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The map label for this gene is fdhA [H]

Identifier: 188587189

GI number: 188587189

Start: 2779838

End: 2780428

Strand: Direct

Name: fdhA [H]

Synonym: Nther_2590

Alternate gene names: 188587189

Gene position: 2779838-2780428 (Clockwise)

Preceding gene: 188587188

Following gene: 188587190

Centisome position: 87.82

GC content: 40.61

Gene sequence:

>591_bases
TTGGGCTTAACCCGTCGTGATTTTTTCAAAGTTACTGGAGTCTCCGTCACCGCTGCCTCTTTAACGTCCATGGGAGTCAA
AAAAGTTCATGGTTCATACCAACCAGTTAGAATAAATTACGCTAAGGAGATCACTACTATCTGTCCATTTTGCTCAGTTG
GTTGTGGAATCATTTGCCATGTACAAGACGGCAAACTTTTAAATACCGAAGGAGATCCTGACCATCCCATTAATGAAGGC
ACACTATGCAGTAAAGGTGCAGCACTTTTCAATATGGTAAACACTTATGATGAAAAAGGTAGCATTGTGCCAAATCCTGA
AAGACTCACGAAAGTAAAATACAGACCTCCCAACAGCGGAGAATGGAAGGAACTCAGTTGGGAAGAAGCTCTTGATAAAA
TTGCAGACAGAATCAAACAAACCAGAGACAATACTTTTGAGCAACAAGATGAAAACGGTGTGACAGTAAACAGAACTAAA
GCTATAGCACATTTGGGAAGTGCAATGTGTAATAATGAAGAAAATTATCTCTACCACAAGTTAATCAGGGCTTTGGGGGT
AATTAATATCGATCACTGCGCCCGCCTTTGA

Upstream 100 bases:

>100_bases
TGTATGCTGAAAAGGAAGGTTTTCAACCGGGTTCAGGACTTAGCTGGGTCAATGAAGGAGATTTAATTAACACCTAATTT
TCTAAGGAGGTGACCGAAAT

Downstream 100 bases:

>100_bases
CACTCTTCTACGGTCGCCGGACTCGGCGCCACGTTTGGAAGAGGTGCTATGACTAATCACTGGATTGATTATCAGCACTC
AGATGTCTTTATGAATATCG

Product: molybdopterin oxidoreductase Fe4S4 region

Products: NA

Alternate protein names: FDH subunit alpha; Formate dehydrogenase large subunit [H]

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MGLTRRDFFKVTGVSVTAASLTSMGVKKVHGSYQPVRINYAKEITTICPFCSVGCGIICHVQDGKLLNTEGDPDHPINEG
TLCSKGAALFNMVNTYDEKGSIVPNPERLTKVKYRPPNSGEWKELSWEEALDKIADRIKQTRDNTFEQQDENGVTVNRTK
AIAHLGSAMCNNEENYLYHKLIRALGVINIDHCARL

Sequences:

>Translated_196_residues
MGLTRRDFFKVTGVSVTAASLTSMGVKKVHGSYQPVRINYAKEITTICPFCSVGCGIICHVQDGKLLNTEGDPDHPINEG
TLCSKGAALFNMVNTYDEKGSIVPNPERLTKVKYRPPNSGEWKELSWEEALDKIADRIKQTRDNTFEQQDENGVTVNRTK
AIAHLGSAMCNNEENYLYHKLIRALGVINIDHCARL
>Mature_195_residues
GLTRRDFFKVTGVSVTAASLTSMGVKKVHGSYQPVRINYAKEITTICPFCSVGCGIICHVQDGKLLNTEGDPDHPINEGT
LCSKGAALFNMVNTYDEKGSIVPNPERLTKVKYRPPNSGEWKELSWEEALDKIADRIKQTRDNTFEQQDENGVTVNRTKA
IAHLGSAMCNNEENYLYHKLIRALGVINIDHCARL

Specific function: Alpha chain of the formate dehydrogenase (FDH) catalyze the reversible two-electron oxidation of formate to carbon dioxide. FDH loses activity in the presence of air, but this activity can be restored. The alpha subunit of formate dehydrogenase forms the

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868719, Length=205, Percent_Identity=35.609756097561, Blast_Score=138, Evalue=2e-34,
Organism=Escherichia coli, GI3868720, Length=205, Percent_Identity=35.1219512195122, Blast_Score=136, Evalue=8e-34,
Organism=Escherichia coli, GI3868721, Length=157, Percent_Identity=31.2101910828025, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1788534, Length=204, Percent_Identity=28.921568627451, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006443
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 21814; Mature: 21683

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLTRRDFFKVTGVSVTAASLTSMGVKKVHGSYQPVRINYAKEITTICPFCSVGCGIICH
CCCCCCHHEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHCCCCEEEE
VQDGKLLNTEGDPDHPINEGTLCSKGAALFNMVNTYDEKGSIVPNPERLTKVKYRPPNSG
ECCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHEEEEECCCCCC
EWKELSWEEALDKIADRIKQTRDNTFEQQDENGVTVNRTKAIAHLGSAMCNNEENYLYHK
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCHHHHHH
LIRALGVINIDHCARL
HHHHHCCCCHHHHHCC
>Mature Secondary Structure 
GLTRRDFFKVTGVSVTAASLTSMGVKKVHGSYQPVRINYAKEITTICPFCSVGCGIICH
CCCCCHHEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHCCCCEEEE
VQDGKLLNTEGDPDHPINEGTLCSKGAALFNMVNTYDEKGSIVPNPERLTKVKYRPPNSG
ECCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHEEEEECCCCCC
EWKELSWEEALDKIADRIKQTRDNTFEQQDENGVTVNRTKAIAHLGSAMCNNEENYLYHK
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCHHHHHH
LIRALGVINIDHCARL
HHHHHCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA