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The map label for this gene is prs [H]

Identifier: 189025528

GI number: 189025528

Start: 308156

End: 309421

Strand: Direct

Name: prs [H]

Synonym: TPASS_0294

Alternate gene names: 189025528

Gene position: 308156-309421 (Clockwise)

Preceding gene: 189025527

Following gene: 189025529

Centisome position: 27.04

GC content: 47.31

Gene sequence:

>1266_bases
ATGAGATGTTCAGGGTTTACTGATTTGGCGATCGTCGCCTGTCCTGGTGGCGAGCACTTCGCGGACGAAACTATCAAACA
TTTGACGCGTGTGTGTGAACGCAAGTTTCACCAGAGAATGGACCGTTTGACGGACCGCTACGGTCTTGACTCGGGGTCGG
TGATACGAGATGCGAACTTTTACCGGGACCTTTTTTCCACAGAGTTGTGTGCGCACGATGACGTACGTCGTTTTAATCCA
CCGCATTTTAAGGTGGATGCACAGTTTATCTGTTTTCTAAATGGTGAGTTAAAAACGCAAATTAATGAATGTATTCGTGG
CAAGGACGTTTTTATTTTCCAAGATGTAGAAAATCATCAACCAGTCCTGGTGAATAACGGAAAAAGTAAAAAAATATTCT
CCGTGAATGATCACGTGATGATGCTCATTGTGACCATAGATGCAGTTCGGCACGCGGGAGCTGGGCGCGTTACCTTGGTT
TTACCCACTTATCCGTATAGCCGTCAGCACAAAAAGTGTGGACGTGAGGGACTGACGGCGGGTTTGCTCGGGAGTGTATA
TGAGTATCTTGGCGTGAGTCACATTGTCACTCTTGATTTGCATTCACGTGAGATTGAAAATGCCTTTCATCGCACGCGGC
TTGAAAACTTACACGCCAGTTATCAGATTATCCGGGAGTTGGCAAAGATTGAAAATCTTTCTGACCCCGATATCCCTTTT
GTAGTAGTGGCGCCGGACAGCGGGGCGGTTGAACGGAATAAATTTTATTCTTCTGGTTTAAAAAAGCCACTCGCGATGAT
TTATAAGGTGCGTGATTATTCGGTGGTCGCGCAAAATGCAAAGCAGAGCAATATTGTAGAAATTAACTTGCTCGGCGATG
TGGAGGGGAAGACGGCGTTTATTGCTGACGATATGCTTGGCAGCGGAGGTACGATGCTAAAGGCGATGGAATTTTTGAAA
AGTCGCGGAGCAAAGCAGGTGATCGCGGCAGTGAGTTTACCTTTCTTTACGGGAAATGCACTTGAGTTATTTGATGAAGC
GTACGAGAAACGGTATTTCTCTCGGATTATTGGCACAAATGCGGTGTTCCACACACAGCTTTCGCACAAGCAGTGGTATA
CTGAAACCGATGTGTCAGGGTTGTTCGCGCGCGTCATCGCGCGCATTCATCATAATCAATCGTTGAGCAGTCTCTTGGAT
GATCGCAGTATCATCGAGCGACTCCTACACGCTCGCTTGTCCGTTGCGGGGACACCGCGCGCATAG

Upstream 100 bases:

>100_bases
TTGGGTGTGTTTCGTTGTATTAGCCTGCGCGGATGGGCTCCCTATCGTGCGGTTGAGACGGTGCTTGTCCAGTCCGCGTT
GACAAGTGTGGAGAGATTGC

Downstream 100 bases:

>100_bases
GGTAGCGTCGCAACGGACATGGGTTCGGGGATCTTTGTCGCGGACATCGGTACGTCTTCCCTAAAAGCGGCGATTATTTC
CCAAGATGGAAAGGTGTTAC

Product: phosphoribosylpyrophosphate synthetase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MRCSGFTDLAIVACPGGEHFADETIKHLTRVCERKFHQRMDRLTDRYGLDSGSVIRDANFYRDLFSTELCAHDDVRRFNP
PHFKVDAQFICFLNGELKTQINECIRGKDVFIFQDVENHQPVLVNNGKSKKIFSVNDHVMMLIVTIDAVRHAGAGRVTLV
LPTYPYSRQHKKCGREGLTAGLLGSVYEYLGVSHIVTLDLHSREIENAFHRTRLENLHASYQIIRELAKIENLSDPDIPF
VVVAPDSGAVERNKFYSSGLKKPLAMIYKVRDYSVVAQNAKQSNIVEINLLGDVEGKTAFIADDMLGSGGTMLKAMEFLK
SRGAKQVIAAVSLPFFTGNALELFDEAYEKRYFSRIIGTNAVFHTQLSHKQWYTETDVSGLFARVIARIHHNQSLSSLLD
DRSIIERLLHARLSVAGTPRA

Sequences:

>Translated_421_residues
MRCSGFTDLAIVACPGGEHFADETIKHLTRVCERKFHQRMDRLTDRYGLDSGSVIRDANFYRDLFSTELCAHDDVRRFNP
PHFKVDAQFICFLNGELKTQINECIRGKDVFIFQDVENHQPVLVNNGKSKKIFSVNDHVMMLIVTIDAVRHAGAGRVTLV
LPTYPYSRQHKKCGREGLTAGLLGSVYEYLGVSHIVTLDLHSREIENAFHRTRLENLHASYQIIRELAKIENLSDPDIPF
VVVAPDSGAVERNKFYSSGLKKPLAMIYKVRDYSVVAQNAKQSNIVEINLLGDVEGKTAFIADDMLGSGGTMLKAMEFLK
SRGAKQVIAAVSLPFFTGNALELFDEAYEKRYFSRIIGTNAVFHTQLSHKQWYTETDVSGLFARVIARIHHNQSLSSLLD
DRSIIERLLHARLSVAGTPRA
>Mature_421_residues
MRCSGFTDLAIVACPGGEHFADETIKHLTRVCERKFHQRMDRLTDRYGLDSGSVIRDANFYRDLFSTELCAHDDVRRFNP
PHFKVDAQFICFLNGELKTQINECIRGKDVFIFQDVENHQPVLVNNGKSKKIFSVNDHVMMLIVTIDAVRHAGAGRVTLV
LPTYPYSRQHKKCGREGLTAGLLGSVYEYLGVSHIVTLDLHSREIENAFHRTRLENLHASYQIIRELAKIENLSDPDIPF
VVVAPDSGAVERNKFYSSGLKKPLAMIYKVRDYSVVAQNAKQSNIVEINLLGDVEGKTAFIADDMLGSGGTMLKAMEFLK
SRGAKQVIAAVSLPFFTGNALELFDEAYEKRYFSRIIGTNAVFHTQLSHKQWYTETDVSGLFARVIARIHHNQSLSSLLD
DRSIIERLLHARLSVAGTPRA

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=315, Percent_Identity=30.7936507936508, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI4506127, Length=311, Percent_Identity=30.5466237942122, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI84875539, Length=318, Percent_Identity=30.5031446540881, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI28557709, Length=311, Percent_Identity=30.5466237942122, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI194018537, Length=337, Percent_Identity=28.1899109792285, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI4506133, Length=341, Percent_Identity=26.3929618768328, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1787458, Length=323, Percent_Identity=29.4117647058824, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17554704, Length=312, Percent_Identity=30.4487179487179, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI25149168, Length=312, Percent_Identity=30.4487179487179, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17554702, Length=312, Percent_Identity=30.4487179487179, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71989924, Length=312, Percent_Identity=30.4487179487179, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17570245, Length=334, Percent_Identity=26.3473053892216, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6321776, Length=306, Percent_Identity=29.7385620915033, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6320946, Length=309, Percent_Identity=31.0679611650485, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6319403, Length=310, Percent_Identity=30.9677419354839, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6322667, Length=184, Percent_Identity=30.4347826086957, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355239, Length=314, Percent_Identity=30.2547770700637, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI45551540, Length=337, Percent_Identity=28.1899109792285, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI281362873, Length=342, Percent_Identity=26.3157894736842, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24651454, Length=342, Percent_Identity=26.3157894736842, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24651458, Length=342, Percent_Identity=26.3157894736842, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24651456, Length=342, Percent_Identity=26.3157894736842, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI45552010, Length=176, Percent_Identity=28.4090909090909, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24651462, Length=176, Percent_Identity=28.4090909090909, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24651464, Length=176, Percent_Identity=28.4090909090909, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 47432; Mature: 47432

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRCSGFTDLAIVACPGGEHFADETIKHLTRVCERKFHQRMDRLTDRYGLDSGSVIRDANF
CCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHH
YRDLFSTELCAHDDVRRFNPPHFKVDAQFICFLNGELKTQINECIRGKDVFIFQDVENHQ
HHHHHHHHHHCCCCHHHCCCCCEEECCEEEEEECCHHHHHHHHHHCCCCEEEEECCCCCC
PVLVNNGKSKKIFSVNDHVMMLIVTIDAVRHAGAGRVTLVLPTYPYSRQHKKCGREGLTA
CEEEECCCCCEEEEECCCEEEEEEEHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHCCHH
GLLGSVYEYLGVSHIVTLDLHSREIENAFHRTRLENLHASYQIIRELAKIENLSDPDIPF
HHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
VVVAPDSGAVERNKFYSSGLKKPLAMIYKVRDYSVVAQNAKQSNIVEINLLGDVEGKTAF
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCEEEEEEEECCCCCEEE
IADDMLGSGGTMLKAMEFLKSRGAKQVIAAVSLPFFTGNALELFDEAYEKRYFSRIIGTN
EEHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCC
AVFHTQLSHKQWYTETDVSGLFARVIARIHHNQSLSSLLDDRSIIERLLHARLSVAGTPR
CEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
A
C
>Mature Secondary Structure
MRCSGFTDLAIVACPGGEHFADETIKHLTRVCERKFHQRMDRLTDRYGLDSGSVIRDANF
CCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHH
YRDLFSTELCAHDDVRRFNPPHFKVDAQFICFLNGELKTQINECIRGKDVFIFQDVENHQ
HHHHHHHHHHCCCCHHHCCCCCEEECCEEEEEECCHHHHHHHHHHCCCCEEEEECCCCCC
PVLVNNGKSKKIFSVNDHVMMLIVTIDAVRHAGAGRVTLVLPTYPYSRQHKKCGREGLTA
CEEEECCCCCEEEEECCCEEEEEEEHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHCCHH
GLLGSVYEYLGVSHIVTLDLHSREIENAFHRTRLENLHASYQIIRELAKIENLSDPDIPF
HHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
VVVAPDSGAVERNKFYSSGLKKPLAMIYKVRDYSVVAQNAKQSNIVEINLLGDVEGKTAF
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCEEEEEEEECCCCCEEE
IADDMLGSGGTMLKAMEFLKSRGAKQVIAAVSLPFFTGNALELFDEAYEKRYFSRIIGTN
EEHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCC
AVFHTQLSHKQWYTETDVSGLFARVIARIHHNQSLSSLLDDRSIIERLLHARLSVAGTPR
CEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]