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The map label for this gene is sstT [H]

Identifier: 188587405

GI number: 188587405

Start: 3041815

End: 3043056

Strand: Reverse

Name: sstT [H]

Synonym: Nther_2814

Alternate gene names: 188587405

Gene position: 3043056-3041815 (Counterclockwise)

Preceding gene: 188587406

Following gene: 188587404

Centisome position: 96.13

GC content: 39.53

Gene sequence:

>1242_bases
GTGATCAAAAATTTAGGTTTAATACCAAGACTTGTTATTGCTATTATTTTAGGTACTGTTATTGGTATGTTTTTTCCTGA
ATGGACGGGAGACTTACTCTATACCCTGTCGAGTATTTTTGGTCAGCTGTTGTTTTATGTAGTTCCTTTAATTATTTTGG
CCTTTATTATTCCAGGTATTGCTGAGCTGGGAGAGAAGCCGGGGAAAATGTTGGGTTTGACTGCAGGAGTGGCTTATCTA
TCAACAATTATTGCGGGAACCATAGCTTTTTTCGCTGCCATGTTTATCATTCCTAGTATTACTCCAGAACTGGTGGAAGT
GGAAGAAAGTACAGGTTTATCAACTTTTATTGAGATTGAAATTGAACCTTTAATGGGTATTATGACTGCATTAGTAACAG
CTTTTATATTTGGTATTGGTATCAACTATCTAAAAAATGTCAAAGAAGAAAAAACATTGTATAGATTCATGTTGGAATTT
AGGGAAGTTACAAGAATGGTAATTCAAAAGGTTATTATCCCATTACTCCCACTGTATATTGCAGGTATTTTTGCCAACAT
GGCTGCTGAAGGGACTGTTTTTACAACACTAGGTTTATTTGCACCTTTATTTGGTCTGGTAATTGGTGTTCAGCTACTCT
ATTTGCTAATGCAATATACAGTAGCCAACCGACTTTCGCCTAAAAACCCGATTTTCGGGAGTATTCGAAAAATGGTCCCA
GCTTATACCACTGCTTTGGGCACGGTATCAAGTGCGGCTACTTTACCGGTTACTTTAAAAAGTGCAAAAACCCTAAGTGT
ACCTGAAAAAATTACTGATTTAGTTGTACCTTTAGGCGCTACCATCCACTTAGCTGGTAGTACCATTGCCCTAACCATTA
GTGCAGTAACTGTTTACCTACTTCATATTGGTACACCAGATTTTCTATCTTTTCTCCCTTTCATCATGATGTTAGGAGTT
GTTATGATCGGTGCACCTGGAGTTCCTGGTGGAGCGGTCATGGCGGCTTTGGGACTTTTGGGTTCGATGCTGGGCTTTGG
TGAAACAGAGATAGCGTTGATGATAGCCCTTTATATGGGTCAAGACCCCTTTGGTACTGCGTGTAACGTAACTGGAGATG
GTGCTAACAGTATTATTGTCAGTGCTTTTGCTAAAGAACCTGGTTCCCAGCCTACAGAACCGGATTCAGGTGTTCAGGAA
CCAATAATTGATGAGCAAATGACTCCAAAGGTAGAGGGTTAG

Upstream 100 bases:

>100_bases
TTATTACTATATTCCTTTTGGATTATCTTTGAGAATTAGAGATTATTCAGGGAATATAAATAAACTCTTCCTAAGAAGAG
TATCCAGGAGGATGGAAAAT

Downstream 100 bases:

>100_bases
GAGATGCTAAAGCTAATATGGCGGGACTTTAGAAGTCCCGCTTTTTTTATGTTTATTCGATTATGTTATAATTTGATAAG
ATGTTAAATAATTTGAGAAG

Product: sodium:dicarboxylate symporter

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: Na(+)/serine-threonine symporter [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MIKNLGLIPRLVIAIILGTVIGMFFPEWTGDLLYTLSSIFGQLLFYVVPLIILAFIIPGIAELGEKPGKMLGLTAGVAYL
STIIAGTIAFFAAMFIIPSITPELVEVEESTGLSTFIEIEIEPLMGIMTALVTAFIFGIGINYLKNVKEEKTLYRFMLEF
REVTRMVIQKVIIPLLPLYIAGIFANMAAEGTVFTTLGLFAPLFGLVIGVQLLYLLMQYTVANRLSPKNPIFGSIRKMVP
AYTTALGTVSSAATLPVTLKSAKTLSVPEKITDLVVPLGATIHLAGSTIALTISAVTVYLLHIGTPDFLSFLPFIMMLGV
VMIGAPGVPGGAVMAALGLLGSMLGFGETEIALMIALYMGQDPFGTACNVTGDGANSIIVSAFAKEPGSQPTEPDSGVQE
PIIDEQMTPKVEG

Sequences:

>Translated_413_residues
MIKNLGLIPRLVIAIILGTVIGMFFPEWTGDLLYTLSSIFGQLLFYVVPLIILAFIIPGIAELGEKPGKMLGLTAGVAYL
STIIAGTIAFFAAMFIIPSITPELVEVEESTGLSTFIEIEIEPLMGIMTALVTAFIFGIGINYLKNVKEEKTLYRFMLEF
REVTRMVIQKVIIPLLPLYIAGIFANMAAEGTVFTTLGLFAPLFGLVIGVQLLYLLMQYTVANRLSPKNPIFGSIRKMVP
AYTTALGTVSSAATLPVTLKSAKTLSVPEKITDLVVPLGATIHLAGSTIALTISAVTVYLLHIGTPDFLSFLPFIMMLGV
VMIGAPGVPGGAVMAALGLLGSMLGFGETEIALMIALYMGQDPFGTACNVTGDGANSIIVSAFAKEPGSQPTEPDSGVQE
PIIDEQMTPKVEG
>Mature_413_residues
MIKNLGLIPRLVIAIILGTVIGMFFPEWTGDLLYTLSSIFGQLLFYVVPLIILAFIIPGIAELGEKPGKMLGLTAGVAYL
STIIAGTIAFFAAMFIIPSITPELVEVEESTGLSTFIEIEIEPLMGIMTALVTAFIFGIGINYLKNVKEEKTLYRFMLEF
REVTRMVIQKVIIPLLPLYIAGIFANMAAEGTVFTTLGLFAPLFGLVIGVQLLYLLMQYTVANRLSPKNPIFGSIRKMVP
AYTTALGTVSSAATLPVTLKSAKTLSVPEKITDLVVPLGATIHLAGSTIALTISAVTVYLLHIGTPDFLSFLPFIMMLGV
VMIGAPGVPGGAVMAALGLLGSMLGFGETEIALMIALYMGQDPFGTACNVTGDGANSIIVSAFAKEPGSQPTEPDSGVQE
PIIDEQMTPKVEG

Specific function: Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI223468564, Length=278, Percent_Identity=28.4172661870504, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI223468566, Length=278, Percent_Identity=28.4172661870504, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI5032093, Length=278, Percent_Identity=28.4172661870504, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI194239697, Length=193, Percent_Identity=30.0518134715026, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI66773030, Length=266, Percent_Identity=29.3233082706767, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI169790839, Length=277, Percent_Identity=27.0758122743682, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1789947, Length=433, Percent_Identity=24.2494226327945, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71983099, Length=304, Percent_Identity=25.3289473684211, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71983106, Length=304, Percent_Identity=25.3289473684211, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24583025, Length=153, Percent_Identity=27.4509803921569, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17137668, Length=153, Percent_Identity=27.4509803921569, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24583023, Length=153, Percent_Identity=27.4509803921569, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR023025 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43921; Mature: 43921

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure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CCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA