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The map label for this gene is udp

Identifier: 189026250

GI number: 189026250

Start: 1121682

End: 1122458

Strand: Direct

Name: udp

Synonym: TPASS_1027

Alternate gene names: 189026250

Gene position: 1121682-1122458 (Clockwise)

Preceding gene: 189026249

Following gene: 189026254

Centisome position: 98.44

GC content: 54.57

Gene sequence:

>777_bases
ATGAAGCTTGTCTACAGTACGGATTGCGAATACCACATTGGACTGAAAGCGTCAGACATCGGACACTATGTTATCTTACC
GGGGGATCCTGCACGAAGCGAAAAGATTGCCCAACATTTTTCTCATCCTCACAAAGTTGGCCACAACCGCGAGTACGTCA
CGTACACGGGCACCCTCTGCGAAACACCAGTCAGCGTCATGTCCACCGGTATTGGGGGGCCGTCAACTGCAATTGGTGTT
GAGGAGCTCATCCATTTGGGCGCACACACCTTTATCCGCGTAGGGACCTCAGGGGGCATGCAGCCTGATATTCTTGCCGG
GACGGTAGTTATTGCAACCGGTGCGATTCGCTTTGAAGGCACCAGTAAAGAATATGCCCCCGTGGAGTTTCCTGCGGTGC
CGGACTTTACGGTCACTGCTGCACTCAAACACGCTGCAGAAGACGTGCAGGTGCGCCACGCGCTCGGTGTGGTTCAGTGT
AAAGACAACTTCTACGGTCAACACTCCCCCCATACCATGCCCGTCCATGCAGAACTCACGCAAAAATGGCACGCATGGAT
TGCATGCAACACACTCGCATCCGAAATGGAGTCTGCAGCGCTCTTTGTGCTCGGGAGCGTACGGCGCGTGCGCACCGGCG
CAGTGCTCTTAGTCATTGGAAACCAAACCCGCAGAGCACAGGGATTGGAAGACATTCAAGTTCACGACACCGAAAACGCC
ATACGGGTTGCAGTCGAAGCGGTCAAATTACTCATCACCCAAGACTCCCCGCGCTAG

Upstream 100 bases:

>100_bases
GATGCCTCGCCAAAAAGAGAACTACCTGTCACCGTCCCCCGTGGTCGGGATTCTTCGTGACTGGGGAGTGCTGTGCACCT
TACGCTTAAAGGGGAAACAC

Downstream 100 bases:

>100_bases
GCGCACTGCAGTGCTTTAGGCAAAGTGTCGCGGATCGGTTATTTCTAACAGCGCGGAGTCAAGCTCGGTCAAAAAGCGGC
TGGGCTTCATCGCCGTGTGT

Product: uridine phosphorylase

Products: NA

Alternate protein names: UPase; UrdPase

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MKLVYSTDCEYHIGLKASDIGHYVILPGDPARSEKIAQHFSHPHKVGHNREYVTYTGTLCETPVSVMSTGIGGPSTAIGV
EELIHLGAHTFIRVGTSGGMQPDILAGTVVIATGAIRFEGTSKEYAPVEFPAVPDFTVTAALKHAAEDVQVRHALGVVQC
KDNFYGQHSPHTMPVHAELTQKWHAWIACNTLASEMESAALFVLGSVRRVRTGAVLLVIGNQTRRAQGLEDIQVHDTENA
IRVAVEAVKLLITQDSPR

Sequences:

>Translated_258_residues
MKLVYSTDCEYHIGLKASDIGHYVILPGDPARSEKIAQHFSHPHKVGHNREYVTYTGTLCETPVSVMSTGIGGPSTAIGV
EELIHLGAHTFIRVGTSGGMQPDILAGTVVIATGAIRFEGTSKEYAPVEFPAVPDFTVTAALKHAAEDVQVRHALGVVQC
KDNFYGQHSPHTMPVHAELTQKWHAWIACNTLASEMESAALFVLGSVRRVRTGAVLLVIGNQTRRAQGLEDIQVHDTENA
IRVAVEAVKLLITQDSPR
>Mature_258_residues
MKLVYSTDCEYHIGLKASDIGHYVILPGDPARSEKIAQHFSHPHKVGHNREYVTYTGTLCETPVSVMSTGIGGPSTAIGV
EELIHLGAHTFIRVGTSGGMQPDILAGTVVIATGAIRFEGTSKEYAPVEFPAVPDFTVTAALKHAAEDVQVRHALGVVQC
KDNFYGQHSPHTMPVHAELTQKWHAWIACNTLASEMESAALFVLGSVRRVRTGAVLLVIGNQTRRAQGLEDIQVHDTENA
IRVAVEAVKLLITQDSPR

Specific function: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synth

COG id: COG2820

COG function: function code F; Uridine phosphorylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/UDP phosphorylase family

Homologues:

Organism=Escherichia coli, GI1790265, Length=247, Percent_Identity=38.8663967611336, Blast_Score=168, Evalue=4e-43,
Organism=Escherichia coli, GI1790844, Length=194, Percent_Identity=29.8969072164948, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UDP_TREPA (O83990)

Other databases:

- EMBL:   AE000520
- PIR:   F71251
- RefSeq:   NP_219464.1
- ProteinModelPortal:   O83990
- SMR:   O83990
- GeneID:   2610897
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP1027
- NMPDR:   fig|243276.1.peg.1022
- TIGR:   TP_1027
- HOGENOM:   HBG617197
- OMA:   GCLASEM
- ProtClustDB:   CLSK793415
- BioCyc:   TPAL243276:TP_1027-MONOMER
- BRENDA:   2.4.2.3
- GO:   GO:0005737
- InterPro:   IPR018017
- InterPro:   IPR018016
- InterPro:   IPR000845
- InterPro:   IPR010058
- PANTHER:   PTHR21234
- TIGRFAMs:   TIGR01718

Pfam domain/function: PF01048 PNP_UDP_1

EC number: =2.4.2.3

Molecular weight: Translated: 27920; Mature: 27920

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS01232 PNP_UDP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVYSTDCEYHIGLKASDIGHYVILPGDPARSEKIAQHFSHPHKVGHNREYVTYTGTLC
CEEEEECCCCEEECEEECCCCCEEEECCCCCHHHHHHHHCCCCHHCCCCCEEEEEECCHH
ETPVSVMSTGIGGPSTAIGVEELIHLGAHTFIRVGTSGGMQPDILAGTVVIATGAIRFEG
HCCHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHCEEEEEEEEEEECC
TSKEYAPVEFPAVPDFTVTAALKHAAEDVQVRHALGVVQCKDNFYGQHSPHTMPVHAELT
CCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCEEEEHHHHH
QKWHAWIACNTLASEMESAALFVLGSVRRVRTGAVLLVIGNQTRRAQGLEDIQVHDTENA
HHHHHEEEHHHHHHHHHHHHEEEHHCHHEECCCEEEEEECCCCHHHCCCCCEEEECCCHH
IRVAVEAVKLLITQDSPR
HHHHHHHHHHEEECCCCC
>Mature Secondary Structure
MKLVYSTDCEYHIGLKASDIGHYVILPGDPARSEKIAQHFSHPHKVGHNREYVTYTGTLC
CEEEEECCCCEEECEEECCCCCEEEECCCCCHHHHHHHHCCCCHHCCCCCEEEEEECCHH
ETPVSVMSTGIGGPSTAIGVEELIHLGAHTFIRVGTSGGMQPDILAGTVVIATGAIRFEG
HCCHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHCEEEEEEEEEEECC
TSKEYAPVEFPAVPDFTVTAALKHAAEDVQVRHALGVVQCKDNFYGQHSPHTMPVHAELT
CCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCEEEEHHHHH
QKWHAWIACNTLASEMESAALFVLGSVRRVRTGAVLLVIGNQTRRAQGLEDIQVHDTENA
HHHHHEEEHHHHHHHHHHHHEEEHHCHHEECCCEEEEEECCCCHHHCCCCCEEEECCCHH
IRVAVEAVKLLITQDSPR
HHHHHHHHHHEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876