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The map label for this gene is cyaB [H]

Identifier: 189025716

GI number: 189025716

Start: 516976

End: 518820

Strand: Reverse

Name: cyaB [H]

Synonym: TPASS_0485

Alternate gene names: 189025716

Gene position: 518820-516976 (Counterclockwise)

Preceding gene: 189025717

Following gene: 189025715

Centisome position: 45.53

GC content: 52.3

Gene sequence:

>1845_bases
ATGAGCAGAAAGAACGCGAATCAGAAAATTGTGTGGCCGCTTACGACGAAACTCATCGGTATTATCAGCACGGTGGTGGT
GCTCGCCACCATTGCGGTTACGGCCATGGCTTCCTGGTTCTTCGCTTCGAGTCTGCACAGTAATGCTGAGCTTAATAATC
TTGCCGCTGCGGAGAACTTTGCTGCGCAAATCAAAGGGGAATTCGAAGCCATTGCCACAAGCGCCAAGTCCTTCGTTTCC
CTTGGCCTCAGAAGTGGCGCGCGCATGCACTCGCGGTCCGCACTTTCTAAAGATTTTTTTTCCTTTTACCCGCGCATCGG
CTACATCGGAGTCGGCGGTGTAGCCGAGCTGTGGAACGGTGACTTCTTCAAGAAAAATCAGCTGCGGGTGGCAGACGCTC
GTCGCTTCCTAGCTGACAACGCACAGGTTATTTCCACACTTCAAACTGCCCCAGCCACGCTCAACGCCGCCCCCTGGTTT
AAAGCGCAGATCATTGCTATCGTCGCGCCCTTTGAAGTTGACGGCGCTACGCGTAACGTTGTGGTTATCTTCTCAGCGGA
TGTCGTTCAGCACCTGCTAGAATCTGGAGCCTCCTCCGGAACCATGTATGCCGTCACCTGGGCGGGGAACTCCCTGTACC
ACCCGGAATACTCTCTCAATTACAGCAACATTAACTTGCAGGACTCGCCCGTTGTGCGCGATTTACGCGAATCTACACAG
CTGACCAAACAAATCAGCTTCATCGGCACGGACAACAAGCGCTACTTCGGCGCGTTCGCCAAGCAAACCTTTGGAAAGTT
CGCCATAGTCCTAGAAACGCCTATGAGTGTGGTGTACCAGGCAGTATATTACGCGATTATCCTCGACGGTATCCTCACCG
GCATGGTGCTCCTCGCCTCTATCTTGCTTGTCTGGTTCATTGCGCAGTCTATCACCCGCCCTATCCTTACCCTCGTCGGC
GCAACGCACGCTATCAGCTCAGGACAGTTCCTCCTGGATATCAAGCCTTCAAGCAAAGACGAAATTGGCCTCCTCACCGA
AACATTCGTGAGTATGGGGCGTGGTCTGGCAGAACGGGAACGCATGAAAGAAGCGTTTGGCAAATTTGTAAATAGAGACA
TCGCAGAGAAGGCCATGAAGGGAGAGCTCGCACTGGGAGGGGAACGGAAAACCGCTACCATTTTTTTCTCAGACGTGCGC
TCCTTTACTGAGATGTCAGAGAAGCTTCCCCCTGAGGACGTAGTAGAGTTTCTCAACGAGTACATGAGCTGTATGGTAGA
CTGCATCGAGCAGACAGGCGGCGTGGTGGACAAGTTTATTGGAGATGCGATTATGGCGATATGGGGAGCGCCAGTTTCCC
TCGGCTCTGCACGCTTAGACGCATTGCAGAGCATGAAAGCGGTCTTCCTCATGCGCGAAAGCCTTATTCAACTGAACGAA
AAGCGCGTCGCATGCTCAAAGCCTCGCATTGGCATCGGATGCGGCGTAAACACAGGCTCCTGCGTCGCAGGTCAAATCGG
CTCTTCCAAACGTATGGAATACACCGTCATCGGAGACGCGGTGAACACCGCAAGCAGGATCGAAGCACTGAATAAGCCGT
TCGGCACTGACTTTCTTATCTCCGAAAACACATATGAGCTTGTTAAAGATATGCTTATAGTGGAGAAAATGCCCCCCATA
ACGGTAAAAGGAAAACGAGAACCACTGAATGTGTACGCTGCTATCAATCTAAAGGGGCATGACGGACCGCAGACGCTCGA
TGAGCTGCGTGCACTTCTTTCCATTGAAAAGCCGGGGCTTTCTGCCGACCCTGACTTCGAAGAAAAGAAGTGTGAAGTTA
TCTAA

Upstream 100 bases:

>100_bases
CCGCCGTCACCGTCACTCCGCGCGGAATTATGGTGCAAACAAAAGAGAAAGGTATGGCCCTATTGCACACACGGACGCTC
GCCGACGCGCTACCCAGAAC

Downstream 100 bases:

>100_bases
GCAGGATGCCACGGTTACGGTCGTTATTCTCCTCCTTATCCTGCTTCTCGGCTGGGGCTACTCCCGCGCGCTCCGTCTGT
CCCAGGGGAAGGGAAATCCA

Product: adenylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 2; Adenylyl cyclase 2; AC2 [H]

Number of amino acids: Translated: 614; Mature: 613

Protein sequence:

>614_residues
MSRKNANQKIVWPLTTKLIGIISTVVVLATIAVTAMASWFFASSLHSNAELNNLAAAENFAAQIKGEFEAIATSAKSFVS
LGLRSGARMHSRSALSKDFFSFYPRIGYIGVGGVAELWNGDFFKKNQLRVADARRFLADNAQVISTLQTAPATLNAAPWF
KAQIIAIVAPFEVDGATRNVVVIFSADVVQHLLESGASSGTMYAVTWAGNSLYHPEYSLNYSNINLQDSPVVRDLRESTQ
LTKQISFIGTDNKRYFGAFAKQTFGKFAIVLETPMSVVYQAVYYAIILDGILTGMVLLASILLVWFIAQSITRPILTLVG
ATHAISSGQFLLDIKPSSKDEIGLLTETFVSMGRGLAERERMKEAFGKFVNRDIAEKAMKGELALGGERKTATIFFSDVR
SFTEMSEKLPPEDVVEFLNEYMSCMVDCIEQTGGVVDKFIGDAIMAIWGAPVSLGSARLDALQSMKAVFLMRESLIQLNE
KRVACSKPRIGIGCGVNTGSCVAGQIGSSKRMEYTVIGDAVNTASRIEALNKPFGTDFLISENTYELVKDMLIVEKMPPI
TVKGKREPLNVYAAINLKGHDGPQTLDELRALLSIEKPGLSADPDFEEKKCEVI

Sequences:

>Translated_614_residues
MSRKNANQKIVWPLTTKLIGIISTVVVLATIAVTAMASWFFASSLHSNAELNNLAAAENFAAQIKGEFEAIATSAKSFVS
LGLRSGARMHSRSALSKDFFSFYPRIGYIGVGGVAELWNGDFFKKNQLRVADARRFLADNAQVISTLQTAPATLNAAPWF
KAQIIAIVAPFEVDGATRNVVVIFSADVVQHLLESGASSGTMYAVTWAGNSLYHPEYSLNYSNINLQDSPVVRDLRESTQ
LTKQISFIGTDNKRYFGAFAKQTFGKFAIVLETPMSVVYQAVYYAIILDGILTGMVLLASILLVWFIAQSITRPILTLVG
ATHAISSGQFLLDIKPSSKDEIGLLTETFVSMGRGLAERERMKEAFGKFVNRDIAEKAMKGELALGGERKTATIFFSDVR
SFTEMSEKLPPEDVVEFLNEYMSCMVDCIEQTGGVVDKFIGDAIMAIWGAPVSLGSARLDALQSMKAVFLMRESLIQLNE
KRVACSKPRIGIGCGVNTGSCVAGQIGSSKRMEYTVIGDAVNTASRIEALNKPFGTDFLISENTYELVKDMLIVEKMPPI
TVKGKREPLNVYAAINLKGHDGPQTLDELRALLSIEKPGLSADPDFEEKKCEVI
>Mature_613_residues
SRKNANQKIVWPLTTKLIGIISTVVVLATIAVTAMASWFFASSLHSNAELNNLAAAENFAAQIKGEFEAIATSAKSFVSL
GLRSGARMHSRSALSKDFFSFYPRIGYIGVGGVAELWNGDFFKKNQLRVADARRFLADNAQVISTLQTAPATLNAAPWFK
AQIIAIVAPFEVDGATRNVVVIFSADVVQHLLESGASSGTMYAVTWAGNSLYHPEYSLNYSNINLQDSPVVRDLRESTQL
TKQISFIGTDNKRYFGAFAKQTFGKFAIVLETPMSVVYQAVYYAIILDGILTGMVLLASILLVWFIAQSITRPILTLVGA
THAISSGQFLLDIKPSSKDEIGLLTETFVSMGRGLAERERMKEAFGKFVNRDIAEKAMKGELALGGERKTATIFFSDVRS
FTEMSEKLPPEDVVEFLNEYMSCMVDCIEQTGGVVDKFIGDAIMAIWGAPVSLGSARLDALQSMKAVFLMRESLIQLNEK
RVACSKPRIGIGCGVNTGSCVAGQIGSSKRMEYTVIGDAVNTASRIEALNKPFGTDFLISENTYELVKDMLIVEKMPPIT
VKGKREPLNVYAAINLKGHDGPQTLDELRALLSIEKPGLSADPDFEEKKCEVI

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Homo sapiens, GI167830411, Length=174, Percent_Identity=29.8850574712644, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI4580422, Length=174, Percent_Identity=29.8850574712644, Blast_Score=73, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71982300, Length=176, Percent_Identity=30.1136363636364, Blast_Score=86, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17534655, Length=218, Percent_Identity=28.4403669724771, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI212645052, Length=315, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17534649, Length=176, Percent_Identity=31.25, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17534653, Length=176, Percent_Identity=31.25, Blast_Score=83, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17534657, Length=193, Percent_Identity=29.0155440414508, Blast_Score=83, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17534651, Length=176, Percent_Identity=30.1136363636364, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17561804, Length=176, Percent_Identity=31.25, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17561802, Length=176, Percent_Identity=31.25, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193207841, Length=232, Percent_Identity=28.8793103448276, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71989822, Length=252, Percent_Identity=29.7619047619048, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17561800, Length=176, Percent_Identity=30.6818181818182, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71989805, Length=252, Percent_Identity=29.7619047619048, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17534665, Length=156, Percent_Identity=34.6153846153846, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI212645647, Length=151, Percent_Identity=35.0993377483444, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71995305, Length=178, Percent_Identity=29.2134831460674, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17534659, Length=173, Percent_Identity=30.635838150289, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71995893, Length=202, Percent_Identity=28.7128712871287, Blast_Score=73, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71995895, Length=202, Percent_Identity=28.7128712871287, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71995899, Length=202, Percent_Identity=28.7128712871287, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71995300, Length=175, Percent_Identity=29.1428571428571, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17508769, Length=184, Percent_Identity=31.5217391304348, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17561794, Length=183, Percent_Identity=32.7868852459016, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI193206632, Length=211, Percent_Identity=26.0663507109005, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI193206054, Length=249, Percent_Identity=28.1124497991968, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI221330470, Length=180, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI221330468, Length=180, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI161076872, Length=225, Percent_Identity=28.8888888888889, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28574512, Length=225, Percent_Identity=28.8888888888889, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24647268, Length=217, Percent_Identity=26.7281105990783, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI85725044, Length=198, Percent_Identity=31.8181818181818, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24663839, Length=177, Percent_Identity=28.2485875706215, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24663843, Length=177, Percent_Identity=28.2485875706215, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI62484477, Length=235, Percent_Identity=27.2340425531915, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI62484298, Length=235, Percent_Identity=27.2340425531915, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI116008008, Length=235, Percent_Identity=27.2340425531915, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI281366459, Length=214, Percent_Identity=29.4392523364486, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281366457, Length=214, Percent_Identity=29.4392523364486, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281366455, Length=214, Percent_Identity=29.4392523364486, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI56292422, Length=214, Percent_Identity=29.4392523364486, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI56292424, Length=214, Percent_Identity=29.4392523364486, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24666940, Length=214, Percent_Identity=29.4392523364486, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161078020, Length=230, Percent_Identity=28.695652173913, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR011006
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00211 Guanylate_cyc; PF00072 Response_reg [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 67031; Mature: 66900

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS50885 HAMP ; PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKNANQKIVWPLTTKLIGIISTVVVLATIAVTAMASWFFASSLHSNAELNNLAAAENF
CCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
AAQIKGEFEAIATSAKSFVSLGLRSGARMHSRSALSKDFFSFYPRIGYIGVGGVAELWNG
HHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHCC
DFFKKNQLRVADARRFLADNAQVISTLQTAPATLNAAPWFKAQIIAIVAPFEVDGATRNV
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHEEEEEEEECEEECCCCCCE
VVIFSADVVQHLLESGASSGTMYAVTWAGNSLYHPEYSLNYSNINLQDSPVVRDLRESTQ
EEEEEHHHHHHHHHCCCCCCEEEEEEECCCEEECCCEEECCCCCCCCCCHHHHHHHHHHH
LTKQISFIGTDNKRYFGAFAKQTFGKFAIVLETPMSVVYQAVYYAIILDGILTGMVLLAS
HHHHHHEEECCCCHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILLVWFIAQSITRPILTLVGATHAISSGQFLLDIKPSSKDEIGLLTETFVSMGRGLAERE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCHHHHH
RMKEAFGKFVNRDIAEKAMKGELALGGERKTATIFFSDVRSFTEMSEKLPPEDVVEFLNE
HHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEHHHHHHHHHHHHCCCHHHHHHHHHH
YMSCMVDCIEQTGGVVDKFIGDAIMAIWGAPVSLGSARLDALQSMKAVFLMRESLIQLNE
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHCC
KRVACSKPRIGIGCGVNTGSCVAGQIGSSKRMEYTVIGDAVNTASRIEALNKPFGTDFLI
CHHCCCCCCEEEECCCCCCCEEECCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCEEE
SENTYELVKDMLIVEKMPPITVKGKREPLNVYAAINLKGHDGPQTLDELRALLSIEKPGL
CCCHHHHHHHHHHHHCCCCEEECCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCC
SADPDFEEKKCEVI
CCCCCCCCCCCCCC
>Mature Secondary Structure 
SRKNANQKIVWPLTTKLIGIISTVVVLATIAVTAMASWFFASSLHSNAELNNLAAAENF
CCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
AAQIKGEFEAIATSAKSFVSLGLRSGARMHSRSALSKDFFSFYPRIGYIGVGGVAELWNG
HHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHCC
DFFKKNQLRVADARRFLADNAQVISTLQTAPATLNAAPWFKAQIIAIVAPFEVDGATRNV
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHEEEEEEEECEEECCCCCCE
VVIFSADVVQHLLESGASSGTMYAVTWAGNSLYHPEYSLNYSNINLQDSPVVRDLRESTQ
EEEEEHHHHHHHHHCCCCCCEEEEEEECCCEEECCCEEECCCCCCCCCCHHHHHHHHHHH
LTKQISFIGTDNKRYFGAFAKQTFGKFAIVLETPMSVVYQAVYYAIILDGILTGMVLLAS
HHHHHHEEECCCCHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILLVWFIAQSITRPILTLVGATHAISSGQFLLDIKPSSKDEIGLLTETFVSMGRGLAERE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCHHHHH
RMKEAFGKFVNRDIAEKAMKGELALGGERKTATIFFSDVRSFTEMSEKLPPEDVVEFLNE
HHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEHHHHHHHHHHHHCCCHHHHHHHHHH
YMSCMVDCIEQTGGVVDKFIGDAIMAIWGAPVSLGSARLDALQSMKAVFLMRESLIQLNE
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHCC
KRVACSKPRIGIGCGVNTGSCVAGQIGSSKRMEYTVIGDAVNTASRIEALNKPFGTDFLI
CHHCCCCCCEEEECCCCCCCEEECCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCEEE
SENTYELVKDMLIVEKMPPITVKGKREPLNVYAAINLKGHDGPQTLDELRALLSIEKPGL
CCCHHHHHHHHHHHHCCCCEEECCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCC
SADPDFEEKKCEVI
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]