Click here to switch to the map view.

The map label for this gene is lctP [H]

Identifier: 188587402

GI number: 188587402

Start: 3036448

End: 3037983

Strand: Reverse

Name: lctP [H]

Synonym: Nther_2811

Alternate gene names: 188587402

Gene position: 3037983-3036448 (Counterclockwise)

Preceding gene: 188587403

Following gene: 188587401

Centisome position: 95.97

GC content: 35.09

Gene sequence:

>1536_bases
ATGATAGTAGATATTTTTGCTGTAATTCCAATTCTAATATTATTAATATTTCTTTTATTGTTTAAATTACCAGCCAGAAA
AGCAGGTGCTATATCATTCTTGACAGCTACTGGGATTTCTTTGTGGGTATTTCAATTACCCCTAGAAGGTATGGTAGTAG
CATTGGGAAAAGGGTTTTCCCTATCACTATTTGTGTTATTGATAATTTGGGCAGCTGTTTTTCTATACAATTTAGTCAAT
GAAGCAGGTGCCATTGAAGTGATCAGTCGTAATTTAACTTTAGTAATCGAAGATAAGTTTGTACAATTTTTATTGTTAAG
TTGGGTCTTCTCCTCTTTTTTACAGGGGATTGCTGGATTTGGAGTGCCTGTGGCTATTGTGACTCCTATACTAGTAAAAT
TAGGTTTTAATCCTTTCGCTTCAGTAGCTGCAGTATTACTTGGGCATAGTTGGTCTATAAGTTTTGGCTCTATGGGATCT
TCTTTTTACACTATTGGACTAGTTACAGGCTTACCTTCTAGTGATCTCGCTTTTTGGATGTCACTATATACATCAGTAGC
TATGTTATTTACAGGTTTTGGAGTTTGCTATATTTATGGAGGATTTCAAGCTATTACTAAGGGAGTCCCTTATATTCTTT
CTACAACTGTTGTCATGGTTGGTTCTATGTTTATCATTACTTATCTACAGATGATGTCCGTTGTTTCCTTATTAACTGCA
TTAGTTGGATTAGTGTTTTTGTTTTTTGTTTATCGAAAGTTGGTTGTCCCTACCAAAGAGAACTATGATAGTGGAATAAA
TTTTTATCGAGGTAAACTCAATCTACTTGAGTCTATTTTACCCTATGGACTAATCATAATTTTATCAGTGTTATTTCAAC
TCTCCCCGATTCAAGGACCAGAATTAAATTTTGATTTTCCTGGCTTTGAAACTGGATTGGGCTATATCGTCACAGAAGAA
TTGCAATATGTAACCATCGATCTATTGACTCATCCAGCACCAATTATATTAATTTCCTCCTTGGCAGGTATATTTGTTTA
TAATAGTAAACAAATACTGTCCCGGACAGAAATTTCTCAAGTCGTTAATAAAACAGTCGAAAAATGTACTGGGACCACAC
TGACCTTGACATGGTTAATTTGTATGGCTTTGTTAATGATGGATTCAGGCATGATAGAAAATATGGCTCATAATGTAGCC
AATTTAACTGGTCAATTTTACCCGATTTTTGCACCGTTCTTTGGTGTTTTAGGTAGCTTTATCACAGGTAGTAATACTAA
TTCAAATGTGATATTTGGAAGTTTTCAGGCTACAGTAGCAACTACTTTGGGGGTTAGCCCGGCTATTATGGCGGCTGTCC
AATCTATCGGAGGATCTGTAGGATGTAGTATTGGCCCTACCCAGGTATTACTGGGGACGTCTTCAGTAAATTTAAATGGT
AAGGAAGCTTATATTTATGGCCGTATAATACATATAACTTTATTGATTGCTGTGATTTTAGGAATGGTTAATTGGGTGTT
GTTAAATACATTATAA

Upstream 100 bases:

>100_bases
TGGTTTACAAAAGAAAGTAGTAGTTATCAGACCAGTAGCAGCAGGACCGTTTAAGGTCCTGTTTTGTTTAGGTCAGCAAT
CAGAAAGGGGATAAAGCTTC

Downstream 100 bases:

>100_bases
ACTTGGGTTTATAGGCTTTTAAACATAGACTGGATTAGAGTTGAATGTTGATAACTGTAAATTTAATTTTACAGTATCAA
CAACTAAATATTACAGTGCC

Product: L-lactate permease

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MIVDIFAVIPILILLIFLLLFKLPARKAGAISFLTATGISLWVFQLPLEGMVVALGKGFSLSLFVLLIIWAAVFLYNLVN
EAGAIEVISRNLTLVIEDKFVQFLLLSWVFSSFLQGIAGFGVPVAIVTPILVKLGFNPFASVAAVLLGHSWSISFGSMGS
SFYTIGLVTGLPSSDLAFWMSLYTSVAMLFTGFGVCYIYGGFQAITKGVPYILSTTVVMVGSMFIITYLQMMSVVSLLTA
LVGLVFLFFVYRKLVVPTKENYDSGINFYRGKLNLLESILPYGLIIILSVLFQLSPIQGPELNFDFPGFETGLGYIVTEE
LQYVTIDLLTHPAPIILISSLAGIFVYNSKQILSRTEISQVVNKTVEKCTGTTLTLTWLICMALLMMDSGMIENMAHNVA
NLTGQFYPIFAPFFGVLGSFITGSNTNSNVIFGSFQATVATTLGVSPAIMAAVQSIGGSVGCSIGPTQVLLGTSSVNLNG
KEAYIYGRIIHITLLIAVILGMVNWVLLNTL

Sequences:

>Translated_511_residues
MIVDIFAVIPILILLIFLLLFKLPARKAGAISFLTATGISLWVFQLPLEGMVVALGKGFSLSLFVLLIIWAAVFLYNLVN
EAGAIEVISRNLTLVIEDKFVQFLLLSWVFSSFLQGIAGFGVPVAIVTPILVKLGFNPFASVAAVLLGHSWSISFGSMGS
SFYTIGLVTGLPSSDLAFWMSLYTSVAMLFTGFGVCYIYGGFQAITKGVPYILSTTVVMVGSMFIITYLQMMSVVSLLTA
LVGLVFLFFVYRKLVVPTKENYDSGINFYRGKLNLLESILPYGLIIILSVLFQLSPIQGPELNFDFPGFETGLGYIVTEE
LQYVTIDLLTHPAPIILISSLAGIFVYNSKQILSRTEISQVVNKTVEKCTGTTLTLTWLICMALLMMDSGMIENMAHNVA
NLTGQFYPIFAPFFGVLGSFITGSNTNSNVIFGSFQATVATTLGVSPAIMAAVQSIGGSVGCSIGPTQVLLGTSSVNLNG
KEAYIYGRIIHITLLIAVILGMVNWVLLNTL
>Mature_511_residues
MIVDIFAVIPILILLIFLLLFKLPARKAGAISFLTATGISLWVFQLPLEGMVVALGKGFSLSLFVLLIIWAAVFLYNLVN
EAGAIEVISRNLTLVIEDKFVQFLLLSWVFSSFLQGIAGFGVPVAIVTPILVKLGFNPFASVAAVLLGHSWSISFGSMGS
SFYTIGLVTGLPSSDLAFWMSLYTSVAMLFTGFGVCYIYGGFQAITKGVPYILSTTVVMVGSMFIITYLQMMSVVSLLTA
LVGLVFLFFVYRKLVVPTKENYDSGINFYRGKLNLLESILPYGLIIILSVLFQLSPIQGPELNFDFPGFETGLGYIVTEE
LQYVTIDLLTHPAPIILISSLAGIFVYNSKQILSRTEISQVVNKTVEKCTGTTLTLTWLICMALLMMDSGMIENMAHNVA
NLTGQFYPIFAPFFGVLGSFITGSNTNSNVIFGSFQATVATTLGVSPAIMAAVQSIGGSVGCSIGPTQVLLGTSSVNLNG
KEAYIYGRIIHITLLIAVILGMVNWVLLNTL

Specific function: Plays a role in L-lactate utilization [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=537, Percent_Identity=24.2085661080074, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1790031, Length=533, Percent_Identity=25.515947467167, Blast_Score=127, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 55270; Mature: 55270

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVDIFAVIPILILLIFLLLFKLPARKAGAISFLTATGISLWVFQLPLEGMVVALGKGFS
CEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHCCCCCEEEEECCCCH
LSLFVLLIIWAAVFLYNLVNEAGAIEVISRNLTLVIEDKFVQFLLLSWVFSSFLQGIAGF
HHHHHHHHHHHHHHHHHHHCCCCHHEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHCC
GVPVAIVTPILVKLGFNPFASVAAVLLGHSWSISFGSMGSSFYTIGLVTGLPSSDLAFWM
CCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEECCCCCCCEEEEEEEECCCCHHHHHHH
SLYTSVAMLFTGFGVCYIYGGFQAITKGVPYILSTTVVMVGSMFIITYLQMMSVVSLLTA
HHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVGLVFLFFVYRKLVVPTKENYDSGINFYRGKLNLLESILPYGLIIILSVLFQLSPIQGP
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ELNFDFPGFETGLGYIVTEELQYVTIDLLTHPAPIILISSLAGIFVYNSKQILSRTEISQ
CCCCCCCCHHCCCCCEEECCHHEEEEEHHHCCCHHHHHHHHHHHEEECCHHHHHHHHHHH
VVNKTVEKCTGTTLTLTWLICMALLMMDSGMIENMAHNVANLTGQFYPIFAPFFGVLGSF
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
ITGSNTNSNVIFGSFQATVATTLGVSPAIMAAVQSIGGSVGCSIGPTQVLLGTSSVNLNG
HCCCCCCCCEEEECHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCEEEEECCEECCCC
KEAYIYGRIIHITLLIAVILGMVNWVLLNTL
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIVDIFAVIPILILLIFLLLFKLPARKAGAISFLTATGISLWVFQLPLEGMVVALGKGFS
CEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHCCCCCEEEEECCCCH
LSLFVLLIIWAAVFLYNLVNEAGAIEVISRNLTLVIEDKFVQFLLLSWVFSSFLQGIAGF
HHHHHHHHHHHHHHHHHHHCCCCHHEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHCC
GVPVAIVTPILVKLGFNPFASVAAVLLGHSWSISFGSMGSSFYTIGLVTGLPSSDLAFWM
CCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEECCCCCCCEEEEEEEECCCCHHHHHHH
SLYTSVAMLFTGFGVCYIYGGFQAITKGVPYILSTTVVMVGSMFIITYLQMMSVVSLLTA
HHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVGLVFLFFVYRKLVVPTKENYDSGINFYRGKLNLLESILPYGLIIILSVLFQLSPIQGP
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ELNFDFPGFETGLGYIVTEELQYVTIDLLTHPAPIILISSLAGIFVYNSKQILSRTEISQ
CCCCCCCCHHCCCCCEEECCHHEEEEEHHHCCCHHHHHHHHHHHEEECCHHHHHHHHHHH
VVNKTVEKCTGTTLTLTWLICMALLMMDSGMIENMAHNVANLTGQFYPIFAPFFGVLGSF
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
ITGSNTNSNVIFGSFQATVATTLGVSPAIMAAVQSIGGSVGCSIGPTQVLLGTSSVNLNG
HCCCCCCCCEEEECHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCEEEEECCEECCCC
KEAYIYGRIIHITLLIAVILGMVNWVLLNTL
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10508058 [H]