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The map label for this gene is hflK

Identifier: 189025347

GI number: 189025347

Start: 129889

End: 130875

Strand: Direct

Name: hflK

Synonym: TPASS_0113

Alternate gene names: 189025347

Gene position: 129889-130875 (Clockwise)

Preceding gene: 189025345

Following gene: 189025348

Centisome position: 11.4

GC content: 46.61

Gene sequence:

>987_bases
ATGCGAATACCAAAGTGGACTCCAGCAACGTGGAGCGTGGTGGCAGGATGCATAGGTGGGGTGCTCGGTATCGTGATTGT
TGGAATTGCCTCCCCTATTAGGATCATTTCTCCCACTGATAATGGGGTGGTCACCCGTTTTGGCAAGTATCATCGGACGC
TAGAACCGGGATTGCATTATCTTATCCCCTTTGTAGAGTGGGTGTATAAAGTGCCGGTAACCAAGGTGCAAAAGGAAGAG
TTCGGGTTCAGAACGTCGAAGAGTTCCGAGCAGAGTCACTATGTGAATAATATCAGTCACGAGTCTCTTATGCTTACGGG
GGATTTGAATATTGTAGACGTCGAGTGGGTGGTTCAGTATCGCATTGTAGATCCAAGAGCATGGGTGTTTAATGTTGAGT
CCCAGGAGCGAAGGCAAACCATTCGAGACATTTCAAAAGCAGTGGTGAACAGTTTAATTGGAGATCGAGCGATTCTTGAT
ATCATGGGGCCGGAGCGCAGTGCGATTCAGATGCGTGCGAAGGATATGATGAATGTTCTCCTGAAAAGGATTGGCCTAGG
TGTTCTTGTTTCCTCCGTGCAGCTGCAAAATGTTGTTCCTCCTCAGGAGGTACAGCAAGCGTTTGAAGACGTGAATATTG
CTATTCAGGATATGAATCGACTCATTAACGAGGGAAAAGAGTCCTACAATAGGGAAATTCCTAAGGCCCGAGGTGACGCG
GACAAGTTGATTCAGGAGGCTATGGGATATGCGAATGAACGCGTAAATAGAGCAAAAGGAGATGTAGCACGTTTTGACTC
AATCTATGCTGAATATGTCAAAGCACCTCATGTTACCAAAACGCGTTTGTACCTTGAGGGACTGGGGGCTATCCTGGAAA
AGACTGAAAATGTGCTGTTGATTGACAAAAAACTGGAGAATCTTTTAACGCTCAAGGATATCAGTAAGGTATCGAAGAAG
GTCGTGGCAGGAACACGCGAGGAGTAG

Upstream 100 bases:

>100_bases
TGTCTACAACGAAGTCTGTGTGAATACGGTGAGTGTTGTCACAGGAAAATGTTTCCCGTAAGATGGGCGAAAAGACGAGC
GTGTGTAGGAAGGTGCCGTG

Downstream 100 bases:

>100_bases
GGGTATGAGGAAACGTGGACTACAGGTACACGCACGTGTACGACCTGTTCTGAACATAGGTATAGTCGTTGGGGTGCTGT
TAGGTGGTGTTGTGCTCCTG

Product: Lambda CII stability-governing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MRIPKWTPATWSVVAGCIGGVLGIVIVGIASPIRIISPTDNGVVTRFGKYHRTLEPGLHYLIPFVEWVYKVPVTKVQKEE
FGFRTSKSSEQSHYVNNISHESLMLTGDLNIVDVEWVVQYRIVDPRAWVFNVESQERRQTIRDISKAVVNSLIGDRAILD
IMGPERSAIQMRAKDMMNVLLKRIGLGVLVSSVQLQNVVPPQEVQQAFEDVNIAIQDMNRLINEGKESYNREIPKARGDA
DKLIQEAMGYANERVNRAKGDVARFDSIYAEYVKAPHVTKTRLYLEGLGAILEKTENVLLIDKKLENLLTLKDISKVSKK
VVAGTREE

Sequences:

>Translated_328_residues
MRIPKWTPATWSVVAGCIGGVLGIVIVGIASPIRIISPTDNGVVTRFGKYHRTLEPGLHYLIPFVEWVYKVPVTKVQKEE
FGFRTSKSSEQSHYVNNISHESLMLTGDLNIVDVEWVVQYRIVDPRAWVFNVESQERRQTIRDISKAVVNSLIGDRAILD
IMGPERSAIQMRAKDMMNVLLKRIGLGVLVSSVQLQNVVPPQEVQQAFEDVNIAIQDMNRLINEGKESYNREIPKARGDA
DKLIQEAMGYANERVNRAKGDVARFDSIYAEYVKAPHVTKTRLYLEGLGAILEKTENVLLIDKKLENLLTLKDISKVSKK
VVAGTREE
>Mature_328_residues
MRIPKWTPATWSVVAGCIGGVLGIVIVGIASPIRIISPTDNGVVTRFGKYHRTLEPGLHYLIPFVEWVYKVPVTKVQKEE
FGFRTSKSSEQSHYVNNISHESLMLTGDLNIVDVEWVVQYRIVDPRAWVFNVESQERRQTIRDISKAVVNSLIGDRAILD
IMGPERSAIQMRAKDMMNVLLKRIGLGVLVSSVQLQNVVPPQEVQQAFEDVNIAIQDMNRLINEGKESYNREIPKARGDA
DKLIQEAMGYANERVNRAKGDVARFDSIYAEYVKAPHVTKTRLYLEGLGAILEKTENVLLIDKKLENLLTLKDISKVSKK
VVAGTREE

Specific function: HflC and HflK could encode or regulate a protease

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily

Homologues:

Organism=Escherichia coli, GI1790616, Length=278, Percent_Identity=30.9352517985612, Blast_Score=137, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HFLK_TREPA (O83151)

Other databases:

- EMBL:   AE000520
- PIR:   H71364
- RefSeq:   NP_218553.1
- ProteinModelPortal:   O83151
- SMR:   O83151
- IntAct:   O83151
- GeneID:   2610890
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0113
- NMPDR:   fig|243276.1.peg.112
- TIGR:   TP_0113
- HOGENOM:   HBG465357
- OMA:   VLAVQMQ
- ProtClustDB:   CLSK2749627
- BioCyc:   TPAL243276:TP_0113-MONOMER
- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR001972
- PANTHER:   PTHR10264
- SMART:   SM00244
- TIGRFAMs:   TIGR01933

Pfam domain/function: PF01145 Band_7

EC number: NA

Molecular weight: Translated: 36967; Mature: 36967

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x204de68c)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIPKWTPATWSVVAGCIGGVLGIVIVGIASPIRIISPTDNGVVTRFGKYHRTLEPGLHY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHH
LIPFVEWVYKVPVTKVQKEEFGFRTSKSSEQSHYVNNISHESLMLTGDLNIVDVEWVVQY
HHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCEEEECCCCEEEEEEEEEE
RIVDPRAWVFNVESQERRQTIRDISKAVVNSLIGDRAILDIMGPERSAIQMRAKDMMNVL
EEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCHHEEEECCCCHHHHHHHHHHHHHHH
LKRIGLGVLVSSVQLQNVVPPQEVQQAFEDVNIAIQDMNRLINEGKESYNREIPKARGDA
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
DKLIQEAMGYANERVNRAKGDVARFDSIYAEYVKAPHVTKTRLYLEGLGAILEKTENVLL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEE
IDKKLENLLTLKDISKVSKKVVAGTREE
EHHHHHHHHHHHHHHHHHHHHHCCCCCH
>Mature Secondary Structure
MRIPKWTPATWSVVAGCIGGVLGIVIVGIASPIRIISPTDNGVVTRFGKYHRTLEPGLHY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHH
LIPFVEWVYKVPVTKVQKEEFGFRTSKSSEQSHYVNNISHESLMLTGDLNIVDVEWVVQY
HHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCEEEECCCCEEEEEEEEEE
RIVDPRAWVFNVESQERRQTIRDISKAVVNSLIGDRAILDIMGPERSAIQMRAKDMMNVL
EEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCHHEEEECCCCHHHHHHHHHHHHHHH
LKRIGLGVLVSSVQLQNVVPPQEVQQAFEDVNIAIQDMNRLINEGKESYNREIPKARGDA
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
DKLIQEAMGYANERVNRAKGDVARFDSIYAEYVKAPHVTKTRLYLEGLGAILEKTENVLL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEE
IDKKLENLLTLKDISKVSKKVVAGTREE
EHHHHHHHHHHHHHHHHHHHHHCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9665876