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The map label for this gene is wecC [H]

Identifier: 188587132

GI number: 188587132

Start: 2722850

End: 2724106

Strand: Reverse

Name: wecC [H]

Synonym: Nther_2529

Alternate gene names: 188587132

Gene position: 2724106-2722850 (Counterclockwise)

Preceding gene: 188587133

Following gene: 188587131

Centisome position: 86.05

GC content: 33.89

Gene sequence:

>1257_bases
GTGAGTATAAATAAAATATGTGTAATGGGACTCGGGTATATTGGGCTTCCTACCGCTAGCATGTTAGCTACTAATGGATT
TCAAGTCTTAGGCGTTGACGTTAATCATCGTGTTGTTAATATGATAAATCAGGGAGAAATACATATTGAAGAACCAGGAT
TAAATACAATGGTTAATGCTTCAGTGAAGTCGGGAAACCTGGTAGCTAGTAATAAACCAGAAGAAGCAGATGCTTTTATT
ATTGCTGTACCTACTCCTATAAATGGTGATAAGACTGTGAATTTAGATTACGTTAAAGATGCGATGAAAGAAATTATTCC
ATATTTACAAAAAGATAATTTAATAGTCTTAGAGTCTACTGTTCCCCCTAGAACAACAGTAGATGTTTTACTGCCTTTGC
TAGAAGAAACAGACTTAAAAGTAGGGGATGATGTATTTGTTGCTCACTGTCCAGAGAGAGTTCTTCCTGGAAATATATTG
CATGAATTAGTAAATAACAATAGAATTATAGGTGGGATTAATAATAAATCATCTGAAAAAGCTAAAGAAATTTATGAGAA
AATAGTACAAGGAGAGATTGTATTGACTGATGCAACTTCTTCAGAAATGGCTAAACTAATGGAGAATGTCTACAGAGATG
TTAATATAGCTCTTGCTAATGAGCTCAGTCAAATTTCTGATGAACTTGATATTGATGCTTTAGAAGTTATTAAACTTTCT
AATATGCATCCAAGAGTAAATATTCATCAGCCCGGTCCGGGTGTAGGAGGGCACTGCTTACCTGTAGATCCATATTTTAT
TACAGAGAAAACTGATAAAGCGCAGATAATTAGTTTGAGTAGAAAGATAAATAATGAGATGCCTGATTTTGTAGTGGAAA
AAGTAAAAGAGAAATTAAGCGATCTAACTCAACCAAAAGTTACAGTGTTAGGTGTATCATATAAAGGCAATGTTGATGAT
ACAAGAGAAACCCCTGCTAGGGACATTATCAATAATCTACAAGAGATAGCTCAAGTTAAAATATATGACCCTCAAGTAAG
GAACTTTGATCATGAATTGGTAAACTTAGAAGAAGCGTTTAAAGATAGTGACATAGTGGTTGTATTGGCTGAACATAGTG
AATTTAAATTCTTAGCTCCAAATGAATTAGGGAAACTTATGAGGACAAAACAAGTTTTTGATACTAAAAACTGCCTGAAT
CACAATTCTTGGGTCGATGGTGGATTTTATGTTGATGTACTAGGGAAAAGAATGTAA

Upstream 100 bases:

>100_bases
ATGATCAAGTTAGCTTTAAATATTATTTAAAATAAACTTATGTAATAAATAGCTGTGAGTATTTTAATGAACCAATTGTT
ATATATAAGGAGATGATACA

Downstream 100 bases:

>100_bases
ACAGGTTAGGTGGTGACGCTAGTGACAAGTTCTAATAACAAACATATACTCATTTTAAATCATCATGCAAGTTCACCGAA
TGTCGGTGGAGGTGCTAGAC

Product: nucleotide sugar dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MSINKICVMGLGYIGLPTASMLATNGFQVLGVDVNHRVVNMINQGEIHIEEPGLNTMVNASVKSGNLVASNKPEEADAFI
IAVPTPINGDKTVNLDYVKDAMKEIIPYLQKDNLIVLESTVPPRTTVDVLLPLLEETDLKVGDDVFVAHCPERVLPGNIL
HELVNNNRIIGGINNKSSEKAKEIYEKIVQGEIVLTDATSSEMAKLMENVYRDVNIALANELSQISDELDIDALEVIKLS
NMHPRVNIHQPGPGVGGHCLPVDPYFITEKTDKAQIISLSRKINNEMPDFVVEKVKEKLSDLTQPKVTVLGVSYKGNVDD
TRETPARDIINNLQEIAQVKIYDPQVRNFDHELVNLEEAFKDSDIVVVLAEHSEFKFLAPNELGKLMRTKQVFDTKNCLN
HNSWVDGGFYVDVLGKRM

Sequences:

>Translated_418_residues
MSINKICVMGLGYIGLPTASMLATNGFQVLGVDVNHRVVNMINQGEIHIEEPGLNTMVNASVKSGNLVASNKPEEADAFI
IAVPTPINGDKTVNLDYVKDAMKEIIPYLQKDNLIVLESTVPPRTTVDVLLPLLEETDLKVGDDVFVAHCPERVLPGNIL
HELVNNNRIIGGINNKSSEKAKEIYEKIVQGEIVLTDATSSEMAKLMENVYRDVNIALANELSQISDELDIDALEVIKLS
NMHPRVNIHQPGPGVGGHCLPVDPYFITEKTDKAQIISLSRKINNEMPDFVVEKVKEKLSDLTQPKVTVLGVSYKGNVDD
TRETPARDIINNLQEIAQVKIYDPQVRNFDHELVNLEEAFKDSDIVVVLAEHSEFKFLAPNELGKLMRTKQVFDTKNCLN
HNSWVDGGFYVDVLGKRM
>Mature_417_residues
SINKICVMGLGYIGLPTASMLATNGFQVLGVDVNHRVVNMINQGEIHIEEPGLNTMVNASVKSGNLVASNKPEEADAFII
AVPTPINGDKTVNLDYVKDAMKEIIPYLQKDNLIVLESTVPPRTTVDVLLPLLEETDLKVGDDVFVAHCPERVLPGNILH
ELVNNNRIIGGINNKSSEKAKEIYEKIVQGEIVLTDATSSEMAKLMENVYRDVNIALANELSQISDELDIDALEVIKLSN
MHPRVNIHQPGPGVGGHCLPVDPYFITEKTDKAQIISLSRKINNEMPDFVVEKVKEKLSDLTQPKVTVLGVSYKGNVDDT
RETPARDIINNLQEIAQVKIYDPQVRNFDHELVNLEEAFKDSDIVVVLAEHSEFKFLAPNELGKLMRTKQVFDTKNCLNH
NSWVDGGFYVDVLGKRM

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=468, Percent_Identity=26.7094017094017, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI296040443, Length=461, Percent_Identity=25.3796095444685, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI296040438, Length=367, Percent_Identity=24.2506811989101, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI48994968, Length=402, Percent_Identity=43.0348258706468, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI1788340, Length=391, Percent_Identity=24.5524296675192, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17560350, Length=458, Percent_Identity=25.5458515283843, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI17136908, Length=462, Percent_Identity=27.0562770562771, Blast_Score=132, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 46400; Mature: 46269

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSINKICVMGLGYIGLPTASMLATNGFQVLGVDVNHRVVNMINQGEIHIEEPGLNTMVNA
CCCCCEEEEECCCCCCCCHHHHHCCCCEEEEEECCHHHHHHCCCCEEEEECCCCCCEEEC
SVKSGNLVASNKPEEADAFIIAVPTPINGDKTVNLDYVKDAMKEIIPYLQKDNLIVLEST
CCCCCCEEECCCCCCCCEEEEEECCCCCCCCEEEHHHHHHHHHHHHHHHCCCCEEEEECC
VPPRTTVDVLLPLLEETDLKVGDDVFVAHCPERVLPGNILHELVNNNRIIGGINNKSSEK
CCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHHCCCEEEEECCCCCHHH
AKEIYEKIVQGEIVLTDATSSEMAKLMENVYRDVNIALANELSQISDELDIDALEVIKLS
HHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHC
NMHPRVNIHQPGPGVGGHCLPVDPYFITEKTDKAQIISLSRKINNEMPDFVVEKVKEKLS
CCCCEEEEECCCCCCCCEEEECCCEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
DLTQPKVTVLGVSYKGNVDDTRETPARDIINNLQEIAQVKIYDPQVRNFDHELVNLEEAF
HCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHEEEEECCHHHCCCHHHHHHHHHC
KDSDIVVVLAEHSEFKFLAPNELGKLMRTKQVFDTKNCLNHNSWVDGGFYVDVLGKRM
CCCCEEEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCC
>Mature Secondary Structure 
SINKICVMGLGYIGLPTASMLATNGFQVLGVDVNHRVVNMINQGEIHIEEPGLNTMVNA
CCCCEEEEECCCCCCCCHHHHHCCCCEEEEEECCHHHHHHCCCCEEEEECCCCCCEEEC
SVKSGNLVASNKPEEADAFIIAVPTPINGDKTVNLDYVKDAMKEIIPYLQKDNLIVLEST
CCCCCCEEECCCCCCCCEEEEEECCCCCCCCEEEHHHHHHHHHHHHHHHCCCCEEEEECC
VPPRTTVDVLLPLLEETDLKVGDDVFVAHCPERVLPGNILHELVNNNRIIGGINNKSSEK
CCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHHCCCEEEEECCCCCHHH
AKEIYEKIVQGEIVLTDATSSEMAKLMENVYRDVNIALANELSQISDELDIDALEVIKLS
HHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHC
NMHPRVNIHQPGPGVGGHCLPVDPYFITEKTDKAQIISLSRKINNEMPDFVVEKVKEKLS
CCCCEEEEECCCCCCCCEEEECCCEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
DLTQPKVTVLGVSYKGNVDDTRETPARDIINNLQEIAQVKIYDPQVRNFDHELVNLEEAF
HCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHEEEEECCHHHCCCHHHHHHHHHC
KDSDIVVVLAEHSEFKFLAPNELGKLMRTKQVFDTKNCLNHNSWVDGGFYVDVLGKRM
CCCCEEEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA