Click here to switch to the map view.

The map label for this gene is gcvPA [H]

Identifier: 188587343

GI number: 188587343

Start: 2968946

End: 2970292

Strand: Reverse

Name: gcvPA [H]

Synonym: Nther_2749

Alternate gene names: 188587343

Gene position: 2970292-2968946 (Counterclockwise)

Preceding gene: 188587344

Following gene: 188587342

Centisome position: 93.83

GC content: 39.72

Gene sequence:

>1347_bases
TTGAATAATAACTATTTACCTCATACTGACAATGAGCGAAGGGAAATGTTAGAGGCTATTGGGGTAGACTCGGTCCGTGA
GCTTTTTAAAGATATTCCCAAGGATGTCCTACTGGACCGAGATCTGGACTTACCACCTTCATTATCTGAGCCAGAGTTGA
TTAAACACATGCAGGACCTGGCCGATAAAAATGAAGACTTAACAGAATACACTCCTTTTTTAGGGGCTGGAGTGTATGAT
CATTATATTCCCAGTGCCATAGGACACATTTTGAAAAGAAGTGAATTTTATACGGCATACACACCATATCAAGCTGAAGC
TAGCCAGGGTACCCTGCAGACAATATTTGAATATCAAACTATGATTTCTGAACTTACCGGTATGGAAGTCGCCAATGCTT
CCATGTACGATGGTGCAACTTCTGTGGCTGAAGCAGCATTAATGAGCTTAAAAGCTGCAAAAGGCAATACTGTCCTGGTT
TCAGAAACCGTTAACCCTAGTTATCGACAAGTATTAAGAACTTATGTAGAAAATCAGGGGTTTGAAGTAAAAACAATTCC
CCAGGATGGTGGCGTAACAAATAAAACAGAAATTGAAAATGCCCTATCGAAAGATGTTGCCTGCTATATTGCTCAGACAC
CTAATTTCTTTGGAAATTTAGAGCAATTGGAAGGAATCAAAGATAAGTTAAAAGAGCATAAAGCCATGTTTGTAGTTTGT
GCTGATCCTATCTCCTTAGGGCTTATCAAGCCCCCTGCAGAACACGGTGCTGATATTGTAGTAGGTGATGGCCAAAGTCT
TGGAAACCCCATGAACATGGGAGGACCTTTACTAGGATTCTTTGCCAGCACGAAAAAATTAATTCGCAAAATGCCTGGTA
GGATAATTGGTGAAACTACTGACACAGAAGGTAATAGGGGGTTTGTGTTAAACTTACAAACTAGAGAACAGCATATCAGA
AGAGAAAAAGCTACATCTAACATTTGCTCCAACCAAGCCCTGAATGCTCTGGCAGCGTGTGTTTACTTAACATTAATGGG
CCCCCAGGGTTTAAAACAAGTAGCTAACTTGTCCCTACAAAAAGCTAATTATGCCAAAGAGAAAATAACAGAATTAGATG
GTTATGAATTGGCCTTTGACCGACCCTTTTTCAAAGAATTCGTAATTAAAACACCCAAACCTGTTAGTGAGATAAATGAG
CAACTTCTTGACAGGAAGATAGTAGGAGGTCTTGACCTGGGACGCTTTTATTCTGGTTTAGAAAATCACATGTTGATCTG
TGTGACTGAGAAAAGAACCAAAGAAGAAATTGACAATTTGGTTCTTGGATTGGAGGGTATTAAATGA

Upstream 100 bases:

>100_bases
TAGCTGTCTTTCAACTTTCTGATGAGTCTGAGTTAGAAGAGTTATTGTCCGCTGAAGAATATCAAAATTATTTACAAGAA
ATTGAAGAGGAGGAATAGTT

Downstream 100 bases:

>100_bases
GTAAACAAAAAGCTCTTATCTTTGAACTAGGAGGCAGTGGGAGGAAGGGCTTCTCCCTGCCAGAAAGCGATGTCCCCGAA
CAAGACCTAAAAGATTTGCT

Product: glycine dehydrogenase (decarboxylating) alpha subunit

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MNNNYLPHTDNERREMLEAIGVDSVRELFKDIPKDVLLDRDLDLPPSLSEPELIKHMQDLADKNEDLTEYTPFLGAGVYD
HYIPSAIGHILKRSEFYTAYTPYQAEASQGTLQTIFEYQTMISELTGMEVANASMYDGATSVAEAALMSLKAAKGNTVLV
SETVNPSYRQVLRTYVENQGFEVKTIPQDGGVTNKTEIENALSKDVACYIAQTPNFFGNLEQLEGIKDKLKEHKAMFVVC
ADPISLGLIKPPAEHGADIVVGDGQSLGNPMNMGGPLLGFFASTKKLIRKMPGRIIGETTDTEGNRGFVLNLQTREQHIR
REKATSNICSNQALNALAACVYLTLMGPQGLKQVANLSLQKANYAKEKITELDGYELAFDRPFFKEFVIKTPKPVSEINE
QLLDRKIVGGLDLGRFYSGLENHMLICVTEKRTKEEIDNLVLGLEGIK

Sequences:

>Translated_448_residues
MNNNYLPHTDNERREMLEAIGVDSVRELFKDIPKDVLLDRDLDLPPSLSEPELIKHMQDLADKNEDLTEYTPFLGAGVYD
HYIPSAIGHILKRSEFYTAYTPYQAEASQGTLQTIFEYQTMISELTGMEVANASMYDGATSVAEAALMSLKAAKGNTVLV
SETVNPSYRQVLRTYVENQGFEVKTIPQDGGVTNKTEIENALSKDVACYIAQTPNFFGNLEQLEGIKDKLKEHKAMFVVC
ADPISLGLIKPPAEHGADIVVGDGQSLGNPMNMGGPLLGFFASTKKLIRKMPGRIIGETTDTEGNRGFVLNLQTREQHIR
REKATSNICSNQALNALAACVYLTLMGPQGLKQVANLSLQKANYAKEKITELDGYELAFDRPFFKEFVIKTPKPVSEINE
QLLDRKIVGGLDLGRFYSGLENHMLICVTEKRTKEEIDNLVLGLEGIK
>Mature_448_residues
MNNNYLPHTDNERREMLEAIGVDSVRELFKDIPKDVLLDRDLDLPPSLSEPELIKHMQDLADKNEDLTEYTPFLGAGVYD
HYIPSAIGHILKRSEFYTAYTPYQAEASQGTLQTIFEYQTMISELTGMEVANASMYDGATSVAEAALMSLKAAKGNTVLV
SETVNPSYRQVLRTYVENQGFEVKTIPQDGGVTNKTEIENALSKDVACYIAQTPNFFGNLEQLEGIKDKLKEHKAMFVVC
ADPISLGLIKPPAEHGADIVVGDGQSLGNPMNMGGPLLGFFASTKKLIRKMPGRIIGETTDTEGNRGFVLNLQTREQHIR
REKATSNICSNQALNALAACVYLTLMGPQGLKQVANLSLQKANYAKEKITELDGYELAFDRPFFKEFVIKTPKPVSEINE
QLLDRKIVGGLDLGRFYSGLENHMLICVTEKRTKEEIDNLVLGLEGIK

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=401, Percent_Identity=33.6658354114713, Blast_Score=224, Evalue=1e-58,
Organism=Escherichia coli, GI1789269, Length=354, Percent_Identity=37.5706214689266, Blast_Score=203, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17535605, Length=351, Percent_Identity=37.3219373219373, Blast_Score=223, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6323843, Length=438, Percent_Identity=33.7899543378995, Blast_Score=232, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24645648, Length=343, Percent_Identity=40.2332361516035, Blast_Score=255, Evalue=4e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 49721; Mature: 49721

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNNYLPHTDNERREMLEAIGVDSVRELFKDIPKDVLLDRDLDLPPSLSEPELIKHMQDL
CCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHCCHHHHCCCCCCCCCCCCCHHHHHHHHHH
ADKNEDLTEYTPFLGAGVYDHYIPSAIGHILKRSEFYTAYTPYQAEASQGTLQTIFEYQT
HCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHH
MISELTGMEVANASMYDGATSVAEAALMSLKAAKGNTVLVSETVNPSYRQVLRTYVENQG
HHHHHCCCHHCCCCHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCC
FEVKTIPQDGGVTNKTEIENALSKDVACYIAQTPNFFGNLEQLEGIKDKLKEHKAMFVVC
CEEEECCCCCCCCCHHHHHHHHHHCCEEEEECCCCHHCCHHHHHHHHHHHHHCCEEEEEE
ADPISLGLIKPPAEHGADIVVGDGQSLGNPMNMGGPLLGFFASTKKLIRKMPGRIIGETT
ECCCCCCCCCCCHHCCCEEEEECCHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCC
DTEGNRGFVLNLQTREQHIRREKATSNICSNQALNALAACVYLTLMGPQGLKQVANLSLQ
CCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
KANYAKEKITELDGYELAFDRPFFKEFVIKTPKPVSEINEQLLDRKIVGGLDLGRFYSGL
HHHHHHHHHHHCCCCEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCC
ENHMLICVTEKRTKEEIDNLVLGLEGIK
CCCEEEEEECHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNNNYLPHTDNERREMLEAIGVDSVRELFKDIPKDVLLDRDLDLPPSLSEPELIKHMQDL
CCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHCCHHHHCCCCCCCCCCCCCHHHHHHHHHH
ADKNEDLTEYTPFLGAGVYDHYIPSAIGHILKRSEFYTAYTPYQAEASQGTLQTIFEYQT
HCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHH
MISELTGMEVANASMYDGATSVAEAALMSLKAAKGNTVLVSETVNPSYRQVLRTYVENQG
HHHHHCCCHHCCCCHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCC
FEVKTIPQDGGVTNKTEIENALSKDVACYIAQTPNFFGNLEQLEGIKDKLKEHKAMFVVC
CEEEECCCCCCCCCHHHHHHHHHHCCEEEEECCCCHHCCHHHHHHHHHHHHHCCEEEEEE
ADPISLGLIKPPAEHGADIVVGDGQSLGNPMNMGGPLLGFFASTKKLIRKMPGRIIGETT
ECCCCCCCCCCCHHCCCEEEEECCHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCC
DTEGNRGFVLNLQTREQHIRREKATSNICSNQALNALAACVYLTLMGPQGLKQVANLSLQ
CCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
KANYAKEKITELDGYELAFDRPFFKEFVIKTPKPVSEINEQLLDRKIVGGLDLGRFYSGL
HHHHHHHHHHHCCCCEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCC
ENHMLICVTEKRTKEEIDNLVLGLEGIK
CCCEEEEEECHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA