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The map label for this gene is mecI [H]

Identifier: 188587187

GI number: 188587187

Start: 2777996

End: 2778505

Strand: Reverse

Name: mecI [H]

Synonym: Nther_2588

Alternate gene names: 188587187

Gene position: 2778505-2777996 (Counterclockwise)

Preceding gene: 188587194

Following gene: 188587186

Centisome position: 87.77

GC content: 37.84

Gene sequence:

>510_bases
GTGGTTAAAAAAACTAATAAAATATCCGATTCCGAATGGGAAGTCATGGAGGTTTTGTGGGATGATTCCCCAATCCCTTC
TAGTGCTATTATAGAAAGATTACAACCTCAAACAGACTGGAAACCCAAGACTATTCACACCTTGATTAGTAGATTAGTAA
AAAAAGGTGTTGTTGGGGTAGAGAAAAATACTACACGTTACTTGTACTATCCTTTGCTGTCGAAAGAGGAGTGTAGGCTT
ACGGAAACAGAAACTTTTTTAGAAAAAGTATATAATGGATCAGTTTCTATGTTAGTGGCAAACTTTATTAAACAGGACAG
ATTATCACAACAAGAGATAAATGAACTTAAAAAACTTTTGGATGACGATACAGAGGGTGAAGCCCGAGAGGATAACAGTA
AAGACCAAAATGGTCATGTTGTGTATGAAGGACATGATGATTGTAAAGGTGCTGACCGCCATGATGAGTGTGAAGGGCAT
AAAGGCCATGATGAGCTAGGGGGAAATTGA

Upstream 100 bases:

>100_bases
GGAGTAAGTTAAAGTGCCTATCTCTATACATTCGGTTGACAAACCTTTCCTACAAATGTAAGATGTAACTACAAGGATTA
CATATGTAGGAGGGGTTTTT

Downstream 100 bases:

>100_bases
TATGAATGCAGTTGATATATTTTCTATCATTATCACACTGTCACTTATGGGAATTGTGGTTACAGGTCTAATTTTATTGA
TCAAATTTTTCTTTGGTAGG

Product: transcriptional repressor, CopY family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 169; Mature: 169

Protein sequence:

>169_residues
MVKKTNKISDSEWEVMEVLWDDSPIPSSAIIERLQPQTDWKPKTIHTLISRLVKKGVVGVEKNTTRYLYYPLLSKEECRL
TETETFLEKVYNGSVSMLVANFIKQDRLSQQEINELKKLLDDDTEGEAREDNSKDQNGHVVYEGHDDCKGADRHDECEGH
KGHDELGGN

Sequences:

>Translated_169_residues
MVKKTNKISDSEWEVMEVLWDDSPIPSSAIIERLQPQTDWKPKTIHTLISRLVKKGVVGVEKNTTRYLYYPLLSKEECRL
TETETFLEKVYNGSVSMLVANFIKQDRLSQQEINELKKLLDDDTEGEAREDNSKDQNGHVVYEGHDDCKGADRHDECEGH
KGHDELGGN
>Mature_169_residues
MVKKTNKISDSEWEVMEVLWDDSPIPSSAIIERLQPQTDWKPKTIHTLISRLVKKGVVGVEKNTTRYLYYPLLSKEECRL
TETETFLEKVYNGSVSMLVANFIKQDRLSQQEINELKKLLDDDTEGEAREDNSKDQNGHVVYEGHDDCKGADRHDECEGH
KGHDELGGN

Specific function: Transcriptional repressor that constitutively blocks the transcription of the gene for the penicillin-binding protein mecA. Binds DNA as a dimer [H]

COG id: COG3682

COG function: function code K; Predicted transcriptional regulator

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BlaI transcriptional regulatory family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005650
- InterPro:   IPR011991 [H]

Pfam domain/function: PF03965 Pencillinase_R [H]

EC number: NA

Molecular weight: Translated: 19377; Mature: 19377

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKKTNKISDSEWEVMEVLWDDSPIPSSAIIERLQPQTDWKPKTIHTLISRLVKKGVVGV
CCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCC
EKNTTRYLYYPLLSKEECRLTETETFLEKVYNGSVSMLVANFIKQDRLSQQEINELKKLL
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHH
DDDTEGEAREDNSKDQNGHVVYEGHDDCKGADRHDECEGHKGHDELGGN
CCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVKKTNKISDSEWEVMEVLWDDSPIPSSAIIERLQPQTDWKPKTIHTLISRLVKKGVVGV
CCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCC
EKNTTRYLYYPLLSKEECRLTETETFLEKVYNGSVSMLVANFIKQDRLSQQEINELKKLL
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHH
DDDTEGEAREDNSKDQNGHVVYEGHDDCKGADRHDECEGHKGHDELGGN
CCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]