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The map label for this gene is yleA [C]

Identifier: 189025503

GI number: 189025503

Start: 285765

End: 287213

Strand: Direct

Name: yleA [C]

Synonym: TPASS_0269

Alternate gene names: 189025503

Gene position: 285765-287213 (Clockwise)

Preceding gene: 189025502

Following gene: 189025504

Centisome position: 25.08

GC content: 50.38

Gene sequence:

>1449_bases
GTGTTTTCCGTTCGCATCGAGACGCTTGGCTGTCGTCTGAATCATGTCGAGTCTGAGTCGCTGGCAGCGCTCTTCTTGCA
GGAGGGCTTTGCGGTATGCCGTGGCAATACCTCCACTGCCCCAGTGGTTCTGTGTGTGATCAACACCTGCACGGTCACAA
GTAAGGCAGAGCAAAAGGCGCGGCGCCTCGTTCGTCTCCTGTTGCGCACATATCCTACTGCAATAGCGCTTGTCACTGGA
TGTTATGCGCAGCTTGAGCCTGCTTCTCTTGAAGCCATGGATGATCGTGTCCTTGCTTTTCCAGGAAAACAAAAAGATGC
CCTCAGCCTTCTGCCCTCGTGTCTCCGTGCGTTACTTGTGCAGCGTGGTCCTGCGCCGATAGATCAGTATGTATGCGGTA
TGCGTGCGCTGCTCGCTTCTTTGAAGAAAAAAATTATTTCTTTGGAACTAACGTCTGAGTTTCCATCGCAGACGCATATG
CCCACAAGGAATGCCCTTCCTCAGTTAACCGGTGTGCCTCATGCGCCGCGCGTTTCTGTATCTTCGTTTTCAGAACCTAC
AGCCGTTCCCCGTTTTGCTTTGTATGCCCCTCGTTTTTTGTTCCACTCACGCGCAAGCATTAAGGTGCAGGACGGTTGTA
ACAGTGGATGCGCTTTTTGTCGCATTCGTTTTGCACGCGGTCGCGCTGTATCACTTGAAACACACGAGGTAATTGGGCGG
GTGCAGGCCCTTGAAGCTCGTGGTATGAGCGAGGTTGTACTTACAGGGGTGAACTTGTCTCAGTATAGAAGTGGCAGTAT
AGATTTTGCGGGTTTATTAGAGTTGATTGTGCAGGAAACGCATACGATTCATATTAGAATTTCGAGTTTGTACCCAGAAA
GCGTAACATCTGCTTTTTTGCGTGCTATTGCGCACACGCGCGTGTCGCCTCATTTTCATTTATCGGTTCAGTCGGGCAGT
GATCGCGTGTTACGACGCATGCGACGCGCTTACACACGTGCGGACATTTATCAGGCAGTTTCCGATTTACGGAGTGTGCG
TGAAGAACCCTTTTTGGGTTGTGACATAATCGTCGGCTTTCCAGGGGAAACAGAGGAAGATTTTGCAGACACCCAGCGTA
TGTGCAAAACTTTGCGTTTTGCAGGTATTCATGTATTTCCGTTTTCTGCACGCCCCGGTACAGAGGCGTTTGCTATGGAT
GCAAAAGTGCCTCAGCGTATTGCAGGAGAACGCGTTGCTGCAATGCAGCAACTGGCAGAGAAAAACTACCGTGCGTATTT
GGAATATTGGAATGGGAGGGAACTATGTGCGGTGGTAGAACAGTCCGTCGCACGTGTTTTGACAGAAAATTATTTGAGCC
TCCCAATCATTGAACGGGGTGGCGTCGCTGCCTCAGCAGGATCACACGTAAGGATTAGAGTTCATAACGAGGGTGCTATC
CTCTTGTGA

Upstream 100 bases:

>100_bases
GGCCTACGACCGAGCGCTCCAGCTGAATAGAGATCTGGCTGATGCTCGCCGGGGCAGGGAGCGGGTGCTGAGGTACGTGT
TCCGTAGGTAGGTTTTCTTC

Downstream 100 bases:

>100_bases
GTTTCTGATTCGCAGTGGAGATTCATTGTTGTTAGAAAAAAACGAGCATGCAGTAGAGCGTGAGGAAGGGTCTGTGCGCG
TGTTTCCTGTCTGTCCGCTG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MFSVRIETLGCRLNHVESESLAALFLQEGFAVCRGNTSTAPVVLCVINTCTVTSKAEQKARRLVRLLLRTYPTAIALVTG
CYAQLEPASLEAMDDRVLAFPGKQKDALSLLPSCLRALLVQRGPAPIDQYVCGMRALLASLKKKIISLELTSEFPSQTHM
PTRNALPQLTGVPHAPRVSVSSFSEPTAVPRFALYAPRFLFHSRASIKVQDGCNSGCAFCRIRFARGRAVSLETHEVIGR
VQALEARGMSEVVLTGVNLSQYRSGSIDFAGLLELIVQETHTIHIRISSLYPESVTSAFLRAIAHTRVSPHFHLSVQSGS
DRVLRRMRRAYTRADIYQAVSDLRSVREEPFLGCDIIVGFPGETEEDFADTQRMCKTLRFAGIHVFPFSARPGTEAFAMD
AKVPQRIAGERVAAMQQLAEKNYRAYLEYWNGRELCAVVEQSVARVLTENYLSLPIIERGGVAASAGSHVRIRVHNEGAI
LL

Sequences:

>Translated_482_residues
MFSVRIETLGCRLNHVESESLAALFLQEGFAVCRGNTSTAPVVLCVINTCTVTSKAEQKARRLVRLLLRTYPTAIALVTG
CYAQLEPASLEAMDDRVLAFPGKQKDALSLLPSCLRALLVQRGPAPIDQYVCGMRALLASLKKKIISLELTSEFPSQTHM
PTRNALPQLTGVPHAPRVSVSSFSEPTAVPRFALYAPRFLFHSRASIKVQDGCNSGCAFCRIRFARGRAVSLETHEVIGR
VQALEARGMSEVVLTGVNLSQYRSGSIDFAGLLELIVQETHTIHIRISSLYPESVTSAFLRAIAHTRVSPHFHLSVQSGS
DRVLRRMRRAYTRADIYQAVSDLRSVREEPFLGCDIIVGFPGETEEDFADTQRMCKTLRFAGIHVFPFSARPGTEAFAMD
AKVPQRIAGERVAAMQQLAEKNYRAYLEYWNGRELCAVVEQSVARVLTENYLSLPIIERGGVAASAGSHVRIRVHNEGAI
LL
>Mature_482_residues
MFSVRIETLGCRLNHVESESLAALFLQEGFAVCRGNTSTAPVVLCVINTCTVTSKAEQKARRLVRLLLRTYPTAIALVTG
CYAQLEPASLEAMDDRVLAFPGKQKDALSLLPSCLRALLVQRGPAPIDQYVCGMRALLASLKKKIISLELTSEFPSQTHM
PTRNALPQLTGVPHAPRVSVSSFSEPTAVPRFALYAPRFLFHSRASIKVQDGCNSGCAFCRIRFARGRAVSLETHEVIGR
VQALEARGMSEVVLTGVNLSQYRSGSIDFAGLLELIVQETHTIHIRISSLYPESVTSAFLRAIAHTRVSPHFHLSVQSGS
DRVLRRMRRAYTRADIYQAVSDLRSVREEPFLGCDIIVGFPGETEEDFADTQRMCKTLRFAGIHVFPFSARPGTEAFAMD
AKVPQRIAGERVAAMQQLAEKNYRAYLEYWNGRELCAVVEQSVARVLTENYLSLPIIERGGVAASAGSHVRIRVHNEGAI
LL

Specific function: Unknown

COG id: COG0621

COG function: function code J; 2-methylthioadenine synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 MTTase N-terminal domain

Homologues:

Organism=Homo sapiens, GI93277076, Length=241, Percent_Identity=28.6307053941909, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI28872782, Length=240, Percent_Identity=28.3333333333333, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI28872784, Length=240, Percent_Identity=28.3333333333333, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI1786882, Length=306, Percent_Identity=30.718954248366, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1787057, Length=445, Percent_Identity=23.3707865168539, Blast_Score=100, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17553146, Length=238, Percent_Identity=29.8319327731092, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71996771, Length=247, Percent_Identity=28.7449392712551, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21356207, Length=483, Percent_Identity=25.2587991718427, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI19922432, Length=423, Percent_Identity=26.0047281323877, Blast_Score=118, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y269_TREPA (O83293)

Other databases:

- EMBL:   AE000520
- PIR:   G71345
- RefSeq:   NP_218710.1
- ProteinModelPortal:   O83293
- SMR:   O83293
- IntAct:   O83293
- GeneID:   2611608
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0269
- NMPDR:   fig|243276.1.peg.269
- TIGR:   TP_0269
- HOGENOM:   HBG457663
- OMA:   LHVFPFS
- ProtClustDB:   CLSK218616
- BioCyc:   TPAL243276:TP_0269-MONOMER
- InterPro:   IPR006638
- InterPro:   IPR005839
- InterPro:   IPR020612
- InterPro:   IPR013848
- InterPro:   IPR006467
- InterPro:   IPR007197
- PANTHER:   PTHR11918
- SMART:   SM00729
- TIGRFAMs:   TIGR01579
- TIGRFAMs:   TIGR00089

Pfam domain/function: PF04055 Radical_SAM; PF00919 UPF0004

EC number: NA

Molecular weight: Translated: 53174; Mature: 53174

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: PS51449 MTTASE_N; PS01278 MTTASE_RADICAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSVRIETLGCRLNHVESESLAALFLQEGFAVCRGNTSTAPVVLCVINTCTVTSKAEQKA
CCEEEEEEECCEECCCCHHHHHHHHHHHCHHEECCCCCCCCEEEEEEECCCCCHHHHHHH
RRLVRLLLRTYPTAIALVTGCYAQLEPASLEAMDDRVLAFPGKQKDALSLLPSCLRALLV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHH
QRGPAPIDQYVCGMRALLASLKKKIISLELTSEFPSQTHMPTRNALPQLTGVPHAPRVSV
HCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHCCCCCCCCCCCCCCCC
SSFSEPTAVPRFALYAPRFLFHSRASIKVQDGCNSGCAFCRIRFARGRAVSLETHEVIGR
CCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCEEEEEEECCCCEEEEHHHHHHHH
VQALEARGMSEVVLTGVNLSQYRSGSIDFAGLLELIVQETHTIHIRISSLYPESVTSAFL
HHHHHHCCCCEEEEECCCHHHHCCCCCCHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHH
RAIAHTRVSPHFHLSVQSGSDRVLRRMRRAYTRADIYQAVSDLRSVREEPFLGCDIIVGF
HHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
PGETEEDFADTQRMCKTLRFAGIHVFPFSARPGTEAFAMDAKVPQRIAGERVAAMQQLAE
CCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHH
KNYRAYLEYWNGRELCAVVEQSVARVLTENYLSLPIIERGGVAASAGSHVRIRVHNEGAI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEECCCCEEEEEEECCCCE
LL
EC
>Mature Secondary Structure
MFSVRIETLGCRLNHVESESLAALFLQEGFAVCRGNTSTAPVVLCVINTCTVTSKAEQKA
CCEEEEEEECCEECCCCHHHHHHHHHHHCHHEECCCCCCCCEEEEEEECCCCCHHHHHHH
RRLVRLLLRTYPTAIALVTGCYAQLEPASLEAMDDRVLAFPGKQKDALSLLPSCLRALLV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHH
QRGPAPIDQYVCGMRALLASLKKKIISLELTSEFPSQTHMPTRNALPQLTGVPHAPRVSV
HCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHCCCCCCCCCCCCCCCC
SSFSEPTAVPRFALYAPRFLFHSRASIKVQDGCNSGCAFCRIRFARGRAVSLETHEVIGR
CCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCEEEEEEECCCCEEEEHHHHHHHH
VQALEARGMSEVVLTGVNLSQYRSGSIDFAGLLELIVQETHTIHIRISSLYPESVTSAFL
HHHHHHCCCCEEEEECCCHHHHCCCCCCHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHH
RAIAHTRVSPHFHLSVQSGSDRVLRRMRRAYTRADIYQAVSDLRSVREEPFLGCDIIVGF
HHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
PGETEEDFADTQRMCKTLRFAGIHVFPFSARPGTEAFAMDAKVPQRIAGERVAAMQQLAE
CCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHH
KNYRAYLEYWNGRELCAVVEQSVARVLTENYLSLPIIERGGVAASAGSHVRIRVHNEGAI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEECCCCEEEEEEECCCCE
LL
EC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876