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The map label for this gene is rsmH

Identifier: 189025617

GI number: 189025617

Start: 409795

End: 410934

Strand: Direct

Name: rsmH

Synonym: TPASS_0384

Alternate gene names: 189025617

Gene position: 409795-410934 (Clockwise)

Preceding gene: 189025616

Following gene: 189025618

Centisome position: 35.96

GC content: 59.56

Gene sequence:

>1140_bases
GTGAGTCTTTCCGGGCATACGCACACAAAAGAGGAGGTGCAGGCTGAGGTGGAGGCAGGAGAGGTTCAGTGCCCAGCGCT
TTGCCATCAGCCGGTACTCGTGCAGGAATGCCTGACGTTGTTGGAACCTGCAATTGTGGGTATCTCGCGAGGTGCAGACA
GCACGAGAGATGGGGCGGGGGCGTTTTTTATTGACGGGACACTGGGGGATGGGGGACACACACAGGCGTTTTTGCACGCG
TACCCTGCGCTCCGTGCGCTCGGTGTTGAAATAGATCCGTCAATGCTCGCACGGGCGCGAGCGCGCTTGACGCCGTTTGG
CAAGCGGCTTCGCTATGTCCTGGGGTGGTCTGATGTCTTTTTTGCCTCCGCATATGCATCAGCTCCTGCCTCTCCTGCAA
CGGGAAGGACTGCAGCTGGCGCCGCAGGTGTGCCGGGTGCGTATCCGGCGCCGCAGGCAGTATTGTTAGACCTTGGTATT
TCTTTTTTCCATTACAGGGGGGCGATGCGGGGCTTTTCCTTCGCAGAAGAACATATGTTGGACATGCGCCTGGATCCTCA
AGCCTCCCAGACCGCTGCAGACCTCCTGAATCGGCTGCCGCAGGCACGTTTGGCACAATTGTTTTTTGAAGGGGGAGAGG
AACGTTACGCGCGTCGGATTGCGCAGGCGGTGTGCGCGCAGCGTCGGCAGGCGCCCTTTTGCTCTGCGCGCGCATTTGCA
GAAGTCGTTGCGCGCGTGGTGCCGCCGATGCGGACGGCGCGGTTTGGGAAGCGGCGCGGTGTTCTTGGGGTTTTGCCGAA
GCTCCATCCGGCAACCAAGGCGTTTCAAGCATTGCGCATTGCGGTGAACAGGGAGCTTGAGCGTTTGCCACGCCTTCTTA
CGGCAGCGTTTACGGCGCTTGCGCCTGGGGGTCGACTTGCGGTTATTAGTTTTCACTCGCGTGAGGATAGGATTGTTAAG
GTACATTTTCGGCACTGGGCGAAACGCTGCAGCTGTCCGGCTCGTGTGCCGATATGCAGCTGCGGCGGTGTGGCGCGTGC
ATCGCTGATTACCAAGAAGCCGCTTGTACCTTCGTGTGTGGAGCGTGCTGCGAATGCCGCTTCGCGGAGTGCTACGTTAC
GCGTCATTGAGAAACGGTAG

Upstream 100 bases:

>100_bases
ACTGCCTTGAGATTTGGGACCGCGCGCGCTACCGCGCCTATCTTGCAGAAAGTGAGGCGGACTTCCGTGCAGGAACCGAA
ACACTGCAGGACCTTTGTCT

Downstream 100 bases:

>100_bases
GAGACTGGGCTGATGCGTGAGAAAGGGGCGATGAGAGAAAAGCAGCGAAGGGGAATACCTCGCCGGCAAAGAGGGATGAC
GGTGCAAAAGGTGAGCGCGT

Product: hypothetical protein

Products: NA

Alternate protein names: 16S rRNA m(4)C1402 methyltransferase; rRNA (cytosine-N(4)-)-methyltransferase RsmH

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MSLSGHTHTKEEVQAEVEAGEVQCPALCHQPVLVQECLTLLEPAIVGISRGADSTRDGAGAFFIDGTLGDGGHTQAFLHA
YPALRALGVEIDPSMLARARARLTPFGKRLRYVLGWSDVFFASAYASAPASPATGRTAAGAAGVPGAYPAPQAVLLDLGI
SFFHYRGAMRGFSFAEEHMLDMRLDPQASQTAADLLNRLPQARLAQLFFEGGEERYARRIAQAVCAQRRQAPFCSARAFA
EVVARVVPPMRTARFGKRRGVLGVLPKLHPATKAFQALRIAVNRELERLPRLLTAAFTALAPGGRLAVISFHSREDRIVK
VHFRHWAKRCSCPARVPICSCGGVARASLITKKPLVPSCVERAANAASRSATLRVIEKR

Sequences:

>Translated_379_residues
MSLSGHTHTKEEVQAEVEAGEVQCPALCHQPVLVQECLTLLEPAIVGISRGADSTRDGAGAFFIDGTLGDGGHTQAFLHA
YPALRALGVEIDPSMLARARARLTPFGKRLRYVLGWSDVFFASAYASAPASPATGRTAAGAAGVPGAYPAPQAVLLDLGI
SFFHYRGAMRGFSFAEEHMLDMRLDPQASQTAADLLNRLPQARLAQLFFEGGEERYARRIAQAVCAQRRQAPFCSARAFA
EVVARVVPPMRTARFGKRRGVLGVLPKLHPATKAFQALRIAVNRELERLPRLLTAAFTALAPGGRLAVISFHSREDRIVK
VHFRHWAKRCSCPARVPICSCGGVARASLITKKPLVPSCVERAANAASRSATLRVIEKR
>Mature_378_residues
SLSGHTHTKEEVQAEVEAGEVQCPALCHQPVLVQECLTLLEPAIVGISRGADSTRDGAGAFFIDGTLGDGGHTQAFLHAY
PALRALGVEIDPSMLARARARLTPFGKRLRYVLGWSDVFFASAYASAPASPATGRTAAGAAGVPGAYPAPQAVLLDLGIS
FFHYRGAMRGFSFAEEHMLDMRLDPQASQTAADLLNRLPQARLAQLFFEGGEERYARRIAQAVCAQRRQAPFCSARAFAE
VVARVVPPMRTARFGKRRGVLGVLPKLHPATKAFQALRIAVNRELERLPRLLTAAFTALAPGGRLAVISFHSREDRIVKV
HFRHWAKRCSCPARVPICSCGGVARASLITKKPLVPSCVERAANAASRSATLRVIEKR

Specific function: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA

COG id: COG0275

COG function: function code M; Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RsmH family

Homologues:

Organism=Homo sapiens, GI165377209, Length=377, Percent_Identity=32.6259946949602, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI165377202, Length=230, Percent_Identity=31.304347826087, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1786270, Length=350, Percent_Identity=33.7142857142857, Blast_Score=160, Evalue=1e-40,
Organism=Drosophila melanogaster, GI62472493, Length=365, Percent_Identity=29.3150684931507, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI28571637, Length=365, Percent_Identity=29.3150684931507, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RSMH_TREPA (O83399)

Other databases:

- EMBL:   AE000520
- PIR:   B71331
- RefSeq:   NP_218824.1
- ProteinModelPortal:   O83399
- IntAct:   O83399
- GeneID:   2611280
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0384
- NMPDR:   fig|243276.1.peg.383
- TIGR:   TP_0384
- HOGENOM:   HBG302779
- OMA:   RQKVIQK
- ProtClustDB:   CLSK218672
- BioCyc:   TPAL243276:TP_0384-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01007
- InterPro:   IPR002903
- PANTHER:   PTHR11265
- PIRSF:   PIRSF004486
- TIGRFAMs:   TIGR00006

Pfam domain/function: PF01795 Methyltransf_5

EC number: NA

Molecular weight: Translated: 40938; Mature: 40807

Theoretical pI: Translated: 10.62; Mature: 10.62

Prosite motif: NA

Important sites: BINDING 90-90 BINDING 157-157 BINDING 164-164

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSGHTHTKEEVQAEVEAGEVQCPALCHQPVLVQECLTLLEPAIVGISRGADSTRDGAG
CCCCCCCCCHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
AFFIDGTLGDGGHTQAFLHAYPALRALGVEIDPSMLARARARLTPFGKRLRYVLGWSDVF
EEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHCCHHHH
FASAYASAPASPATGRTAAGAAGVPGAYPAPQAVLLDLGISFFHYRGAMRGFSFAEEHML
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
DMRLDPQASQTAADLLNRLPQARLAQLFFEGGEERYARRIAQAVCAQRRQAPFCSARAFA
HCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHH
EVVARVVPPMRTARFGKRRGVLGVLPKLHPATKAFQALRIAVNRELERLPRLLTAAFTAL
HHHHHHCCCHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
APGGRLAVISFHSREDRIVKVHFRHWAKRCSCPARVPICSCGGVARASLITKKPLVPSCV
CCCCCEEEEEECCCCCCEEEHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHCCCCCHHHH
ERAANAASRSATLRVIEKR
HHHHHHHHCCCEEEEEECC
>Mature Secondary Structure 
SLSGHTHTKEEVQAEVEAGEVQCPALCHQPVLVQECLTLLEPAIVGISRGADSTRDGAG
CCCCCCCCHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
AFFIDGTLGDGGHTQAFLHAYPALRALGVEIDPSMLARARARLTPFGKRLRYVLGWSDVF
EEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHCCHHHH
FASAYASAPASPATGRTAAGAAGVPGAYPAPQAVLLDLGISFFHYRGAMRGFSFAEEHML
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
DMRLDPQASQTAADLLNRLPQARLAQLFFEGGEERYARRIAQAVCAQRRQAPFCSARAFA
HCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHH
EVVARVVPPMRTARFGKRRGVLGVLPKLHPATKAFQALRIAVNRELERLPRLLTAAFTAL
HHHHHHCCCHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
APGGRLAVISFHSREDRIVKVHFRHWAKRCSCPARVPICSCGGVARASLITKKPLVPSCV
CCCCCEEEEEECCCCCCEEEHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHCCCCCHHHH
ERAANAASRSATLRVIEKR
HHHHHHHHCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876