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The map label for this gene is norM [H]

Identifier: 188586966

GI number: 188586966

Start: 2509927

End: 2511330

Strand: Reverse

Name: norM [H]

Synonym: Nther_2358

Alternate gene names: 188586966

Gene position: 2511330-2509927 (Counterclockwise)

Preceding gene: 188586967

Following gene: 188586965

Centisome position: 79.33

GC content: 42.24

Gene sequence:

>1404_bases
ATGGAGCCTGAAGAAAAGCAAAGCAGTCCCGGTAATAGTTTAGAAGGGAGAATTGCCCCTGACAGAGAAAATATCTTAAG
AAACCTGTGGAAACTCAGTTGGCCGGTAATGTTGGGGATGATGCTTCACTCCACCCTGGCAGTAGCCGATACTTTTTTCG
TAGGTCGTTTGGGGGATTATGCCGTTGCAGCTATTTCCTTGTCGGGCAATATCTTTTGGCTATTGATCACAATATCTGAA
GTCATTAATGTAGGTACAGTATCCATGGTAGCAAGATTTATCGGTGCCGAAGAACCAGGAAAGGTTAAAAATACCATTCT
CCATTCAGGACTGTTTGCCTTGTTGTTATCTCTGTTGGTATCTTCTTTGTTAATCTACTTTTCGGCACCTTTTTTGAGTT
TATTTACTCAAGATGAACAGATCCTGGCTTCTGGAACTGCCTATCTTAGAATCATGGCTGTGGGTATGTTCATTCTATTT
TTGTATATTGTTATGAGTGCATCGTTTCAGGGTGCTGGAGATACTAAGACACCAATGAAGATGCTATTTTTTGCCAATGG
CTTAAATATTATTCTTAATCCAGTTTTTATCCTGGGCCTGGGTCCTGCCCCGCGCTTAGAAGTCATGGGAGCCGGGGTAG
CTACTTTGGTCTCCAATTCCCTGGCCCTGTTAATATTGGGGCGTTGGTTTTTCCGGACCAATAAGTTGCCGGCTATTAAG
GTAAGTGATTTTCAGTTTAATAGGTCTATAGCAAGAAATATCATGGCTATCGGATTTCCGGCTGGAGTTCAAGCCATATC
CAGACCATTGACGGGTATGATATTAATGTACATGGTCTCTATCTTTGGTGATGATGCCATTGCAGCTTTTGGCGTGGGTC
AACGGGCCCTGTCTTATGCTTTTATAGTATCAGCAGGTCTAATGGTGGCCACTACTACCATGGTAGGACAGGGACTAGGT
ACAGGAGATCTGGACTATACTAGAAGTATATCTAGAAAAAGTATTATAATCGGATTTTTATTTCAAGGTGCTATAGCTTT
GGTTTACTTTGTCCTGGCACGGCCGATTATGGATTTATTTATTACTGAATCCCAATTGGCTGTAGAGATGGGTGTCAACT
ATCTGCGAATTATTGCCCTGGGCCTTTTATTTGCAGGTCCAATCCGGGCTTTTGTAGGGACTTTTAAAGGAGCAGGTGAC
ACGGTTCCGGGTATGGTGGCCGCCTTTATATCTAATTGGATAGTCAAACTTTCTCTGGCTTATCTAATGGCTTTCCATAT
GGAAATAGGAACTAATGGTATCTGGTGGGCTATTACTATTTCTATTGGAATAGAGATAGCAATTTTATATTACTGGTACC
AAAAGGGGACCTGGCTGTATCGCAAGATACAGGTTCAGGAATAG

Upstream 100 bases:

>100_bases
AATTGACCAGGTTTATGCCAGAAGATGAGGGTGAGGCCTTTTATCTCATGGAACGATCCTTTAAATAAAATTTAATGAGA
TCCCGTGTGGTGATGTGAAA

Downstream 100 bases:

>100_bases
GGTAAATAAGATAAAGAGGAGTTTTAACACAGATCAGGTTTAAGGAGAAAATTTAGATGACTTATAATCTGGAAATTGCT
TTAAATAGTTTAATAGATCG

Product: MATE efflux family protein

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MEPEEKQSSPGNSLEGRIAPDRENILRNLWKLSWPVMLGMMLHSTLAVADTFFVGRLGDYAVAAISLSGNIFWLLITISE
VINVGTVSMVARFIGAEEPGKVKNTILHSGLFALLLSLLVSSLLIYFSAPFLSLFTQDEQILASGTAYLRIMAVGMFILF
LYIVMSASFQGAGDTKTPMKMLFFANGLNIILNPVFILGLGPAPRLEVMGAGVATLVSNSLALLILGRWFFRTNKLPAIK
VSDFQFNRSIARNIMAIGFPAGVQAISRPLTGMILMYMVSIFGDDAIAAFGVGQRALSYAFIVSAGLMVATTTMVGQGLG
TGDLDYTRSISRKSIIIGFLFQGAIALVYFVLARPIMDLFITESQLAVEMGVNYLRIIALGLLFAGPIRAFVGTFKGAGD
TVPGMVAAFISNWIVKLSLAYLMAFHMEIGTNGIWWAITISIGIEIAILYYWYQKGTWLYRKIQVQE

Sequences:

>Translated_467_residues
MEPEEKQSSPGNSLEGRIAPDRENILRNLWKLSWPVMLGMMLHSTLAVADTFFVGRLGDYAVAAISLSGNIFWLLITISE
VINVGTVSMVARFIGAEEPGKVKNTILHSGLFALLLSLLVSSLLIYFSAPFLSLFTQDEQILASGTAYLRIMAVGMFILF
LYIVMSASFQGAGDTKTPMKMLFFANGLNIILNPVFILGLGPAPRLEVMGAGVATLVSNSLALLILGRWFFRTNKLPAIK
VSDFQFNRSIARNIMAIGFPAGVQAISRPLTGMILMYMVSIFGDDAIAAFGVGQRALSYAFIVSAGLMVATTTMVGQGLG
TGDLDYTRSISRKSIIIGFLFQGAIALVYFVLARPIMDLFITESQLAVEMGVNYLRIIALGLLFAGPIRAFVGTFKGAGD
TVPGMVAAFISNWIVKLSLAYLMAFHMEIGTNGIWWAITISIGIEIAILYYWYQKGTWLYRKIQVQE
>Mature_467_residues
MEPEEKQSSPGNSLEGRIAPDRENILRNLWKLSWPVMLGMMLHSTLAVADTFFVGRLGDYAVAAISLSGNIFWLLITISE
VINVGTVSMVARFIGAEEPGKVKNTILHSGLFALLLSLLVSSLLIYFSAPFLSLFTQDEQILASGTAYLRIMAVGMFILF
LYIVMSASFQGAGDTKTPMKMLFFANGLNIILNPVFILGLGPAPRLEVMGAGVATLVSNSLALLILGRWFFRTNKLPAIK
VSDFQFNRSIARNIMAIGFPAGVQAISRPLTGMILMYMVSIFGDDAIAAFGVGQRALSYAFIVSAGLMVATTTMVGQGLG
TGDLDYTRSISRKSIIIGFLFQGAIALVYFVLARPIMDLFITESQLAVEMGVNYLRIIALGLLFAGPIRAFVGTFKGAGD
TVPGMVAAFISNWIVKLSLAYLMAFHMEIGTNGIWWAITISIGIEIAILYYWYQKGTWLYRKIQVQE

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=468, Percent_Identity=23.9316239316239, Blast_Score=91, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 50982; Mature: 50982

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPEEKQSSPGNSLEGRIAPDRENILRNLWKLSWPVMLGMMLHSTLAVADTFFVGRLGDY
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AVAAISLSGNIFWLLITISEVINVGTVSMVARFIGAEEPGKVKNTILHSGLFALLLSLLV
EEEEEEECCCEEEEEEEHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
SSLLIYFSAPFLSLFTQDEQILASGTAYLRIMAVGMFILFLYIVMSASFQGAGDTKTPMK
HHHHHHHHCHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
MLFFANGLNIILNPVFILGLGPAPRLEVMGAGVATLVSNSLALLILGRWFFRTNKLPAIK
HHHHHCCCHHHCCCEEEEECCCCCCCHHHCCCHHHHHHCCHHHHHHHHHHHHCCCCCEEE
VSDFQFNRSIARNIMAIGFPAGVQAISRPLTGMILMYMVSIFGDDAIAAFGVGQRALSYA
ECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHH
FIVSAGLMVATTTMVGQGLGTGDLDYTRSISRKSIIIGFLFQGAIALVYFVLARPIMDLF
HHHHCCHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITESQLAVEMGVNYLRIIALGLLFAGPIRAFVGTFKGAGDTVPGMVAAFISNWIVKLSLA
HCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
YLMAFHMEIGTNGIWWAITISIGIEIAILYYWYQKGTWLYRKIQVQE
HHHHHHHHHCCCCEEEEEEEEECCEEEEEEEEECCCCEEEEEEEECC
>Mature Secondary Structure
MEPEEKQSSPGNSLEGRIAPDRENILRNLWKLSWPVMLGMMLHSTLAVADTFFVGRLGDY
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AVAAISLSGNIFWLLITISEVINVGTVSMVARFIGAEEPGKVKNTILHSGLFALLLSLLV
EEEEEEECCCEEEEEEEHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
SSLLIYFSAPFLSLFTQDEQILASGTAYLRIMAVGMFILFLYIVMSASFQGAGDTKTPMK
HHHHHHHHCHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
MLFFANGLNIILNPVFILGLGPAPRLEVMGAGVATLVSNSLALLILGRWFFRTNKLPAIK
HHHHHCCCHHHCCCEEEEECCCCCCCHHHCCCHHHHHHCCHHHHHHHHHHHHCCCCCEEE
VSDFQFNRSIARNIMAIGFPAGVQAISRPLTGMILMYMVSIFGDDAIAAFGVGQRALSYA
ECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHH
FIVSAGLMVATTTMVGQGLGTGDLDYTRSISRKSIIIGFLFQGAIALVYFVLARPIMDLF
HHHHCCHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITESQLAVEMGVNYLRIIALGLLFAGPIRAFVGTFKGAGDTVPGMVAAFISNWIVKLSLA
HCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
YLMAFHMEIGTNGIWWAITISIGIEIAILYYWYQKGTWLYRKIQVQE
HHHHHHHHHCCCCEEEEEEEEECCEEEEEEEEECCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]