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The map label for this gene is comEC [H]

Identifier: 188586730

GI number: 188586730

Start: 2241472

End: 2242980

Strand: Direct

Name: comEC [H]

Synonym: Nther_2120

Alternate gene names: 188586730

Gene position: 2241472-2242980 (Clockwise)

Preceding gene: 188586721

Following gene: 188586739

Centisome position: 70.81

GC content: 38.04

Gene sequence:

>1509_bases
GTGAAAAAAATCATCTGCTTTGGATTATGTATGGTATTAGTTTTCTCATTAAATTCTTTATGTTTTGCTGAAGAAACCAA
GGTTATAGTCGATGGAGAAGAGATTGACTTACAAGATCCCGTGAGAATTATTGAGGGAAGGACACTATTACCTGCTAGAC
CTTTATTTGAAAGTTTAGATGCAGAGATGAATTGGAACCCTAAAACCGAAACAGCCATTGGTAAGATGAATGGTCATCAG
GTTGAAATTCCCCTCAATGAAGAACAGGCTAAAATCAATGATGAGCCCCGCAATTTGGAAGTACAAGCTGAAACCTATGA
GGGAAGAACTTACATACCACTACGATTTGCAGGAGAGGCTTTGGGTGGAACTGTCGAATGGGATAGCAAAAAAAACGCAG
CAATTATCACAACTGATGCAGTAGAACCAGATCCGGCTAAAAAAGAAACAAGCCCAGAAAAAACTGAGCCAGGACAGTTA
ACAGCTCATTTTATAGATGTAGGCCAGGGAGATGCCATATTTTTAGAAGCTCCTTGTGATAGTCACATTTTAGTCGATGG
TGGCTTAGAACTAGAAAGTCAACCTGTAGTTAATTATCTAGAGGAACTTGGAATAAATAAAATTGAAAAAGTAGTAGCAA
CTCATCCCCATCAAGATCATATTGGTGGGCTGATTGATGTTTATCAAAACTTCGATGTTAAAACCACTTATGATAGCGGT
TATGAACATGATACCCTCACTTATGAAAAATATTACGAAATAGCAAATGATGTTTCTAACTTTAAAACTGCTAGACAAGG
AGACAAACTGGAAATTGACTCCTTGGGGGCCGAATTTATTCATCCACCCCAGGGACATACAGGTGAAGTTCACGATTTGA
ACCTTGTTTTAGAGGTTGAATTTAAAAATCAATCCCTTTTACTAACAGGTGATGCTGAAAAAGATACAGAGCAGATGATA
ATAGAAAGAGCCAGTGACATTTCTAGTGAAATTTTAAAAATCGGTCACCACGGCAGTTATACTAGCAGCAGTGAAGAGTT
TTTAGAAGCAGTTGATCCTGAAGCAGCGGTAATTCAAGTTGGAGAAGACAATCAGTACGGTCATCCTCATGACCAAGTCC
TAGAAAGGTTAGCTGAACAAAATATAGAAATTTATAGAACTGATTATCATGATGACATAGTAATGGAACTAGACGAAAAC
ACTTGGCAAGCTGAAGTTGAACCTTGGAAAAAAGAAGATGGAGAACTCCCAACAGATCAAGACGCAGATGATAAAGACAC
AGTTACTGAGGAAAAAGACGATCAGGATCAAGAACTGATTAATATAAATCAAGCCGAGAAAGAAGAATTAACTCAGATCA
TTAATATCGATGTGGACAGGGCAGAACAAATTGTAGAGTTACGAAAAGAACGACCTTTTACTTCCCTAGATGACCTGGAA
CGTGTTAAAGGGCTAGCCGAAGTAACCATTGGAGAAATAAAGGATGAAGGAATAGCTTACGTCGATTAA

Upstream 100 bases:

>100_bases
TGTCATCATTTTATGACATTTTTTCACCATTACATAAACTTGTTAACATAGGGATTAAAATGGTATTTTGGTAATAGAAT
TTAACTTCGGAGGTGATTCT

Downstream 100 bases:

>100_bases
AAAAACAGTGCTGTCACCATATAATGGGTGACAGCACTGTTTTTTAATCCTGTATATTTATTCGCTATTCATCAAAGCCT
TCCTCTTCTTCAAATTTAGC

Product: copper amine oxidase domain protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MKKIICFGLCMVLVFSLNSLCFAEETKVIVDGEEIDLQDPVRIIEGRTLLPARPLFESLDAEMNWNPKTETAIGKMNGHQ
VEIPLNEEQAKINDEPRNLEVQAETYEGRTYIPLRFAGEALGGTVEWDSKKNAAIITTDAVEPDPAKKETSPEKTEPGQL
TAHFIDVGQGDAIFLEAPCDSHILVDGGLELESQPVVNYLEELGINKIEKVVATHPHQDHIGGLIDVYQNFDVKTTYDSG
YEHDTLTYEKYYEIANDVSNFKTARQGDKLEIDSLGAEFIHPPQGHTGEVHDLNLVLEVEFKNQSLLLTGDAEKDTEQMI
IERASDISSEILKIGHHGSYTSSSEEFLEAVDPEAAVIQVGEDNQYGHPHDQVLERLAEQNIEIYRTDYHDDIVMELDEN
TWQAEVEPWKKEDGELPTDQDADDKDTVTEEKDDQDQELININQAEKEELTQIINIDVDRAEQIVELRKERPFTSLDDLE
RVKGLAEVTIGEIKDEGIAYVD

Sequences:

>Translated_502_residues
MKKIICFGLCMVLVFSLNSLCFAEETKVIVDGEEIDLQDPVRIIEGRTLLPARPLFESLDAEMNWNPKTETAIGKMNGHQ
VEIPLNEEQAKINDEPRNLEVQAETYEGRTYIPLRFAGEALGGTVEWDSKKNAAIITTDAVEPDPAKKETSPEKTEPGQL
TAHFIDVGQGDAIFLEAPCDSHILVDGGLELESQPVVNYLEELGINKIEKVVATHPHQDHIGGLIDVYQNFDVKTTYDSG
YEHDTLTYEKYYEIANDVSNFKTARQGDKLEIDSLGAEFIHPPQGHTGEVHDLNLVLEVEFKNQSLLLTGDAEKDTEQMI
IERASDISSEILKIGHHGSYTSSSEEFLEAVDPEAAVIQVGEDNQYGHPHDQVLERLAEQNIEIYRTDYHDDIVMELDEN
TWQAEVEPWKKEDGELPTDQDADDKDTVTEEKDDQDQELININQAEKEELTQIINIDVDRAEQIVELRKERPFTSLDDLE
RVKGLAEVTIGEIKDEGIAYVD
>Mature_502_residues
MKKIICFGLCMVLVFSLNSLCFAEETKVIVDGEEIDLQDPVRIIEGRTLLPARPLFESLDAEMNWNPKTETAIGKMNGHQ
VEIPLNEEQAKINDEPRNLEVQAETYEGRTYIPLRFAGEALGGTVEWDSKKNAAIITTDAVEPDPAKKETSPEKTEPGQL
TAHFIDVGQGDAIFLEAPCDSHILVDGGLELESQPVVNYLEELGINKIEKVVATHPHQDHIGGLIDVYQNFDVKTTYDSG
YEHDTLTYEKYYEIANDVSNFKTARQGDKLEIDSLGAEFIHPPQGHTGEVHDLNLVLEVEFKNQSLLLTGDAEKDTEQMI
IERASDISSEILKIGHHGSYTSSSEEFLEAVDPEAAVIQVGEDNQYGHPHDQVLERLAEQNIEIYRTDYHDDIVMELDEN
TWQAEVEPWKKEDGELPTDQDADDKDTVTEEKDDQDQELININQAEKEELTQIINIDVDRAEQIVELRKERPFTSLDDLE
RVKGLAEVTIGEIKDEGIAYVD

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=260, Percent_Identity=23.8461538461538, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 56530; Mature: 56530

Theoretical pI: Translated: 4.04; Mature: 4.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIICFGLCMVLVFSLNSLCFAEETKVIVDGEEIDLQDPVRIIEGRTLLPARPLFESLD
CCCHHHHHHHHHHHHHHCCCEEECCCEEEECCCCCCCCCCHHHHCCCCCCCCHHHHHHCC
AEMNWNPKTETAIGKMNGHQVEIPLNEEQAKINDEPRNLEVQAETYEGRTYIPLRFAGEA
CCCCCCCCCCCEEECCCCCEEEEECCCCHHCCCCCCCCEEEEEEEECCCEEEEEEECCHH
LGGTVEWDSKKNAAIITTDAVEPDPAKKETSPEKTEPGQLTAHFIDVGQGDAIFLEAPCD
HCCEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCC
SHILVDGGLELESQPVVNYLEELGINKIEKVVATHPHQDHIGGLIDVYQNFDVKTTYDSG
CEEEEECCCCCCCCHHHHHHHHHCHHHHHHHHHCCCCHHHHCHHHHHHHCCCEEEECCCC
YEHDTLTYEKYYEIANDVSNFKTARQGDKLEIDSLGAEFIHPPQGHTGEVHDLNLVLEVE
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHCCHHHCCCCCCCCCCEEEEEEEEEEE
FKNQSLLLTGDAEKDTEQMIIERASDISSEILKIGHHGSYTSSSEEFLEAVDPEAAVIQV
ECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCEEEEEE
GEDNQYGHPHDQVLERLAEQNIEIYRTDYHDDIVMELDENTWQAEVEPWKKEDGELPTDQ
CCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCEEECCCCCCCCCCCCCCCC
DADDKDTVTEEKDDQDQELININQAEKEELTQIINIDVDRAEQIVELRKERPFTSLDDLE
CCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHH
RVKGLAEVTIGEIKDEGIAYVD
HHHHHHHHHHHHHCCCCCEECC
>Mature Secondary Structure
MKKIICFGLCMVLVFSLNSLCFAEETKVIVDGEEIDLQDPVRIIEGRTLLPARPLFESLD
CCCHHHHHHHHHHHHHHCCCEEECCCEEEECCCCCCCCCCHHHHCCCCCCCCHHHHHHCC
AEMNWNPKTETAIGKMNGHQVEIPLNEEQAKINDEPRNLEVQAETYEGRTYIPLRFAGEA
CCCCCCCCCCCEEECCCCCEEEEECCCCHHCCCCCCCCEEEEEEEECCCEEEEEEECCHH
LGGTVEWDSKKNAAIITTDAVEPDPAKKETSPEKTEPGQLTAHFIDVGQGDAIFLEAPCD
HCCEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCC
SHILVDGGLELESQPVVNYLEELGINKIEKVVATHPHQDHIGGLIDVYQNFDVKTTYDSG
CEEEEECCCCCCCCHHHHHHHHHCHHHHHHHHHCCCCHHHHCHHHHHHHCCCEEEECCCC
YEHDTLTYEKYYEIANDVSNFKTARQGDKLEIDSLGAEFIHPPQGHTGEVHDLNLVLEVE
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHCCHHHCCCCCCCCCCEEEEEEEEEEE
FKNQSLLLTGDAEKDTEQMIIERASDISSEILKIGHHGSYTSSSEEFLEAVDPEAAVIQV
ECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCEEEEEE
GEDNQYGHPHDQVLERLAEQNIEIYRTDYHDDIVMELDENTWQAEVEPWKKEDGELPTDQ
CCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCEEECCCCCCCCCCCCCCCC
DADDKDTVTEEKDDQDQELININQAEKEELTQIINIDVDRAEQIVELRKERPFTSLDDLE
CCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHH
RVKGLAEVTIGEIKDEGIAYVD
HHHHHHHHHHHHHCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]