Click here to switch to the map view.

The map label for this gene is hemN [H]

Identifier: 189025419

GI number: 189025419

Start: 203020

End: 204201

Strand: Direct

Name: hemN [H]

Synonym: TPASS_0186

Alternate gene names: 189025419

Gene position: 203020-204201 (Clockwise)

Preceding gene: 189025418

Following gene: 189025420

Centisome position: 17.82

GC content: 54.48

Gene sequence:

>1182_bases
ATGTCTTCTGAGGTCGGTGCGTCTTTGTACGTGCACATCCCCTTCTGTGCGCAACGCTGTGCTTACTGCGATTTTTACTC
CCTGGTGCGTTCAACCTATTTTAGGCCTCATCAGCCTTGTCCGCATTTTATCGATCGGCTGCTACAGGATGTGGCATTGC
AGCGGGAGTGCTTTGGGGTCCAGGGGTGGCAGACAGTGTATATGGGTGGAGGTACCCCTTCGCTATTGGCACCGCAGGAC
ATTCGTCATTTTTGCGTAGCGTTACGCGCCGCGCAGCGGTATCCGATTCAGGAGTTCACTCTTGAGGTGAATCCTGAGGA
TGTGACCGAAGAGTTTTTGTGTGCGTGTGCAGAAGGCGGAGTAAACCGTTTATCCCTTGGGGTACAAAGTCTGCGTGATG
AGGTGTTGCGTGCGGAGCGTCGTGCAGCCTCTGCTGAATGTGCTCGTACCGCGCTCCGCGTGATGACGGCAAATGCGCGC
TTTTTCTCTGGCGGGGTGCGTATTTCAGCAGATCTCATCGCTGGATTGCGCGGGCAAACGGCGCGAATGGTGCGTGAGGA
TATAGATGAGCTTTTGTCTTTTGGGCTGAGACACGTGTCGCTATATGGGTTGTGTGTACCGCATCCGACTGAAACGCAAG
AGGAGCGAATTGCAGCGCTTTGGGCACACGGCAGCGCGTATCTGGTGCGTGCAGGATTTAACCGGTATGAGCTTTCGAAT
TTTGCACGTACTGCGGCGGACGAGAGCGCGCACAACAGAGCATATTGGCGGATGGCACCGCACGCAGGGGTGGGGCCTGG
CGCAGTTGGCACGCGTTTTGTCAACCTTTCTTTATCAAAGGAGGGGGCGTGGGCGATCCGCAGCACGGTGCGGAAACATC
TTGGCCAATACTTAGCAGAAGTGTGTCGGGAAAATGTGTATGAGCACGAATTCCTTACAGAACATATGTGTGTGCAAGAA
GCATTGTTAATGGGATTACGTCTTGAACAGGGACTGGATGTGGTTACATTTCGTGCGCGGTTCGGGAAGGGAATTGAAGC
GTACATTGGCAAAACAATCGCGCGGTGGCAGTGTCATGGCCGAATGCAGCGGACGGCGACGTCATTGCGTTTGAGTGCGC
AGGCACGGGTATTTCTGGACAGTTTTTTGCGAGAGGCGTTTGCAGAACTTGCGCGCACGTGA

Upstream 100 bases:

>100_bases
GGCATTCATGCGTTATTTCCCTTTCGGAGCATTTGGTGTCTTGTAGTGTGTAGGCGCCGCATTTGTGGTGCGTGCTGCGC
ATCGTGCTGTTCCTTTTATC

Downstream 100 bases:

>100_bases
GTGGTCGTGAGAATGGGTACGCCGTGTACTATTTGAATTCGGGTATATTTCCTTTGGAAGAGCTTGACAGCCTGCGTTTG
TCTTATTACCATCGGCCGCA

Product: oxygen-independent coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MSSEVGASLYVHIPFCAQRCAYCDFYSLVRSTYFRPHQPCPHFIDRLLQDVALQRECFGVQGWQTVYMGGGTPSLLAPQD
IRHFCVALRAAQRYPIQEFTLEVNPEDVTEEFLCACAEGGVNRLSLGVQSLRDEVLRAERRAASAECARTALRVMTANAR
FFSGGVRISADLIAGLRGQTARMVREDIDELLSFGLRHVSLYGLCVPHPTETQEERIAALWAHGSAYLVRAGFNRYELSN
FARTAADESAHNRAYWRMAPHAGVGPGAVGTRFVNLSLSKEGAWAIRSTVRKHLGQYLAEVCRENVYEHEFLTEHMCVQE
ALLMGLRLEQGLDVVTFRARFGKGIEAYIGKTIARWQCHGRMQRTATSLRLSAQARVFLDSFLREAFAELART

Sequences:

>Translated_393_residues
MSSEVGASLYVHIPFCAQRCAYCDFYSLVRSTYFRPHQPCPHFIDRLLQDVALQRECFGVQGWQTVYMGGGTPSLLAPQD
IRHFCVALRAAQRYPIQEFTLEVNPEDVTEEFLCACAEGGVNRLSLGVQSLRDEVLRAERRAASAECARTALRVMTANAR
FFSGGVRISADLIAGLRGQTARMVREDIDELLSFGLRHVSLYGLCVPHPTETQEERIAALWAHGSAYLVRAGFNRYELSN
FARTAADESAHNRAYWRMAPHAGVGPGAVGTRFVNLSLSKEGAWAIRSTVRKHLGQYLAEVCRENVYEHEFLTEHMCVQE
ALLMGLRLEQGLDVVTFRARFGKGIEAYIGKTIARWQCHGRMQRTATSLRLSAQARVFLDSFLREAFAELART
>Mature_392_residues
SSEVGASLYVHIPFCAQRCAYCDFYSLVRSTYFRPHQPCPHFIDRLLQDVALQRECFGVQGWQTVYMGGGTPSLLAPQDI
RHFCVALRAAQRYPIQEFTLEVNPEDVTEEFLCACAEGGVNRLSLGVQSLRDEVLRAERRAASAECARTALRVMTANARF
FSGGVRISADLIAGLRGQTARMVREDIDELLSFGLRHVSLYGLCVPHPTETQEERIAALWAHGSAYLVRAGFNRYELSNF
ARTAADESAHNRAYWRMAPHAGVGPGAVGTRFVNLSLSKEGAWAIRSTVRKHLGQYLAEVCRENVYEHEFLTEHMCVQEA
LLMGLRLEQGLDVVTFRARFGKGIEAYIGKTIARWQCHGRMQRTATSLRLSAQARVFLDSFLREAFAELART

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=292, Percent_Identity=37.3287671232877, Blast_Score=144, Evalue=1e-34,
Organism=Escherichia coli, GI1789325, Length=402, Percent_Identity=28.1094527363184, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI87082341, Length=253, Percent_Identity=26.4822134387352, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 44106; Mature: 43975

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSEVGASLYVHIPFCAQRCAYCDFYSLVRSTYFRPHQPCPHFIDRLLQDVALQRECFGV
CCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCC
QGWQTVYMGGGTPSLLAPQDIRHFCVALRAAQRYPIQEFTLEVNPEDVTEEFLCACAEGG
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHEEEECCHHHHHHHHHHHHHHCC
VNRLSLGVQSLRDEVLRAERRAASAECARTALRVMTANARFFSGGVRISADLIAGLRGQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEHHHHHCCCCHH
ARMVREDIDELLSFGLRHVSLYGLCVPHPTETQEERIAALWAHGSAYLVRAGFNRYELSN
HHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHH
FARTAADESAHNRAYWRMAPHAGVGPGAVGTRFVNLSLSKEGAWAIRSTVRKHLGQYLAE
HHHHHHCCHHCCCEEEEECCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHH
VCRENVYEHEFLTEHMCVQEALLMGLRLEQGLDVVTFRARFGKGIEAYIGKTIARWQCHG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHCCCHHHHHHHHHHHHHHHH
RMQRTATSLRLSAQARVFLDSFLREAFAELART
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSEVGASLYVHIPFCAQRCAYCDFYSLVRSTYFRPHQPCPHFIDRLLQDVALQRECFGV
CCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCC
QGWQTVYMGGGTPSLLAPQDIRHFCVALRAAQRYPIQEFTLEVNPEDVTEEFLCACAEGG
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHEEEECCHHHHHHHHHHHHHHCC
VNRLSLGVQSLRDEVLRAERRAASAECARTALRVMTANARFFSGGVRISADLIAGLRGQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEHHHHHCCCCHH
ARMVREDIDELLSFGLRHVSLYGLCVPHPTETQEERIAALWAHGSAYLVRAGFNRYELSN
HHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHH
FARTAADESAHNRAYWRMAPHAGVGPGAVGTRFVNLSLSKEGAWAIRSTVRKHLGQYLAE
HHHHHHCCHHCCCEEEEECCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHH
VCRENVYEHEFLTEHMCVQEALLMGLRLEQGLDVVTFRARFGKGIEAYIGKTIARWQCHG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHCCCHHHHHHHHHHHHHHHH
RMQRTATSLRLSAQARVFLDSFLREAFAELART
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]