| Definition | Natranaerobius thermophilus JW/NM-WN-LF, complete genome. |
|---|---|
| Accession | NC_010718 |
| Length | 3,165,557 |
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The map label for this gene is pbpA [H]
Identifier: 188586427
GI number: 188586427
Start: 1881032
End: 1883857
Strand: Direct
Name: pbpA [H]
Synonym: Nther_1812
Alternate gene names: 188586427
Gene position: 1881032-1883857 (Clockwise)
Preceding gene: 188586420
Following gene: 188586446
Centisome position: 59.42
GC content: 39.53
Gene sequence:
>2826_bases ATGAGTCAAAACAAGAAAACCGTAACTAGGTCCCGGTCAAATAAAAAGAAGACCAAAAAAACTTTTAAGTTCAGCAATAA CTCTATGAGAAATATATTAAAGTACGCGGGTATTGCAATTTTAGTTATCATTTTCTTATCTGGTGGAGTTGCCTTTGGCA TGACAATTGCAGCATTACAAGGCACTCCCGATTTCGACCCGGAAAGGATGAGTTCAGCTCTACCGTCGGAAATCCGAGAC CGCAATGGTAATTTAATTGTCAGGTTAGATAGAGAGCAGTACCGGGTTGAAACTGATTTAGATGATGTCCCCGAACATAC TCAGCAGGCTTTTATAGCCATCGAAGATGATAATTTTTACGACCATAGAGGCTTCGATCCTAGGGGGATCATGCGCGCTG CTACCACCAACTTTAGAACAACTGGGAATCCTTTTAGAGGGCCACAGGGTGGAAGTACTATTACACAACAGCTTGTCAAA CATGCTTTTCTGTCACCAAAACAACAATTAGAGCGCAAAATTCAGGAATTATGGTTGGCAATTCAAGTTGAGAGAGTTTA CACTAAAGATGAAATCCTGGAATTTTACTTAAATAATGCAGTTTATTTTAACCATAATGCTTACGGCATTCAAGCTGGCA GCCAAGTTTATTTTGATAAAGATGTCTCAGAACTAACAGTAGAAGAATCTGCCCTATTAGCAGGTGTAATTAAACACCCT AGCAGATTGTCTCCATTTAATAACCCAGAAGATGCAAAACAAAGGCAGGAATTAGTTCTAAGATCTATGAAATCGCAAGA TTTCATTACAAAAGATGAATACAAAACAGCGAAAAGCGTTGGTATAGATGACATGTTAACAGAGCTACCGGAAAGGACAT ATCCTAATCCACATTTTGTCGATTATGTAATAAACGAAGAAGTTATCCCTATTTTAACAGAAATTACAGGTGGGAGTTCT GAAGAGGCCAGGGGTCAAGCAGAAAACCTTCTGTATCATGGTGGATTGACTATCTATACTACTATGGACAAAAGTATGCA GCAAACTGCTGAAAACGTGGTCAATGACTCAAATAATTATCCAACTACCCGTGAAGATGCATCTGGTGTTACTCAACCAC AATCTGCAGTGGTGCTTGCGGATCCGGAAAGTGGTGAATTAAGAGCCCTTGTGGGAGGACGTAATTACGGAATTAATAAT ATGGTTAACAGAACTCTCAGTCGCCGCCAACCTGGTTCAGTAATGAAGCCCATAAATATCTATGCACCAGCAATTGAGGA AAGAATTATTTCACCAGGATCTGTTTTAGATGACGCCCCAATGGTTTTTGATATACCAGACACCAATAGAACTTATACTC CTGAGAACTTTAACCGCAGTTTTGCAGGATTAGTAACAGCTAGAACAGCTTTAGTACGGTCTTTAAATGTACCAGCTGTC GATTTATATGTTAATGAATTAGGAGCAAATAAAGCCGCTGAATACACTGAACAATTTGGAATTACTACCATGACAGAATC TGATAAAAGGAATCCAGCTGCTGCTATCGGTGGCTGGGACCATGGTGTTAAACCAATAGAGGTGAATGCAGCCTTTGCTA CTTTGGCAAATGAAGGAGTAAGGGTGGAACCATATGCTGTTAGGGAAATACAGGACAGAAATGGTGACATCATATATGAA GCAGTACCCGAGAAAAAACCAGTATTATCTGAAGAAACAGCCTGGTTAGTTTCCGATATGTTAAAAGATACAGTTAATTG GGGAACTGCCAGCCAAGTAAACTTGGGAAGACCGGCAGCCGCTAAAACAGGAACTTCCCAAAATCAAAGAGATGGATGGC TATCAACCTATACACCTAACCTTGCTATGACGGTTTGGATTGGTTATGACCGACATGATGCACAAGGTAGTTCCATCTCC AATCCGTGGAGATATACTACTAGTATGGTCAATCAAATTATGGGCCCTTCTCTAGAAGGAATGGAAATAAGAAATTTTCA GAGACCTTCAGGTATCCAAGGTCCAATATCAATTAGCACCAAATCGGGATTATTACCAAGCGATATAACACCTGATGACT ATATAACTTCAGATTATTTTTTGAATAATATGGTCCCAACTCAAGAAGATAATGCCTTTGAAGAAGTTGAAATTTGTTTG GAAAGCGAACAGTTAGCTACTGAAGATTGCCCAGAACACACTTTAGAAACGAAAGTATTCTTAAAAGATCGGTCATATAT GACAACTGATGATCGTTGGACTGGTGGTCCAGGTAGAGTACCGGCAGATACTGAATTGATGGCACCGGAAGAGTCATGTG AAATTCACGGAGACGGTGAAGAAGGTGTTTCACCAGGATTAAGAGGGGATGTAATTCATGATGGTAGAGCGATTAGACTT AGATGGTCTTCTTTAAGAGAAGATATAGCTGGCTATAACCTATACAAACAAGGTCCCCAAGATGATGAATTTGTTTTAAT TAAGGAAAATACAGCCAATACCTTTTTCGTTGACAACGATATCAGTGAAGGTGAAACCTATACCTATCGCTTAACAGAAA TTGATGAAGAAGGAAATGAATCTACTTTTGCACAAACAGTTACCATCAGTGTTGTTACTGATGATACATCCACTGAACAA GAAGATCAGGTTGAGGACGAAACACCTCCAGACCAAGAACAAGAAAATAATCAAGACACAGATGACCCAGAAGAGGACGA AGAAACTGAAACTAAAGAGAATGAACATGAGCCCGAAGAAGAAGAAAATGGTCATTCAACTGATCCTACCGATGATTTAG AAAATGGCAATAACCAGAATGATTAG
Upstream 100 bases:
>100_bases ATTAGTGATTTTAACACAATAAACTATTTTTGGCAAAGCAATTAATCACCTTTTTTACAAAATTTATGTTATAATATTAT TCGTTAAGGAGGGGGTTTAC
Downstream 100 bases:
>100_bases GTTTTAAAAATGATGTAAAAAACAGAATTAATTAAAACAGTACCAATAAAAAACTCTTCCCTAAACTGCGCGGGAAGAGT TTTTTATTCAAAGGACTATA
Product: penicillin-binding protein, 1A family
Products: NA
Alternate protein names: PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]
Number of amino acids: Translated: 941; Mature: 940
Protein sequence:
>941_residues MSQNKKTVTRSRSNKKKTKKTFKFSNNSMRNILKYAGIAILVIIFLSGGVAFGMTIAALQGTPDFDPERMSSALPSEIRD RNGNLIVRLDREQYRVETDLDDVPEHTQQAFIAIEDDNFYDHRGFDPRGIMRAATTNFRTTGNPFRGPQGGSTITQQLVK HAFLSPKQQLERKIQELWLAIQVERVYTKDEILEFYLNNAVYFNHNAYGIQAGSQVYFDKDVSELTVEESALLAGVIKHP SRLSPFNNPEDAKQRQELVLRSMKSQDFITKDEYKTAKSVGIDDMLTELPERTYPNPHFVDYVINEEVIPILTEITGGSS EEARGQAENLLYHGGLTIYTTMDKSMQQTAENVVNDSNNYPTTREDASGVTQPQSAVVLADPESGELRALVGGRNYGINN MVNRTLSRRQPGSVMKPINIYAPAIEERIISPGSVLDDAPMVFDIPDTNRTYTPENFNRSFAGLVTARTALVRSLNVPAV DLYVNELGANKAAEYTEQFGITTMTESDKRNPAAAIGGWDHGVKPIEVNAAFATLANEGVRVEPYAVREIQDRNGDIIYE AVPEKKPVLSEETAWLVSDMLKDTVNWGTASQVNLGRPAAAKTGTSQNQRDGWLSTYTPNLAMTVWIGYDRHDAQGSSIS NPWRYTTSMVNQIMGPSLEGMEIRNFQRPSGIQGPISISTKSGLLPSDITPDDYITSDYFLNNMVPTQEDNAFEEVEICL ESEQLATEDCPEHTLETKVFLKDRSYMTTDDRWTGGPGRVPADTELMAPEESCEIHGDGEEGVSPGLRGDVIHDGRAIRL RWSSLREDIAGYNLYKQGPQDDEFVLIKENTANTFFVDNDISEGETYTYRLTEIDEEGNESTFAQTVTISVVTDDTSTEQ EDQVEDETPPDQEQENNQDTDDPEEDEETETKENEHEPEEEENGHSTDPTDDLENGNNQND
Sequences:
>Translated_941_residues MSQNKKTVTRSRSNKKKTKKTFKFSNNSMRNILKYAGIAILVIIFLSGGVAFGMTIAALQGTPDFDPERMSSALPSEIRD RNGNLIVRLDREQYRVETDLDDVPEHTQQAFIAIEDDNFYDHRGFDPRGIMRAATTNFRTTGNPFRGPQGGSTITQQLVK HAFLSPKQQLERKIQELWLAIQVERVYTKDEILEFYLNNAVYFNHNAYGIQAGSQVYFDKDVSELTVEESALLAGVIKHP SRLSPFNNPEDAKQRQELVLRSMKSQDFITKDEYKTAKSVGIDDMLTELPERTYPNPHFVDYVINEEVIPILTEITGGSS EEARGQAENLLYHGGLTIYTTMDKSMQQTAENVVNDSNNYPTTREDASGVTQPQSAVVLADPESGELRALVGGRNYGINN MVNRTLSRRQPGSVMKPINIYAPAIEERIISPGSVLDDAPMVFDIPDTNRTYTPENFNRSFAGLVTARTALVRSLNVPAV DLYVNELGANKAAEYTEQFGITTMTESDKRNPAAAIGGWDHGVKPIEVNAAFATLANEGVRVEPYAVREIQDRNGDIIYE AVPEKKPVLSEETAWLVSDMLKDTVNWGTASQVNLGRPAAAKTGTSQNQRDGWLSTYTPNLAMTVWIGYDRHDAQGSSIS NPWRYTTSMVNQIMGPSLEGMEIRNFQRPSGIQGPISISTKSGLLPSDITPDDYITSDYFLNNMVPTQEDNAFEEVEICL ESEQLATEDCPEHTLETKVFLKDRSYMTTDDRWTGGPGRVPADTELMAPEESCEIHGDGEEGVSPGLRGDVIHDGRAIRL RWSSLREDIAGYNLYKQGPQDDEFVLIKENTANTFFVDNDISEGETYTYRLTEIDEEGNESTFAQTVTISVVTDDTSTEQ EDQVEDETPPDQEQENNQDTDDPEEDEETETKENEHEPEEEENGHSTDPTDDLENGNNQND >Mature_940_residues SQNKKTVTRSRSNKKKTKKTFKFSNNSMRNILKYAGIAILVIIFLSGGVAFGMTIAALQGTPDFDPERMSSALPSEIRDR NGNLIVRLDREQYRVETDLDDVPEHTQQAFIAIEDDNFYDHRGFDPRGIMRAATTNFRTTGNPFRGPQGGSTITQQLVKH AFLSPKQQLERKIQELWLAIQVERVYTKDEILEFYLNNAVYFNHNAYGIQAGSQVYFDKDVSELTVEESALLAGVIKHPS RLSPFNNPEDAKQRQELVLRSMKSQDFITKDEYKTAKSVGIDDMLTELPERTYPNPHFVDYVINEEVIPILTEITGGSSE EARGQAENLLYHGGLTIYTTMDKSMQQTAENVVNDSNNYPTTREDASGVTQPQSAVVLADPESGELRALVGGRNYGINNM VNRTLSRRQPGSVMKPINIYAPAIEERIISPGSVLDDAPMVFDIPDTNRTYTPENFNRSFAGLVTARTALVRSLNVPAVD LYVNELGANKAAEYTEQFGITTMTESDKRNPAAAIGGWDHGVKPIEVNAAFATLANEGVRVEPYAVREIQDRNGDIIYEA VPEKKPVLSEETAWLVSDMLKDTVNWGTASQVNLGRPAAAKTGTSQNQRDGWLSTYTPNLAMTVWIGYDRHDAQGSSISN PWRYTTSMVNQIMGPSLEGMEIRNFQRPSGIQGPISISTKSGLLPSDITPDDYITSDYFLNNMVPTQEDNAFEEVEICLE SEQLATEDCPEHTLETKVFLKDRSYMTTDDRWTGGPGRVPADTELMAPEESCEIHGDGEEGVSPGLRGDVIHDGRAIRLR WSSLREDIAGYNLYKQGPQDDEFVLIKENTANTFFVDNDISEGETYTYRLTEIDEEGNESTFAQTVTISVVTDDTSTEQE DQVEDETPPDQEQENNQDTDDPEEDEETETKENEHEPEEEENGHSTDPTDDLENGNNQND
Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal
COG id: COG0744
COG function: function code M; Membrane carboxypeptidase (penicillin-binding protein)
Gene ontology:
Cell location: Cell membrane; Single-pass type II membrane protein (Potential) [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI1786343, Length=585, Percent_Identity=29.2307692307692, Blast_Score=194, Evalue=2e-50, Organism=Escherichia coli, GI87082258, Length=326, Percent_Identity=34.9693251533742, Blast_Score=186, Evalue=8e-48, Organism=Escherichia coli, GI1788867, Length=548, Percent_Identity=28.6496350364964, Blast_Score=173, Evalue=4e-44, Organism=Escherichia coli, GI1789601, Length=164, Percent_Identity=37.8048780487805, Blast_Score=94, Evalue=6e-20,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR001264 - InterPro: IPR011816 - InterPro: IPR001460 [H]
Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]
EC number: 2.4.2.-; 3.4.-.-
Molecular weight: Translated: 105251; Mature: 105120
Theoretical pI: Translated: 4.25; Mature: 4.25
Prosite motif: PS50853 FN3
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 2.6 %Cys+Met (Translated Protein) 0.3 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 2.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSQNKKTVTRSRSNKKKTKKTFKFSNNSMRNILKYAGIAILVIIFLSGGVAFGMTIAALQ CCCCCHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHCCHHHCEEEEEEC GTPDFDPERMSSALPSEIRDRNGNLIVRLDREQYRVETDLDDVPEHTQQAFIAIEDDNFY CCCCCCHHHHHHHCCHHHHCCCCCEEEEECHHHHEEECCCHHCCCCCCEEEEEEECCCCC DHRGFDPRGIMRAATTNFRTTGNPFRGPQGGSTITQQLVKHAFLSPKQQLERKIQELWLA CCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH IQVERVYTKDEILEFYLNNAVYFNHNAYGIQAGSQVYFDKDVSELTVEESALLAGVIKHP EEHHHHHHHHHHHHHHHCCEEEECCCEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHCC SRLSPFNNPEDAKQRQELVLRSMKSQDFITKDEYKTAKSVGIDDMLTELPERTYPNPHFV CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCEE DYVINEEVIPILTEITGGSSEEARGQAENLLYHGGLTIYTTMDKSMQQTAENVVNDSNNY EEEECCCCEEHHHCCCCCCCHHHCCHHHHEEEECCEEEEEECCHHHHHHHHHHHCCCCCC PTTREDASGVTQPQSAVVLADPESGELRALVGGRNYGINNMVNRTLSRRQPGSVMKPINI CCCCCCCCCCCCCCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCE YAPAIEERIISPGSVLDDAPMVFDIPDTNRTYTPENFNRSFAGLVTARTALVRSLNVPAV ECCHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEE DLYVNELGANKAAEYTEQFGITTMTESDKRNPAAAIGGWDHGVKPIEVNAAFATLANEGV EEEHHHHCCCHHHHHHHHCCCEEECCCCCCCCCEEECCCCCCCCEEEECHHHHHHHCCCE RVEPYAVREIQDRNGDIIYEAVPEKKPVLSEETAWLVSDMLKDTVNWGTASQVNLGRPAA EECCHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC AKTGTSQNQRDGWLSTYTPNLAMTVWIGYDRHDAQGSSISNPWRYTTSMVNQIMGPSLEG CCCCCCCCCCCCCCEEECCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC MEIRNFQRPSGIQGPISISTKSGLLPSDITPDDYITSDYFLNNMVPTQEDNAFEEVEICL CEECCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHH ESEQLATEDCPEHTLETKVFLKDRSYMTTDDRWTGGPGRVPADTELMAPEESCEIHGDGE CCHHHHHCCCCCHHHCEEEEEECCCEECCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCC EGVSPGLRGDVIHDGRAIRLRWSSLREDIAGYNLYKQGPQDDEFVLIKENTANTFFVDND CCCCCCCCCCEEECCCEEEEEHHHHHHHHHCCCHHCCCCCCCCEEEEEECCCCEEEEECC ISEGETYTYRLTEIDEEGNESTFAQTVTISVVTDDTSTEQEDQVEDETPPDQEQENNQDT CCCCCEEEEEEEECCCCCCCCEEEEEEEEEEEECCCCCCCHHHCCCCCCCCCHHCCCCCC DDPEEDEETETKENEHEPEEEENGHSTDPTDDLENGNNQND CCCCCCHHHHHHHCCCCCCHHHCCCCCCCCHHHHCCCCCCC >Mature Secondary Structure SQNKKTVTRSRSNKKKTKKTFKFSNNSMRNILKYAGIAILVIIFLSGGVAFGMTIAALQ CCCCHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHCCHHHCEEEEEEC GTPDFDPERMSSALPSEIRDRNGNLIVRLDREQYRVETDLDDVPEHTQQAFIAIEDDNFY CCCCCCHHHHHHHCCHHHHCCCCCEEEEECHHHHEEECCCHHCCCCCCEEEEEEECCCCC DHRGFDPRGIMRAATTNFRTTGNPFRGPQGGSTITQQLVKHAFLSPKQQLERKIQELWLA CCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH IQVERVYTKDEILEFYLNNAVYFNHNAYGIQAGSQVYFDKDVSELTVEESALLAGVIKHP EEHHHHHHHHHHHHHHHCCEEEECCCEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHCC SRLSPFNNPEDAKQRQELVLRSMKSQDFITKDEYKTAKSVGIDDMLTELPERTYPNPHFV CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCEE DYVINEEVIPILTEITGGSSEEARGQAENLLYHGGLTIYTTMDKSMQQTAENVVNDSNNY EEEECCCCEEHHHCCCCCCCHHHCCHHHHEEEECCEEEEEECCHHHHHHHHHHHCCCCCC PTTREDASGVTQPQSAVVLADPESGELRALVGGRNYGINNMVNRTLSRRQPGSVMKPINI CCCCCCCCCCCCCCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCE YAPAIEERIISPGSVLDDAPMVFDIPDTNRTYTPENFNRSFAGLVTARTALVRSLNVPAV ECCHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEE DLYVNELGANKAAEYTEQFGITTMTESDKRNPAAAIGGWDHGVKPIEVNAAFATLANEGV EEEHHHHCCCHHHHHHHHCCCEEECCCCCCCCCEEECCCCCCCCEEEECHHHHHHHCCCE RVEPYAVREIQDRNGDIIYEAVPEKKPVLSEETAWLVSDMLKDTVNWGTASQVNLGRPAA EECCHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC AKTGTSQNQRDGWLSTYTPNLAMTVWIGYDRHDAQGSSISNPWRYTTSMVNQIMGPSLEG CCCCCCCCCCCCCCEEECCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC MEIRNFQRPSGIQGPISISTKSGLLPSDITPDDYITSDYFLNNMVPTQEDNAFEEVEICL CEECCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHH ESEQLATEDCPEHTLETKVFLKDRSYMTTDDRWTGGPGRVPADTELMAPEESCEIHGDGE CCHHHHHCCCCCHHHCEEEEEECCCEECCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCC EGVSPGLRGDVIHDGRAIRLRWSSLREDIAGYNLYKQGPQDDEFVLIKENTANTFFVDND CCCCCCCCCCEEECCCEEEEEHHHHHHHHHCCCHHCCCCCCCCEEEEEECCCCEEEEECC ISEGETYTYRLTEIDEEGNESTFAQTVTISVVTDDTSTEQEDQVEDETPPDQEQENNQDT CCCCCEEEEEEEECCCCCCCCEEEEEEEEEEEECCCCCCCHHHCCCCCCCCCHHCCCCCC DDPEEDEETETKENEHEPEEEENGHSTDPTDDLENGNNQND CCCCCCHHHHHHHCCCCCCHHHCCCCCCCCHHHHCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 12552129 [H]