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The map label for this gene is cat2 [H]

Identifier: 188587337

GI number: 188587337

Start: 2961204

End: 2962502

Strand: Reverse

Name: cat2 [H]

Synonym: Nther_2743

Alternate gene names: 188587337

Gene position: 2962502-2961204 (Counterclockwise)

Preceding gene: 188587338

Following gene: 188587336

Centisome position: 93.59

GC content: 38.95

Gene sequence:

>1299_bases
ATGCGTCTCAAAGAGGAATATCGTAAAAAACTAGTTTCTTTGGACGAAGGGGTTTCACAAATTAAATCCGGTGATGAGGT
GGTAACAGCCATGGCTGCTTCACAACCCCCTGGGCTAATGAACCAGCTGGGAAGTAGAAGAGATTATGTGAGGGATGTCA
GGGTTATCACCTGTTTACCTCTGGCAGAGTATAGTTTTTACAGTCAGGAAGGTATGGAGGATAGTTTTTTCATGGAAAGC
TGGTTTTATGGCCCTCATGTCAGAAAAGCTGCCAAACAAGGTGCCAATGTCAGCTATATTCCCAATCATCTTCATTTATC
GGCCACTCGTAGGTTCCAATATAGAAAACCTGATGTTTTTCTAGGTACTGCCACCCCAATGGACAAACACGGGAATTTTT
CCTTGTCCCTTGGTATTACCTACGAGAAAGAGGCTATAGAACAAGCCAATATAGTTATTTTAGAGATTAATGAAAATTTA
CCCAGGACCTATGGAGATATCAATGTTCATATATCTCAGGTTGATTATTTAGTTGAAAATAATACTTCTCTATTTACTTT
GCCAGAAATAGAACCTACAGACAAAGATCATAAGATAGGTGGTTACATTGCCGAACTCGTTGAAGACGAGTCAACTTTGC
AATTGGGAATAGGTGGAATACCAAACGCAGTAGCAAAAGCCCTGGAAGATAAACGAGATTTAGGTATTCATACCGAAATG
ATGACAGATGGTATGGTAGATCTATATGAAAAAGGTGTTATTACTAATAGGAAAAAAACCCTTTGGAAAGATAAAATGTT
GGCTACCTTTGCCTATGGTTCTCAAAAGCTCTATGACTTTCTAGACAATAATTTGGGAGTGGAATTTCAGAGGGGTAAAG
TAGTAAATAACCCATATATTATTGGTCATAACTGGAAAATGGTTAGCATTAACACTGCATTGCAGGTAGATTTAACAGGT
CAAGTTTGTTCTGAAAGTCTGGGTCATTCTATATACAGTGGAACCGGCGGCCAATGTGATACAGCTGTAGGTTCACAGAA
GTCAGAGGGTGGTAAGTCAATTATTGCCCTTTACTCCTCAGTCAAAGATGATACTATCTCGACAATAGTTCCTGCATTGA
ATGAAGGAGCAGGAATCACCTTACCTAGAAATGACGTAGATTATGTAGTTACAGAATACGGTGTAGCAGCCCTGAGAGGG
CGCTCAATTAAAGAACGAGTCGAAAATTTAATAAATATAGCTCACCCGAATTTTAGAGAAGAATTAAAATCTGAGGCAAA
AAGTAAAGGGATTATTTAG

Upstream 100 bases:

>100_bases
AATGGGGTAATTAAAGAAGGATATGTTACTTTAATCTAGCCTGGGCTTAATAGATTTTTTAATTGAATCTTATCAAAGTT
AACTTTTGGGAGGGACTAAA

Downstream 100 bases:

>100_bases
AGAACTAAATTTTAAATATAACTGGAGGGATTGATTGTGAAATTACAAGATAAAGTGGCATTGATTACAGGAGGGGCAGC
TGGAATTGGTAAAGTTACAG

Product: acetyl-CoA hydrolase/transferase

Products: propionate; succinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MRLKEEYRKKLVSLDEGVSQIKSGDEVVTAMAASQPPGLMNQLGSRRDYVRDVRVITCLPLAEYSFYSQEGMEDSFFMES
WFYGPHVRKAAKQGANVSYIPNHLHLSATRRFQYRKPDVFLGTATPMDKHGNFSLSLGITYEKEAIEQANIVILEINENL
PRTYGDINVHISQVDYLVENNTSLFTLPEIEPTDKDHKIGGYIAELVEDESTLQLGIGGIPNAVAKALEDKRDLGIHTEM
MTDGMVDLYEKGVITNRKKTLWKDKMLATFAYGSQKLYDFLDNNLGVEFQRGKVVNNPYIIGHNWKMVSINTALQVDLTG
QVCSESLGHSIYSGTGGQCDTAVGSQKSEGGKSIIALYSSVKDDTISTIVPALNEGAGITLPRNDVDYVVTEYGVAALRG
RSIKERVENLINIAHPNFREELKSEAKSKGII

Sequences:

>Translated_432_residues
MRLKEEYRKKLVSLDEGVSQIKSGDEVVTAMAASQPPGLMNQLGSRRDYVRDVRVITCLPLAEYSFYSQEGMEDSFFMES
WFYGPHVRKAAKQGANVSYIPNHLHLSATRRFQYRKPDVFLGTATPMDKHGNFSLSLGITYEKEAIEQANIVILEINENL
PRTYGDINVHISQVDYLVENNTSLFTLPEIEPTDKDHKIGGYIAELVEDESTLQLGIGGIPNAVAKALEDKRDLGIHTEM
MTDGMVDLYEKGVITNRKKTLWKDKMLATFAYGSQKLYDFLDNNLGVEFQRGKVVNNPYIIGHNWKMVSINTALQVDLTG
QVCSESLGHSIYSGTGGQCDTAVGSQKSEGGKSIIALYSSVKDDTISTIVPALNEGAGITLPRNDVDYVVTEYGVAALRG
RSIKERVENLINIAHPNFREELKSEAKSKGII
>Mature_432_residues
MRLKEEYRKKLVSLDEGVSQIKSGDEVVTAMAASQPPGLMNQLGSRRDYVRDVRVITCLPLAEYSFYSQEGMEDSFFMES
WFYGPHVRKAAKQGANVSYIPNHLHLSATRRFQYRKPDVFLGTATPMDKHGNFSLSLGITYEKEAIEQANIVILEINENL
PRTYGDINVHISQVDYLVENNTSLFTLPEIEPTDKDHKIGGYIAELVEDESTLQLGIGGIPNAVAKALEDKRDLGIHTEM
MTDGMVDLYEKGVITNRKKTLWKDKMLATFAYGSQKLYDFLDNNLGVEFQRGKVVNNPYIIGHNWKMVSINTALQVDLTG
QVCSESLGHSIYSGTGGQCDTAVGSQKSEGGKSIIALYSSVKDDTISTIVPALNEGAGITLPRNDVDYVVTEYGVAALRG
RSIKERVENLINIAHPNFREELKSEAKSKGII

Specific function: Unknown

COG id: COG0427

COG function: function code C; Acetyl-CoA hydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetyl-CoA hydrolase/transferase family [H]

Homologues:

Organism=Escherichia coli, GI1789287, Length=216, Percent_Identity=28.7037037037037, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI32563853, Length=435, Percent_Identity=39.3103448275862, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17538151, Length=442, Percent_Identity=33.9366515837104, Blast_Score=224, Evalue=6e-59,
Organism=Saccharomyces cerevisiae, GI6319456, Length=276, Percent_Identity=29.3478260869565, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21358615, Length=423, Percent_Identity=38.7706855791962, Blast_Score=272, Evalue=4e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003702 [H]

Pfam domain/function: PF02550 AcetylCoA_hydro [H]

EC number: NA

Molecular weight: Translated: 48031; Mature: 48031

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLKEEYRKKLVSLDEGVSQIKSGDEVVTAMAASQPPGLMNQLGSRRDYVRDVRVITCLP
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHCCHHHHHHHEEEEEEEE
LAEYSFYSQEGMEDSFFMESWFYGPHVRKAAKQGANVSYIPNHLHLSATRRFQYRKPDVF
HHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHCCCCEEECCCEEEEEEHHCEECCCCCEE
LGTATPMDKHGNFSLSLGITYEKEAIEQANIVILEINENLPRTYGDINVHISQVDYLVEN
EECCCCCCCCCCEEEEEEEEECHHHHCCCCEEEEEECCCCCCCCCCEEEEEEEEEEEEEC
NTSLFTLPEIEPTDKDHKIGGYIAELVEDESTLQLGIGGIPNAVAKALEDKRDLGIHTEM
CCEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCHHH
MTDGMVDLYEKGVITNRKKTLWKDKMLATFAYGSQKLYDFLDNNLGVEFQRGKVVNNPYI
HHCCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEECCEEECCCEE
IGHNWKMVSINTALQVDLTGQVCSESLGHSIYSGTGGQCDTAVGSQKSEGGKSIIALYSS
EECCEEEEEECEEEEEEECHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCCEEEEHHHH
VKDDTISTIVPALNEGAGITLPRNDVDYVVTEYGVAALRGRSIKERVENLINIAHPNFRE
CCCCHHHHHHHHHCCCCCEEECCCCCCCHHHHHCHHHHCCCHHHHHHHHHHHHCCCCHHH
ELKSEAKSKGII
HHHHHHHHCCCC
>Mature Secondary Structure
MRLKEEYRKKLVSLDEGVSQIKSGDEVVTAMAASQPPGLMNQLGSRRDYVRDVRVITCLP
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHCCHHHHHHHEEEEEEEE
LAEYSFYSQEGMEDSFFMESWFYGPHVRKAAKQGANVSYIPNHLHLSATRRFQYRKPDVF
HHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHCCCCEEECCCEEEEEEHHCEECCCCCEE
LGTATPMDKHGNFSLSLGITYEKEAIEQANIVILEINENLPRTYGDINVHISQVDYLVEN
EECCCCCCCCCCEEEEEEEEECHHHHCCCCEEEEEECCCCCCCCCCEEEEEEEEEEEEEC
NTSLFTLPEIEPTDKDHKIGGYIAELVEDESTLQLGIGGIPNAVAKALEDKRDLGIHTEM
CCEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCHHH
MTDGMVDLYEKGVITNRKKTLWKDKMLATFAYGSQKLYDFLDNNLGVEFQRGKVVNNPYI
HHCCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEECCEEECCCEE
IGHNWKMVSINTALQVDLTGQVCSESLGHSIYSGTGGQCDTAVGSQKSEGGKSIIALYSS
EECCEEEEEECEEEEEEECHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCCEEEEHHHH
VKDDTISTIVPALNEGAGITLPRNDVDYVVTEYGVAALRGRSIKERVENLINIAHPNFRE
CCCCHHHHHHHHHCCCCCEEECCCCCCCHHHHHCHHHHCCCHHHHHHHHHHHHCCCCHHH
ELKSEAKSKGII
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: propionyl-CoA; succinate [C]

Specific reaction: propionyl-CoA + succinate = propionate + succinyl-CoA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550525 [H]