASLRKLCTPEVRLPLCQLMPSSIKLVNEVFSEVVIR
>Mature_297_residues
TKKMFNGLITALVTPFKNAAKQIDFCALEKLLDLQIKAQVDGILVAGSTGESLSLSYEEYISLINFTIKYVNGRTLVIAG
CCASDIDKAVMMVKECERLAVQGIMCVTPFYSRPSQEGLHQYFKTIHDACNLPIMLYTVPSRTGVNLNDETVIKLAKLDR
IVAIKDATGNLEAPLRIRSKLDIDKEFAFLCGVDSLALGFNAQGGSGLVSVTANVAPFESKEIQLLWNHGKTEEAFQLHM
KLMPIYSAISIETNPVPVKYAASLRKLCTPEVRLPLCQLMPSSIKLVNEVFSEVVIR

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=278, Percent_Identity=25.5395683453237, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI13540533, Length=243, Percent_Identity=27.5720164609054, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1788823, Length=285, Percent_Identity=38.2456140350877, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1786463, Length=255, Percent_Identity=30.1960784313725, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI87082415, Length=255, Percent_Identity=29.0196078431373, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1789620, Length=240, Percent_Identity=25, Blast_Score=82, Evalue=3e-17,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 32840; Mature: 32709

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: PS00665 DHDPS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKMFNGLITALVTPFKNAAKQIDFCALEKLLDLQIKAQVDGILVAGSTGESLSLSYEE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECEEEEECCCCCCEEECHHH
YISLINFTIKYVNGRTLVIAGCCASDIDKAVMMVKECERLAVQGIMCVTPFYSRPSQEGL
HHHHHHHHEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHH
HQYFKTIHDACNLPIMLYTVPSRTGVNLNDETVIKLAKLDRIVAIKDATGNLEAPLRIRS
HHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCEEEHH
KLDIDKEFAFLCGVDSLALGFNAQGGSGLVSVTANVAPFESKEIQLLWNHGKTEEAFQLH
HCCCCHHHHHHCCCHHHHCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCHHHHHHH
MKLMPIYSAISIETNPVPVKYAASLRKLCTPEVRLPLCQLMPSSIKLVNEVFSEVVIR
HHHHHHHHEEEECCCCCCHHHHHHHHHHCCCCCCCCHHHHCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TKKMFNGLITALVTPFKNAAKQIDFCALEKLLDLQIKAQVDGILVAGSTGESLSLSYEE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECEEEEECCCCCCEEECHHH
YISLINFTIKYVNGRTLVIAGCCASDIDKAVMMVKECERLAVQGIMCVTPFYSRPSQEGL
HHHHHHHHEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHH
HQYFKTIHDACNLPIMLYTVPSRTGVNLNDETVIKLAKLDRIVAIKDATGNLEAPLRIRS
HHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCEEEHH
KLDIDKEFAFLCGVDSLALGFNAQGGSGLVSVTANVAPFESKEIQLLWNHGKTEEAFQLH
HCCCCHHHHHHCCCHHHHCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCHHHHHHH
MKLMPIYSAISIETNPVPVKYAASLRKLCTPEVRLPLCQLMPSSIKLVNEVFSEVVIR
HHHHHHHHEEEECCCCCCHHHHHHHHHHCCCCCCCCHHHHCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA