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The map label for this gene is nagA [H]

Identifier: 188587362

GI number: 188587362

Start: 2990638

End: 2991861

Strand: Reverse

Name: nagA [H]

Synonym: Nther_2769

Alternate gene names: 188587362

Gene position: 2991861-2990638 (Counterclockwise)

Preceding gene: 188587364

Following gene: 188587361

Centisome position: 94.51

GC content: 39.3

Gene sequence:

>1224_bases
ATGGCTCTGATTTTGCGGAATGCACAATTGATTACGGAACAGGGGGTTCTTTCTCCGGGTTATCTAATAGCCGGAAACGA
TGGCTATATTTGGGATTTAGGTCGAGATGTTGATGATAATGTTCTGGCTCCTAGTGATACTTCTATTGATCAGGGAGAGT
TGGGGCTCATTGAGAGCAAAGAAATTGACTTACAGGGAAAATACTTGGCGCCAGGCTTCATTGATCTACATACTCACGGC
GGACTAGGATTCGATATAATGGATGCGGATACAAAAGGACTAGAAAAAATAAGCGCATTCTATTTAAAACAGGGTGTGAC
TGGTTTTTTAGCTACTACTTTCTCATCATCCTGGTCGGAAATCAAACAAGCTGTAGGGACTGTCAGAAAATATTTAGATA
ACAAAGCTAGCAATCAAATTGACACTAATTTACTGGGAATGCATTTAGAAGGCCCTTTTATTAATCCAGAAAAAAAGGGA
GTTCAAACGGAGAAAAATATCATTCCCCCTTCATTAAAAAGTGTTAACGAGTTATGGGAACTTGCTGGGGCGCATTTGTA
CATGATATCTCTGGCTCCTGAAATGAAAAATGCATCTCAACTGATTAAATGGGGGAGAAGACACAACATAATTATGTCAG
CTGCCCACACAGATGCTACTTATGAAGAGATGAACAATGCTTTTAGTGCAGGATTATCCCACGGGGCTCATTTATTTAAT
GGCATGAGTGCAATTCACCATAGAGCTCCTGGTGCTGCTATAGCCTTGCTCCTACATCCTGAAGCGACCATTGAATTAAT
TGTCGATGGGAAACATCTTCATCCAGCTATCCTTGATTTAGTAATTAAGCAGAAACCCTTAGATAAAATTGTCCTTGTTA
CTGACTCCATCCGAGGGACTGGTTTAGAAGAGGGAAAATTTCAACTAGATAAACAGATAGTTACTGTAAAAAATAACACT
GCAAAAACTCAAGAAGGGCAATTAGCTGGCAGCACCCTCACTATACCAGAGGCCCTGAAAAATATTATGAAATTCACCTC
TCTATCTTTGACTGAAGCTGTAAAGATGATATCTTTAACACCGGCCAAAATTCTTGGGTTGTCACAGGAAAGAGGCAGCT
TATTACCCGGCAAAAGAGCGGATGCAGCAGTATTAACAGAAAAACTGGAAGTAAAAAACACAATTTTAAAAGGAAAATTG
ATAAATAATGAAATTAACAGCTAA

Upstream 100 bases:

>100_bases
GAATACTTTTAAGTTTAATTGAAGTTTTACAGTTATCAATATTCATCTTTTACATCTTAAAACTAAGTAGTACGTAGAAT
TATTTTAGGGAGGGCTTTAT

Downstream 100 bases:

>100_bases
TTTTTCTCTAAAAAACTATCGCCGGGTGGTTTGGGGGGTGTTAGCCCTTGCCTATTTACTGGGCTTTTTCCATCGCTATT
CTCTTGGCGTTGTAGCAGAT

Product: N-acetylglucosamine-6-phosphate deacetylase

Products: NA

Alternate protein names: GlcNAc 6-P deacetylase [H]

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MALILRNAQLITEQGVLSPGYLIAGNDGYIWDLGRDVDDNVLAPSDTSIDQGELGLIESKEIDLQGKYLAPGFIDLHTHG
GLGFDIMDADTKGLEKISAFYLKQGVTGFLATTFSSSWSEIKQAVGTVRKYLDNKASNQIDTNLLGMHLEGPFINPEKKG
VQTEKNIIPPSLKSVNELWELAGAHLYMISLAPEMKNASQLIKWGRRHNIIMSAAHTDATYEEMNNAFSAGLSHGAHLFN
GMSAIHHRAPGAAIALLLHPEATIELIVDGKHLHPAILDLVIKQKPLDKIVLVTDSIRGTGLEEGKFQLDKQIVTVKNNT
AKTQEGQLAGSTLTIPEALKNIMKFTSLSLTEAVKMISLTPAKILGLSQERGSLLPGKRADAAVLTEKLEVKNTILKGKL
INNEINS

Sequences:

>Translated_407_residues
MALILRNAQLITEQGVLSPGYLIAGNDGYIWDLGRDVDDNVLAPSDTSIDQGELGLIESKEIDLQGKYLAPGFIDLHTHG
GLGFDIMDADTKGLEKISAFYLKQGVTGFLATTFSSSWSEIKQAVGTVRKYLDNKASNQIDTNLLGMHLEGPFINPEKKG
VQTEKNIIPPSLKSVNELWELAGAHLYMISLAPEMKNASQLIKWGRRHNIIMSAAHTDATYEEMNNAFSAGLSHGAHLFN
GMSAIHHRAPGAAIALLLHPEATIELIVDGKHLHPAILDLVIKQKPLDKIVLVTDSIRGTGLEEGKFQLDKQIVTVKNNT
AKTQEGQLAGSTLTIPEALKNIMKFTSLSLTEAVKMISLTPAKILGLSQERGSLLPGKRADAAVLTEKLEVKNTILKGKL
INNEINS
>Mature_406_residues
ALILRNAQLITEQGVLSPGYLIAGNDGYIWDLGRDVDDNVLAPSDTSIDQGELGLIESKEIDLQGKYLAPGFIDLHTHGG
LGFDIMDADTKGLEKISAFYLKQGVTGFLATTFSSSWSEIKQAVGTVRKYLDNKASNQIDTNLLGMHLEGPFINPEKKGV
QTEKNIIPPSLKSVNELWELAGAHLYMISLAPEMKNASQLIKWGRRHNIIMSAAHTDATYEEMNNAFSAGLSHGAHLFNG
MSAIHHRAPGAAIALLLHPEATIELIVDGKHLHPAILDLVIKQKPLDKIVLVTDSIRGTGLEEGKFQLDKQIVTVKNNTA
KTQEGQLAGSTLTIPEALKNIMKFTSLSLTEAVKMISLTPAKILGLSQERGSLLPGKRADAAVLTEKLEVKNTILKGKLI
NNEINS

Specific function: N-acetylglucosamine utilization. [C]

COG id: COG1820

COG function: function code G; N-acetylglucosamine-6-phosphate deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nagA family [H]

Homologues:

Organism=Homo sapiens, GI21361513, Length=387, Percent_Identity=28.9405684754522, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI224922791, Length=387, Percent_Identity=28.6821705426357, Blast_Score=142, Evalue=4e-34,
Organism=Escherichia coli, GI1786892, Length=345, Percent_Identity=32.463768115942, Blast_Score=164, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17553768, Length=361, Percent_Identity=31.5789473684211, Blast_Score=150, Evalue=8e-37,
Organism=Drosophila melanogaster, GI281361140, Length=370, Percent_Identity=30.2702702702703, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI19920392, Length=357, Percent_Identity=30.812324929972, Blast_Score=150, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR003764
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.1.25 [H]

Molecular weight: Translated: 44190; Mature: 44059

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALILRNAQLITEQGVLSPGYLIAGNDGYIWDLGRDVDDNVLAPSDTSIDQGELGLIESK
CEEEEECCCHHHHCCCCCCCEEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEECC
EIDLQGKYLAPGFIDLHTHGGLGFDIMDADTKGLEKISAFYLKQGVTGFLATTFSSSWSE
CCCCCCCEECCCEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHCCCHHH
IKQAVGTVRKYLDNKASNQIDTNLLGMHLEGPFINPEKKGVQTEKNIIPPSLKSVNELWE
HHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHCCCCCCCCCCCCCHHHHHHHHH
LAGAHLYMISLAPEMKNASQLIKWGRRHNIIMSAAHTDATYEEMNNAFSAGLSHGAHLFN
HCCCEEEEEEECCCCCCHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
GMSAIHHRAPGAAIALLLHPEATIELIVDGKHLHPAILDLVIKQKPLDKIVLVTDSIRGT
HHHHHHHCCCCEEEEEEECCCCEEEEEEECCCCCHHHHHHHHCCCCCCEEEEEECCCCCC
GLEEGKFQLDKQIVTVKNNTAKTQEGQLAGSTLTIPEALKNIMKFTSLSLTEAVKMISLT
CCCCCCEEECCEEEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCC
PAKILGLSQERGSLLPGKRADAAVLTEKLEVKNTILKGKLINNEINS
HHHHHCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEECCCCCC
>Mature Secondary Structure 
ALILRNAQLITEQGVLSPGYLIAGNDGYIWDLGRDVDDNVLAPSDTSIDQGELGLIESK
EEEEECCCHHHHCCCCCCCEEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEECC
EIDLQGKYLAPGFIDLHTHGGLGFDIMDADTKGLEKISAFYLKQGVTGFLATTFSSSWSE
CCCCCCCEECCCEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHCCCHHH
IKQAVGTVRKYLDNKASNQIDTNLLGMHLEGPFINPEKKGVQTEKNIIPPSLKSVNELWE
HHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHCCCCCCCCCCCCCHHHHHHHHH
LAGAHLYMISLAPEMKNASQLIKWGRRHNIIMSAAHTDATYEEMNNAFSAGLSHGAHLFN
HCCCEEEEEEECCCCCCHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
GMSAIHHRAPGAAIALLLHPEATIELIVDGKHLHPAILDLVIKQKPLDKIVLVTDSIRGT
HHHHHHHCCCCEEEEEEECCCCEEEEEEECCCCCHHHHHHHHCCCCCCEEEEEECCCCCC
GLEEGKFQLDKQIVTVKNNTAKTQEGQLAGSTLTIPEALKNIMKFTSLSLTEAVKMISLT
CCCCCCEEECCEEEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCC
PAKILGLSQERGSLLPGKRADAAVLTEKLEVKNTILKGKLINNEINS
HHHHHCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]