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The map label for this gene is 188586104

Identifier: 188586104

GI number: 188586104

Start: 1550867

End: 1551853

Strand: Direct

Name: 188586104

Synonym: Nther_1478

Alternate gene names: NA

Gene position: 1550867-1551853 (Clockwise)

Preceding gene: 188586103

Following gene: 188586105

Centisome position: 48.99

GC content: 35.76

Gene sequence:

>987_bases
ATGGAATGGCAAGCACTTCATGACAAAACTTTTATTGTCGATGGACATAGTGATACTATTTTAAATTATGACCGTTACGA
GAATTTCGATTTTCTCTACAGTAATGACAATGTTCATATGGACTTACCTAAAATCGATACAGGAGGGATTGATTTACAGT
TTTTTGCTGTATTTATAGAGGATCAATTTCTTCCTAATGCGGGTTTTAAAAATTGTGTCCGTTTATTAGAGACATTTCGG
AACAATATTATAGATAGTCCCAACTTTTCTATGATTGAAACTAAGAAAGACTTAAGAAATGCCATTGATGATGGATCACA
AAAGAAATATGGTTTACTCACCATAGAAGGTGGTGAAGTCCTAGAAGGTGATATAAACCTATTAAGAGCTCTTTATCGAT
TGGGGATCAGGGGAATCACTTTAACGTGGAATAGACGAAATGAATTGGCAGATGGCTGTAGTTTAGGCAAGTATGCCGGT
GGTTTAAGTGATTTTGGCTGTCAAGTAGTTCGAGAAATGAGTAGATTGGGTATGATGGTAGATGTCAGCCATTTGTCTTT
AAATAGTTTTAATCATGTGTTGGAAATTCATGACGAACCTGTAGTTGCAACTCATTCAAATGCTAGTTCAATTTTAAATC
ATCCAAGAAATTTAGACGATAATCAGCTTAAAAAAATTGCTGAAAGTGGTGGAGTTATAGGTCTGAATTATGCATCCCAC
TTCATCACCAACTCTCAGAAAAGAGCTGGCTTAGATGAATTATTTCAACATTTACAATACATGATAAATCTAGTAGGAGA
GGATCATGTGGCTCTAGGCAGTGACTTTGATGGAATATCCAATCCACCCAAAGAAATAAACACAGCCGCCGATTTACCTA
AACTCACCGAATATCTTTGCAAATGTAATCTTAGTGAAACTACTATTCAGAAAGTTTTAGGGGATAATTGGCTCAGGGTA
TTAAACGAGGTATTACCGGAGGATTGA

Upstream 100 bases:

>100_bases
AAGTTGAATGTTGATAACTGTAAAATTCAATTGAAAATTTTACAGTCTAAATAAAACCAGTGCTTAATATTTTAAACCTT
AAGGGAAGGGTGGAATACTA

Downstream 100 bases:

>100_bases
CATTAGAGGTGATTATATGAAATGCTTTGGTGATCTACACATACATACAACAGCTTCTGACGGAGTTCTTCATCCTCATG
AAATTATTGACAGGGCAGAA

Product: Membrane dipeptidase

Products: NA

Alternate protein names: ORF X [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MEWQALHDKTFIVDGHSDTILNYDRYENFDFLYSNDNVHMDLPKIDTGGIDLQFFAVFIEDQFLPNAGFKNCVRLLETFR
NNIIDSPNFSMIETKKDLRNAIDDGSQKKYGLLTIEGGEVLEGDINLLRALYRLGIRGITLTWNRRNELADGCSLGKYAG
GLSDFGCQVVREMSRLGMMVDVSHLSLNSFNHVLEIHDEPVVATHSNASSILNHPRNLDDNQLKKIAESGGVIGLNYASH
FITNSQKRAGLDELFQHLQYMINLVGEDHVALGSDFDGISNPPKEINTAADLPKLTEYLCKCNLSETTIQKVLGDNWLRV
LNEVLPED

Sequences:

>Translated_328_residues
MEWQALHDKTFIVDGHSDTILNYDRYENFDFLYSNDNVHMDLPKIDTGGIDLQFFAVFIEDQFLPNAGFKNCVRLLETFR
NNIIDSPNFSMIETKKDLRNAIDDGSQKKYGLLTIEGGEVLEGDINLLRALYRLGIRGITLTWNRRNELADGCSLGKYAG
GLSDFGCQVVREMSRLGMMVDVSHLSLNSFNHVLEIHDEPVVATHSNASSILNHPRNLDDNQLKKIAESGGVIGLNYASH
FITNSQKRAGLDELFQHLQYMINLVGEDHVALGSDFDGISNPPKEINTAADLPKLTEYLCKCNLSETTIQKVLGDNWLRV
LNEVLPED
>Mature_328_residues
MEWQALHDKTFIVDGHSDTILNYDRYENFDFLYSNDNVHMDLPKIDTGGIDLQFFAVFIEDQFLPNAGFKNCVRLLETFR
NNIIDSPNFSMIETKKDLRNAIDDGSQKKYGLLTIEGGEVLEGDINLLRALYRLGIRGITLTWNRRNELADGCSLGKYAG
GLSDFGCQVVREMSRLGMMVDVSHLSLNSFNHVLEIHDEPVVATHSNASSILNHPRNLDDNQLKKIAESGGVIGLNYASH
FITNSQKRAGLDELFQHLQYMINLVGEDHVALGSDFDGISNPPKEINTAADLPKLTEYLCKCNLSETTIQKVLGDNWLRV
LNEVLPED

Specific function: Unknown

COG id: COG2355

COG function: function code E; Zn-dependent dipeptidase, microsomal dipeptidase homolog

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M19 family [H]

Homologues:

Organism=Homo sapiens, GI189458885, Length=326, Percent_Identity=27.6073619631902, Blast_Score=144, Evalue=9e-35,
Organism=Homo sapiens, GI4758190, Length=326, Percent_Identity=27.6073619631902, Blast_Score=144, Evalue=9e-35,
Organism=Homo sapiens, GI11641269, Length=334, Percent_Identity=28.1437125748503, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI193211608, Length=331, Percent_Identity=26.5861027190332, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI193211610, Length=331, Percent_Identity=26.5861027190332, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI221475880, Length=342, Percent_Identity=31.2865497076023, Blast_Score=157, Evalue=9e-39,
Organism=Drosophila melanogaster, GI281362638, Length=334, Percent_Identity=29.940119760479, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI281362636, Length=334, Percent_Identity=29.940119760479, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI161083233, Length=335, Percent_Identity=28.3582089552239, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI21356391, Length=223, Percent_Identity=27.3542600896861, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008257 [H]

Pfam domain/function: PF01244 Peptidase_M19 [H]

EC number: NA

Molecular weight: Translated: 36909; Mature: 36909

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00869 RENAL_DIPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEWQALHDKTFIVDGHSDTILNYDRYENFDFLYSNDNVHMDLPKIDTGGIDLQFFAVFIE
CCCCCCCCCEEEEECCCCCEECCCCCCCCEEEECCCCEEEECCCCCCCCCCCEEEEEEHH
DQFLPNAGFKNCVRLLETFRNNIIDSPNFSMIETKKDLRNAIDDGSQKKYGLLTIEGGEV
HHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCE
LEGDINLLRALYRLGIRGITLTWNRRNELADGCSLGKYAGGLSDFGCQVVREMSRLGMMV
EHHHHHHHHHHHHCCCCEEEEEECCCHHHHHCCCHHHHCCCCHHHHHHHHHHHHHCCCEE
DVSHLSLNSFNHVLEIHDEPVVATHSNASSILNHPRNLDDNQLKKIAESGGVIGLNYASH
EEHHHHHHCCHHEEEECCCCEEEECCCHHHHHCCCCCCCHHHHHHHHHCCCEEEECHHHH
FITNSQKRAGLDELFQHLQYMINLVGEDHVALGSDFDGISNPPKEINTAADLPKLTEYLC
HHCCCHHCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHCCHHHHHHHH
KCNLSETTIQKVLGDNWLRVLNEVLPED
HCCCCHHHHHHHHCHHHHHHHHHHCCCC
>Mature Secondary Structure
MEWQALHDKTFIVDGHSDTILNYDRYENFDFLYSNDNVHMDLPKIDTGGIDLQFFAVFIE
CCCCCCCCCEEEEECCCCCEECCCCCCCCEEEECCCCEEEECCCCCCCCCCCEEEEEEHH
DQFLPNAGFKNCVRLLETFRNNIIDSPNFSMIETKKDLRNAIDDGSQKKYGLLTIEGGEV
HHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCE
LEGDINLLRALYRLGIRGITLTWNRRNELADGCSLGKYAGGLSDFGCQVVREMSRLGMMV
EHHHHHHHHHHHHCCCCEEEEEECCCHHHHHCCCHHHHCCCCHHHHHHHHHHHHHCCCEE
DVSHLSLNSFNHVLEIHDEPVVATHSNASSILNHPRNLDDNQLKKIAESGGVIGLNYASH
EEHHHHHHCCHHEEEECCCCEEEECCCHHHHHCCCCCCCHHHHHHHHHCCCEEEECHHHH
FITNSQKRAGLDELFQHLQYMINLVGEDHVALGSDFDGISNPPKEINTAADLPKLTEYLC
HHCCCHHCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHCCHHHHHHHH
KCNLSETTIQKVLGDNWLRVLNEVLPED
HCCCCHHHHHHHHCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1313537 [H]