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The map label for this gene is pbpE [H]

Identifier: 188587322

GI number: 188587322

Start: 2942976

End: 2944436

Strand: Reverse

Name: pbpE [H]

Synonym: Nther_2727

Alternate gene names: 188587322

Gene position: 2944436-2942976 (Counterclockwise)

Preceding gene: 188587323

Following gene: 188587320

Centisome position: 93.01

GC content: 38.95

Gene sequence:

>1461_bases
GTGGATTTTGGTGCAAAATTATCTCAAAGAGAACTTAAGTCTTTGGAAAGTTTTTTAGCTAATGTTCAAAGGGATCATGA
TTCCCCGGGATTAGCAGTAGCTATCACTAAAGGCGATGAACTGATATACGCTTCTGGATTTGGGTACCGGGATTTAGGTG
AAAAAGCTTACATTGATGAAAATACCATTATGGGGATTGCCTCTATTACAAAGACGTTTACTGCTGCGGCAATATTAAAG
CTGCAAGAACAGGGCAAGCTATCTCTGGATGATTCAGTTCAAACGTTTCTTCCTCAATTACAATTCGGTAGGAAAAAAGA
TCTAAGAGATACAACCATTTTGAACATGTTAACTCATACTACCGGATTACCACCTTTAAAAGCATTGATTTACAGTATTA
GAGAGAATTCTGAACACGAGGATGAGCTGGTCCAAAAACTTGGCGATAAAACAGAAAACAATAATGAAGAAGAACAGGTA
CAGCTTAACAGTTATCAAGATCTGATAGATTATGTGTCCAGAGAAGGGATCGATTTGTTAGGTAGCCCTGGAGAATACAC
CAGTTATTCTAACGATTGCTATGCTTTGTTGGGAAAAATTATTGAAGAAGTTTCCGGGAAAAGTTATCAAGATTATATAT
CGGAAAATTTTCTCAAGCCTTTAAATATGAATCGGAGCACTTTTTCTCTGGATGAAGTTTTACACAGTGACAATGTAACT
TCTTTATATTATTACGATGAAAATACGGAAGAGGTCAAAAAAGCCCAGGGATGGCAGGAAGCACCTCCTTATCAAGCAGG
AGGTTGGCTCAGGTCAACTGCCCGGGACTTAGTGAAGTTTTTTCAGATGTTAGCTCTCGGTGGAAGGCAGGGGCTAAAAC
CTGATAATAGGATTTTAACAAAAAGTTCAATACAAAAACTACTACATCCTGTGACATATTCACCTTGGGATCTGGTCAGT
ACATATAACCTGGGTTCTTGGATTCAGTCAAATTACTATGGCAGAACCCTGATTCAACATGGCGGTAGCTTGACGGGAGT
CTCTTCTCATGCCGGCTTTATTCCGGAAGAAGAATTAGCTGTGGTAGTACTGAGTAATCTCCGCGGTTTTCCTGTTTATA
AAGCTTGGCATGGGATCGTTAATATATTACTTGGATTGCACGTGGACACTTCAAAGGTGAGCTACTACCAGCGGAACTGG
CCTAGTGAGCTACTTGTATCCCGGTCAGGTGTCTTTAAATCAGGTGAAGGTATGGAACTGGAGTTATTTGTTCAACAAAA
TACTCTTCAATGCAGAATGATTAGAGAAGATAAAGTATATCAGATTAAACCTGTAACTCGATATGTAGGTACTATAAATG
TTAAAGGCGATGAAAAAGAAATCTGGTTTTATCATAACAGAAAAGACAGTAAACCTTGGGCTATTGGATTTGGCGGCAGA
ATGATTAAGAGGGTGGAATAA

Upstream 100 bases:

>100_bases
ATTTCGGTCCATGGGAACAAATCTTTTACGGTGAATTTGATGGTCGTCGTAAGAAGCGGGTTTTAGTTAAAGTCATTGGT
GAATAAGGGAGTGGGTGTGT

Downstream 100 bases:

>100_bases
AGATTAAAGAAATTGAAGGTAGGTGCGGTCAAGGTCACAACAAATTGCCGCACCTGCCTATGCTTTACATCAATAATTTC
TGTTTTTGTTGTTCCACCAC

Product: beta-lactamase

Products: NA

Alternate protein names: PBP 4*; PBP 4A; Penicillin-binding protein E [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MDFGAKLSQRELKSLESFLANVQRDHDSPGLAVAITKGDELIYASGFGYRDLGEKAYIDENTIMGIASITKTFTAAAILK
LQEQGKLSLDDSVQTFLPQLQFGRKKDLRDTTILNMLTHTTGLPPLKALIYSIRENSEHEDELVQKLGDKTENNNEEEQV
QLNSYQDLIDYVSREGIDLLGSPGEYTSYSNDCYALLGKIIEEVSGKSYQDYISENFLKPLNMNRSTFSLDEVLHSDNVT
SLYYYDENTEEVKKAQGWQEAPPYQAGGWLRSTARDLVKFFQMLALGGRQGLKPDNRILTKSSIQKLLHPVTYSPWDLVS
TYNLGSWIQSNYYGRTLIQHGGSLTGVSSHAGFIPEEELAVVVLSNLRGFPVYKAWHGIVNILLGLHVDTSKVSYYQRNW
PSELLVSRSGVFKSGEGMELELFVQQNTLQCRMIREDKVYQIKPVTRYVGTINVKGDEKEIWFYHNRKDSKPWAIGFGGR
MIKRVE

Sequences:

>Translated_486_residues
MDFGAKLSQRELKSLESFLANVQRDHDSPGLAVAITKGDELIYASGFGYRDLGEKAYIDENTIMGIASITKTFTAAAILK
LQEQGKLSLDDSVQTFLPQLQFGRKKDLRDTTILNMLTHTTGLPPLKALIYSIRENSEHEDELVQKLGDKTENNNEEEQV
QLNSYQDLIDYVSREGIDLLGSPGEYTSYSNDCYALLGKIIEEVSGKSYQDYISENFLKPLNMNRSTFSLDEVLHSDNVT
SLYYYDENTEEVKKAQGWQEAPPYQAGGWLRSTARDLVKFFQMLALGGRQGLKPDNRILTKSSIQKLLHPVTYSPWDLVS
TYNLGSWIQSNYYGRTLIQHGGSLTGVSSHAGFIPEEELAVVVLSNLRGFPVYKAWHGIVNILLGLHVDTSKVSYYQRNW
PSELLVSRSGVFKSGEGMELELFVQQNTLQCRMIREDKVYQIKPVTRYVGTINVKGDEKEIWFYHNRKDSKPWAIGFGGR
MIKRVE
>Mature_486_residues
MDFGAKLSQRELKSLESFLANVQRDHDSPGLAVAITKGDELIYASGFGYRDLGEKAYIDENTIMGIASITKTFTAAAILK
LQEQGKLSLDDSVQTFLPQLQFGRKKDLRDTTILNMLTHTTGLPPLKALIYSIRENSEHEDELVQKLGDKTENNNEEEQV
QLNSYQDLIDYVSREGIDLLGSPGEYTSYSNDCYALLGKIIEEVSGKSYQDYISENFLKPLNMNRSTFSLDEVLHSDNVT
SLYYYDENTEEVKKAQGWQEAPPYQAGGWLRSTARDLVKFFQMLALGGRQGLKPDNRILTKSSIQKLLHPVTYSPWDLVS
TYNLGSWIQSNYYGRTLIQHGGSLTGVSSHAGFIPEEELAVVVLSNLRGFPVYKAWHGIVNILLGLHVDTSKVSYYQRNW
PSELLVSRSGVFKSGEGMELELFVQQNTLQCRMIREDKVYQIKPVTRYVGTINVKGDEKEIWFYHNRKDSKPWAIGFGGR
MIKRVE

Specific function: Probably involved in peptidoglycan modification during cortex synthesis [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-lactamase family [H]

Homologues:

Organism=Homo sapiens, GI26051231, Length=419, Percent_Identity=24.8210023866348, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI26051233, Length=248, Percent_Identity=25, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115533026, Length=371, Percent_Identity=25.8760107816712, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466
- InterPro:   IPR021860 [H]

Pfam domain/function: PF00144 Beta-lactamase; PF11954 DUF3471 [H]

EC number: NA

Molecular weight: Translated: 55084; Mature: 55084

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFGAKLSQRELKSLESFLANVQRDHDSPGLAVAITKGDELIYASGFGYRDLGEKAYIDE
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEECCCCCHHCCCCCEECC
NTIMGIASITKTFTAAAILKLQEQGKLSLDDSVQTFLPQLQFGRKKDLRDTTILNMLTHT
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHC
TGLPPLKALIYSIRENSEHEDELVQKLGDKTENNNEEEQVQLNSYQDLIDYVSREGIDLL
CCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEC
GSPGEYTSYSNDCYALLGKIIEEVSGKSYQDYISENFLKPLNMNRSTFSLDEVLHSDNVT
CCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCE
SLYYYDENTEEVKKAQGWQEAPPYQAGGWLRSTARDLVKFFQMLALGGRQGLKPDNRILT
EEEEECCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEC
KSSIQKLLHPVTYSPWDLVSTYNLGSWIQSNYYGRTLIQHGGSLTGVSSHAGFIPEEELA
HHHHHHHHHCCCCCCHHHHHHCCCHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHH
VVVLSNLRGFPVYKAWHGIVNILLGLHVDTSKVSYYQRNWPSELLVSRSGVFKSGEGMEL
HHEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHCCCCCCCCCCCEE
ELFVQQNTLQCRMIREDKVYQIKPVTRYVGTINVKGDEKEIWFYHNRKDSKPWAIGFGGR
EEEEECCCEEEEEECCCCEEEEEEHHEEEEEEEECCCCCEEEEEECCCCCCCEEEECCCH
MIKRVE
HHHCCC
>Mature Secondary Structure
MDFGAKLSQRELKSLESFLANVQRDHDSPGLAVAITKGDELIYASGFGYRDLGEKAYIDE
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEECCCCCHHCCCCCEECC
NTIMGIASITKTFTAAAILKLQEQGKLSLDDSVQTFLPQLQFGRKKDLRDTTILNMLTHT
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHC
TGLPPLKALIYSIRENSEHEDELVQKLGDKTENNNEEEQVQLNSYQDLIDYVSREGIDLL
CCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEC
GSPGEYTSYSNDCYALLGKIIEEVSGKSYQDYISENFLKPLNMNRSTFSLDEVLHSDNVT
CCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCE
SLYYYDENTEEVKKAQGWQEAPPYQAGGWLRSTARDLVKFFQMLALGGRQGLKPDNRILT
EEEEECCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEC
KSSIQKLLHPVTYSPWDLVSTYNLGSWIQSNYYGRTLIQHGGSLTGVSSHAGFIPEEELA
HHHHHHHHHCCCCCCHHHHHHCCCHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHH
VVVLSNLRGFPVYKAWHGIVNILLGLHVDTSKVSYYQRNWPSELLVSRSGVFKSGEGMEL
HHEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHCCCCCCCCCCCEE
ELFVQQNTLQCRMIREDKVYQIKPVTRYVGTINVKGDEKEIWFYHNRKDSKPWAIGFGGR
EEEEECCCEEEEEECCCCEEEEEEHHEEEEEEEECCCCCEEEEEECCCCCCCEEEECCCH
MIKRVE
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8491712; 9384377 [H]