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The map label for this gene is thrC [H]

Identifier: 188586676

GI number: 188586676

Start: 2183987

End: 2185018

Strand: Reverse

Name: thrC [H]

Synonym: Nther_2066

Alternate gene names: 188586676

Gene position: 2185018-2183987 (Counterclockwise)

Preceding gene: 188586677

Following gene: 188586675

Centisome position: 69.02

GC content: 37.5

Gene sequence:

>1032_bases
ATGAATTTTCTTTGTCAAAATTGCGGTAAAATGTATGAAATAACTAGTTTAAATTACACTTGTTCTTGTGGGGGTTTGTT
TGACTTTCAAGGGACTTTTATTGGTGAAATGAAAGAAATGGTTTCTCTGGGGGAACCAGTAACTCCCATAATAACTAAGT
CTTTTAATAATTATCCCTTGAAACTAAAACTTGATCACTTAATGCCTACTGGTTCATTTAAAGATCGAGGGGCTAAGGTA
CTTATAAGTGCATTGAAAAAGTTGGGTATAGAGGAAGTAGTAGAAGACTCGTCAGGTAATGCGGGAGCTGCTATTGCGGC
TTACTGTGCTGCTGCCGGGATTGATTGCCAAATTTATGTTCCTGAGTCTGCTTCGGGCAGCAAATTAAAGCAAATTCAGG
CCTATGGTGCTGAGGTAGTTAAAGTACCTGGGGATAGAGATGATACGTCAAGGGCAGTAAAAAAAGCATGTAAAAACAAT
TATTATGCATCGCATATATATAATCCTTTATTTTTTGAAGGGACTAAAACAATAGCCCATGAAATTTATCAGCAAATAGG
TATACCAAAAACAATGGTGATTCCTGCAGGAAATGGTACTTTATTGCTTGGTGTATATAAAGGATTTTATGAATTAGGGA
ATCTTCCTAAAATTATTGCTGTACAAAGTGAACGTTGTGCCCCATTAACTCAAGAAAGCGATGATACAACTGTTTCAGCT
AGTTCGAATCCGACAGGTGACACTATAGCCAAGGGAATTGCGGCTAAAAACCCACCAAGAAAACTGGAGATGCTTAAGGC
TATTTCAGATAGTAGGGGGCAAGTACTCACTGTATCTGAAGATGAGATAAAATCCTCTAGACAAGCTCTCTGGAATAAGG
GTATTTTTGTTGAAACAACAGCTGCCGTTGCAGTGGCTGGTGCTATAAAGTTATTTGATGCAACTTCATCTTTTGAAAGT
ACTGGCACTTTAAAAACTGATATGCAAGATGTATTGGTGCCATTAACTGGTACTGGATTAAAAGAGTTTTAA

Upstream 100 bases:

>100_bases
GATTTTGTTGTTTTTAAATTATAGTGGATAGAGAAAGAATTTAAATTAACGAACTTTTGAATTATGTATTATCATAAACT
TTGCTAAGGGGAGAATAGCT

Downstream 100 bases:

>100_bases
TTATTAATTTGTTTGGAAGGTGATAATATGACCATGATTATAATTATATTAATAATAAATATAGTTTACGTATCCTTTTT
AACTATTCGGATGTTATTCA

Product: Pyridoxal-5'-phosphate-dependent protein beta subunit

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MNFLCQNCGKMYEITSLNYTCSCGGLFDFQGTFIGEMKEMVSLGEPVTPIITKSFNNYPLKLKLDHLMPTGSFKDRGAKV
LISALKKLGIEEVVEDSSGNAGAAIAAYCAAAGIDCQIYVPESASGSKLKQIQAYGAEVVKVPGDRDDTSRAVKKACKNN
YYASHIYNPLFFEGTKTIAHEIYQQIGIPKTMVIPAGNGTLLLGVYKGFYELGNLPKIIAVQSERCAPLTQESDDTTVSA
SSNPTGDTIAKGIAAKNPPRKLEMLKAISDSRGQVLTVSEDEIKSSRQALWNKGIFVETTAAVAVAGAIKLFDATSSFES
TGTLKTDMQDVLVPLTGTGLKEF

Sequences:

>Translated_343_residues
MNFLCQNCGKMYEITSLNYTCSCGGLFDFQGTFIGEMKEMVSLGEPVTPIITKSFNNYPLKLKLDHLMPTGSFKDRGAKV
LISALKKLGIEEVVEDSSGNAGAAIAAYCAAAGIDCQIYVPESASGSKLKQIQAYGAEVVKVPGDRDDTSRAVKKACKNN
YYASHIYNPLFFEGTKTIAHEIYQQIGIPKTMVIPAGNGTLLLGVYKGFYELGNLPKIIAVQSERCAPLTQESDDTTVSA
SSNPTGDTIAKGIAAKNPPRKLEMLKAISDSRGQVLTVSEDEIKSSRQALWNKGIFVETTAAVAVAGAIKLFDATSSFES
TGTLKTDMQDVLVPLTGTGLKEF
>Mature_343_residues
MNFLCQNCGKMYEITSLNYTCSCGGLFDFQGTFIGEMKEMVSLGEPVTPIITKSFNNYPLKLKLDHLMPTGSFKDRGAKV
LISALKKLGIEEVVEDSSGNAGAAIAAYCAAAGIDCQIYVPESASGSKLKQIQAYGAEVVKVPGDRDDTSRAVKKACKNN
YYASHIYNPLFFEGTKTIAHEIYQQIGIPKTMVIPAGNGTLLLGVYKGFYELGNLPKIIAVQSERCAPLTQESDDTTVSA
SSNPTGDTIAKGIAAKNPPRKLEMLKAISDSRGQVLTVSEDEIKSSRQALWNKGIFVETTAAVAVAGAIKLFDATSSFES
TGTLKTDMQDVLVPLTGTGLKEF

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=303, Percent_Identity=28.7128712871287, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1789505, Length=239, Percent_Identity=28.4518828451883, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17508781, Length=294, Percent_Identity=30.2721088435374, Blast_Score=81, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 36804; Mature: 36804

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFLCQNCGKMYEITSLNYTCSCGGLFDFQGTFIGEMKEMVSLGEPVTPIITKSFNNYPL
CCCHHHHCCCEEEEECCCEEEECCCEECCCCHHHHHHHHHHHCCCCCCHHHHCCCCCCCE
KLKLDHLMPTGSFKDRGAKVLISALKKLGIEEVVEDSSGNAGAAIAAYCAAAGIDCQIYV
EEEECCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEE
PESASGSKLKQIQAYGAEVVKVPGDRDDTSRAVKKACKNNYYASHIYNPLFFEGTKTIAH
CCCCCCHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHCCCCHHHCCCCCEECCHHHHHH
EIYQQIGIPKTMVIPAGNGTLLLGVYKGFYELGNLPKIIAVQSERCAPLTQESDDTTVSA
HHHHHHCCCEEEEEECCCCEEEEHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEEEC
SSNPTGDTIAKGIAAKNPPRKLEMLKAISDSRGQVLTVSEDEIKSSRQALWNKGIFVETT
CCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHCCEEEEEH
AAVAVAGAIKLFDATSSFESTGTLKTDMQDVLVPLTGTGLKEF
HHHHHHHHHHEEECCCCCCCCCCCHHCHHHHEEECCCCCCCCC
>Mature Secondary Structure
MNFLCQNCGKMYEITSLNYTCSCGGLFDFQGTFIGEMKEMVSLGEPVTPIITKSFNNYPL
CCCHHHHCCCEEEEECCCEEEECCCEECCCCHHHHHHHHHHHCCCCCCHHHHCCCCCCCE
KLKLDHLMPTGSFKDRGAKVLISALKKLGIEEVVEDSSGNAGAAIAAYCAAAGIDCQIYV
EEEECCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEE
PESASGSKLKQIQAYGAEVVKVPGDRDDTSRAVKKACKNNYYASHIYNPLFFEGTKTIAH
CCCCCCHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHCCCCHHHCCCCCEECCHHHHHH
EIYQQIGIPKTMVIPAGNGTLLLGVYKGFYELGNLPKIIAVQSERCAPLTQESDDTTVSA
HHHHHHCCCEEEEEECCCCEEEEHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEEEC
SSNPTGDTIAKGIAAKNPPRKLEMLKAISDSRGQVLTVSEDEIKSSRQALWNKGIFVETT
CCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHCCEEEEEH
AAVAVAGAIKLFDATSSFESTGTLKTDMQDVLVPLTGTGLKEF
HHHHHHHHHHEEECCCCCCCCCCCHHCHHHHEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]