Click here to switch to the map view.

The map label for this gene is hflC

Identifier: 189025348

GI number: 189025348

Start: 130880

End: 131875

Strand: Direct

Name: hflC

Synonym: TPASS_0114

Alternate gene names: 189025348

Gene position: 130880-131875 (Clockwise)

Preceding gene: 189025347

Following gene: 189025350

Centisome position: 11.49

GC content: 49.6

Gene sequence:

>996_bases
ATGAGGAAACGTGGACTACAGGTACACGCACGTGTACGACCTGTTCTGAACATAGGTATAGTCGTTGGGGTGCTGTTAGG
TGGTGTTGTGCTCCTGCAACCGTTTTACCTCATCCAGGAAGGACAGGTTGCGCTCATCACCCAGTTCGGAGAAATCATAA
AAACGAATAACACCGCTGGATTGTATGTCAGAGCTCCTTTTCTGCATCACGTGCATAAGTATACAGCCAAGCTCCTGCGC
GTTGATGGAGATCCTCAGAAGATTCCCACAAAGGAAAAACAGTTCATTGAGGTGGATACCACCAGTAGGTGGAGGATTGA
AGACGTCAAAAAGTTTTATCAGTCTTTGGGGACTTATGAGGCGGCTTACTCGCGTATTTCTGACATTATCGATTCCTCAG
TTAGGGATATTATCACTGTCAATGGCCTAGACGATGTTGTGCGAAGCACGAACGCTATCAACGAGTCCAATCACTCCGAG
CAGTTTGACGTCCCGGTGTCGCAGCTTGCCTTTGATAGGGGTGCGGAGAAAACTGCGCATATGACGATAGAAAAGGGGCG
AGAGTCTCTTGCGCGGGAGATCTCACAGGCGGCGAATGATCAGTTAAAAGATTTCGGTATTGTCGTTGTCGATGTGATCT
TCAAGGGGATTAAGTACTCAGATGAGCTGCAAGCATCTGTGTTCAATCGGATGGTAAAAGAGCGCAACCAGATCGCGCAA
ATGTTCCGCTCCACAGGCGAAGGAAAGAAGGCAGAGTGGCTTGGAAAGCTCGACAACGAAAAACGCAGTTTACTTTCAAA
AGCGTACGAGGAGGCAGAGCGTATCAAGGGTGAAGCAGACGCCCGCGCCGCGGCCGTGTACGCGCAGTCGTACGGGAAAT
CTCCTGAGTTCTACGGCTTCTGGAAAAGCTTGGAGGTGTACAAGAAATCGCTCCCCGACACGGAGAAGATCCTCTCAACC
GACTTGGAATACTTCAAGCACCTATACCAGCACTGA

Upstream 100 bases:

>100_bases
GTGCTGTTGATTGACAAAAAACTGGAGAATCTTTTAACGCTCAAGGATATCAGTAAGGTATCGAAGAAGGTCGTGGCAGG
AACACGCGAGGAGTAGGGGT

Downstream 100 bases:

>100_bases
TCGCCCACGTATGTACCGCCTGAGTCAGTGGAAGCGGTCGCGCCATTTGCTGAGGTTTCCTGTTCCAACCCACTGGTTGA
CTTGGAATCCGTGGCGGAGG

Product: Lambda CII stability-governing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MRKRGLQVHARVRPVLNIGIVVGVLLGGVVLLQPFYLIQEGQVALITQFGEIIKTNNTAGLYVRAPFLHHVHKYTAKLLR
VDGDPQKIPTKEKQFIEVDTTSRWRIEDVKKFYQSLGTYEAAYSRISDIIDSSVRDIITVNGLDDVVRSTNAINESNHSE
QFDVPVSQLAFDRGAEKTAHMTIEKGRESLAREISQAANDQLKDFGIVVVDVIFKGIKYSDELQASVFNRMVKERNQIAQ
MFRSTGEGKKAEWLGKLDNEKRSLLSKAYEEAERIKGEADARAAAVYAQSYGKSPEFYGFWKSLEVYKKSLPDTEKILST
DLEYFKHLYQH

Sequences:

>Translated_331_residues
MRKRGLQVHARVRPVLNIGIVVGVLLGGVVLLQPFYLIQEGQVALITQFGEIIKTNNTAGLYVRAPFLHHVHKYTAKLLR
VDGDPQKIPTKEKQFIEVDTTSRWRIEDVKKFYQSLGTYEAAYSRISDIIDSSVRDIITVNGLDDVVRSTNAINESNHSE
QFDVPVSQLAFDRGAEKTAHMTIEKGRESLAREISQAANDQLKDFGIVVVDVIFKGIKYSDELQASVFNRMVKERNQIAQ
MFRSTGEGKKAEWLGKLDNEKRSLLSKAYEEAERIKGEADARAAAVYAQSYGKSPEFYGFWKSLEVYKKSLPDTEKILST
DLEYFKHLYQH
>Mature_331_residues
MRKRGLQVHARVRPVLNIGIVVGVLLGGVVLLQPFYLIQEGQVALITQFGEIIKTNNTAGLYVRAPFLHHVHKYTAKLLR
VDGDPQKIPTKEKQFIEVDTTSRWRIEDVKKFYQSLGTYEAAYSRISDIIDSSVRDIITVNGLDDVVRSTNAINESNHSE
QFDVPVSQLAFDRGAEKTAHMTIEKGRESLAREISQAANDQLKDFGIVVVDVIFKGIKYSDELQASVFNRMVKERNQIAQ
MFRSTGEGKKAEWLGKLDNEKRSLLSKAYEEAERIKGEADARAAAVYAQSYGKSPEFYGFWKSLEVYKKSLPDTEKILST
DLEYFKHLYQH

Specific function: HflC and HflK could encode or regulate a protease

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily

Homologues:

Organism=Escherichia coli, GI1790617, Length=314, Percent_Identity=26.4331210191083, Blast_Score=117, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HFLC_TREPA (O83152)

Other databases:

- EMBL:   AE000520
- PIR:   A71365
- RefSeq:   NP_218554.1
- ProteinModelPortal:   O83152
- IntAct:   O83152
- GeneID:   2610895
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0114
- NMPDR:   fig|243276.1.peg.113
- TIGR:   TP_0114
- HOGENOM:   HBG427952
- OMA:   NEISITT
- ProtClustDB:   CLSK218538
- BioCyc:   TPAL243276:TP_0114-MONOMER
- InterPro:   IPR001107
- InterPro:   IPR010200
- SMART:   SM00244
- TIGRFAMs:   TIGR01932

Pfam domain/function: PF01145 Band_7

EC number: 3.4.-.-

Molecular weight: Translated: 37594; Mature: 37594

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1eb8d3b0)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKRGLQVHARVRPVLNIGIVVGVLLGGVVLLQPFYLIQEGQVALITQFGEIIKTNNTAG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCE
LYVRAPFLHHVHKYTAKLLRVDGDPQKIPTKEKQFIEVDTTSRWRIEDVKKFYQSLGTYE
EEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCHHH
AAYSRISDIIDSSVRDIITVNGLDDVVRSTNAINESNHSEQFDVPVSQLAFDRGAEKTAH
HHHHHHHHHHHHHHHHHEEECCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCHHHH
MTIEKGRESLAREISQAANDQLKDFGIVVVDVIFKGIKYSDELQASVFNRMVKERNQIAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
MFRSTGEGKKAEWLGKLDNEKRSLLSKAYEEAERIKGEADARAAAVYAQSYGKSPEFYGF
HHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHH
WKSLEVYKKSLPDTEKILSTDLEYFKHLYQH
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MRKRGLQVHARVRPVLNIGIVVGVLLGGVVLLQPFYLIQEGQVALITQFGEIIKTNNTAG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCE
LYVRAPFLHHVHKYTAKLLRVDGDPQKIPTKEKQFIEVDTTSRWRIEDVKKFYQSLGTYE
EEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCHHH
AAYSRISDIIDSSVRDIITVNGLDDVVRSTNAINESNHSEQFDVPVSQLAFDRGAEKTAH
HHHHHHHHHHHHHHHHHEEECCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCHHHH
MTIEKGRESLAREISQAANDQLKDFGIVVVDVIFKGIKYSDELQASVFNRMVKERNQIAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
MFRSTGEGKKAEWLGKLDNEKRSLLSKAYEEAERIKGEADARAAAVYAQSYGKSPEFYGF
HHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHH
WKSLEVYKKSLPDTEKILSTDLEYFKHLYQH
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9665876