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The map label for this gene is hflX [H]

Identifier: 188586871

GI number: 188586871

Start: 2405050

End: 2406357

Strand: Reverse

Name: hflX [H]

Synonym: Nther_2262

Alternate gene names: 188586871

Gene position: 2406357-2405050 (Counterclockwise)

Preceding gene: 188586872

Following gene: 188586870

Centisome position: 76.02

GC content: 43.81

Gene sequence:

>1308_bases
ATGAGTAATAGTTTTGATGGCTTTGACAATAGAATGGAGCCCAAAAGGGCTATTTTAGTAGCTTTAGAGCAAACGGACAG
GAACGAGCGTTTTAGTACGGAAGAATCTCTGGAGGAGTTACAGCGTTTGGCAGATACGGCAGAGATAGAGTGCGTAACGG
AAATTGTGCAAAAACGACCTAAACCCCATCCCGGGTTTTTCATTGGTAAAGGTAAAGCTCGTGAGATCGGATTGCTGCTA
GAAGAACTTGATTGTAATATGGTGATTTTTGATGATGAATTGTCTCCAGGTCAGATTCGCAACTTAGAAGATACTTTAGA
TACCGATGTTTGGGATCGGACAGCTTTAATCTTGGATATATTTTACCGGCGGGCTAATTCCAAAGAGGCCAAGCTGCAAG
TAGAACTGGCCCGTTTAGAGTATCTACTCCCCCGATTGGTGGGCCGCGGAAGTGAGATGAGCCGACTTGCCGGTGGTATC
GGTACTAGAGGACGGGGAGAACAGAAACTAGAGATCGACAGACGCCATTTGAGAGAACAAATTCAAGAGATTAGGCGTAA
GCTGGCAGAAGTAAGAAAGCGTCGGGAAGAAAATCGCCAGTACCGCAAAAAACATAATTTACCCGTGGTATCCCTCGTTG
GTTATACCAATGCTGGTAAATCAACCCTTTTATCTACCTTGACGGGAAGCAAAGTGACTGCCAAGGACGAGCTCTTTAAT
ACTTTAGACCCTAAACTAGCAGATATGAGCATGTCATCTGGTTCCAAAGCCCTGCTTTCGGATACTGTGGGATTTATTAA
TAAACTGCCCCATCACCTGGTGGCAGCTTTTAGAGCTACACTTGAAGAGGTGGAAGAGGCAGATTTAATACTTCATGTAA
TCGACGCTTCGAGCCCTAGAATGTATGAAGAGATAGAAGCAGTGGAAGAAGTATTATCCTCCCTTGATTTGGAAGGGACC
CCCATAATCAAAGTGTATAACAAAACAGATCTGTTGCAAGAATCCGAGCCTTTGATGGAGAGTGGTTTCCCCAAGGAAGT
TGCCATTTCCGCCTTAAAAAAAGATGGTCTTCACAGGTTGAGAAAGGCTATCCAACGTTATTTGGAAAGTTCCTGGGTCC
GAAAAGAATATATCATTCCCTATCATAGGGAAGATCTAAAAGCCAGATTGTATGAAGTGGGTGAAGTTCTAGATATAGAG
TATAAAGAAACAGTTATGGAAGTTTACGCCAGGGTGCCGCCCCACGAGGATCAGCGCCTAGAAAAAGATCTAGCTGAAAT
TAAAGGAGGTAATTCTCGTCATGAATAG

Upstream 100 bases:

>100_bases
ACTCAAGGAGAAAGTCACTGCCCCCTGCTCCCTGTGTTGTAGCTTCCTTTGTTGTAGCTGTGGGAGCGTGTTAAGAGTAT
GACAATGGAGGTAAGTTTAC

Downstream 100 bases:

>100_bases
TAATGAAATTAATTCCCATACCAATTCCCATTCCAATTCCAATATTTCTCATGTGGAAGATCGCTATTCCCTAGAGAAAA
AACCCGAGACTATATCACGC

Product: GTP-binding proten HflX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MSNSFDGFDNRMEPKRAILVALEQTDRNERFSTEESLEELQRLADTAEIECVTEIVQKRPKPHPGFFIGKGKAREIGLLL
EELDCNMVIFDDELSPGQIRNLEDTLDTDVWDRTALILDIFYRRANSKEAKLQVELARLEYLLPRLVGRGSEMSRLAGGI
GTRGRGEQKLEIDRRHLREQIQEIRRKLAEVRKRREENRQYRKKHNLPVVSLVGYTNAGKSTLLSTLTGSKVTAKDELFN
TLDPKLADMSMSSGSKALLSDTVGFINKLPHHLVAAFRATLEEVEEADLILHVIDASSPRMYEEIEAVEEVLSSLDLEGT
PIIKVYNKTDLLQESEPLMESGFPKEVAISALKKDGLHRLRKAIQRYLESSWVRKEYIIPYHREDLKARLYEVGEVLDIE
YKETVMEVYARVPPHEDQRLEKDLAEIKGGNSRHE

Sequences:

>Translated_435_residues
MSNSFDGFDNRMEPKRAILVALEQTDRNERFSTEESLEELQRLADTAEIECVTEIVQKRPKPHPGFFIGKGKAREIGLLL
EELDCNMVIFDDELSPGQIRNLEDTLDTDVWDRTALILDIFYRRANSKEAKLQVELARLEYLLPRLVGRGSEMSRLAGGI
GTRGRGEQKLEIDRRHLREQIQEIRRKLAEVRKRREENRQYRKKHNLPVVSLVGYTNAGKSTLLSTLTGSKVTAKDELFN
TLDPKLADMSMSSGSKALLSDTVGFINKLPHHLVAAFRATLEEVEEADLILHVIDASSPRMYEEIEAVEEVLSSLDLEGT
PIIKVYNKTDLLQESEPLMESGFPKEVAISALKKDGLHRLRKAIQRYLESSWVRKEYIIPYHREDLKARLYEVGEVLDIE
YKETVMEVYARVPPHEDQRLEKDLAEIKGGNSRHE
>Mature_434_residues
SNSFDGFDNRMEPKRAILVALEQTDRNERFSTEESLEELQRLADTAEIECVTEIVQKRPKPHPGFFIGKGKAREIGLLLE
ELDCNMVIFDDELSPGQIRNLEDTLDTDVWDRTALILDIFYRRANSKEAKLQVELARLEYLLPRLVGRGSEMSRLAGGIG
TRGRGEQKLEIDRRHLREQIQEIRRKLAEVRKRREENRQYRKKHNLPVVSLVGYTNAGKSTLLSTLTGSKVTAKDELFNT
LDPKLADMSMSSGSKALLSDTVGFINKLPHHLVAAFRATLEEVEEADLILHVIDASSPRMYEEIEAVEEVLSSLDLEGTP
IIKVYNKTDLLQESEPLMESGFPKEVAISALKKDGLHRLRKAIQRYLESSWVRKEYIIPYHREDLKARLYEVGEVLDIEY
KETVMEVYARVPPHEDQRLEKDLAEIKGGNSRHE

Specific function: Unknown

COG id: COG2262

COG function: function code R; GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain [H]

Homologues:

Organism=Homo sapiens, GI310133118, Length=272, Percent_Identity=36.3970588235294, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI310133116, Length=265, Percent_Identity=35.8490566037736, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI310124269, Length=250, Percent_Identity=36.8, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI310124267, Length=250, Percent_Identity=36.8, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI310124171, Length=250, Percent_Identity=36.8, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI310124169, Length=250, Percent_Identity=36.8, Blast_Score=136, Evalue=4e-32,
Organism=Escherichia coli, GI1790615, Length=420, Percent_Identity=42.1428571428571, Blast_Score=298, Evalue=5e-82,
Organism=Caenorhabditis elegans, GI17561038, Length=287, Percent_Identity=33.7979094076655, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24650079, Length=327, Percent_Identity=34.5565749235474, Blast_Score=122, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR016496
- InterPro:   IPR006073
- InterPro:   IPR002917 [H]

Pfam domain/function: PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 49867; Mature: 49735

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSFDGFDNRMEPKRAILVALEQTDRNERFSTEESLEELQRLADTAEIECVTEIVQKRP
CCCCCCCCCCCCCCCHHEEEEEHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KPHPGFFIGKGKAREIGLLLEELDCNMVIFDDELSPGQIRNLEDTLDTDVWDRTALILDI
CCCCCEEEECCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHCCHHHHHHHHHHHH
FYRRANSKEAKLQVELARLEYLLPRLVGRGSEMSRLAGGIGTRGRGEQKLEIDRRHLREQ
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
IQEIRRKLAEVRKRREENRQYRKKHNLPVVSLVGYTNAGKSTLLSTLTGSKVTAKDELFN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCCCHHHHHHH
TLDPKLADMSMSSGSKALLSDTVGFINKLPHHLVAAFRATLEEVEEADLILHVIDASSPR
HCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCH
MYEEIEAVEEVLSSLDLEGTPIIKVYNKTDLLQESEPLMESGFPKEVAISALKKDGLHRL
HHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHH
RKAIQRYLESSWVRKEYIIPYHREDLKARLYEVGEVLDIEYKETVMEVYARVPPHEDQRL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHH
EKDLAEIKGGNSRHE
HHHHHHHCCCCCCCC
>Mature Secondary Structure 
SNSFDGFDNRMEPKRAILVALEQTDRNERFSTEESLEELQRLADTAEIECVTEIVQKRP
CCCCCCCCCCCCCCHHEEEEEHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KPHPGFFIGKGKAREIGLLLEELDCNMVIFDDELSPGQIRNLEDTLDTDVWDRTALILDI
CCCCCEEEECCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHCCHHHHHHHHHHHH
FYRRANSKEAKLQVELARLEYLLPRLVGRGSEMSRLAGGIGTRGRGEQKLEIDRRHLREQ
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
IQEIRRKLAEVRKRREENRQYRKKHNLPVVSLVGYTNAGKSTLLSTLTGSKVTAKDELFN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCCCHHHHHHH
TLDPKLADMSMSSGSKALLSDTVGFINKLPHHLVAAFRATLEEVEEADLILHVIDASSPR
HCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCH
MYEEIEAVEEVLSSLDLEGTPIIKVYNKTDLLQESEPLMESGFPKEVAISALKKDGLHRL
HHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHH
RKAIQRYLESSWVRKEYIIPYHREDLKARLYEVGEVLDIEYKETVMEVYARVPPHEDQRL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHH
EKDLAEIKGGNSRHE
HHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8248183; 7610040; 9278503; 2020545; 3040675 [H]