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The map label for this gene is gyaR [H]

Identifier: 188586942

GI number: 188586942

Start: 2481599

End: 2482627

Strand: Reverse

Name: gyaR [H]

Synonym: Nther_2334

Alternate gene names: 188586942

Gene position: 2482627-2481599 (Counterclockwise)

Preceding gene: 188586943

Following gene: 188586941

Centisome position: 78.43

GC content: 40.33

Gene sequence:

>1029_bases
ATGACCTTTTCAAAGGATAATGCCTCTGGCTTGAACAGACAGAAAAATAATTTGAGGGAGCAAGATGAACAACAAGAACG
AGGTTTAAAAATCCTGTTTACCGCAAATTTAAAGGAACACCATTATAAAAATATAACAGCTAGTTTCCCTTCCATAGAGC
TGGTGGCCAGTGCCGAAAAAGAAGTAATTGATAAAGAGATTAAAGATACTGATATATTAGTGGCCTGGGGACGGTTTATC
TCCAAAGAATTACTACAAAAAGCTACCAAATTAGAATGGATTCACGCCTTGAGTACAGGTGTGGATGAATTTTTAATCCC
GGAAGTAATTGATTCTTCTGTAATACTTACTAATTCCCGGGGAATTCACCGGGAACAAATGTCAGAGCATGTGTTCTCTT
TTTTACTGGCTTTTGTCAGGCGCCAGTTTGATTATCATAATCAGAAACAGGACAGTCAGTGGCAGTCCCTGGAAATGTCT
ACTCTGGCCAATAGGACTATTGGAATCCTGGGGCTAGGAGCCCTGGGAGAAGAAATAGCCAGAAAAGCCAAAGCTTTTGA
TATGAAAGTACTGGCAACTAAAGAAACTCCCAGGATTTTTCCTCATGTTGACGAAATTTATTCTTCAGATGAACTTGATA
AAATTTTGCCGGAAGTTGACTATCTGGTACTAACAGTTCCTCTAACGGAAAAAACCAAAAATATGATTGGGGAACATGAA
TTGAGACAGATGAAAGAAACAGCTTTCTTGGTAAACGTTGCCCGGGGAGAAGTAGTTGACGAACAAGCTCTATATCGAGC
TCTTAAAAAACGTTGGTTGGCAGGAGCTGGCCTGGATGTGTTTTCTCAAGAACCGCTACCTGGCGAATCACCATTATGGA
ATCTGGATAACTGCTACATAACCCCTCATGTGGGTGGGGCATCTCCCGATTATGTAAAAAAAGCTGTAGAGCTATTTAAG
CGGAATCTTACCGCTTATTTAGGCGGAAATGTTCTACCGACAGAAGTTGATAAGACTAGAGGTTATTAA

Upstream 100 bases:

>100_bases
AGGGAGTAGCTGTTGAAAGCTACGCTTTTAAGGTGACTCCTGAAGGTTTAAATTATTGTCAGCGACTGCCTGTAACAACA
CAACGGGAGGTTGAATAAAA

Downstream 100 bases:

>100_bases
ACTAGGACTAGAGGATATTAATTGGAACCAGCTTGGAGAAAGGGGATAAGATATGAACTTCAATCTCACTAGTAAAATCA
AGACAGGCCGGGTTATCTTA

Product: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MTFSKDNASGLNRQKNNLREQDEQQERGLKILFTANLKEHHYKNITASFPSIELVASAEKEVIDKEIKDTDILVAWGRFI
SKELLQKATKLEWIHALSTGVDEFLIPEVIDSSVILTNSRGIHREQMSEHVFSFLLAFVRRQFDYHNQKQDSQWQSLEMS
TLANRTIGILGLGALGEEIARKAKAFDMKVLATKETPRIFPHVDEIYSSDELDKILPEVDYLVLTVPLTEKTKNMIGEHE
LRQMKETAFLVNVARGEVVDEQALYRALKKRWLAGAGLDVFSQEPLPGESPLWNLDNCYITPHVGGASPDYVKKAVELFK
RNLTAYLGGNVLPTEVDKTRGY

Sequences:

>Translated_342_residues
MTFSKDNASGLNRQKNNLREQDEQQERGLKILFTANLKEHHYKNITASFPSIELVASAEKEVIDKEIKDTDILVAWGRFI
SKELLQKATKLEWIHALSTGVDEFLIPEVIDSSVILTNSRGIHREQMSEHVFSFLLAFVRRQFDYHNQKQDSQWQSLEMS
TLANRTIGILGLGALGEEIARKAKAFDMKVLATKETPRIFPHVDEIYSSDELDKILPEVDYLVLTVPLTEKTKNMIGEHE
LRQMKETAFLVNVARGEVVDEQALYRALKKRWLAGAGLDVFSQEPLPGESPLWNLDNCYITPHVGGASPDYVKKAVELFK
RNLTAYLGGNVLPTEVDKTRGY
>Mature_341_residues
TFSKDNASGLNRQKNNLREQDEQQERGLKILFTANLKEHHYKNITASFPSIELVASAEKEVIDKEIKDTDILVAWGRFIS
KELLQKATKLEWIHALSTGVDEFLIPEVIDSSVILTNSRGIHREQMSEHVFSFLLAFVRRQFDYHNQKQDSQWQSLEMST
LANRTIGILGLGALGEEIARKAKAFDMKVLATKETPRIFPHVDEIYSSDELDKILPEVDYLVLTVPLTEKTKNMIGEHEL
RQMKETAFLVNVARGEVVDEQALYRALKKRWLAGAGLDVFSQEPLPGESPLWNLDNCYITPHVGGASPDYVKKAVELFKR
NLTAYLGGNVLPTEVDKTRGY

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=267, Percent_Identity=32.5842696629214, Blast_Score=131, Evalue=7e-31,
Organism=Homo sapiens, GI23308577, Length=263, Percent_Identity=28.5171102661597, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI61743967, Length=265, Percent_Identity=29.0566037735849, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4557497, Length=265, Percent_Identity=29.0566037735849, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI145580578, Length=238, Percent_Identity=28.5714285714286, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI4557499, Length=238, Percent_Identity=28.5714285714286, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI145580575, Length=247, Percent_Identity=28.7449392712551, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI87081824, Length=256, Percent_Identity=35.15625, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI87082289, Length=260, Percent_Identity=29.6153846153846, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1789279, Length=271, Percent_Identity=28.0442804428044, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787645, Length=162, Percent_Identity=28.3950617283951, Blast_Score=78, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=266, Percent_Identity=28.1954887218045, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI25147481, Length=242, Percent_Identity=23.1404958677686, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324964, Length=307, Percent_Identity=23.4527687296417, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320925, Length=265, Percent_Identity=27.5471698113208, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322116, Length=265, Percent_Identity=27.5471698113208, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6324055, Length=219, Percent_Identity=30.1369863013699, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325144, Length=162, Percent_Identity=30.8641975308642, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6321253, Length=155, Percent_Identity=30.3225806451613, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324980, Length=186, Percent_Identity=24.7311827956989, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI28574286, Length=267, Percent_Identity=31.0861423220974, Blast_Score=134, Evalue=7e-32,
Organism=Drosophila melanogaster, GI28574284, Length=246, Percent_Identity=31.3008130081301, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24585514, Length=246, Percent_Identity=31.3008130081301, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI28574282, Length=246, Percent_Identity=31.3008130081301, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI45551003, Length=246, Percent_Identity=31.3008130081301, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI45552429, Length=246, Percent_Identity=31.3008130081301, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI28571528, Length=272, Percent_Identity=31.9852941176471, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24585516, Length=298, Percent_Identity=26.510067114094, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI19921140, Length=273, Percent_Identity=27.1062271062271, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24646446, Length=265, Percent_Identity=27.5471698113208, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24646448, Length=265, Percent_Identity=27.5471698113208, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24646452, Length=265, Percent_Identity=27.5471698113208, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24646450, Length=265, Percent_Identity=27.5471698113208, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI62472511, Length=265, Percent_Identity=26.7924528301887, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 38860; Mature: 38729

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFSKDNASGLNRQKNNLREQDEQQERGLKILFTANLKEHHYKNITASFPSIELVASAEK
CCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEECCHHHHHCCCCCCCCCCHHHHHHHH
EVIDKEIKDTDILVAWGRFISKELLQKATKLEWIHALSTGVDEFLIPEVIDSSVILTNSR
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCEEEECCC
GIHREQMSEHVFSFLLAFVRRQFDYHNQKQDSQWQSLEMSTLANRTIGILGLGALGEEIA
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHEEECHHHHHHHH
RKAKAFDMKVLATKETPRIFPHVDEIYSSDELDKILPEVDYLVLTVPLTEKTKNMIGEHE
HHHHHHCEEEEEECCCCCCCCCHHHHHCCCHHHHHHCCCCEEEEEECCCHHHHHHHHHHH
LRQMKETAFLVNVARGEVVDEQALYRALKKRWLAGAGLDVFSQEPLPGESPLWNLDNCYI
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCCCCCEE
TPHVGGASPDYVKKAVELFKRNLTAYLGGNVLPTEVDKTRGY
ECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCC
>Mature Secondary Structure 
TFSKDNASGLNRQKNNLREQDEQQERGLKILFTANLKEHHYKNITASFPSIELVASAEK
CCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEECCHHHHHCCCCCCCCCCHHHHHHHH
EVIDKEIKDTDILVAWGRFISKELLQKATKLEWIHALSTGVDEFLIPEVIDSSVILTNSR
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCEEEECCC
GIHREQMSEHVFSFLLAFVRRQFDYHNQKQDSQWQSLEMSTLANRTIGILGLGALGEEIA
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHEEECHHHHHHHH
RKAKAFDMKVLATKETPRIFPHVDEIYSSDELDKILPEVDYLVLTVPLTEKTKNMIGEHE
HHHHHHCEEEEEECCCCCCCCCHHHHHCCCHHHHHHCCCCEEEEEECCCHHHHHHHHHHH
LRQMKETAFLVNVARGEVVDEQALYRALKKRWLAGAGLDVFSQEPLPGESPLWNLDNCYI
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCCCCCEE
TPHVGGASPDYVKKAVELFKRNLTAYLGGNVLPTEVDKTRGY
ECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA