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The map label for this gene is uvrB

Identifier: 188586647

GI number: 188586647

Start: 2152042

End: 2154018

Strand: Reverse

Name: uvrB

Synonym: Nther_2037

Alternate gene names: 188586647

Gene position: 2154018-2152042 (Counterclockwise)

Preceding gene: 188586648

Following gene: 188586646

Centisome position: 68.05

GC content: 37.48

Gene sequence:

>1977_bases
ATGAATGAATTTAAATTACAATCTGACTTTTCACTTGAAGGAGATCAACCCAAAGCTGTTGATGAACTGTGTGAAAGTTT
AAATGGAGGTAATTCTCATCAAACACTGTTGGGAGTTACTGGTTCAGGTAAAACCTTTACAATGGCTAATGTTATTCAAA
GATTACAGCGTCCCACCCTTGTTATTGCTCATAATAAAACACTGGCAGCCCAATTATGTGGTGAGTTTAAAGAATTTTTC
CCCGAAAATGCAGTGGAATATTTTGTGAGTTATTACGATTACTATCAACCTGAAGCTTATATACCTCAAACAGATACTTA
TATTGAGAAAGATGCTTCAATTAATGATGAAATTGATAAATTACGCCATTCGGCAACAAGTGCTTTGTTTGAGAGAAGAG
ATGTGATAATTGTAGCTAGTGTTTCCTGTATATATGGTTTGGGGTCACCGGAAGAATACAGAGAACAGGTGTTATCTTTA
AGATGTGGAATGGAAAAGGACCGCGATGAAATTCTAAAAGGATTAGTGGACATCCAATATTCAAGAAATGATGTTAACTT
TACCCGCGGGACCTTTCGAGTAAGAGGCGATGTAATTGAAGTTTTCCCAGCTTCTTATACTGAAACAGCTGTTAGGATAG
AACTGTTTGGTGATGAAATTGAAAGGATAACTGAAATAGATACTTTGACAGGGGAAATACTGGGAGAAAGAAATCATGTG
GCTATTTTTCCTGCATCCCACTTTGTTACCCGTCGAAGCAAATTAGAAAAAGCCATTGAAAGCATTCAGGAAGAGCTTCA
TGAACAACTGGAATACTTAAAAAGACAAGGTAAAGCCGTAGAAGCTAAACGTTTAGAACAACGAACCAACTACGACTTGG
AAATGCTACAAGAGATGGGTTTTTGTCAAGGAATTGAGAACTATTCTAGACATTTGATCGGAAGACCTGCAGGAAGTAGA
CCTTATTGCTTAATTGACTACTTTCCAGATGATTATTTAATGGTAGTAGATGAATCTCATATGACTATCCCTCAAATCAG
GGGTATGTATGCAGGGGATATGTCCCGGAAACAAAATCTTGTAGACCATGGGTTTCGGCTTCCATCAGCCCTTGACAATA
GGCCGTTGAAATTTCAGGAATTTGAAAAAATGATCAATCAAAATATTTACGTTTCTGCTACACCAGGACCATACGAGAAA
GAACATAGTGAAAGAATAGTGGAGCAGATAATCCGACCTACAGGTCTAGTTGACCCTGAAACAGAAGTTAGGCCTGTGAA
AGGGCAAATAGATGATCTATATAGTGAAATTAATAAGCGAACAGACCGTAATGAGAGAGTTTTAGTGACAACATTAACTA
AAAAGATGGCTGAAGATTTAACTGATTATTTGCGTGAAATGGGAATTAGAGTAAGATATATGCATTCAGAAATTGATACT
TTGGAGAGAATGGAAATAATTCGTGATTTGAGACTTGGTAAATTCGATGTACTTGTAGGTATTAACTTGCTAAGAGAAGG
ACTCGATCTACCAGAAGTAAGTCTAGTTGCCATTTTGGATGCAGACAAAGAAGGCTATTTAAGGGATGAAAGGTCTTTAA
TCCAAACTATGGGCCGGGCTGCCCGAAATGTAAACGGGCGAGTAATTATGTATGGGGATGCCATTACAGATTCCATGCGA
AGAGCCATTGATGAAACTAATCGTAGGAGAGAAAAGCAGATTGAATTTAATGCGCGCCATAATATCACACCACAAACTGT
TCAAAAGAAAGTACATGATGTAATTGAAGCTACTAGATCTGCAGAGGACGAAACTGAAGCTGCTACACCAGAAAACATTC
AAGAAATGAGTGCCAAAGAACGTAAAGAGTTAATCGCTAAATTACAGGAAGAAATGAAACAGGCAGCGAAGGAATTAGAA
TTTGAAAAAGCAGCGGAATTAAGAGATTTAATCATGGAGTTAAAAACTGCTCAATAG

Upstream 100 bases:

>100_bases
TTAAAAGTTTACTTGTGAAAAAAAATTTTATAAAATATAATTGATGTTAATAACTATTATTGTCAGCATGTGATATAATT
ATAGCTGGGGGTGGGAAAAT

Downstream 100 bases:

>100_bases
TTTAGTTGGGTCCGATCCGTAGACAGACCTTCTTTCATCCATCGATGTTAATCAATGAAAATTCTTTTAATTAACTATTT
TTATTAGAGGAGTGTTGTCC

Product: Excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 658; Mature: 658

Protein sequence:

>658_residues
MNEFKLQSDFSLEGDQPKAVDELCESLNGGNSHQTLLGVTGSGKTFTMANVIQRLQRPTLVIAHNKTLAAQLCGEFKEFF
PENAVEYFVSYYDYYQPEAYIPQTDTYIEKDASINDEIDKLRHSATSALFERRDVIIVASVSCIYGLGSPEEYREQVLSL
RCGMEKDRDEILKGLVDIQYSRNDVNFTRGTFRVRGDVIEVFPASYTETAVRIELFGDEIERITEIDTLTGEILGERNHV
AIFPASHFVTRRSKLEKAIESIQEELHEQLEYLKRQGKAVEAKRLEQRTNYDLEMLQEMGFCQGIENYSRHLIGRPAGSR
PYCLIDYFPDDYLMVVDESHMTIPQIRGMYAGDMSRKQNLVDHGFRLPSALDNRPLKFQEFEKMINQNIYVSATPGPYEK
EHSERIVEQIIRPTGLVDPETEVRPVKGQIDDLYSEINKRTDRNERVLVTTLTKKMAEDLTDYLREMGIRVRYMHSEIDT
LERMEIIRDLRLGKFDVLVGINLLREGLDLPEVSLVAILDADKEGYLRDERSLIQTMGRAARNVNGRVIMYGDAITDSMR
RAIDETNRRREKQIEFNARHNITPQTVQKKVHDVIEATRSAEDETEAATPENIQEMSAKERKELIAKLQEEMKQAAKELE
FEKAAELRDLIMELKTAQ

Sequences:

>Translated_658_residues
MNEFKLQSDFSLEGDQPKAVDELCESLNGGNSHQTLLGVTGSGKTFTMANVIQRLQRPTLVIAHNKTLAAQLCGEFKEFF
PENAVEYFVSYYDYYQPEAYIPQTDTYIEKDASINDEIDKLRHSATSALFERRDVIIVASVSCIYGLGSPEEYREQVLSL
RCGMEKDRDEILKGLVDIQYSRNDVNFTRGTFRVRGDVIEVFPASYTETAVRIELFGDEIERITEIDTLTGEILGERNHV
AIFPASHFVTRRSKLEKAIESIQEELHEQLEYLKRQGKAVEAKRLEQRTNYDLEMLQEMGFCQGIENYSRHLIGRPAGSR
PYCLIDYFPDDYLMVVDESHMTIPQIRGMYAGDMSRKQNLVDHGFRLPSALDNRPLKFQEFEKMINQNIYVSATPGPYEK
EHSERIVEQIIRPTGLVDPETEVRPVKGQIDDLYSEINKRTDRNERVLVTTLTKKMAEDLTDYLREMGIRVRYMHSEIDT
LERMEIIRDLRLGKFDVLVGINLLREGLDLPEVSLVAILDADKEGYLRDERSLIQTMGRAARNVNGRVIMYGDAITDSMR
RAIDETNRRREKQIEFNARHNITPQTVQKKVHDVIEATRSAEDETEAATPENIQEMSAKERKELIAKLQEEMKQAAKELE
FEKAAELRDLIMELKTAQ
>Mature_658_residues
MNEFKLQSDFSLEGDQPKAVDELCESLNGGNSHQTLLGVTGSGKTFTMANVIQRLQRPTLVIAHNKTLAAQLCGEFKEFF
PENAVEYFVSYYDYYQPEAYIPQTDTYIEKDASINDEIDKLRHSATSALFERRDVIIVASVSCIYGLGSPEEYREQVLSL
RCGMEKDRDEILKGLVDIQYSRNDVNFTRGTFRVRGDVIEVFPASYTETAVRIELFGDEIERITEIDTLTGEILGERNHV
AIFPASHFVTRRSKLEKAIESIQEELHEQLEYLKRQGKAVEAKRLEQRTNYDLEMLQEMGFCQGIENYSRHLIGRPAGSR
PYCLIDYFPDDYLMVVDESHMTIPQIRGMYAGDMSRKQNLVDHGFRLPSALDNRPLKFQEFEKMINQNIYVSATPGPYEK
EHSERIVEQIIRPTGLVDPETEVRPVKGQIDDLYSEINKRTDRNERVLVTTLTKKMAEDLTDYLREMGIRVRYMHSEIDT
LERMEIIRDLRLGKFDVLVGINLLREGLDLPEVSLVAILDADKEGYLRDERSLIQTMGRAARNVNGRVIMYGDAITDSMR
RAIDETNRRREKQIEFNARHNITPQTVQKKVHDVIEATRSAEDETEAATPENIQEMSAKERKELIAKLQEEMKQAAKELE
FEKAAELRDLIMELKTAQ

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=662, Percent_Identity=61.0271903323263, Blast_Score=787, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_NATTJ (B2A713)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001918192.1
- ProteinModelPortal:   B2A713
- SMR:   B2A713
- GeneID:   6317155
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_2037
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 75790; Mature: 75790

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEFKLQSDFSLEGDQPKAVDELCESLNGGNSHQTLLGVTGSGKTFTMANVIQRLQRPTL
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCEEHHHHHHHHHCCCCE
VIAHNKTLAAQLCGEFKEFFPENAVEYFVSYYDYYQPEAYIPQTDTYIEKDASINDEIDK
EEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCHHHHH
LRHSATSALFERRDVIIVASVSCIYGLGSPEEYREQVLSLRCGMEKDRDEILKGLVDIQY
HHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
SRNDVNFTRGTFRVRGDVIEVFPASYTETAVRIELFGDEIERITEIDTLTGEILGERNHV
CCCCCCCCCCEEEEECCEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCE
AIFPASHFVTRRSKLEKAIESIQEELHEQLEYLKRQGKAVEAKRLEQRTNYDLEMLQEMG
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHH
FCQGIENYSRHLIGRPAGSRPYCLIDYFPDDYLMVVDESHMTIPQIRGMYAGDMSRKQNL
HHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEECCCCCHHHHCCCHHCCHHHHHHH
VDHGFRLPSALDNRPLKFQEFEKMINQNIYVSATPGPYEKEHSERIVEQIIRPTGLVDPE
HHHCCCCCHHHCCCCCCHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCC
TEVRPVKGQIDDLYSEINKRTDRNERVLVTTLTKKMAEDLTDYLREMGIRVRYMHSEIDT
CCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHH
LERMEIIRDLRLGKFDVLVGINLLREGLDLPEVSLVAILDADKEGYLRDERSLIQTMGRA
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHH
ARNVNGRVIMYGDAITDSMRRAIDETNRRREKQIEFNARHNITPQTVQKKVHDVIEATRS
HHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHC
AEDETEAATPENIQEMSAKERKELIAKLQEEMKQAAKELEFEKAAELRDLIMELKTAQ
CCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNEFKLQSDFSLEGDQPKAVDELCESLNGGNSHQTLLGVTGSGKTFTMANVIQRLQRPTL
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCEEHHHHHHHHHCCCCE
VIAHNKTLAAQLCGEFKEFFPENAVEYFVSYYDYYQPEAYIPQTDTYIEKDASINDEIDK
EEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCHHHHH
LRHSATSALFERRDVIIVASVSCIYGLGSPEEYREQVLSLRCGMEKDRDEILKGLVDIQY
HHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
SRNDVNFTRGTFRVRGDVIEVFPASYTETAVRIELFGDEIERITEIDTLTGEILGERNHV
CCCCCCCCCCEEEEECCEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCE
AIFPASHFVTRRSKLEKAIESIQEELHEQLEYLKRQGKAVEAKRLEQRTNYDLEMLQEMG
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHH
FCQGIENYSRHLIGRPAGSRPYCLIDYFPDDYLMVVDESHMTIPQIRGMYAGDMSRKQNL
HHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEECCCCCHHHHCCCHHCCHHHHHHH
VDHGFRLPSALDNRPLKFQEFEKMINQNIYVSATPGPYEKEHSERIVEQIIRPTGLVDPE
HHHCCCCCHHHCCCCCCHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCC
TEVRPVKGQIDDLYSEINKRTDRNERVLVTTLTKKMAEDLTDYLREMGIRVRYMHSEIDT
CCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHH
LERMEIIRDLRLGKFDVLVGINLLREGLDLPEVSLVAILDADKEGYLRDERSLIQTMGRA
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHH
ARNVNGRVIMYGDAITDSMRRAIDETNRRREKQIEFNARHNITPQTVQKKVHDVIEATRS
HHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHC
AEDETEAATPENIQEMSAKERKELIAKLQEEMKQAAKELEFEKAAELRDLIMELKTAQ
CCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA