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The map label for this gene is Dml [H]

Identifier: 188586763

GI number: 188586763

Start: 2278916

End: 2279785

Strand: Reverse

Name: Dml [H]

Synonym: Nther_2154

Alternate gene names: 188586763

Gene position: 2279785-2278916 (Counterclockwise)

Preceding gene: 188586764

Following gene: 188586762

Centisome position: 72.02

GC content: 39.08

Gene sequence:

>870_bases
ATGAACAATACAACTAAATTAAAAGAATTAATTAATAAAAACGAAATTTTAATGGCACCAGGAGCTCATGATGCGCTAAC
AGCTCGAGTTATCGAACAAGCAGGCTTTAATGCTGTATATATGACAGGTTATGGACAAGCCGCAAGTGTCCTGGGAAAGC
CCGATGTAGGATTGTTAACTATGACGGAAATGCTTGATAGAGCAAATAAAATTGTCAATGCCGTGAATGTGCCAGTAATT
GCTGATGCTGATACCGGGTTTGGTAATGCCATCAATGTAATCCGAACTGTAGAGGAATACGAGAAGGCCGGAGTTGCGGC
CATTCAGTTAGAAGACCAAGTCATGCCCAAAAAGTGCGGCCATATGGTGGGGAGACAAATTGTTTCTCAAGATGAAATGG
TAGGGAAAATAGAAGCTGCCATCTCCGCTAGGAAAAATAAAGATTTTCAGATAATAGCCAGAACTGATGCCAGAACAACT
TATGGATTAGAAGAAGCTTTAAAAAGAGCAGATGCTTATGTTAAAGCCGGGGCAGATATAATTTTCTTGGAATCCCCGGA
GAGCATGGATGAGATGCAGACTATTAATGAAAAAGTTGAAGCACCTACCCTGGCTAATATGGTAGAAGGTGGAAGAACAC
CAACATTGAAAGCAGATAAACTTGAAGAACTAGGCTTTAACTTGGTTATTTATCCAACAGCTTCAACCTATGTAACAGCA
AAGGCCATGTCCGAACTAATGAGTACTTTGAAAACAGAAGGTTCCACAGAATCTTTTGAAAGTGAAATGTTACTTTTTGA
ACAATTTAACGAATTAATTGGACTTAAAGAGATCAAAGACTTAGAAGGAAAATTTGTCAGAGGCCAGTAA

Upstream 100 bases:

>100_bases
AGAGTCGATGAAGATTACGCCTTTCAGATATTGAAACAGGCATATCAATTGTAACACTGACAAATATCAATAATTAAATG
CAAAACGAGGAGGTTATGTT

Downstream 100 bases:

>100_bases
AATCACCTGAATATGAGGAGGGAAAAGCCAATGATATTATCCGAGTTTGATTATTTAGCTCCCAAGTCACTGTCAGAAGC
TCTTAATATACTAGATAAAG

Product: carboxyvinyl-carboxyphosphonate phosphorylmutase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MNNTTKLKELINKNEILMAPGAHDALTARVIEQAGFNAVYMTGYGQAASVLGKPDVGLLTMTEMLDRANKIVNAVNVPVI
ADADTGFGNAINVIRTVEEYEKAGVAAIQLEDQVMPKKCGHMVGRQIVSQDEMVGKIEAAISARKNKDFQIIARTDARTT
YGLEEALKRADAYVKAGADIIFLESPESMDEMQTINEKVEAPTLANMVEGGRTPTLKADKLEELGFNLVIYPTASTYVTA
KAMSELMSTLKTEGSTESFESEMLLFEQFNELIGLKEIKDLEGKFVRGQ

Sequences:

>Translated_289_residues
MNNTTKLKELINKNEILMAPGAHDALTARVIEQAGFNAVYMTGYGQAASVLGKPDVGLLTMTEMLDRANKIVNAVNVPVI
ADADTGFGNAINVIRTVEEYEKAGVAAIQLEDQVMPKKCGHMVGRQIVSQDEMVGKIEAAISARKNKDFQIIARTDARTT
YGLEEALKRADAYVKAGADIIFLESPESMDEMQTINEKVEAPTLANMVEGGRTPTLKADKLEELGFNLVIYPTASTYVTA
KAMSELMSTLKTEGSTESFESEMLLFEQFNELIGLKEIKDLEGKFVRGQ
>Mature_289_residues
MNNTTKLKELINKNEILMAPGAHDALTARVIEQAGFNAVYMTGYGQAASVLGKPDVGLLTMTEMLDRANKIVNAVNVPVI
ADADTGFGNAINVIRTVEEYEKAGVAAIQLEDQVMPKKCGHMVGRQIVSQDEMVGKIEAAISARKNKDFQIIARTDARTT
YGLEEALKRADAYVKAGADIIFLESPESMDEMQTINEKVEAPTLANMVEGGRTPTLKADKLEELGFNLVIYPTASTYVTA
KAMSELMSTLKTEGSTESFESEMLLFEQFNELIGLKEIKDLEGKFVRGQ

Specific function: Catalyzes the formation of proponate and pyruvate from (2R,3S)-2,3-dimethylmalate. Has no activity toward dimethylmaleate, malate, citramalate, isocitrate and citrate [H]

COG id: COG2513

COG function: function code G; PEP phosphonomutase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786525, Length=285, Percent_Identity=35.7894736842105, Blast_Score=185, Evalue=3e-48,
Organism=Escherichia coli, GI1790445, Length=213, Percent_Identity=27.2300469483568, Blast_Score=67, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17561814, Length=185, Percent_Identity=28.1081081081081, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71982926, Length=185, Percent_Identity=28.1081081081081, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.32 [H]

Molecular weight: Translated: 31580; Mature: 31580

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNTTKLKELINKNEILMAPGAHDALTARVIEQAGFNAVYMTGYGQAASVLGKPDVGLLT
CCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHCCCCCCCHHH
MTEMLDRANKIVNAVNVPVIADADTGFGNAINVIRTVEEYEKAGVAAIQLEDQVMPKKCG
HHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHH
HMVGRQIVSQDEMVGKIEAAISARKNKDFQIIARTDARTTYGLEEALKRADAYVKAGADI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCE
IFLESPESMDEMQTINEKVEAPTLANMVEGGRTPTLKADKLEELGFNLVIYPTASTYVTA
EEEECCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHCCCCEEEEECCCHHHHH
KAMSELMSTLKTEGSTESFESEMLLFEQFNELIGLKEIKDLEGKFVRGQ
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCHHHHHHCCCCEECCC
>Mature Secondary Structure
MNNTTKLKELINKNEILMAPGAHDALTARVIEQAGFNAVYMTGYGQAASVLGKPDVGLLT
CCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHCCCCCCCHHH
MTEMLDRANKIVNAVNVPVIADADTGFGNAINVIRTVEEYEKAGVAAIQLEDQVMPKKCG
HHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHH
HMVGRQIVSQDEMVGKIEAAISARKNKDFQIIARTDARTTYGLEEALKRADAYVKAGADI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCE
IFLESPESMDEMQTINEKVEAPTLANMVEGGRTPTLKADKLEELGFNLVIYPTASTYVTA
EEEECCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHCCCCEEEEECCCHHHHH
KAMSELMSTLKTEGSTESFESEMLLFEQFNELIGLKEIKDLEGKFVRGQ
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCHHHHHHCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA