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The map label for this gene is fdhA [H]

Identifier: 188587190

GI number: 188587190

Start: 2780477

End: 2782819

Strand: Direct

Name: fdhA [H]

Synonym: Nther_2591

Alternate gene names: 188587190

Gene position: 2780477-2782819 (Clockwise)

Preceding gene: 188587189

Following gene: 188587191

Centisome position: 87.84

GC content: 41.7

Gene sequence:

>2343_bases
ATGACTAATCACTGGATTGATTATCAGCACTCAGATGTCTTTATGAATATCGGGCTCAACACAGCCGAAAATCATCCTGT
ATCCATGAAATGGATCGATAAAGCTAGGCAGGAAAAAGGAGCTAAATTAATCTGTGTAGACCCTAGAATCACCAGAACAG
CAGCCGTCGCTGACATCTATGCTCCTATTCGTCCTGGTACCAATACTGCTTTTTTAGCAGGGCTTATTAATTACGCCCTA
GCAAATGAATATTATCACGAAGAATACGTGAAACATTACACTAATGCCTCTTATCTAATTAAAGAAGAGTTTAGTTTTGA
AGACGGTATGTTTACTTCCCCAGAAGAGGTAAATGGCGACTATTACCAGCGAAATGAAAACGGAGAGATTATAACAGATC
CTGATTTAGAAGATCCCAATTGTGTCTTTCAATTACTAAAGGATCATTATCAAAGATACGATTTAGACACTGTCAGCGAG
ATCACAGGTTGTCCGAAAGATAGTTTGAAGGAAGTGGCTAAAACATTTTGCAGCACTGGTGAACCTGCTAAAGCTGGTAA
TATCATGTACGCCATGGGTATCACCCAGTTTACTCACGGAGCTCAAAATGTACGCAGTATAGCTATACTGCAGCTATTAC
TTGGCAATATGGGAATTGCCGGAGGTGGAGTGAACGCCCAGAGAGGTCAGTCTAATGTGCAGGGCTCTACTGATATGGCC
ATGCTATATCACATCATCCCTGGTTATATGGGAACTCCCTCGGCACAGCTCCATCCTACTTTTGAAGATTATAAGGAACA
GGAAACTCCGGATTCTGGTTACTGGGAAAACACTCCCAAATTCATTACAAGTATGTTAAAAGCTTTTTGGGGTGATTACG
CCACAGCAGGAAACGACTATTGTTATGATTTCATGCCGAAGTTAGATGAAAAAGACAGATCTCATATCGGTATGTTCAGA
GAAATGGCCGAAGGTAATGTAGAAGGGATGATATGTTGGGCCGATAACCCCGCCGTAAGTGGCCCTTCTACAGCTCACAA
ACGGGATTACATGGGTAAGCTTAAATGGATGGTATCTATCGATATTTTTGAAAATGAAACTGCCGCCTTCTGGAAGGCTC
CAGGAGTTGATCCCGAAGAAATCGATACAGAAGTTTTCTTACTGCCCGCGGCATTACACGTAGAAAGGGAAGGTTCTATA
AGTAATAGCGGTCGATGGATTCAATGGCGCAATAAGGCAGTAAATCCACCGGGAGAAGCGAAATCCGACTTGGAAATAGT
AGATCTAATCTACAAAAATATCAAATCAAAATACGAAGCTGAAAATGGAGTGTTTCCAGAGCCCATATTGAATTTAAATT
GGGACTACGGCGAACCCGCAGATCCTGAAACAGTAGCGAAAGAGATCAATGGCTTTAATACTATAACTGGTGAACTGATA
GAAAACTTCACCCACTTACAAAGTAATGGCAGCACTGCTTCGGGGAATTGGTTATACTGCGGATATTATAATGATCACAA
CGCTCCTCCTACAAAGAGAAGACATAGAGAAGTTCAGGGAATTGGACTTCATCCCGACTGGTCTTTTGCATGGCCTCTTA
ATAGGAGAGTGATTTACAATCGTTGTGCTGCCGATCCAAAAGGTAAACCTTGGAATCCAGAAACACCTTTAGTATGGTAC
GAAAATGGTCAGTGGAAAACCAATGATGTCCCCGATTTCAATACCGATGTTCCGCCGGAAGATACAGCCAATACACCTTT
TATCATGCTCCCCGAAGGTCAAGGTAGACTTTTTGGTAATGTAGCTTTAGTTGATGGACCTTTCCCTGAACATTATGAAC
CTTGGGAAAGTCCAGTGGAAAATATTATGTCGTCAACACAGTTTAATCCCCATGTCACAGAATGGTATCCCGATCAGAGA
GCAGAGATAGATAGTGAAGAATATCCCTACATTGCCACAAGTTACAGAATTACTGAGCACTATCAAACCGGCATGATGAC
TAGGAATATGCCATGGCTTTACGAAACTATGCCTGATATATTCGTTGAAATTAGTAAAAGTTTAGCAGATAAACTTGGTA
TAACAAAAGGTGAATCAGTGGAAGTGATTACCCCCAGGGGCAAATATCAAGCCGGAACGTGTATAACTAATAGAATCAGG
CCAATTCAAGTTAATGGTAGGAAATTAGAGATGGTGGGATTATTGTGGCACTGGGGTTATCAGGGAGCGGCAAAAGGAGC
TGTGGCCAACGATGTTTCACCTTCAATCGGAGATGCAAACACCACCATCCCTGAATACAAAGCTTTTCTGTGTAATATAA
GGAAGGTGAATAACTATGACTAA

Upstream 100 bases:

>100_bases
GTTAATCAGGGCTTTGGGGGTAATTAATATCGATCACTGCGCCCGCCTTTGACACTCTTCTACGGTCGCCGGACTCGGCG
CCACGTTTGGAAGAGGTGCT

Downstream 100 bases:

>100_bases
AAGCATGTTGATAGATACATCTAAATGTACTGCTTGCAGAGCCTGTCAAATTGCTTGTAAACAATGGAATCAACTTCCTG
CAGAAAAGACCAGTTTCACC

Product: Formate dehydrogenase

Products: NA

Alternate protein names: FDH subunit alpha; Formate dehydrogenase large subunit [H]

Number of amino acids: Translated: 780; Mature: 779

Protein sequence:

>780_residues
MTNHWIDYQHSDVFMNIGLNTAENHPVSMKWIDKARQEKGAKLICVDPRITRTAAVADIYAPIRPGTNTAFLAGLINYAL
ANEYYHEEYVKHYTNASYLIKEEFSFEDGMFTSPEEVNGDYYQRNENGEIITDPDLEDPNCVFQLLKDHYQRYDLDTVSE
ITGCPKDSLKEVAKTFCSTGEPAKAGNIMYAMGITQFTHGAQNVRSIAILQLLLGNMGIAGGGVNAQRGQSNVQGSTDMA
MLYHIIPGYMGTPSAQLHPTFEDYKEQETPDSGYWENTPKFITSMLKAFWGDYATAGNDYCYDFMPKLDEKDRSHIGMFR
EMAEGNVEGMICWADNPAVSGPSTAHKRDYMGKLKWMVSIDIFENETAAFWKAPGVDPEEIDTEVFLLPAALHVEREGSI
SNSGRWIQWRNKAVNPPGEAKSDLEIVDLIYKNIKSKYEAENGVFPEPILNLNWDYGEPADPETVAKEINGFNTITGELI
ENFTHLQSNGSTASGNWLYCGYYNDHNAPPTKRRHREVQGIGLHPDWSFAWPLNRRVIYNRCAADPKGKPWNPETPLVWY
ENGQWKTNDVPDFNTDVPPEDTANTPFIMLPEGQGRLFGNVALVDGPFPEHYEPWESPVENIMSSTQFNPHVTEWYPDQR
AEIDSEEYPYIATSYRITEHYQTGMMTRNMPWLYETMPDIFVEISKSLADKLGITKGESVEVITPRGKYQAGTCITNRIR
PIQVNGRKLEMVGLLWHWGYQGAAKGAVANDVSPSIGDANTTIPEYKAFLCNIRKVNNYD

Sequences:

>Translated_780_residues
MTNHWIDYQHSDVFMNIGLNTAENHPVSMKWIDKARQEKGAKLICVDPRITRTAAVADIYAPIRPGTNTAFLAGLINYAL
ANEYYHEEYVKHYTNASYLIKEEFSFEDGMFTSPEEVNGDYYQRNENGEIITDPDLEDPNCVFQLLKDHYQRYDLDTVSE
ITGCPKDSLKEVAKTFCSTGEPAKAGNIMYAMGITQFTHGAQNVRSIAILQLLLGNMGIAGGGVNAQRGQSNVQGSTDMA
MLYHIIPGYMGTPSAQLHPTFEDYKEQETPDSGYWENTPKFITSMLKAFWGDYATAGNDYCYDFMPKLDEKDRSHIGMFR
EMAEGNVEGMICWADNPAVSGPSTAHKRDYMGKLKWMVSIDIFENETAAFWKAPGVDPEEIDTEVFLLPAALHVEREGSI
SNSGRWIQWRNKAVNPPGEAKSDLEIVDLIYKNIKSKYEAENGVFPEPILNLNWDYGEPADPETVAKEINGFNTITGELI
ENFTHLQSNGSTASGNWLYCGYYNDHNAPPTKRRHREVQGIGLHPDWSFAWPLNRRVIYNRCAADPKGKPWNPETPLVWY
ENGQWKTNDVPDFNTDVPPEDTANTPFIMLPEGQGRLFGNVALVDGPFPEHYEPWESPVENIMSSTQFNPHVTEWYPDQR
AEIDSEEYPYIATSYRITEHYQTGMMTRNMPWLYETMPDIFVEISKSLADKLGITKGESVEVITPRGKYQAGTCITNRIR
PIQVNGRKLEMVGLLWHWGYQGAAKGAVANDVSPSIGDANTTIPEYKAFLCNIRKVNNYD
>Mature_779_residues
TNHWIDYQHSDVFMNIGLNTAENHPVSMKWIDKARQEKGAKLICVDPRITRTAAVADIYAPIRPGTNTAFLAGLINYALA
NEYYHEEYVKHYTNASYLIKEEFSFEDGMFTSPEEVNGDYYQRNENGEIITDPDLEDPNCVFQLLKDHYQRYDLDTVSEI
TGCPKDSLKEVAKTFCSTGEPAKAGNIMYAMGITQFTHGAQNVRSIAILQLLLGNMGIAGGGVNAQRGQSNVQGSTDMAM
LYHIIPGYMGTPSAQLHPTFEDYKEQETPDSGYWENTPKFITSMLKAFWGDYATAGNDYCYDFMPKLDEKDRSHIGMFRE
MAEGNVEGMICWADNPAVSGPSTAHKRDYMGKLKWMVSIDIFENETAAFWKAPGVDPEEIDTEVFLLPAALHVEREGSIS
NSGRWIQWRNKAVNPPGEAKSDLEIVDLIYKNIKSKYEAENGVFPEPILNLNWDYGEPADPETVAKEINGFNTITGELIE
NFTHLQSNGSTASGNWLYCGYYNDHNAPPTKRRHREVQGIGLHPDWSFAWPLNRRVIYNRCAADPKGKPWNPETPLVWYE
NGQWKTNDVPDFNTDVPPEDTANTPFIMLPEGQGRLFGNVALVDGPFPEHYEPWESPVENIMSSTQFNPHVTEWYPDQRA
EIDSEEYPYIATSYRITEHYQTGMMTRNMPWLYETMPDIFVEISKSLADKLGITKGESVEVITPRGKYQAGTCITNRIRP
IQVNGRKLEMVGLLWHWGYQGAAKGAVANDVSPSIGDANTTIPEYKAFLCNIRKVNNYD

Specific function: Alpha chain of the formate dehydrogenase (FDH) catalyze the reversible two-electron oxidation of formate to carbon dioxide. FDH loses activity in the presence of air, but this activity can be restored. The alpha subunit of formate dehydrogenase forms the

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868719, Length=809, Percent_Identity=43.3868974042027, Blast_Score=670, Evalue=0.0,
Organism=Escherichia coli, GI3868720, Length=814, Percent_Identity=41.7690417690418, Blast_Score=644, Evalue=0.0,
Organism=Escherichia coli, GI3868721, Length=430, Percent_Identity=24.6511627906977, Blast_Score=109, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006443
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 88235; Mature: 88104

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNHWIDYQHSDVFMNIGLNTAENHPVSMKWIDKARQEKGAKLICVDPRITRTAAVADIY
CCCCEEECCCCCEEEEECCCCCCCCCEEHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHH
APIRPGTNTAFLAGLINYALANEYYHEEYVKHYTNASYLIKEEFSFEDGMFTSPEEVNGD
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHCCCC
YYQRNENGEIITDPDLEDPNCVFQLLKDHYQRYDLDTVSEITGCPKDSLKEVAKTFCSTG
CEEECCCCCEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHCCC
EPAKAGNIMYAMGITQFTHGAQNVRSIAILQLLLGNMGIAGGGVNAQRGQSNVQGSTDMA
CCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHH
MLYHIIPGYMGTPSAQLHPTFEDYKEQETPDSGYWENTPKFITSMLKAFWGDYATAGNDY
HHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
CYDFMPKLDEKDRSHIGMFREMAEGNVEGMICWADNPAVSGPSTAHKRDYMGKLKWMVSI
HHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHEEEEEEEE
DIFENETAAFWKAPGVDPEEIDTEVFLLPAALHVEREGSISNSGRWIQWRNKAVNPPGEA
EEECCCCEEEEECCCCCHHHCCCEEEEEEEEEEEECCCCCCCCCCEEEECCCCCCCCCCC
KSDLEIVDLIYKNIKSKYEAENGVFPEPILNLNWDYGEPADPETVAKEINGFNTITGELI
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCHHHHHHHHCCCCHHHHHHH
ENFTHLQSNGSTASGNWLYCGYYNDHNAPPTKRRHREVQGIGLHPDWSFAWPLNRRVIYN
HHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHCCCCCCCCCCEECCCCCHHHHH
RCAADPKGKPWNPETPLVWYENGQWKTNDVPDFNTDVPPEDTANTPFIMLPEGQGRLFGN
HHCCCCCCCCCCCCCCEEEEECCEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEE
VALVDGPFPEHYEPWESPVENIMSSTQFNPHVTEWYPDQRAEIDSEEYPYIATSYRITEH
EEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEHHH
YQTGMMTRNMPWLYETMPDIFVEISKSLADKLGITKGESVEVITPRGKYQAGTCITNRIR
HHHCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHCCCE
PIQVNGRKLEMVGLLWHWGYQGAAKGAVANDVSPSIGDANTTIPEYKAFLCNIRKVNNYD
EEEECCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TNHWIDYQHSDVFMNIGLNTAENHPVSMKWIDKARQEKGAKLICVDPRITRTAAVADIY
CCCEEECCCCCEEEEECCCCCCCCCEEHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHH
APIRPGTNTAFLAGLINYALANEYYHEEYVKHYTNASYLIKEEFSFEDGMFTSPEEVNGD
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHCCCC
YYQRNENGEIITDPDLEDPNCVFQLLKDHYQRYDLDTVSEITGCPKDSLKEVAKTFCSTG
CEEECCCCCEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHCCC
EPAKAGNIMYAMGITQFTHGAQNVRSIAILQLLLGNMGIAGGGVNAQRGQSNVQGSTDMA
CCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHH
MLYHIIPGYMGTPSAQLHPTFEDYKEQETPDSGYWENTPKFITSMLKAFWGDYATAGNDY
HHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
CYDFMPKLDEKDRSHIGMFREMAEGNVEGMICWADNPAVSGPSTAHKRDYMGKLKWMVSI
HHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHEEEEEEEE
DIFENETAAFWKAPGVDPEEIDTEVFLLPAALHVEREGSISNSGRWIQWRNKAVNPPGEA
EEECCCCEEEEECCCCCHHHCCCEEEEEEEEEEEECCCCCCCCCCEEEECCCCCCCCCCC
KSDLEIVDLIYKNIKSKYEAENGVFPEPILNLNWDYGEPADPETVAKEINGFNTITGELI
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCHHHHHHHHCCCCHHHHHHH
ENFTHLQSNGSTASGNWLYCGYYNDHNAPPTKRRHREVQGIGLHPDWSFAWPLNRRVIYN
HHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHCCCCCCCCCCEECCCCCHHHHH
RCAADPKGKPWNPETPLVWYENGQWKTNDVPDFNTDVPPEDTANTPFIMLPEGQGRLFGN
HHCCCCCCCCCCCCCCEEEEECCEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEE
VALVDGPFPEHYEPWESPVENIMSSTQFNPHVTEWYPDQRAEIDSEEYPYIATSYRITEH
EEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEHHH
YQTGMMTRNMPWLYETMPDIFVEISKSLADKLGITKGESVEVITPRGKYQAGTCITNRIR
HHHCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHCCCE
PIQVNGRKLEMVGLLWHWGYQGAAKGAVANDVSPSIGDANTTIPEYKAFLCNIRKVNNYD
EEEECCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA