Click here to switch to the map view.

The map label for this gene is ywlC [H]

Identifier: 188587452

GI number: 188587452

Start: 3093270

End: 3094373

Strand: Reverse

Name: ywlC [H]

Synonym: Nther_2862

Alternate gene names: 188587452

Gene position: 3094373-3093270 (Counterclockwise)

Preceding gene: 188587455

Following gene: 188587451

Centisome position: 97.75

GC content: 40.58

Gene sequence:

>1104_bases
ATGACTAAGTTTGAAAAAGTCGACAAAATAAAACCAGATAAAACTATTATAAAACAAGCGGCAGGAATTGTCCGCCAGAA
CGGTTTAGTCGCCTTTCCAACAGAGACTGTCTATGGACTAGGAGGGAATGGACTTAGTCCTGCTGCAATACAAAAAATAT
TCCAGGCAAAAAACCGCCCATTGGATAATCCGGTGATTTTACATTTGCACTCTGTCAATCAAGTTGAAACACTAGGCTTT
CCACCTGAAGAATTCTTTTTTTTAGCCGAAAAATTTTGGCCTGGTCCCTTGACTATGATTATACCTAAAAAAAATATTGT
CCCAAGGGAGGCCTCTGGAGGTTTAGATACAGTAGCGGTTAGAATGCCGGATCATAACGTAGCCCTTGCTTTAATCCAGG
AAGCTCAGGTTCCCATGGCTGCTCCTAGTGCTAATTTATCAGGACGTCCCAGTCCAACAACAGCTGCCCATGTGGAACTC
GATCTTAGCGGTCGAATAGACATGATCATAGATGGAGGAACAACAGGGGTTGGTTTGGAATCAACTGTGATTGATCTTTC
CGAGAAACCTTATCAGGTGTTGCGCCCAGGAGGAATCACAGCAGAACAACTTGCTTCTGCCCTTGATTATTGTCAGGATA
CCTTTTTGTATACAGGATCAGAGGAGGATTATTACGCGGAAGGAAATCAATCAAGTTGTGACGAAATGATTACAAAGGAT
AAAAATTCCATTAAATCACCAGGTGTTAAATATCGACACTATTCTCCTCAAGGTGAGTTATATCTGGTGGAAGGTAGTGG
ACACAAGCTTTTACATAAAATGTATGAATATGCAAATGATTTTTCAAAGCAGGGTTATAGGATCGGAATATTGTTGACTA
ATGAACTATTAGAAGAGGATGGCAACCTTCATAAGTTTTGCTATGTAAGACGCCTCGGCAATGAAGATCAACTGACAGAA
GTGGCTCATAGCTTATACGATGCCCTTAGGGAAATGGACCAACAAGGAATAGAAATCATTTTATGTCGTACATTTTCTCC
CAAGGGAATTGGTGTTGCTCTTATGAATAGGCTCTTAAAGGCATCAAATGGTAAAGTCCTTTAA

Upstream 100 bases:

>100_bases
TATATGTCATGGTGAAAAATGGGTCAATTAACAGGAAATAATTAATAAATGTAGAAAATCATAGAGAATCAAAAAGCTTG
CAATAAGGAAGTGATAAAAA

Downstream 100 bases:

>100_bases
ATCACTACTTGTTTACACAATTATTAAACAGCTAGATCCAATAAATGAAAGGAGGACTTATTATTAGGACTATATTATTT
GTTTGCACAGGAAATACATG

Product: Sua5/YciO/YrdC/YwlC family protein

Products: NA

Alternate protein names: t(6)A37 threonylcarbamoyladenosine biosynthesis protein YwlC [H]

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MTKFEKVDKIKPDKTIIKQAAGIVRQNGLVAFPTETVYGLGGNGLSPAAIQKIFQAKNRPLDNPVILHLHSVNQVETLGF
PPEEFFFLAEKFWPGPLTMIIPKKNIVPREASGGLDTVAVRMPDHNVALALIQEAQVPMAAPSANLSGRPSPTTAAHVEL
DLSGRIDMIIDGGTTGVGLESTVIDLSEKPYQVLRPGGITAEQLASALDYCQDTFLYTGSEEDYYAEGNQSSCDEMITKD
KNSIKSPGVKYRHYSPQGELYLVEGSGHKLLHKMYEYANDFSKQGYRIGILLTNELLEEDGNLHKFCYVRRLGNEDQLTE
VAHSLYDALREMDQQGIEIILCRTFSPKGIGVALMNRLLKASNGKVL

Sequences:

>Translated_367_residues
MTKFEKVDKIKPDKTIIKQAAGIVRQNGLVAFPTETVYGLGGNGLSPAAIQKIFQAKNRPLDNPVILHLHSVNQVETLGF
PPEEFFFLAEKFWPGPLTMIIPKKNIVPREASGGLDTVAVRMPDHNVALALIQEAQVPMAAPSANLSGRPSPTTAAHVEL
DLSGRIDMIIDGGTTGVGLESTVIDLSEKPYQVLRPGGITAEQLASALDYCQDTFLYTGSEEDYYAEGNQSSCDEMITKD
KNSIKSPGVKYRHYSPQGELYLVEGSGHKLLHKMYEYANDFSKQGYRIGILLTNELLEEDGNLHKFCYVRRLGNEDQLTE
VAHSLYDALREMDQQGIEIILCRTFSPKGIGVALMNRLLKASNGKVL
>Mature_366_residues
TKFEKVDKIKPDKTIIKQAAGIVRQNGLVAFPTETVYGLGGNGLSPAAIQKIFQAKNRPLDNPVILHLHSVNQVETLGFP
PEEFFFLAEKFWPGPLTMIIPKKNIVPREASGGLDTVAVRMPDHNVALALIQEAQVPMAAPSANLSGRPSPTTAAHVELD
LSGRIDMIIDGGTTGVGLESTVIDLSEKPYQVLRPGGITAEQLASALDYCQDTFLYTGSEEDYYAEGNQSSCDEMITKDK
NSIKSPGVKYRHYSPQGELYLVEGSGHKLLHKMYEYANDFSKQGYRIGILLTNELLEEDGNLHKFCYVRRLGNEDQLTEV
AHSLYDALREMDQQGIEIILCRTFSPKGIGVALMNRLLKASNGKVL

Specific function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (Probable) [H]

COG id: COG0009

COG function: function code J; Putative translation factor (SUA5)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 YrdC-like domain [H]

Homologues:

Organism=Homo sapiens, GI58761510, Length=190, Percent_Identity=30, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI2367210, Length=152, Percent_Identity=32.2368421052632, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87081864, Length=199, Percent_Identity=28.1407035175879, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17537239, Length=196, Percent_Identity=29.5918367346939, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321269, Length=387, Percent_Identity=34.3669250645995, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI78707274, Length=194, Percent_Identity=28.8659793814433, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR005145
- InterPro:   IPR004388
- InterPro:   IPR006070
- InterPro:   IPR010923 [H]

Pfam domain/function: PF03481 SUA5; PF01300 Sua5_yciO_yrdC [H]

EC number: NA

Molecular weight: Translated: 40410; Mature: 40279

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS51163 YRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKFEKVDKIKPDKTIIKQAAGIVRQNGLVAFPTETVYGLGGNGLSPAAIQKIFQAKNRP
CCCCHHHHCCCCHHHHHHHHHHHHHCCCEEEECCCEEEECCCCCCCHHHHHHHHHHHCCC
LDNPVILHLHSVNQVETLGFPPEEFFFLAEKFWPGPLTMIIPKKNIVPREASGGLDTVAV
CCCCEEEEEECCCCEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEEE
RMPDHNVALALIQEAQVPMAAPSANLSGRPSPTTAAHVELDLSGRIDMIIDGGTTGVGLE
ECCCCCEEEEEEHHCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCEEEEEECCCCCCCCC
STVIDLSEKPYQVLRPGGITAEQLASALDYCQDTFLYTGSEEDYYAEGNQSSCDEMITKD
CEEEECCCCCHHHCCCCCCCHHHHHHHHHHHHHCEEEECCCCCEECCCCCCHHHHHHHCC
KNSIKSPGVKYRHYSPQGELYLVEGSGHKLLHKMYEYANDFSKQGYRIGILLTNELLEED
CHHHCCCCCEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHCCEEEEEEEEHHHHHCC
GNLHKFCYVRRLGNEDQLTEVAHSLYDALREMDQQGIEIILCRTFSPKGIGVALMNRLLK
CCEEEEEHEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHH
ASNGKVL
CCCCCCC
>Mature Secondary Structure 
TKFEKVDKIKPDKTIIKQAAGIVRQNGLVAFPTETVYGLGGNGLSPAAIQKIFQAKNRP
CCCHHHHCCCCHHHHHHHHHHHHHCCCEEEECCCEEEECCCCCCCHHHHHHHHHHHCCC
LDNPVILHLHSVNQVETLGFPPEEFFFLAEKFWPGPLTMIIPKKNIVPREASGGLDTVAV
CCCCEEEEEECCCCEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEEE
RMPDHNVALALIQEAQVPMAAPSANLSGRPSPTTAAHVELDLSGRIDMIIDGGTTGVGLE
ECCCCCEEEEEEHHCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCEEEEEECCCCCCCCC
STVIDLSEKPYQVLRPGGITAEQLASALDYCQDTFLYTGSEEDYYAEGNQSSCDEMITKD
CEEEECCCCCHHHCCCCCCCHHHHHHHHHHHHHCEEEECCCCCEECCCCCCHHHHHHHCC
KNSIKSPGVKYRHYSPQGELYLVEGSGHKLLHKMYEYANDFSKQGYRIGILLTNELLEED
CHHHCCCCCEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHCCEEEEEEEEHHHHHCC
GNLHKFCYVRRLGNEDQLTEVAHSLYDALREMDQQGIEIILCRTFSPKGIGVALMNRLLK
CCEEEEEHEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHH
ASNGKVL
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]