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The map label for this gene is capD [H]

Identifier: 188587103

GI number: 188587103

Start: 2687985

End: 2689826

Strand: Direct

Name: capD [H]

Synonym: Nther_2497

Alternate gene names: 188587103

Gene position: 2687985-2689826 (Clockwise)

Preceding gene: 188587096

Following gene: 188587116

Centisome position: 84.91

GC content: 39.63

Gene sequence:

>1842_bases
ATGACTGCAAAATACATAAAAAGAGGAATCCAGGTCCTAGTAGATATGTATCTGTTCAACCTGGCCTTTATCATGGCACT
ATTGTTTAGATTCGATGGTTTTGTCCCGGAAGAATACTTGATTATGTATCAGGATAGTTTCTGGTGGATAACGGCAGTAT
TCATTCTCACTTGTATAGTCTTTCGGCTGTATCACAGATTGTGGTCTTATGCCAGTATTCACGATGTGATAGTCCTGGGA
ACAGCCATCACCATCGGTTCCATTTCCGTTTATGCAGCTACTGTTGCTTTAGACATGATGTTTCCCAGAAGCATTTATCT
TATCTCCTTATTTTTGAACCTGGTATTTCTCGGAGGATATCGGCTGGGCTTTCGAGTCCTCAATATATATAAACGGTTTG
GCTTGAGTCCTCTAAAAAAGCAAAAACCCAAAAATAGAAAAAACGTACTAATAGTAGGTGCTGGAGATGCCGGCAATATG
GCTCTAAAGGAATTAAACCAACACCAGCTAGACCTCTCAGTAAATATTGTTGGTTTTTTGGATGATGACCAGGAAAAACA
GGGTTGTCGTGTGAACGGAGTCAAAGTTCTAGGTTCTACCGATGAACTTGTTAAAATCTCCAAGAAAAAAGATGTAGACG
AAGTTGTAATTGCCATGCCTTCAGCTCCTCAACAGGTGATTCGCTATCTCATAAAAACTTGTAGCGATTATTCTATTAAA
ACTAAGATTATACCCGCTGTTCATGACTTAATTTCTGGTAGGGTTTCTATCAATCATTTAAGAGAAGTAGAAATCGAAGA
CCTTTTGAAAAGGGATCCCATCGAACTGGATATAAATCAAATTGCCGGTTATTTAACTAATAAAGTGGTCTTGGTTACAG
GGGCCGGAGGCTCCATCGGTTCGGAACTCGTCAGGCAGATTGCCAACTTTAATCCTCAAACTATATTACTTTTAGGACAC
GGTGAAAACAGTATTTTCGAAATTTATAGAGAAATGGTAGAAAAATTTCCTAAAAATAGATTGGTACCCATCATTGCCGA
TGTTAAAGACAGGGAAAAAATATTTCAAATCGCCAAAGATTACGAGCCCGATGTAGTATTTCACGCCGCCGCACATAAAC
ACGTGCCATTAATGGAACAAAATCCAGAAGAAGCCATTAAAAACAATATCTACGGCACAAAAAACCTGGTAGATGCAGCT
CATCACCATAAATCCCAGCGCTTTGTATTGGTTTCCACAGATAAAGCCGTTAACCCCACTAGTGTCATGGGAGCTACTAA
ACGAGTTGCAGAACTAATCGTAGAAAACATGGCTCAAACAAGTGAAACCAAATATACAGCTGTCAGGTTTGGTAATGTCT
TGGGAAGCAGAGGTAGTGTGATACCTCACTTTAAGGAACAGATCAGTAAAGGTGGGCCAGTCACAATTACCCACCCCGAA
ATGACAAGATACTTCATGACAATTCCTGAAGCTTCCCAGTTAGTCATAGAGGCCGGAGGAATGAGTAAAGGCGGAGAGAT
TTATGTACTAGATATGGGGCAACCGGTAAAAATTGTTGACCTGGCAAAAGATCTAATCAAATTGTCCGGGCTGGAGCCGG
AAAAGGATATTAAATTAAGCTATACCGGAATAAGGCCTGGAGAAAAACTCTACGAAGAACTCCTGACAGAAAAGGAAAAT
GTCTCCAAGACAAAACATGACAAAATTTACATCACTGACAATACGGTTTCCGATACAAATGAAATGAAAAAAGAACTACA
TGCCATGGAGGAAATAATAGCTGCAGATTTAACTTTCTTAGAAAAACAGCTCCTACAAGAATCGAAAACTGGAACTGAAT
AG

Upstream 100 bases:

>100_bases
GTTTTGCAGAGAATTTATAGTTTGGAGGTTTTTTCCTATCAATGAATAAATTATCAATAATAGCTTATCTATAATAATTT
AATAAATGGAGTTGATTATT

Downstream 100 bases:

>100_bases
GTAGGTAGTTGACAAATAAAAAACCTAGAATTCTGGACCATGCCATACATAAGTTTTAGCAGTCCAGATTCTAGGTTTTT
CTTATTTTAAATTTTGTACT

Product: polysaccharide biosynthesis protein CapD

Products: dTDP-4-dehydro-6-deoxy-D-glucose; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 613; Mature: 612

Protein sequence:

>613_residues
MTAKYIKRGIQVLVDMYLFNLAFIMALLFRFDGFVPEEYLIMYQDSFWWITAVFILTCIVFRLYHRLWSYASIHDVIVLG
TAITIGSISVYAATVALDMMFPRSIYLISLFLNLVFLGGYRLGFRVLNIYKRFGLSPLKKQKPKNRKNVLIVGAGDAGNM
ALKELNQHQLDLSVNIVGFLDDDQEKQGCRVNGVKVLGSTDELVKISKKKDVDEVVIAMPSAPQQVIRYLIKTCSDYSIK
TKIIPAVHDLISGRVSINHLREVEIEDLLKRDPIELDINQIAGYLTNKVVLVTGAGGSIGSELVRQIANFNPQTILLLGH
GENSIFEIYREMVEKFPKNRLVPIIADVKDREKIFQIAKDYEPDVVFHAAAHKHVPLMEQNPEEAIKNNIYGTKNLVDAA
HHHKSQRFVLVSTDKAVNPTSVMGATKRVAELIVENMAQTSETKYTAVRFGNVLGSRGSVIPHFKEQISKGGPVTITHPE
MTRYFMTIPEASQLVIEAGGMSKGGEIYVLDMGQPVKIVDLAKDLIKLSGLEPEKDIKLSYTGIRPGEKLYEELLTEKEN
VSKTKHDKIYITDNTVSDTNEMKKELHAMEEIIAADLTFLEKQLLQESKTGTE

Sequences:

>Translated_613_residues
MTAKYIKRGIQVLVDMYLFNLAFIMALLFRFDGFVPEEYLIMYQDSFWWITAVFILTCIVFRLYHRLWSYASIHDVIVLG
TAITIGSISVYAATVALDMMFPRSIYLISLFLNLVFLGGYRLGFRVLNIYKRFGLSPLKKQKPKNRKNVLIVGAGDAGNM
ALKELNQHQLDLSVNIVGFLDDDQEKQGCRVNGVKVLGSTDELVKISKKKDVDEVVIAMPSAPQQVIRYLIKTCSDYSIK
TKIIPAVHDLISGRVSINHLREVEIEDLLKRDPIELDINQIAGYLTNKVVLVTGAGGSIGSELVRQIANFNPQTILLLGH
GENSIFEIYREMVEKFPKNRLVPIIADVKDREKIFQIAKDYEPDVVFHAAAHKHVPLMEQNPEEAIKNNIYGTKNLVDAA
HHHKSQRFVLVSTDKAVNPTSVMGATKRVAELIVENMAQTSETKYTAVRFGNVLGSRGSVIPHFKEQISKGGPVTITHPE
MTRYFMTIPEASQLVIEAGGMSKGGEIYVLDMGQPVKIVDLAKDLIKLSGLEPEKDIKLSYTGIRPGEKLYEELLTEKEN
VSKTKHDKIYITDNTVSDTNEMKKELHAMEEIIAADLTFLEKQLLQESKTGTE
>Mature_612_residues
TAKYIKRGIQVLVDMYLFNLAFIMALLFRFDGFVPEEYLIMYQDSFWWITAVFILTCIVFRLYHRLWSYASIHDVIVLGT
AITIGSISVYAATVALDMMFPRSIYLISLFLNLVFLGGYRLGFRVLNIYKRFGLSPLKKQKPKNRKNVLIVGAGDAGNMA
LKELNQHQLDLSVNIVGFLDDDQEKQGCRVNGVKVLGSTDELVKISKKKDVDEVVIAMPSAPQQVIRYLIKTCSDYSIKT
KIIPAVHDLISGRVSINHLREVEIEDLLKRDPIELDINQIAGYLTNKVVLVTGAGGSIGSELVRQIANFNPQTILLLGHG
ENSIFEIYREMVEKFPKNRLVPIIADVKDREKIFQIAKDYEPDVVFHAAAHKHVPLMEQNPEEAIKNNIYGTKNLVDAAH
HHKSQRFVLVSTDKAVNPTSVMGATKRVAELIVENMAQTSETKYTAVRFGNVLGSRGSVIPHFKEQISKGGPVTITHPEM
TRYFMTIPEASQLVIEAGGMSKGGEIYVLDMGQPVKIVDLAKDLIKLSGLEPEKDIKLSYTGIRPGEKLYEELLTEKENV
SKTKHDKIYITDNTVSDTNEMKKELHAMEEIIAADLTFLEKQLLQESKTGTE

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG1086

COG function: function code MG; Predicted nucleoside-diphosphate sugar epimerases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the polysaccharide synthase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=298, Percent_Identity=25.503355704698, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR003869 [H]

Pfam domain/function: PF02719 Polysacc_synt_2 [H]

EC number: 4.2.1.46 [C]

Molecular weight: Translated: 68951; Mature: 68820

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAKYIKRGIQVLVDMYLFNLAFIMALLFRFDGFVPEEYLIMYQDSFWWITAVFILTCIV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHH
FRLYHRLWSYASIHDVIVLGTAITIGSISVYAATVALDMMFPRSIYLISLFLNLVFLGGY
HHHHHHHHHHHHHHHHHHEEHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCH
RLGFRVLNIYKRFGLSPLKKQKPKNRKNVLIVGAGDAGNMALKELNQHQLDLSVNIVGFL
HHHHHHHHHHHHHCCCCHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHEEEEEEEEEEEE
DDDQEKQGCRVNGVKVLGSTDELVKISKKKDVDEVVIAMPSAPQQVIRYLIKTCSDYSIK
CCCCCCCCCEEECEEEECCCHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCEE
TKIIPAVHDLISGRVSINHLREVEIEDLLKRDPIELDINQIAGYLTNKVVLVTGAGGSIG
EHHHHHHHHHHCCCEEHHHHHCCCHHHHHCCCCCEEEHHHHHHHHCCCEEEEECCCCCHH
SELVRQIANFNPQTILLLGHGENSIFEIYREMVEKFPKNRLVPIIADVKDREKIFQIAKD
HHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHC
YEPDVVFHAAAHKHVPLMEQNPEEAIKNNIYGTKNLVDAAHHHKSQRFVLVSTDKAVNPT
CCCCEEEEECCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCH
SVMGATKRVAELIVENMAQTSETKYTAVRFGNVLGSRGSVIPHFKEQISKGGPVTITHPE
HHHHHHHHHHHHHHHHHHHHCCCCCHHEEHHHHHCCCCCCCCHHHHHHCCCCCEEEECHH
MTRYFMTIPEASQLVIEAGGMSKGGEIYVLDMGQPVKIVDLAKDLIKLSGLEPEKDIKLS
HHHHEEECCCCCEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCEEE
YTGIRPGEKLYEELLTEKENVSKTKHDKIYITDNTVSDTNEMKKELHAMEEIIAADLTFL
EECCCCHHHHHHHHHHCHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
EKQLLQESKTGTE
HHHHHHHCCCCCC
>Mature Secondary Structure 
TAKYIKRGIQVLVDMYLFNLAFIMALLFRFDGFVPEEYLIMYQDSFWWITAVFILTCIV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHH
FRLYHRLWSYASIHDVIVLGTAITIGSISVYAATVALDMMFPRSIYLISLFLNLVFLGGY
HHHHHHHHHHHHHHHHHHEEHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCH
RLGFRVLNIYKRFGLSPLKKQKPKNRKNVLIVGAGDAGNMALKELNQHQLDLSVNIVGFL
HHHHHHHHHHHHHCCCCHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHEEEEEEEEEEEE
DDDQEKQGCRVNGVKVLGSTDELVKISKKKDVDEVVIAMPSAPQQVIRYLIKTCSDYSIK
CCCCCCCCCEEECEEEECCCHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCEE
TKIIPAVHDLISGRVSINHLREVEIEDLLKRDPIELDINQIAGYLTNKVVLVTGAGGSIG
EHHHHHHHHHHCCCEEHHHHHCCCHHHHHCCCCCEEEHHHHHHHHCCCEEEEECCCCCHH
SELVRQIANFNPQTILLLGHGENSIFEIYREMVEKFPKNRLVPIIADVKDREKIFQIAKD
HHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHC
YEPDVVFHAAAHKHVPLMEQNPEEAIKNNIYGTKNLVDAAHHHKSQRFVLVSTDKAVNPT
CCCCEEEEECCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCH
SVMGATKRVAELIVENMAQTSETKYTAVRFGNVLGSRGSVIPHFKEQISKGGPVTITHPE
HHHHHHHHHHHHHHHHHHHHCCCCCHHEEHHHHHCCCCCCCCHHHHHHCCCCCEEEECHH
MTRYFMTIPEASQLVIEAGGMSKGGEIYVLDMGQPVKIVDLAKDLIKLSGLEPEKDIKLS
HHHHEEECCCCCEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCEEE
YTGIRPGEKLYEELLTEKENVSKTKHDKIYITDNTVSDTNEMKKELHAMEEIIAADLTFL
EECCCCHHHHHHHHHHCHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
EKQLLQESKTGTE
HHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.093 {dTDPglucose}} [C]

Substrates: dTDPglucose [C]

Specific reaction: dTDPglucose --> dTDP-4-dehydro-6-deoxy-D-glucose + H2O [C]

General reaction: Elimination (of H2O C-O bond cleavage [C]

Inhibitor: p-Chloromercuribenzoate; TMP [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]