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The map label for this gene is rnc

Identifier: 189026034

GI number: 189026034

Start: 879313

End: 880077

Strand: Direct

Name: rnc

Synonym: TPASS_0809

Alternate gene names: 189026034

Gene position: 879313-880077 (Clockwise)

Preceding gene: 189026033

Following gene: 189026035

Centisome position: 77.17

GC content: 56.86

Gene sequence:

>765_bases
ATGAGCCTGTGTCTCGGTCATATTTTTTCCCGCTCTCGTTCTCCCCTCACCCCCGAGCGTAGGGAGTCTCTCCGGCGCCT
GCAAGAGACGCTCGGCGTTAAATTCCGCGATCCTACCGCACTCGACCAGGCACTTTCTCACCGGTCTTTGTTTTCCTCAA
AAGAGGACCATTGCGGTGTGCGCCACAATGAGCGCATGGAGTTTCTCGGGGATGCCGTGCTTGGCGCGGTAGCCGCCGCT
TGCCTGTATCGCGCACTTCCCGACAGTCACGAGGGGGATTTAGCAAAGACTAAGGCGGTGCTCGTGTCTACTGACACCCT
CTCGGACATTGCCTTGAGCCTGCGTATAGACCACTACCTTCTGCTAGGAAAAGGGGAGGAGCTTTCAGGAGGTCGGCACA
AAAAAGCCATCCTTGCCGACGCTACCGAAGCTGTCATCGGTGCGCTTTTTTTGGATTCAGGGTTCAAGGCGGCAGAGCGT
TTTGTTCTCCGTCTCCTGCTCCCCCGTGTCCGCCCCATACGAGAGAAAAATTTGCACCATGACTACAAATCTACCCTCCA
GGTGCTTGCACATCAGCGCTATCGTAGTAAGCCGGAGTACACGGTCGTCAAGCGCACCGGACCTGATCACAGCGTACGCT
TCTGGGTGGATGTTACCGTTGGCGATGCACGCTTCGGACCCGGTTATGGCACCAGCAAAAAAAGCGCAGAACAGTGCGCC
GCTCGCCTTGCATGGGAACAATTATCCGGCACCCTCCGGGAGTAG

Upstream 100 bases:

>100_bases
ATGCGATCGAAGAGGAGATGGGGATTACTATCCCCGACGAAAAAGCAAACGAGTTCGAAACAGTCAGAGATGCGTACGAG
TTCATCAAGTCCAAAGTGAC

Downstream 100 bases:

>100_bases
CGCGTATGCTGCCCTGTAAGGATACTCTCCTTGTCCCGCTCTGACACCGCCCGCCCCTTCGTAAAATGGGCAGGAGGAAA
GCGCGCCCTCGCCCCAACCC

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MSLCLGHIFSRSRSPLTPERRESLRRLQETLGVKFRDPTALDQALSHRSLFSSKEDHCGVRHNERMEFLGDAVLGAVAAA
CLYRALPDSHEGDLAKTKAVLVSTDTLSDIALSLRIDHYLLLGKGEELSGGRHKKAILADATEAVIGALFLDSGFKAAER
FVLRLLLPRVRPIREKNLHHDYKSTLQVLAHQRYRSKPEYTVVKRTGPDHSVRFWVDVTVGDARFGPGYGTSKKSAEQCA
ARLAWEQLSGTLRE

Sequences:

>Translated_254_residues
MSLCLGHIFSRSRSPLTPERRESLRRLQETLGVKFRDPTALDQALSHRSLFSSKEDHCGVRHNERMEFLGDAVLGAVAAA
CLYRALPDSHEGDLAKTKAVLVSTDTLSDIALSLRIDHYLLLGKGEELSGGRHKKAILADATEAVIGALFLDSGFKAAER
FVLRLLLPRVRPIREKNLHHDYKSTLQVLAHQRYRSKPEYTVVKRTGPDHSVRFWVDVTVGDARFGPGYGTSKKSAEQCA
ARLAWEQLSGTLRE
>Mature_253_residues
SLCLGHIFSRSRSPLTPERRESLRRLQETLGVKFRDPTALDQALSHRSLFSSKEDHCGVRHNERMEFLGDAVLGAVAAAC
LYRALPDSHEGDLAKTKAVLVSTDTLSDIALSLRIDHYLLLGKGEELSGGRHKKAILADATEAVIGALFLDSGFKAAERF
VLRLLLPRVRPIREKNLHHDYKSTLQVLAHQRYRSKPEYTVVKRTGPDHSVRFWVDVTVGDARFGPGYGTSKKSAEQCAA
RLAWEQLSGTLRE

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=231, Percent_Identity=29.4372294372294, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI155030236, Length=231, Percent_Identity=29.4372294372294, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI1788920, Length=212, Percent_Identity=37.2641509433962, Blast_Score=128, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17506883, Length=246, Percent_Identity=30.0813008130081, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI193202651, Length=246, Percent_Identity=30.0813008130081, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17137682, Length=233, Percent_Identity=29.6137339055794, Blast_Score=91, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_TREPA (O83787)

Other databases:

- EMBL:   AE000520
- PIR:   G71277
- RefSeq:   NP_219246.1
- ProteinModelPortal:   O83787
- SMR:   O83787
- IntAct:   O83787
- GeneID:   2610873
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0809
- NMPDR:   fig|243276.1.peg.805
- TIGR:   TP_0809
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- ProtClustDB:   CLSK218876
- BioCyc:   TPAL243276:TP_0809-MONOMER
- BRENDA:   3.1.26.3
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 28342; Mature: 28211

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLCLGHIFSRSRSPLTPERRESLRRLQETLGVKFRDPTALDQALSHRSLFSSKEDHCGV
CCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
RHNERMEFLGDAVLGAVAAACLYRALPDSHEGDLAKTKAVLVSTDTLSDIALSLRIDHYL
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHEEEEECCCHHHHHHHHEECEEE
LLGKGEELSGGRHKKAILADATEAVIGALFLDSGFKAAERFVLRLLLPRVRPIREKNLHH
EEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHCCH
DYKSTLQVLAHQRYRSKPEYTVVKRTGPDHSVRFWVDVTVGDARFGPGYGTSKKSAEQCA
HHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHH
ARLAWEQLSGTLRE
HHHHHHHHHHHCCC
>Mature Secondary Structure 
SLCLGHIFSRSRSPLTPERRESLRRLQETLGVKFRDPTALDQALSHRSLFSSKEDHCGV
CHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
RHNERMEFLGDAVLGAVAAACLYRALPDSHEGDLAKTKAVLVSTDTLSDIALSLRIDHYL
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHEEEEECCCHHHHHHHHEECEEE
LLGKGEELSGGRHKKAILADATEAVIGALFLDSGFKAAERFVLRLLLPRVRPIREKNLHH
EEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHCCH
DYKSTLQVLAHQRYRSKPEYTVVKRTGPDHSVRFWVDVTVGDARFGPGYGTSKKSAEQCA
HHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHH
ARLAWEQLSGTLRE
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876