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Identifier: 189025279

GI number: 189025279

Start: 54535

End: 55434

Strand: Reverse

Name: add

Synonym: TPASS_0045

Alternate gene names: 189025279

Gene position: 55434-54535 (Counterclockwise)

Preceding gene: 189025280

Following gene: 189025272

Centisome position: 4.86

GC content: 43.33

Gene sequence:

>900_bases
ATGAAGAGTCTTGAATATTATCGATCACAGCCAAAAGCAGATGTGCACACGCATCTGAATTTGAGTATGAAATACGAACG
ATATAAGCAATGGTCAGGAGTAGTCATTCCAAACTTTCCACGTAAAATGCGCGGGCTCGACGAAATGCATGAAATTATTG
GTGAGTACACGCGTCCTCAGTGTAAAACTGCGCAAGACGTGTTGAATTTGTTTACCATGTCCATAGAGGATGCCATTGCA
GACAATGTCGTCGTAATGGAGACATCAGTTGATATTGGCTTTATCACCCATTATGAAGAAAATTTGGATCATTTCTTATG
TGATTTAAGCGATCTGCATCGACGCTACAAGCGCAATGTTACCCTTCACTTTGAGCTCGGTATCTCCAAAATACGAGAGC
GCAGCTTCGTAGAACAGTGGGCTGAGCCCATGATGCGAAGCGGTATCTTTGAAAATATTGACCTCTACGGTCCAGAGATT
TCCGAAGGAATCGAAGATTTCATCTATATTTTTAAACTGGCCGAGAAGTATCACTTAAAAAAGAAAGCCCACGTAGGCGA
GTTCTCTGATGCGCAATCGGTACGGCACTTTGTCGAAATATTTAACCTGGACGAAGTCCAACATGGCATCGGAGCCGCTA
CTGACGAGAACGTTTTGCGGTTTCTAGCTGAAAGAAAAGTTCGCTGTAACGTATGTCCAACCAGTAATGTCATGCTCAAC
GCGGTGGAATGCCTAGAAAAACATCCTATAAAAAAAATGATGGATGCAGGGGTCCGTGTTGGGTTAGGAACTGACGATCT
TCTCTTTTTTGGAAAAACAAATAGCGAACAATTGTTTGATATGGTTTCCTGTGGCCTTATCACCGAACTTCACGCCGAAG
CGCTCCTTGCTGTGCGTTAA

Upstream 100 bases:

>100_bases
GATTTTTTATAAGTCTCCATTGAATATAGGAAACGAGTATACCCGTTAAAAGCATAGCATTGCTCGACATTATCTATTGT
TTTACGCAAGAGGATGCAGA

Downstream 100 bases:

>100_bases
AAGTACGTACAAACACCTGCCTGATAAGGCGGTTCTTCTATCTCTGCGGTAGCTGCTACCGCTTTAAGTGGGCGAGCAAC
AGCATTACGTCAGAGGGTCT

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MKSLEYYRSQPKADVHTHLNLSMKYERYKQWSGVVIPNFPRKMRGLDEMHEIIGEYTRPQCKTAQDVLNLFTMSIEDAIA
DNVVVMETSVDIGFITHYEENLDHFLCDLSDLHRRYKRNVTLHFELGISKIRERSFVEQWAEPMMRSGIFENIDLYGPEI
SEGIEDFIYIFKLAEKYHLKKKAHVGEFSDAQSVRHFVEIFNLDEVQHGIGAATDENVLRFLAERKVRCNVCPTSNVMLN
AVECLEKHPIKKMMDAGVRVGLGTDDLLFFGKTNSEQLFDMVSCGLITELHAEALLAVR

Sequences:

>Translated_299_residues
MKSLEYYRSQPKADVHTHLNLSMKYERYKQWSGVVIPNFPRKMRGLDEMHEIIGEYTRPQCKTAQDVLNLFTMSIEDAIA
DNVVVMETSVDIGFITHYEENLDHFLCDLSDLHRRYKRNVTLHFELGISKIRERSFVEQWAEPMMRSGIFENIDLYGPEI
SEGIEDFIYIFKLAEKYHLKKKAHVGEFSDAQSVRHFVEIFNLDEVQHGIGAATDENVLRFLAERKVRCNVCPTSNVMLN
AVECLEKHPIKKMMDAGVRVGLGTDDLLFFGKTNSEQLFDMVSCGLITELHAEALLAVR
>Mature_299_residues
MKSLEYYRSQPKADVHTHLNLSMKYERYKQWSGVVIPNFPRKMRGLDEMHEIIGEYTRPQCKTAQDVLNLFTMSIEDAIA
DNVVVMETSVDIGFITHYEENLDHFLCDLSDLHRRYKRNVTLHFELGISKIRERSFVEQWAEPMMRSGIFENIDLYGPEI
SEGIEDFIYIFKLAEKYHLKKKAHVGEFSDAQSVRHFVEIFNLDEVQHGIGAATDENVLRFLAERKVRCNVCPTSNVMLN
AVECLEKHPIKKMMDAGVRVGLGTDDLLFFGKTNSEQLFDMVSCGLITELHAEALLAVR

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family

Homologues:

Organism=Escherichia coli, GI1787910, Length=114, Percent_Identity=28.9473684210526, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324188, Length=133, Percent_Identity=29.3233082706767, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADD_TREPA (O83085)

Other databases:

- EMBL:   AE000520
- PIR:   D71374
- RefSeq:   NP_218485.1
- ProteinModelPortal:   O83085
- IntAct:   O83085
- GeneID:   2610787
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0045
- NMPDR:   fig|243276.1.peg.44
- TIGR:   TP_0045
- HOGENOM:   HBG630382
- OMA:   WIEPMIS
- ProtClustDB:   PRK09358
- BioCyc:   TPAL243276:TP_0045-MONOMER
- BRENDA:   3.5.4.4
- HAMAP:   MF_00540
- InterPro:   IPR001365
- InterPro:   IPR006330
- PANTHER:   PTHR11409

Pfam domain/function: PF00962 A_deaminase

EC number: =3.5.4.4

Molecular weight: Translated: 34543; Mature: 34543

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00485 A_DEAMINASE

Important sites: ACT_SITE 187-187 BINDING 18-18 BINDING 157-157 BINDING 266-266

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLEYYRSQPKADVHTHLNLSMKYERYKQWSGVVIPNFPRKMRGLDEMHEIIGEYTRPQ
CCCCHHHHCCCCCCHHHEEEEEEEHHHHHHCCCCCCCCCCHHHCCHHHHHHHHHHHCCCC
CKTAQDVLNLFTMSIEDAIADNVVVMETSVDIGFITHYEENLDHFLCDLSDLHRRYKRNV
CCCHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCE
TLHFELGISKIRERSFVEQWAEPMMRSGIFENIDLYGPEISEGIEDFIYIFKLAEKYHLK
EEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KKAHVGEFSDAQSVRHFVEIFNLDEVQHGIGAATDENVLRFLAERKVRCNVCPTSNVMLN
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEECCCCCHHHHH
AVECLEKHPIKKMMDAGVRVGLGTDDLLFFGKTNSEQLFDMVSCGLITELHAEALLAVR
HHHHHHHCCHHHHHHCCCEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKSLEYYRSQPKADVHTHLNLSMKYERYKQWSGVVIPNFPRKMRGLDEMHEIIGEYTRPQ
CCCCHHHHCCCCCCHHHEEEEEEEHHHHHHCCCCCCCCCCHHHCCHHHHHHHHHHHCCCC
CKTAQDVLNLFTMSIEDAIADNVVVMETSVDIGFITHYEENLDHFLCDLSDLHRRYKRNV
CCCHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCE
TLHFELGISKIRERSFVEQWAEPMMRSGIFENIDLYGPEISEGIEDFIYIFKLAEKYHLK
EEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KKAHVGEFSDAQSVRHFVEIFNLDEVQHGIGAATDENVLRFLAERKVRCNVCPTSNVMLN
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEECCCCCHHHHH
AVECLEKHPIKKMMDAGVRVGLGTDDLLFFGKTNSEQLFDMVSCGLITELHAEALLAVR
HHHHHHHCCHHHHHHCCCEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876