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The map label for this gene is cbbA

Identifier: 189025887

GI number: 189025887

Start: 725737

End: 726735

Strand: Reverse

Name: cbbA

Synonym: TPASS_0662

Alternate gene names: 189025887

Gene position: 726735-725737 (Counterclockwise)

Preceding gene: 189025890

Following gene: 189025886

Centisome position: 63.78

GC content: 53.35

Gene sequence:

>999_bases
ATGACTAGTTACAAGGCACTCGGTTTGGTGAATACCAAGGACCTGTTCGCAAAGGCAGTAAAGGGCGGATACGCGATCCC
TGCGTATAATTTTAACAACCTGGAACAGCTCCAGGCAATCATACAGGCGTGTGTTGAAACGCGTTCTCCCGTCATTCTGC
AGGTTTCTTCCGGTGCGCGCAAGTACGCAAATGCGACGCTCCTGCGCAATATGGCACGCGGCGCAGTTGAGTATGCCCAT
GAGCTCGGCGTTGATATTCCCATTGTTTTGCATCTGGACCATGGTGACAGCCTAGAGCTGTGCATTGACTGCATAGAGAG
TGGCTTTTCGTCTGTGATGATTGACGGTTCGGCGTTGCCGTACGACGAGAATGTAGCGCTAAGCAGGAAGGTGTGCGAGT
ATGCCCATGCGCGTGCGGACTATGTCACCGTGGAAGGGGAGCTTGGGGTACTCGCTGGTGTGGAAGACGATGTAGTGGCA
GAGAAGAGCCACTACACTATGCCTGACGAAGTTGAGGACTTTGTGAAAAAAACGGGGGTGGATTCCCTTGCCATCTCCAT
CGGAACAAGTCACGGGAGAGCAAAGTTTACGCCAGAGCAGTGTACGCGCAATGCTGATGGAGTGTTGATCCCCCCTCCGC
TACGTTTTGACATCCTCGCAGAGATAGAAAAGCGTATTCCTGGCTTTCCCATCGTGCTGCACGGTGCTTCGTCTGTGCCC
GTTGAGTACGTACGGGAGGTTGAAAGGTACGGTGGAAATCTGCCGGATTCTGTGGGTATTCCAGAAGAGCAGTTGCGGAA
AGCTGCCAAAAGCGCGGTGTGCAAGGTGAACATTGACTCGGACGGTCGCCTCGCTATGACTGCAGCTATACGCAGGGTGC
TGACCACCAAGGTAGATGAGTTTGATCCGAGAAAGTATTTGGGTCCTGCGCGCGATGAGCTTAAGAAGTTGTACATGCAC
AAAAACAAGGAAGTGCTCGGAAGCGCCGGCCGCGCATAG

Upstream 100 bases:

>100_bases
TAGAGCGTCCCGATCGCCCTACCATGCCCCTCTTGCCGAGGGTGGCACGCTTCTCTATTTCGTGACTCTTCTCGAAGCAA
TCCTAACAAAGGGGGTTCTC

Downstream 100 bases:

>100_bases
AGCCAGCAGGTGCGAGCCGTCCAGTAGCCTGCGGAGCTGCAGACCACTGGACGGTTTTTTATTTCACTAAAAAGTAAAGC
GCTCGGGAAAGGTGCCGAGA

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MTSYKALGLVNTKDLFAKAVKGGYAIPAYNFNNLEQLQAIIQACVETRSPVILQVSSGARKYANATLLRNMARGAVEYAH
ELGVDIPIVLHLDHGDSLELCIDCIESGFSSVMIDGSALPYDENVALSRKVCEYAHARADYVTVEGELGVLAGVEDDVVA
EKSHYTMPDEVEDFVKKTGVDSLAISIGTSHGRAKFTPEQCTRNADGVLIPPPLRFDILAEIEKRIPGFPIVLHGASSVP
VEYVREVERYGGNLPDSVGIPEEQLRKAAKSAVCKVNIDSDGRLAMTAAIRRVLTTKVDEFDPRKYLGPARDELKKLYMH
KNKEVLGSAGRA

Sequences:

>Translated_332_residues
MTSYKALGLVNTKDLFAKAVKGGYAIPAYNFNNLEQLQAIIQACVETRSPVILQVSSGARKYANATLLRNMARGAVEYAH
ELGVDIPIVLHLDHGDSLELCIDCIESGFSSVMIDGSALPYDENVALSRKVCEYAHARADYVTVEGELGVLAGVEDDVVA
EKSHYTMPDEVEDFVKKTGVDSLAISIGTSHGRAKFTPEQCTRNADGVLIPPPLRFDILAEIEKRIPGFPIVLHGASSVP
VEYVREVERYGGNLPDSVGIPEEQLRKAAKSAVCKVNIDSDGRLAMTAAIRRVLTTKVDEFDPRKYLGPARDELKKLYMH
KNKEVLGSAGRA
>Mature_331_residues
TSYKALGLVNTKDLFAKAVKGGYAIPAYNFNNLEQLQAIIQACVETRSPVILQVSSGARKYANATLLRNMARGAVEYAHE
LGVDIPIVLHLDHGDSLELCIDCIESGFSSVMIDGSALPYDENVALSRKVCEYAHARADYVTVEGELGVLAGVEDDVVAE
KSHYTMPDEVEDFVKKTGVDSLAISIGTSHGRAKFTPEQCTRNADGVLIPPPLRFDILAEIEKRIPGFPIVLHGASSVPV
EYVREVERYGGNLPDSVGIPEEQLRKAAKSAVCKVNIDSDGRLAMTAAIRRVLTTKVDEFDPRKYLGPARDELKKLYMHK
NKEVLGSAGRA

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family

Homologues:

Organism=Escherichia coli, GI1789526, Length=327, Percent_Identity=35.7798165137615, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI87082041, Length=312, Percent_Identity=31.7307692307692, Blast_Score=161, Evalue=6e-41,
Organism=Escherichia coli, GI1788072, Length=278, Percent_Identity=29.136690647482, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1789293, Length=318, Percent_Identity=24.8427672955975, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322790, Length=324, Percent_Identity=26.8518518518519, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALF_TREPA (O83668)

Other databases:

- EMBL:   AE000520
- PIR:   G71297
- RefSeq:   NP_219099.1
- ProteinModelPortal:   O83668
- SMR:   O83668
- IntAct:   O83668
- GeneID:   2611197
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0662
- NMPDR:   fig|243276.1.peg.658
- TIGR:   TP_0662
- HOGENOM:   HBG327581
- OMA:   RIEEIHR
- ProtClustDB:   PRK07084
- BioCyc:   TPAL243276:TP_0662-MONOMER
- BRENDA:   4.1.2.13
- GO:   GO:0006096
- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF001359
- TIGRFAMs:   TIGR00167
- TIGRFAMs:   TIGR01859

Pfam domain/function: PF01116 F_bP_aldolase

EC number: =4.1.2.13

Molecular weight: Translated: 36190; Mature: 36059

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00602 ALDOLASE_CLASS_II_1; PS00806 ALDOLASE_CLASS_II_2

Important sites: ACT_SITE 93-93 BINDING 56-56 BINDING 192-192

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSYKALGLVNTKDLFAKAVKGGYAIPAYNFNNLEQLQAIIQACVETRSPVILQVSSGAR
CCCCCEEECCCHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCH
KYANATLLRNMARGAVEYAHELGVDIPIVLHLDHGDSLELCIDCIESGFSSVMIDGSALP
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEECCCCCC
YDENVALSRKVCEYAHARADYVTVEGELGVLAGVEDDVVAEKSHYTMPDEVEDFVKKTGV
CCCCHHHHHHHHHHHHCCCCEEEEECCCEEEECCCHHHHCCCCCCCCCHHHHHHHHHCCC
DSLAISIGTSHGRAKFTPEQCTRNADGVLIPPPLRFDILAEIEKRIPGFPIVLHGASSVP
CEEEEEEECCCCCCEECHHHHCCCCCCEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCC
VEYVREVERYGGNLPDSVGIPEEQLRKAAKSAVCKVNIDSDGRLAMTAAIRRVLTTKVDE
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHHHHHCCC
FDPRKYLGPARDELKKLYMHKNKEVLGSAGRA
CCCHHHCCCHHHHHHHHHHHCCHHHHCCCCCC
>Mature Secondary Structure 
TSYKALGLVNTKDLFAKAVKGGYAIPAYNFNNLEQLQAIIQACVETRSPVILQVSSGAR
CCCCEEECCCHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCH
KYANATLLRNMARGAVEYAHELGVDIPIVLHLDHGDSLELCIDCIESGFSSVMIDGSALP
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEECCCCCC
YDENVALSRKVCEYAHARADYVTVEGELGVLAGVEDDVVAEKSHYTMPDEVEDFVKKTGV
CCCCHHHHHHHHHHHHCCCCEEEEECCCEEEECCCHHHHCCCCCCCCCHHHHHHHHHCCC
DSLAISIGTSHGRAKFTPEQCTRNADGVLIPPPLRFDILAEIEKRIPGFPIVLHGASSVP
CEEEEEEECCCCCCEECHHHHCCCCCCEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCC
VEYVREVERYGGNLPDSVGIPEEQLRKAAKSAVCKVNIDSDGRLAMTAAIRRVLTTKVDE
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHHHHHCCC
FDPRKYLGPARDELKKLYMHKNKEVLGSAGRA
CCCHHHCCCHHHHHHHHHHHCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876