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The map label for this gene is dut [H]

Identifier: 188586583

GI number: 188586583

Start: 2077799

End: 2078221

Strand: Direct

Name: dut [H]

Synonym: Nther_1970

Alternate gene names: 188586583

Gene position: 2077799-2078221 (Clockwise)

Preceding gene: 188586582

Following gene: 188586584

Centisome position: 65.64

GC content: 37.35

Gene sequence:

>423_bases
ATGAAAATTAAAATATCTGCCAAGGATGAACACATGCCGAAATATCAAAATCCTGGTGATGTAGGAGCAGATCTCAAAAG
CGCAGAAGAAGAAACCATTATAATTCCAGCGGGAGAAAATAAACTTATTAAAACTGGAGTCAAAATAGAGTTACCACAAG
ATATCATGGCTACAGTTCATCCCCGAAGCGGACTAGCTAAAAAAGGTATTATAGCCATAACGGGAATTATAGATATAGGT
TTTAGAGGGGAAATAAAAGTAAACTTGGCTAACTTAAGTACCAATCATGTAGAAATCAATCCAGGAGATCGAATAGCTCA
AATGGTATTCAATCCAGTTGTAAAACCAGAGTTTGTTCAAGTGGACAAGCTATCTGAAACAAAGCGGGGAGAAGAAGGTT
TTGGAAGTACTGGCCTGAGTTAA

Upstream 100 bases:

>100_bases
ATTACATTTTTGTTTATAGATGATATAATTAGGAATTAGATGAATCATCAACCGAATTGCAAAGAAGACTAAGTAGATTC
AATAGTTAAGGAGGTATTCG

Downstream 100 bases:

>100_bases
ATTTATTTTGCTGTGATATTTTGTGCTAATATGAACAATTTTTCTATAAATCCTAAGCTAAGAGGTGGATTCATATGTTA
TTATTTGTTGCTTTTAGAAT

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase Dut

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 140; Mature: 140

Protein sequence:

>140_residues
MKIKISAKDEHMPKYQNPGDVGADLKSAEEETIIIPAGENKLIKTGVKIELPQDIMATVHPRSGLAKKGIIAITGIIDIG
FRGEIKVNLANLSTNHVEINPGDRIAQMVFNPVVKPEFVQVDKLSETKRGEEGFGSTGLS

Sequences:

>Translated_140_residues
MKIKISAKDEHMPKYQNPGDVGADLKSAEEETIIIPAGENKLIKTGVKIELPQDIMATVHPRSGLAKKGIIAITGIIDIG
FRGEIKVNLANLSTNHVEINPGDRIAQMVFNPVVKPEFVQVDKLSETKRGEEGFGSTGLS
>Mature_140_residues
MKIKISAKDEHMPKYQNPGDVGADLKSAEEETIIIPAGENKLIKTGVKIELPQDIMATVHPRSGLAKKGIIAITGIIDIG
FRGEIKVNLANLSTNHVEINPGDRIAQMVFNPVVKPEFVQVDKLSETKRGEEGFGSTGLS

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=141, Percent_Identity=39.0070921985816, Blast_Score=94, Evalue=3e-20,
Organism=Homo sapiens, GI4503423, Length=141, Percent_Identity=39.0070921985816, Blast_Score=94, Evalue=5e-20,
Organism=Homo sapiens, GI70906441, Length=141, Percent_Identity=39.0070921985816, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1790071, Length=135, Percent_Identity=36.2962962962963, Blast_Score=92, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71988561, Length=139, Percent_Identity=41.0071942446043, Blast_Score=102, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6319729, Length=140, Percent_Identity=35, Blast_Score=82, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19921126, Length=119, Percent_Identity=42.0168067226891, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24583610, Length=119, Percent_Identity=42.0168067226891, Blast_Score=97, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 15145; Mature: 15145

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKISAKDEHMPKYQNPGDVGADLKSAEEETIIIPAGENKLIKTGVKIELPQDIMATVH
CEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEECCEEEECCHHHHEEEC
PRSGLAKKGIIAITGIIDIGFRGEIKVNLANLSTNHVEINPGDRIAQMVFNPVVKPEFVQ
CCCCCCCCCEEEEEEEEECCCCCEEEEEEECCCCCEEEECCCHHHHHHHHCCCCCCCEEE
VDKLSETKRGEEGFGSTGLS
ECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKIKISAKDEHMPKYQNPGDVGADLKSAEEETIIIPAGENKLIKTGVKIELPQDIMATVH
CEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEECCEEEECCHHHHEEEC
PRSGLAKKGIIAITGIIDIGFRGEIKVNLANLSTNHVEINPGDRIAQMVFNPVVKPEFVQ
CCCCCCCCCEEEEEEEEECCCCCEEEEEEECCCCCEEEECCCHHHHHHHHCCCCCCCEEE
VDKLSETKRGEEGFGSTGLS
ECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA