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The map label for this gene is tdk [H]

Identifier: 188586375

GI number: 188586375

Start: 1826796

End: 1827386

Strand: Direct

Name: tdk [H]

Synonym: Nther_1760

Alternate gene names: 188586375

Gene position: 1826796-1827386 (Clockwise)

Preceding gene: 188586374

Following gene: 188586376

Centisome position: 57.71

GC content: 36.04

Gene sequence:

>591_bases
ATGTTTAGACCCGACTGCGGCTGGATTGAAACAATCCATTCATGTGCCATGTTTGCAGGAAAAACCAGAGAACTTTTAAG
AAGATTAGATCACTTGGGCTGGGCCCAAAAGTCTTACATATTATTTAAACCTCATAAAGATAATAGAAATGAACATAATA
TTGCTAAATCCCACAATGGAAATACTTTATCTGCCACCTCTGTATCTTCTCCTCAGGAAATTTTAGACATAACCATTAGA
AAACAACCTGATGCGGTAGCAATTGATGAGGCACAATTTTTTGATACCAAAATTATTGATATTGTCAGCCAGCTAAGAGA
TCAAGGATACTGGGTTATTATAGCCGGATTATCCTCAACTTCAGAGGGGAGACCTTTTAATTCCATGCCTTATTTATTGT
CTATATCCGATAATATTACGCCAATATATGGGGTTTGTGCCAAATGTGGTGGTATAGCTACTAAAACCATAGCTCTCTTT
CCTAAATCCACGGATGTTGAAGTAGGTGGAAAAGAAAAATATGAACCAAGATGTAATAAATGCTGGCAAGAAGATTATAA
TAATACTGACGAAACTGTTGCTAATTCTTAA

Upstream 100 bases:

>100_bases
CCTATTTATTTCATTCTTACAAATGATTATAATATGAGTGTACTTATTTTATTATGATTGAGATATTAAAAATAATTTCG
TTTTTGAGGAGGCTGGACTA

Downstream 100 bases:

>100_bases
CATATTTAAAACAAATCAATTCAATATGTTCCTATAATGCAGGATTTTTCCATTATATGTCGAAATATTAATTATCAAGT
CAACTCTTCTATAAGGAGAT

Product: Thymidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MFRPDCGWIETIHSCAMFAGKTRELLRRLDHLGWAQKSYILFKPHKDNRNEHNIAKSHNGNTLSATSVSSPQEILDITIR
KQPDAVAIDEAQFFDTKIIDIVSQLRDQGYWVIIAGLSSTSEGRPFNSMPYLLSISDNITPIYGVCAKCGGIATKTIALF
PKSTDVEVGGKEKYEPRCNKCWQEDYNNTDETVANS

Sequences:

>Translated_196_residues
MFRPDCGWIETIHSCAMFAGKTRELLRRLDHLGWAQKSYILFKPHKDNRNEHNIAKSHNGNTLSATSVSSPQEILDITIR
KQPDAVAIDEAQFFDTKIIDIVSQLRDQGYWVIIAGLSSTSEGRPFNSMPYLLSISDNITPIYGVCAKCGGIATKTIALF
PKSTDVEVGGKEKYEPRCNKCWQEDYNNTDETVANS
>Mature_196_residues
MFRPDCGWIETIHSCAMFAGKTRELLRRLDHLGWAQKSYILFKPHKDNRNEHNIAKSHNGNTLSATSVSSPQEILDITIR
KQPDAVAIDEAQFFDTKIIDIVSQLRDQGYWVIIAGLSSTSEGRPFNSMPYLLSISDNITPIYGVCAKCGGIATKTIALF
PKSTDVEVGGKEKYEPRCNKCWQEDYNNTDETVANS

Specific function: Phosphorylates Both Thymidine And Deoxyuridine. [C]

COG id: COG1435

COG function: function code F; Thymidine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine kinase family [H]

Homologues:

Organism=Homo sapiens, GI164698438, Length=180, Percent_Identity=28.8888888888889, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17543396, Length=177, Percent_Identity=28.8135593220339, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001267
- InterPro:   IPR020633
- InterPro:   IPR020634 [H]

Pfam domain/function: PF00265 TK [H]

EC number: =2.7.1.21 [H]

Molecular weight: Translated: 21989; Mature: 21989

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00603 TK_CELLULAR_TYPE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRPDCGWIETIHSCAMFAGKTRELLRRLDHLGWAQKSYILFKPHKDNRNEHNIAKSHNG
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHCCCC
NTLSATSVSSPQEILDITIRKQPDAVAIDEAQFFDTKIIDIVSQLRDQGYWVIIAGLSST
CEEEECCCCCCHHHHEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
SEGRPFNSMPYLLSISDNITPIYGVCAKCGGIATKTIALFPKSTDVEVGGKEKYEPRCNK
CCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCCEECCCCCCCCHHHH
CWQEDYNNTDETVANS
HHHHHCCCCCHHHCCC
>Mature Secondary Structure
MFRPDCGWIETIHSCAMFAGKTRELLRRLDHLGWAQKSYILFKPHKDNRNEHNIAKSHNG
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHCCCC
NTLSATSVSSPQEILDITIRKQPDAVAIDEAQFFDTKIIDIVSQLRDQGYWVIIAGLSST
CEEEECCCCCCHHHHEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
SEGRPFNSMPYLLSISDNITPIYGVCAKCGGIATKTIALFPKSTDVEVGGKEKYEPRCNK
CCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCCEECCCCCCCCHHHH
CWQEDYNNTDETVANS
HHHHHCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA